主要研究内容包括医学图像处理及医学图像人工智能、超声成像、三维超声及可视化、生物医学信号处理和医学影像软件。主持与参与多项国家自然科学基金项目、香港政府RGC（研究资助局）项目和香港政府ITF（创新及科技基金）项目。 已经在超声成像系统、超声图像处理，脊柱侧凸超声检测、肌肉骨骼组织功能分析、等方面取得了多项成果，累计发表学术论文50余篇（其中SCI收录论文近30篇），授权专利2项，部分论文以第一作者或通讯作者发表在图像成像与分析领域具有广泛影响力的期刊，如《IEEE Transactions on Medical Imaging》、《Medical Image Analysis》、《IEEE Journal of Biomedical and Health Informatics》、《IEEE Transactions on Biomedical Engineering》、《IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control》、《Ultrasonics》、《Ultrasound in Medicine & Biology》等。

1.     国家自然科学基金委员会，面上项目，61771130，用于脊柱侧凸诊断的三维超声成像关键技术研究，2018/01 至 2021/12，结题，主持

2.     国家自然科学基金委员会，面上项目，61871130，基于OCTA技术的视网膜微血管网络三维提取和量化研究，2019/01至 2022/12，在研，参与

3.     科技部，国家重点研发计划子课题，2018YFA0704102，实体和腔道介入手术机器人及其混合智能系统研发，2019/09 至 2024/08，在研，骨干参与

4.     江苏省社会发展--面上项目，BE2020718，基于神经电生理及肌骨超声评估的原发性肌肉减少症早期预警与康复干预技术体系的构建与推广应用，2020/12-2023/06, 在研，参与

1.       Kai-Ni Wang#, Xin Yang#, Juzheng Miao, Lei Li, Jing Yao, Ping Zhou, Wufeng Xue, Guangquan Zhou*, Xiahai Zhuang*, Dong Ni*. AWSnet: An Auto-weighted Supervision Attention Network for Myocardial Scar and Edema Segmentation in Multi-sequence Cardiac Magnetic Resonance Images. Medical Image Analysis, 2022

2.       Jianan He#, Guangquan Zhou#, Shoujun Zhou*, Yang Chen*. Online Hard Patch Mining using Shape Models and Bandit Algorithm for Multi-organ Segmentation. IEEE Journal of Biomedical and Health Informatics, 2022

3.       Hui-Wen Xie#, Hao Guo#, Guangquan Zhou*, Nghia Q Nguyen, Richard W Prager. Improved ultrasound image quality with pixel-based beamforming using a Wiener-filter and a SNR-dependent coherence factor. Ultrasonics, 2022, 119.

4.       Guangquan Zhou*, Juzheng Miao, Xin Yang*, Rui Li, En-Ze Huo, Wenlong Shi, Yuhao, Huang, Jikuan Qian, Chaoyu Chen, Dong Ni*. Learn Fine-grained Adaptive Loss for Multiple Anatomical Landmark Detection in Medical Images. IEEE Journal of Biomedical and Health Informatics, 2021, 25: 3854-3864

5.       Guangquan Zhou*, En-Ze Huo, Mei Yuan, Ping Zhou, Ruo-Li Wang, Kai-Ni Wang, Yang Chen*, Xiao-Pu He*, A Single-Shot Region-Adaptive Network for Myotendinous Junction Segmentation in Muscular Ultrasound Images, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2020, 67: 2531-2542

6.       Guangquan Zhou*, Dong-Sheng Li, Ping Zhou, Weiwei Jiang, Yongping Zheng. Automating Spine Curvature Measurement in Volumetric Ultrasound via Adaptive Phase Features. Ultrasound in Medicine & Biology, 2020, 46: 828-841

7.       Guangquan Zhou, Weiwei Jiang, KaLee Lai, Yongping Zheng*. Automatic Measurement of Spine Curvature on 3-D Ultrasound Volume Projection Image with Phase Features. IEEE Transactions on Medical Imaging, 2017, 36: 1250-1262

8.       ChungWai James Cheung#, GuangQuan Zhou#, SiuYin Law, TakMan Mak, KaLee Lai, Yongping Zheng#*, Ultrasound Volume Projection Imaging for Assessment of Scoliosis, IEEE Transactions on Medical Imaging, 2015,34: 1760-1768.

9.       Guangquan Zhou, Yongping Zheng*, Automatic Fascicle Length Estimation on Muscle Ultrasound Images with an Orientation-Sensitive Segmentation, IEEE Transactions on Biomedical Engineering, 2015, 62: 2828-2836.

10.     Guangquan Zhou, Yongping Zheng*, Automatic measurement of pennation angle and fascicle length of gastrocnemius muscles using real-time ultrasound imaging, Ultrasonics, 2015, 57:72-83.