(1)   国家自然科学基金面上项目, 22374019, 基于纳通道技术的新型血脑屏障体外模型的构建及应用, 2024-2027,50万元, 主持。

（2）国家自然科学基金面上项目，22174016，脑胶质瘤单细胞多标志物同时检测新方法及异质性分析研究，2022.01-2025.12，58万元，主持。

（3）国家自然科学基金青年科学基金项目，21705018，基于DNA凝胶的仿生智能离子通道和离子泵的研究及应用，2018.01-2020.12，25万元，主持。

（4）东南大学-南京医科大学合作研究项目，2242017K3DN11，基于纳米技术的miRNA检测与肝癌精准治疗研究，2017.07-2020.06，18万元，主持。

（5）南京大学生命分析化学国家重点实验室开放研究基金，SKLACLS1913，诊疗一体化纳米探针用于耐药肿瘤细胞表面p-糖蛋白的同时检测和抑制：体内和体外评估，2019.03-2020.12, 5万元，主持。

科研奖励：

 第三届高校分析测试优秀青年人才奖

中国化学快报第四届青年编委会委员

中国化学会第十四届全国电分析化学学术会议优秀青年报告奖

 江苏省优秀博士学位论文

东南大学优秀博士学位论文

发表的部分论文：

[33] Hui Liu, Yu Liu, Songqin Liu, and Yafeng Wu*. Simultaneous Monitoring ofIntracellular Glucose and Extracellular Lactate in Single Cells to Assess CellTumorigenicity. Anal. Chem. 2025, 97, 22061-22070.

[32] Zixuan Chen, Yafeng Wu∗,Zhaoyan Tian, Zhaohan Wang, Weiwei Liu, Songqin Liu. A reproducible hybridmembrane for in situ analysis of cell secretions with a wide size range. Chin.Chem. Lett. 2025,36, 110917.

[31] Weiwei Liu, Yu Liu, Zhaoyan Tian, Zhaohan Wang,Hui Liu, Songqin Liu, Yafeng Wu*. Online detecting living cells released TNF-α and studying intercellular communication using SuperDNA self-assembled conical nanochannel. Chin. Chem. Lett. 2025, 36, 110561.

[30] Zixuan Chen, Zhaoyan Tian, Yafeng Wu*, Songqin Liu. DNA tetrahedron nanomedicine for enhanced antitumor and antimetastatic effect through the amplification of mitochondrial oxidative stress. ACTA BIOMATERIALIA 2025, 195, 378-389.

[29] Zhuo Li, Zhaohan Wang, Jun Chen*, Yafeng Wu*. An integrated electrochemical nanodevice for single-cell MiRNA-155 detection and drug evaluation. Biosens. Bioelectron. 2025, 288, 117804.

[28] Yafeng Wu, Qinglin Gu, Zhi Wang, ZhaoyanTian, Zhaohan Wang, Weiwei Liu, Jianyu Han*, Songqin Liu*. Electrochemiluminescence Analysis of Multiple Glycans on Single Living Cell with a Closed Bipolar Electrode Array Chip. Anal. Chem. 2024, 96, 2165-2172.

[27] Zixuan Chen, Zhaoyan Tian, Zhi Wang, Zhaohan Wang, Weiwei Liu, Qinglin Gu, Songqin Liu, Yafeng Wu*. A Portable Device for in Situ Noninvasive Monitoring of Cell Secretions and Communications with Fluorescence and Nanochannel Electrochemistry. Anal. Chem. 2024, 96, 9218-9227.

[26] Zhaohan Wang, Yafeng Wu*, Zhi Wang, Zhaoyan Tian, Yu Liu, Songqin Liu. In situ noninvasive monitoring of cell secretions based on MOFs/AAO hybrid membrane induced asymmetric ion transport. Biosens. Bioelectron. 2024, 266, 116735.

[25] Fengying Shao, Jianyu Han, Zhaoyan Tian, ZhiWang, Songqin Liu, Yafeng Wu*. Synergistic ROS generation and directional overloading of endogenous calcium induce mitochondrial dysfunction in living cells. Biomaterials 2023, 122284.

[24] Zhaoyan Tian, Xiang Qin, Fengying Shao, Xiuxiu Li, Zhi Wang, Songqin Liu*, Yafeng Wu*. Electrofluorochromic imaging analysis of dopamine release from living PC12cells with bipolar nanoelectrodes array. Chin. Chem. Lett. 2023, 34, 107656.

[23] Jianyu Han, Songqin Liu, Zhi Wang, Yafeng Wu*.Micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis. Trends Anal. Chem. 2022, 157, 116799.

[22] Xiuxiu Li, Xiang Qin, Yafeng Wu*,Kang Wang, Xinghua Xia, and Songqin Liu*. Monitoring the electrochemical reactions on a gold nanoelectrode array via fluorescence-enabled electrochemical imaging. Chem. Commun. 2022, 58, 12499.

[21] Xiuxiu Li, Xiang Qin, Zhaoyan Tian, Kang Wang, Xinghua Xia, Yafeng Wu*,and Songqin Liu*. Gold nanowires array-based closed bipolar nanoelectrode systemfor electrochemiluminescence detection of α‑fetoprotein on cell surface. Anal. Chem. 2022,94, 7350-7357.

[20] Juan Su, Zhipeng Yao, Zixuan Chen, Sisi Zhou, Zhi Wang, Hongping Xia*, Songqin Liu*, and Yafeng Wu*. TfR aptamer enhanced Blood-Brain Barrier penetration of biomimetic nanocomplexes for intracellular transglutaminase2 imaging and silencing in glioma. Small 2022, 2203448.

[19] Xiuxiu Li, Xiang Qin, Zhi Wang, Yafeng Wu*, Kang Wang, Xinghua Xia, and Songqin Liu*. In situ imaging of endogenous hydrogen peroxide efflux from living cellsvia bipolar gold nanoelectrode array and electrochemiluminescence technology. ACS Sens. 2022,7, 2446-2453.

[18] Zixuan Chen, Yafeng Wu*, Zhipeng Yao, Juan Su, Zhi Wang, Hongping Xia*, and Songqin Liu*. 2D Copper(II) Metalated Metal-Organic Framework nanocomplexes for dual-enhanced photodynamic therapy and amplified antitumor immunity. ACS Appl. Mater. Interfaces 2022,14, 44199-44210.

[17] Yafeng Wu, Zixuan Chen, Zhipeng Yao, Kaige Zhao, Fengying Shao, Juan Su, Songqin Liu*. Black phosphorus quantum dots encapsulated biodegradable hollow mesoporous MnO2:dual-modality cancer imaging and synergistic chemo-phototherapy. Adv. Funct. Mater. 2021, 31, 2104643.

[16] Sisi Zhou, Yao Yang*, Yafeng Wu*, Songqin Liu*. Multiplexed profiling of biomarkers in extracellular vesicles for cancer diagnosis and therapy monitoring. Anal. Chim. Acta 2021, 1175, 338633.

[15] Fengying Shao, Yafeng Wu*, Zhaoyan Tian, Songqin Liu. Biomimetic nanoreactor for targeted cancer starvation therapy and cascade amplificated chemotherapy. Biomaterials 2021, 274, 120869.

[14] ZhaoyanTian, Yafeng Wu*, Fengying Shao, Dezhi, Tang,Xiang Qin, Chenchen Wang, Songqin Liu*. Electrofluorochromic imaging analysis of glycan expression on living single cell with bipolar electrode arrays. Anal. Chem. 2021, 93, 5114-5122.

[13] SisiZhou, Tao Hu, Gaohua Han, Yafeng Wu*, Xin Hua, Juan Su, Weiwei Jin, Yiping Mou, Xiaozhou Mou, Quan Li, Songqin Liu. Accurate cancer diagnosis and stage monitoring enabled by comprehensive profiling of different types of exosomal biomarkers: surface proteins and miRNAs. Small 2020, 16, 2004492.

[12] Yafeng Wu, Yaqiong Gao, Juan Su, Zixuan Chen, Songqin Liu*. In situ detection of intracellular tissue transglutaminase based on aggregation-induced emission. Chem. Commun. 2020, 56, 9008-9011.

[11] Juan Su, Fubing Wu, Hongping Xia,* Yafeng Wu*, Songqin Liu*. Accurate cancer cell identification and microRNA silencing induced therapy using tailored DNA tetrahedron nanostructures. Chem. Sci. 2020, 11, 80-86.

[10] Sisi Zhou, Tao Hu, Feng Zhang, Dezhi Tang, Dake Li*, Jian Cao, Wei Wei, Yafeng Wu*, Songqin Liu*. Integrated microfluidic device for accurate extracellular vesicle quantification and protein markers analysis directly from human whole blood. Anal.Chem.2020,92, 1574-1581.

[9] Yafeng Wu, Guang Yang, Mingchang Lin, Xiangyu Kong, Li Mi, Songqin Liu, Guosong Chen*, Ye Tian*, Lei Jiang. Continuously tunable ion rectification and conductance insubmicro-channel stemming from thermoresponsive polymer self-assembly. Angew. Chem. Int. Ed. 2019, 58, 1-6.

[8] Yafeng Wu, Fen Zhang, KanWang, Peicheng Luo, Yuanqing Wei, Songqin Liu*. Activatable fluorescence imaging and targeted drug delivery via extracellular vesicle-like porous coordination polymer nanoparticles. Anal. Chem. 2019, 91, 14036-14042.

[7] Yuanqing Wei,Hongping Xia, Fen Zhang, Kan Wang, Peicheng Luo, Yafeng Wu*, Songqin Liu. Theranostic nanoprobe mediated simultaneous monitoring and inhibition of P-glycoprotein potentiating multidrug-resistant cancer therapy. Anal.Chem. 2019,91, 11200-11208.

[6] LiMi, Jing Sui, Yafeng Wu*, Geyu Liang, Yuanjian Zhang, Yuepu Pu, Ye Tian*, Songqin Liu*, Lei Jiang. Bioinspired in vitro lung airway model for inflammatory analysis via hydrophobic nanochannel membrane with joint three-phase interface. Anal. Chem. 2019,91, 15804-15810.

[5] Zhaoyan Tian, Li Mi, Yafeng Wu*, Fengying Shao, Mingqiang Zou, Zhenxian Zhou, and Songqin Liu*. Visual electrofluorochromic detection of cancer cell surface glycoprotein on a closed bipolar electrode chip. Anal. Chem. 2019, 91, 7902-7910.

[4] Cheng Zheng, XueyingQiu, Jianyu Han*, Yafeng Wu*, Songqin Liu. Zero-dimensional-g-CNQD-coordinated two-dimensional porphyrin MOF hybrids for boosting photocatalytic CO2 reduction. ACS Appl. Mater. Interfaces 2019, 11, 42243-42249.

[3] Yaqiong Gao, Yafeng Wu*, Kaige Zhao, Huaisheng Wang, Songqin Liu. In-Situ imaging detection of cell membrane and intracellular cholesterol via cascade reactions. Biosens. Bioelectron. 2019, 126, 249-254.

[2] Kaige Zhao, MinTang, Huaisheng Wang, Zhenxian Zhou, Yafeng Wu*, Songqin Liu*.Simultaneous detection of three biomarkers related to acute myocardial infarction based on immunosensing biochip. Biosens. Bioelectron. 2019,126, 767-772.

[1] Yafeng Wu, Dianyu Wang, Itamar Willner*, Ye Tian*, Lei Jiang*. Smart DNA hydrogel integrated nanochannels with high ion flux and adjustable selective ionic transport. Angew. Chem. Int. Ed. 2018, 57, 7790-7794.

生物传感、单细胞/单分子分析、生物电分析、肿瘤及神经性疾病的精准诊疗

硕、博士研究生招生，欢迎报考！