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汉,1964.4, 籍贯:常州市,党派:民盟,学历:
987年获原南京铁道医学院学士学位。1993年获原南京铁道医学院微生物学和免疫学专业硕士学位。 2000年获原江苏大学生物环境工程学院博士学位。2002.2-2005.7 先后在美国马里兰大学医学院微生物学和免疫学系,分子细菌学实验室从事霍乱弧菌基因工程疫苗的研究和约翰霍普金斯大学医学院分子生物学实验室从事DNA损伤和修复的研究工作。
主持国家自然科学基金《Eha调控靶基因影响迟缓爱德华菌在巨噬细胞内生存的机制研究》,主要参与国家自然科学基金《TMOs量子点增强的电化学发光研究及在分泌型自噬小体检测中的应用》和《PITX1对胃癌抑瘤作用分子途径及其调控机制的研究 》
江苏省自然科学基金《食管鳞癌hOGG1和MYH蛋白变化及临床意义》《食管鳞状上皮癌细胞中hOGG1蛋白降低对DNA氧化损伤和修复以及对放化疗的影响》《聚合酶链反应对小儿病毒性肠炎、喘憋性肺炎病原的研究》。国家自然科学基金《基因修饰DC诱导调节性T细胞及对EAT治疗作用的研究》。江苏省教委《迟缓爱德华菌毒力因子的研究》。江苏省科委《人体健康与有益微生物应用--SZ21菌用于微生态制剂的研究》。镇江市科委等基金《PCR检测胃幽门螺杆菌》《PCR-SSCP检测抗癌基因P53突变》《PCR检测肿瘤P53基因在肺癌中的意义》《迟缓爱德华菌溶血素的研究》《大学生乙肝流行病学和接种乙肝疫苗研究》
1. Gao D#, Liu N, Tian C, Liu R, Zhao L, Zhang Y, Zheng E, Lu C.Target genes directly regulated by Eha are required for Edwardsiella tarda survival within macrophages.Vet Microbiol. 2020 ;247:108739.
2. Fang Z, Li X, Xu Z,Du F, Wang W, Shi R, Gao D#. Hyaluronic acid-modified mesoporous silica-coated superparamagnetic Fe3O4nanoparticles for targeted drug delivery.
1.Gao D#., Zhang Y, Liu R, Fang Z, Lu C. EsR240, a non-coding sRNA, is required for the resistance of Edwardsiella tarda to stresses in macrophages and for virulence.Vet Microbiol. 2019 ;231:254-263
2.Gao D#., Liu N,Li Y, Zhang Y, Liu G, Xiao G and Lu. C. Deep Sequencing Analysis of the Eha-Regulated Transcriptome of Edwardsiella tarda Following Acidification. Metabolomics. 2017,7(3),196-
3.Gao D#., Li Y, Zheng E, Liu N, Shao Z, Lu C. Eha, a regulator of Edwardsiella tarda, required for resistance to oxidative stress in macrophages. FEMS Microbiol Lett.2016. 363(20)
4.Gao D#., Li Y, Zheng E, Liu N, Shao Z, Lu C. The role of regulator Eha in Edwardsiella tarda pathogenesis andvirulence gene transcription. Microbial Pathogenesis, 2016, 95:216-223,
5.Gao D#., Cheng J, Zheng E, Li Y, Shao Z, Xu Z, Lu C. Eha, a transcriptional regulator of hemolytic activity of Edwardsiella tarda. FEMS Microbiol Lett,2014, 353 (2) 132–140,
6.Gao D#., Hu J, Zhang X, Gao C, Hong J. Effect of hOGG1 Over- expression on Cisplatin Resistance in Esophageal Squamous Carcinoma Cells. Cancer Biother Radiopharm,2013, 28(6):433-440.
7.Bonde P, Gao D, Chen L, Miyashita T, Montgomery E, Harmon JW, Wei C#.. Duodenal reflux leads to down regulation of DNA mismatch repair pathway in an animal model of esophageal cancer. Ann Thorac Surg 2007.83(2):433-40.
8.Bonde P1, Gao D1, Chen L, Duncan M, Miyashita T, Montgomery E, Harmon JW, Wei C#.. Selective decrease in the DNA base excision repair pathway in squamous cell cancer of the esophagus. Thorac Cardiovasc Surg 2007.133(1):74-81
9.Roseborough G1, Gao D1, Chen L, Trush MA, Zhou S, Williams GM, Wei C#..The Mitochondrial K-ATP channel opener, Diazoxide, Prevents Ischemial reperfusion Injury in rabbit spinal cord Am J pathol.2006. 168(5):1443-1451
10.Barouch LA, Gao D, Chen L, Miller KL, Xu W, Phan AC, Kittleson MM, Minhas KM, Berkowitz DE, Wei C, Hare JM#..Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circ Res. 2006 Jan 6;98(1):119-24.
11.McGowan JE, Chen L, Gao D, Trush M, Wei C#. Increased mitochondrial reactive oxygen species production in newborn brain during hypoglycemia Neurosci Lett. 2006 May 15;399(1-2):111-4
12.Zhou X, Gao D, Michalski J, Benitez JA, Kaper JB#.. Induction of IL-8 in T84 cells by Vibrio cholerae .Infect Immun. 2004 Jan;72(1):389-97.
13.Gao D, Wei C, Chen L, Huang J, Yang S, Diehl AM#.. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty disease Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G1070-7.
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