(1)   国家自然科学基金面上项目, 22374019, 基于纳通道技术的新型血脑屏障体外模型的构建及应用, 2024-2027,50万元, 主持。

（2）国家自然科学基金面上项目，22174016，脑胶质瘤单细胞多标志物同时检测新方法及异质性分析研究，2022.01-2025.12，58万元，主持。

（3）国家自然科学基金青年科学基金项目，21705018，基于DNA凝胶的仿生智能离子通道和离子泵的研究及应用，2018.01-2020.12，25万元，主持。

（4）东南大学-南京医科大学合作研究项目，2242017K3DN11，基于纳米技术的miRNA检测与肝癌精准治疗研究，2017.07-2020.06，18万元，主持。

（5）南京大学生命分析化学国家重点实验室开放研究基金，SKLACLS1913，诊疗一体化纳米探针用于耐药肿瘤细胞表面p-糖蛋白的同时检测和抑制：体内和体外评估，2019.03-2020.12, 5万元，主持。

[1] Yafeng Wu, Qinglin Gu, Zhi Wang, Zhaoyan Tian, Yu Liu, Songqin Liu*. Ultrasensitive Electrochemiluminescence Imaging Detection of Multiple miRNAs in Single Cells with a Closed Bipolar Electrode Array Chip. Anal. Chem. 2024, 96, 12112-12119.

[2] Yafeng Wu, Qinglin Gu, Zhi Wang, Zhaoyan Tian, Zhaohan Wang, Weiwei Liu, Jianyu Han*, Songqin Liu*. Electrochemiluminescence Analysis of Multiple Glycans on Single Living Cell with a Closed Bipolar Electrode Array Chip. Anal. Chem. 2024, 96, 2165-2172.

[3] Zixuan Chen, Zhaoyan Tian, Zhi Wang, Zhaohan Wang, Weiwei Liu, Qinglin Gu, Songqin Liu, Yafeng Wu*. A Portable Device for in Situ Noninvasive Monitoring of Cell Secretions and Communications with Fluorescence and Nanochannel Electrochemistry. Anal. Chem. 2024, 96, 9218-9227.

[4] Zhaohan Wang, Yafeng Wu*, Zhi Wang, Zhaoyan Tian, Yu Liu, Songqin Liu. In situ noninvasive monitoring of cell secretions based on MOFs/AAO hybrid membrane induced asymmetric ion transport. Biosens. Bioelectron. 2024, 266, 116735.

[5] Yafeng Wu,* ZhaoyanTian, Zhi Wang, Zixuan Chen, Fengying Shao,* and Songqin Liu. Site-SpecificLocation of Black Phosphorus Quantum Dot Cluster Based Nanocomplexes forSynergistic Ion Channel Therapy and Hypoxic Microenvironment Activated Chemotherapy. ACS Appl. Mater. Interfaces 2024,16, 52059-52067.

[6] Fengying Shao, Jianyu Han, Zhaoyan Tian, ZhiWang, Songqin Liu, YafengWu*. Synergistic ROS generation and directionaloverloading of endogenous calcium induce mitochondrial dysfunction in livingcells. Biomaterials 2023, 122284.

[7] Zhaoyan Tian, Xiang Qin, Fengying Shao, Xiuxiu Li, Zhi Wang, Songqin Liu*, Yafeng Wu*.Electrofluorochromic imaging analysis of dopamine release from living PC12 cells with bipolar nanoelectrodes array. Chin. Chem. Lett. 2023,34, 107656.

[8] Jianyu Han, Songqin Liu, Zhi Wang, Yafeng Wu*.Micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis. Trends Anal. Chem. 2022, 157, 116799.

[9] Xiuxiu Li, Xiang Qin, Yafeng Wu*,Kang Wang, Xinghua Xia, and Songqin Liu*. Monitoring the electrochemical reactions on a gold nanoelectrode array via fluorescence-enabled electrochemical imaging. Chem. Commun. 2022, 58, 12499.

[10]Xiuxiu Li, Xiang Qin, Zhaoyan Tian, Kang Wang, Xinghua Xia, Yafeng Wu*,and Songqin Liu*. Gold nanowires array-based closed bipolar nanoelectrode system for electrochemiluminescence detection of α‑fetoprotein on cell surface. Anal. Chem. 2022,94, 7350-7357.

[11]Juan Su, Zhipeng Yao, Zixuan Chen, Sisi Zhou, Zhi Wang, Hongping Xia*, Songqin Liu*, and YafengWu*. TfR aptamer enhanced Blood-Brain Barrier penetration of biomimetic nanocomplexes for intracellular transglutaminase2 imaging and silencing in glioma. Small 2022,2203448.

[12] Xiuxiu Li, XiangQin, Zhi Wang, Yafeng Wu*, Kang Wang, Xinghua Xia, and SongqinLiu*. In situ imaging of endogenous hydrogen peroxide efflux from living cellsvia bipolar gold nanoelectrode array and electrochemiluminescence technology. ACS Sens. 2022,7, 2446-2453.

[13] Zixuan Chen, YafengWu*, Zhipeng Yao, Juan Su, Zhi Wang, Hongping Xia*, and Songqin Liu*. 2DCopper(II) Metalated Metal-Organic Framework nanocomplexes for dual-enhanced photodynamictherapy and amplified antitumor immunity. ACS Appl. Mater. Interfaces 2022,14, 44199-44210.

[14] Yafeng Wu,Zixuan Chen, Zhipeng Yao, Kaige Zhao, Fengying Shao, Juan Su, Songqin Liu*. Blackphosphorus quantum dots encapsulated biodegradable hollow mesoporous MnO2:dual-modality cancer imaging and synergistic chemo-phototherapy. Adv. Funct. Mater. 2021, 31, 2104643.

[15] Sisi Zhou, Yao Yang*, Yafeng Wu*, Songqin Liu*. Multiplexedprofiling of biomarkers in extracellular vesicles for cancer diagnosis andtherapy monitoring. Anal. Chim. Acta 2021, 1175, 338633.

[16] FengyingShao, Yafeng Wu*,Zhaoyan Tian, Songqin Liu. Biomimetic nanoreactor for targeted cancer starvationtherapy and cascade amplificated chemotherapy. Biomaterials 2021, 274, 120869.

[17]ZhaoyanTian, Yafeng Wu*, Fengying Shao, Dezhi, Tang,Xiang Qin, Chenchen Wang, Songqin Liu*. Electrofluorochromic imaging analysis of glycan expressionon living single cell with bipolar electrode arrays. Anal. Chem. 2021, 93, 5114-5122.

[18] SisiZhou, Tao Hu, Gaohua Han, Yafeng Wu*, Xin Hua, Juan Su,Weiwei Jin, Yiping Mou, Xiaozhou Mou, Quan Li, Songqin Liu. Accuratecancer diagnosis and stage monitoring enabledby comprehensive profiling of different types of exosomalbiomarkers: surface proteins and miRNAs. Small 2020, 16, 2004492.

[19] Yafeng Wu, Yaqiong Gao, Juan Su, Zixuan Chen, SongqinLiu*. In situ detection of intracellular tissuetransglutaminase based on aggregation-induced emission. Chem. Commun. 2020, 56, 9008-9011.

[20] JuanSu, Fubing Wu, Hongping Xia,* Yafeng Wu*, Songqin Liu*. Accuratecancer cell identification and microRNA silencing induced therapy usingtailored DNA tetrahedron nanostructures. Chem. Sci. 2020, 11, 80-86.

[21] Sisi Zhou, Tao Hu, Feng Zhang, Dezhi Tang,Dake Li*, Jian Cao, Wei Wei, Yafeng Wu*, Songqin Liu*. Integrated microfluidic device for accurateextracellular vesicle quantification and protein markers analysis directly fromhuman whole blood. Anal.Chem.2020,92, 1574-1581.

[22] Yafeng Wu, Guang Yang,Mingchang Lin, Xiangyu Kong, Li Mi, Songqin Liu, Guosong Chen*, Ye Tian*, LeiJiang. Continuously tunable ion rectification and conductance insubmicro-channel stemming from thermoresponsive polymer self-assembly. Angew.Chem. Int. Ed. 2019, 58, 1-6.

[23] Yafeng Wu, Fen Zhang, KanWang, Peicheng Luo, Yuanqing Wei, Songqin Liu*. Activatable fluorescence imagingand targeted drug delivery via extracellular vesicle-like porous coordination polymernanoparticles. Anal.Chem.2019, 91, 14036-14042.

[24] Yuanqing Wei,Hongping Xia, Fen Zhang, Kan Wang, Peicheng Luo, Yafeng Wu*,Songqin Liu. Theranostic nanoprobe mediated simultaneous monitoring and inhibitionof P-glycoprotein potentiating multidrug-resistant cancer therapy. Anal.Chem. 2019,91, 11200-11208.

[25] LiMi, Jing Sui, Yafeng Wu*, Geyu Liang, Yuanjian Zhang,Yuepu Pu, Ye Tian*, Songqin Liu*, Lei Jiang. Bioinspired in vitro lung airway model forinflammatory analysis via hydrophobic nanochannel membrane with jointthree-phase interface. Anal. Chem. 2019,91, 15804-15810.

[26] Zhaoyan Tian, LiMi, Yafeng Wu*, Fengying Shao, Mingqiang Zou, Zhenxian Zhou, andSongqin Liu*. Visual electrofluorochromic detection of cancer cell surface glycoproteinon a closed bipolar electrode chip. Anal. Chem. 2019, 91, 7902-7910.

[27] Cheng Zheng,Xueying Qiu, Jianyu Han*, Yafeng Wu*, Songqin Liu. Zero-dimensional-g-CNQD-coordinatedtwo-dimensional porphyrin MOF hybrids for boosting photocatalytic CO2reduction. ACSAppl. Mater. Interfaces 2019, 11, 42243-42249.

[28] Yaqiong Gao, Yafeng Wu*, KaigeZhao, Huaisheng Wang, Songqin Liu. In-Situ imaging detection of cell membraneand intracellular cholesterol via cascade reactions. Biosens. Bioelectron.2019, 126, 249-254.

[29] Kaige Zhao, MinTang, Huaisheng Wang, Zhenxian Zhou, Yafeng Wu*, Songqin Liu*.Simultaneous detection of three biomarkers related to acute myocardialinfarction based on immunosensing biochip. Biosens. Bioelectron. 2019,126, 767-772.

[30] Yafeng Wu, Dianyu Wang, Itamar Willner*, Ye Tian*, LeiJiang*. Smart DNA hydrogel integrated nanochannels with high ion flux and adjustableselective ionic transport. Angew. Chem. Int. Ed.2018, 57, 7790-7794.

[31] JianyuHan§, Hongping Xia§, Yafeng Wu§(co-first author), Shik Nie Kong, Amudha Deivasigamani, Rong Xu*, Kam M. Hui*,Yuejun Kang*. Single-layer MoS2 nanosheet grafted upconversionnanoparticles for near-infrared fluorescence imaging-guided deep tissue cancerphototherapy. Nanoscale 2016, 8, 7861-7865.

[32] YafengWu, Jianyu Han, Peng Xue, Rong Xu, Yuejun Kang*. Nano Metal-OrganicFramework (NMOF)-Based Strategies for Multiplexed MicroRNA Detection inSolution and Living Cancer Cells. Nanoscale 2015, 7, 1753-1759.

[33] Yafeng Wu,Peng Xue, Kam M. Hui*, Yuejun Kang*. A paper-based microfluidic electrochemicalimmunodevice integrated with amplification-by-polymerization for theultrasensitive multiplexed detection of cancer biomarkers. Biosens.Bioelectron. 2014, 52, 180-187.

[34] Yafeng Wu,Peng Xue, Kam M. Hui*, Yuejun Kang*. Electrochemical- and Fluorescent-MediatedSignal Amplifications for Rapid Detection of Low-Abundance Circulating TumorCells on a Paper-Based Microfluidic Immunodevice. ChemElectroChem2014, 1, 722-727.

[35] Yafeng Wu,Peng Xue, Yuejun Kang*, Kam M. Hui*. Paper-Based Microfluidic ElectrochemicalImmunodevice Integrated with Nanobioprobes onto Graphene Film forUltrasensitive Multiplexed Detection of Cancer Biomarkers. Anal.Chem. 2013, 85, 8661-8668.

[36] Yafeng Wu,Peng Xue, Yuejun Kang*, Kam M. Hui*. Highly Specific and UltrasensitiveGraphene-Enhanced Electrochemical Detection of Low-Abundance Tumor Cells UsingSilica Nanoparticles Coated with Antibody-Conjugated Quantum Dots. Anal. Chem. 2013, 85, 3166-3173.

[37] Yafeng Wu,Songqin Liu*. Target-triggered polymerization for biosensing. AccountsChem. Res. 2012, 45, 1441-1450.

[38] Yafeng Wu,Hao Zhou, Wei Wei, Xin Hua, Lixin Wang, Zhenxian Zhou, Songqin Liu*, SignalAmplification Cytosensor for Evaluation of Drug-Induced Cancer Cell Apoptosis. Anal. Chem. 2012, 84, 1894-1899.

[39] Yafeng Wu, Songqin Liu*, Lin He,Polymerization-assisted signal amplification for electrochemical detection ofbiomarkers. Analyst 2011, 136, 2558-2563.

[40] Yafeng Wu,Songqin Liu*, Lin He, Activators Generated Electron Transfer for Atom TransferRadical Polymerization for Immunosensing. Biosens. Bioelectron. 2010,26, 970-975.

[41] Yafeng Wu,Hongyan Shi, Liang Yuan, Songqin Liu*, A novel electrochemiluminescenceimmunosensor via polymerization-assisted amplification. Chem. Commun. 2010,46, 7763-7765.

[42] Yafeng Wu,Songqin Liu*, Lin He*, Electrochemical biosensing usingamplification-by-polymerization. Anal. Chem. 2009, 81, 7015-7021.

[43] Yafeng Wu,Chengliang Chen, Songqin Liu*, Enzyme-Functionalized Silica Nanoparticles AsSensitive Labels in Biosensing. Anal. Chem. 2009, 81, 1600-1607.

[44] Yafeng Wu,Songqin Liu*, Immunosensing system for ɑ-fetoprotein through boronateimmunoaffinity column in combination with flow injection chemiluminescence. Analyst2009, 134, 230-235.

[45] Yafeng Wu,Yafeng Zhuang, Songqin Liu*, Lin He, Phenylboronic acid immunoaffinity reactorcoupled with flow injection chemiluminescence for determination ofα-fetoprotein. Anal. Chim. Acta 2008, 630, 186-193.

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