【陶艳梅导师】招生“医学院”研究生介绍
陶艳梅
教授
硕，博士生导师
女
医学院
基础医学
神经疾病机制
ytao@seu.edu.cn
陶艳梅教授的主要研究兴趣是通过构建大脑高级功能（如认知、学习、记忆、情绪、社交能力等）失调的遗传小鼠模型，研究神经精神疾病疑似致病基因的功能和分子机制。重点关注中枢神经系统最晚成熟和最具可塑性的结构——突触和髓鞘——的分子和细胞病理发生机制及其对大脑高级功能的影响。作为第一作者或通讯作者在Nature Neuroscience、PNAS、Journal of Neuroscience、Cell Discovery等杂志上发表论文数十篇，曾获NDC年青研究员奖、浙江省特聘教授、浙江省151人才工程第一层次。迄今先后主持5项国家自然科学基金面上项目，并为2030科技部脑科学与类脑研究重大项目课题骨干。担任Cell&Bioscience的Editorial Board成员，以及eLife、Neuroscience Bulletin、Molecular Brain等多个杂志的评审，并参与国自然、教育部、法国AFM等基金项目评审工作。
主要学习和工作经历：
1991.09-1995.09，南京大学生物系生理专业，大学本科
1995.09-1997.08，南京大学生物系生理专业，硕士
1997.08-2001.09，东南大学医学院生理教研室，助教-讲师
2001.09-2005.10，中科院神经科学研究所，博士
2005.10-2012.01，美国佐治亚医学院，研究人员-助理研究科学家（教职）
2012.01-2023.03，杭州师范大学生命与环境科学学院教授，A类人才引进，浙江省钱江学者特聘教授
2023.04- ，东南大学医学院生理系，教授
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科研项目
1.国家自然科学基金面上项目，智力障碍风险基因LRRC7突变所致早期生长激素缺乏的机制研究，负责人，50万，2026.01-2029.12
2. 国家自然科学基金面上项目，FGFR2调控PV/SST抑制性突触发育的机制及其应用研究，负责人，58万，2022.01-2025.12.
3. 科技创新2030-脑科学与类脑研究重大项目，脑智异常的脑白质发育机制，课题骨干，承担经费125万，2021.12-2026.11.
4. 国家自然科学基金面上项目, ErbB受体的广谱性配体HB-EGF特异性调控中枢局域性髓鞘发育的机制研究， 负责人，59万, 2019.01-2022.12.
5. 国家自然科学基金面上项目，自闭症关联突触蛋白Densin-180的致病机理研究，负责人，62万，2017.01-2020.12.
6. 国家自然科学基金面上项目，ErbB信号通路调节精神分裂症病理病症发生的髓鞘机制研究，负责人，97万，2014.01-2017.12.
7. 国家自然科学基金面上项目，中枢髓鞘晚期发育的关键分子机制及其与精神性疾病相关性的研究，负责人，15万，2012.01-2012.12.
8. 杭州市高层次留学回国人员在杭创新项目，局域性白质损伤与精神分裂症病理病症发生机制的研究，负责人，15万，2016.01-2018.12.
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研究成果
主要发表论文： (*, correspondence or co-correspondence. # , equal contributing first author. )
1. Z. Wei#, S. Zhang#, K. Bai#, Y. Liu#, Y. Luan, Z. Hu, Y. Li, Z. Qu, X. Hu, X. Ding, W. Liang, H. Li, H. He*, Y. Tao*. Distinct FGF-FGFR sets regulate inhibitory presynaptic differentiation from parvalbumin- and somatostatin-positive interneurons. Development 152(13):dev204532. doi: 10.1242/dev.204532, 2025.
(当期重点推荐： Research Highlight “FGF-FGFR combinations control inhibitory synapses”.
人物专访“The people behind the papers - Yanmei Tao and Zhengdong Wei”）
2. X. Hu, Q. Zhu, T. Lou, Q. Hu, H. Li, Y. Xu, X. Niu, L. He, H. Huang, M.Qiu,Y. Shen, J.-M. Jia, Y. Tao*. Pan-ErbB inhibition impairs cognition via disrupting myelination andaerobic glycolysis in oligodendrocytes. Proc. Natl. Acad. Sci. U. S. A. 121(45), e2405152121. doi.org/10.1073/pnas.2405152121, 2024.
(PNAS专文评述: “Revisiting the role of ErbBs in oligodendrocyte development.” doi: 10.1073/pnas.2422181121）
3. X. Hu#, G. Xiao#, L. He#, X. Niu, H. Li, T. Lou, Q. Hu, Y. Yang, Q. Xu, Z. Wei, M. Qiu, K. F. Tanaka, Y. Shen, Y. Tao*. Sustained ErbB activation causes demyelination and hypomyelination by driving necroptosis of mature oligodendrocytes and apoptosis of oligodendrocyte precursor cells. Journal of Neuroscience 41 (48) 9872-9890, 2021. doi: 10.1523/JNEUROSCI.2922-20.2021.
（Featured article, 受到“This week in The Journal”版块重点推荐）
4. X. Hu#, G. Xiao#, L. He#, Q. Zhu, X. Niu, H. Li, Q. Xu, Z. Wei, H. Huang, Y. Luan, M. Qiu, K. F. Tanaka, Y. Shen, Y. Tao*. ErbB dysregulation impairs cognition via myelination-dependent and - independent oligodendropathy. BioRxiv, doi: 10.1101/2020.09.09.289223, 2020.
5. G. Xiao#, H. Li#, X. Hu, X. Niu, Q. Xu, Y. Tao*. Interference of commissural connections through the genu of the corpus callosum specifically impairs sensorimotor gating. Behavioural Brain Research, 411, 113383, 2021.
6. Z.-Y. Luo, L. Huang, S. Lin, Y.-N. Yin, W. Jie, N.-Y. Hu, Y.-Y. Hu, Y.-F. Guan, J.-H. Liu, Q.-L. You, Y.-H. Chen, Z.-C. Luo, S.-R. Zhang, X.-W. Li, J.-M. Yang, Y. Tao, L. Mei, T.-M. Gao*, Erbin in Amygdala Parvalbumin-Positive Neurons Modulates Anxiety-like Behaviors. Biological Psychiatry 87(10):926-936, 2019.
7. X. Ge#, G. Xiao#, H. Huang, J. Du, Y. Tao, A. Yang, H. Wu, Z. Zhang, M. Qiu*. Stage-dependent regulation of oligodendrocyte development and enhancement of myelin repair by dominant negative Master-mind 1 protein. Glia, 67(9):1654-1666, 2019.
8. J. Chen, W. He, X. Hu, Y. Shen, J. Cao, Z. Wei, Y. Luan, L. He, F. Jiang, and Y. Tao*, A role for ErbB signaling in the induction of reactive astrogliosis. Cell Discovery 3: 17044, 2017.
9. Y. Tao#, C. Shen#, S. Luo#, W. Traore, S. Marchetto, M.-J. Santoni, L. Xu, C. Shi, J. Mei, R. Bates, X. Liu, K. Zhao, W.-C. Xiong, J.-P. Borg, L. Mei*, Role of Erbin in ErbB2-dependent breast tumor growth. Proc. Natl. Acad. Sci. U. S. A. doi/10.1073/pnas.1407139111, 2014.
10. Y. Tao, W.-C. Xiong, L. Mei*，Erbin in cortical inhibition. Future Neurology, 8(4): 369-372. doi: 10.2217/fnl.13.18, 2013.
11. Y. Tao*, Isolation and culture of Schwann cells. Neural Development: Methods in Molecular Biology, Vol 1018: 93-104, 2013. (著作)
12. Y. Tao#, Y. Chen#, C. Shen#, Z. Luo, C.R. Bates, D. Lee, S. Marchetto, T. Gao, J. P. Borg, W. -C. Xiong, L. Mei*. Erbin interacts with TARP g-2 for surface expression of AMPA receptors in cortical interneurons. Nature Neuroscience 16(3):290-9. doi: 10.1038/nn.3320, 2013.
13. C. Liang#, Y. Tao*#, C. Shen, W. -C. Xiong, L. Mei*. Erbin is required for axon regeneration and remyelination after nerve injury in adulthood. Journal of Neuroscience 32(43):15169-15180, 2012.
14. A. Ting, Y. Chen, L.Wen, D.-M. Yin, C. Shen, Y. Tao, X. Liu, W.-C. Xiong, L. Mei*. Neuregulin1 promotes excitatory synapse development and function in GABAergic interneurons. Journal of Neuroscience 31(1):15-25, 2011.
15. Y. Tao, P. Dai, Y. Liu, W. -C. Xiong, J. P. Borg, L. Mei*. Erbin regulates neuregulin signaling and myelination. Proc. Natl. Acad. Sci. U. S. A. 106(23):9477-9482, 2009.
( FACULTY OF 1000 BIOLOGY重点推荐)
16. S. Luo, B.Zhang, X.P. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C. Chiu, W. -C. Xiong, L. Mei*. HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron 60(1):97-110, 2008.
17. J. Arikkath, I. Israely, Y. Tao, L. Mei, X. Liu, L. F. Reichardt*. Erbin controls dendritic morphogenesis by regulating localization of delta-Catenin. Journal of Neuroscience 28(28), 7047-7056, 2008.
18. C. Brooks, Q. Wei, L. Feng, G. Dong, Y. Tao, L. Mei, Z.-J. Xie, D. C Chan, Z. Dong*. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with Mitofusins. Proc. Natl. Acad. Sci. U. S. A. 104(28):11649-11654, 2007.
19. R.-S. Woo#, X.M. Li#, Y. Tao, E Carpenter-Hyland, J. Wu, C. Lai, W.-C. Xiong, and L. Mei*. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54(4):599-610, 2007.
20. Y. Liu, Y. Tao, R.-S. Woo, W.-C. Xiong, and Lin Mei*. Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons. Biochemical and Biophysical Research Communications 354(2):505-510, 2007.
21. Y. Tao#, D. Yan#, Q. Yang, R. Zeng, Y. Wang*. Low K+ promotes NF-κB/DNA binding in neuronal apoptosis induced by K+ loss. Molecular and Cellular Biology 26(3):1038-1050, 2006. #, equal contributing first author.
22. Y. Tao#, R. Zeng#, B. Shen#, J. Jia, Y. Wang*. Neuronal transmission stimulates the phosphorylation of Kv1.4 channel at Ser229 through protein kinase A. Journal of Neurochemistry 94(6):1512-1522, 2005. #, equal contributing first author.
23. Y. Tao*, W. Dong, S. Jia, X. Dai. Effect of ginkgo biloba extract (EGb761) on the changes of intracellular calcium concentration and mobility induced by amikacin in outer hair cell isolated from guinea pig cochlear. Chinese Journal of Pharmacology and Toxicology, 15(5):372-376, 2001.
24. Y. Tao*, J. Wu, Y. Wang, Z. Zhang, J. Wang, Z. Hu. Effects of low level laser irradiation on intracellular free calcium concentration and SOD activity in vitro and in vivo study. Applied Laser, 17(2):89-93, 1997.
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