[1] 国家自然科学基金面上项目，21978047，面向新型药物载体设计、制备及释药的热力学建模及应用，2020/01-2023/12，66万元，主持

[2] 国家自然科学基金面上项目，21776046，聚合物辅料对药物结晶速率调控的非平衡热力学研究，2018/01-2021/12，64万元，主持[3] 国家自然科学基金青年科学基金项目，21606043，难溶性药物在生物相关性介质中溶解度和溶解机理的研究，2017/01-2019/12，20万元，主持

[4] 江苏省“六大人才高峰”项目，XCL-079，二氧化锰基多功能纳米材料制备关键技术及其在肿瘤治疗中的应用，2018/10-2021/09，主持

[5] 中组部“青年千人计划”，2016年，化学工程，主持

[6] 国际知名药企AbbVie Deutschland GmbH & Co.研究项目，药物在聚合物中溶解动力学模型预测，2015/09-2016/06，主持

[7] 国家自然科学基金面上项目，21176112，面向润滑用的离子液体粘度数据估算研究，2012/01-2015/12，60万元，参与

[8] 德国洪堡基金，2011/12-2014/02，主持

[9] 国家自然科学基金面上项目，20976080，高级氧化技术处理废水中有机毒物的热力学研究，2010/01-2012/12，34万元，参与

[10] 国家自然科学基金青年科学基金项目，20706028，调控二钛酸钾微相结构合成有序介孔氧化钛，2008/01-2010/12，17万元，参与

在国内外重要学术期刊上发表研究论文60余篇，其中SCI收录期刊论文50余篇，EI收录期刊论文46篇，教学改革论文2篇。包括化学工程国际主流期刊AIChE J.，Chem. Eng. Sci.，Ind. Eng. Chem. Res.等以及制药工程、药剂学领域主流期刊Journal of Controlled Release, Pharm. Res., Eur. J. Pharm. Biopharm.和Int. J.Pharm.等。此外，申请人近年来在中、美、德、法等9个国家的国际会议上做口头报告和墙报共35次。

部分代表性论文如下：

[1] Yuanhui Ji*, Dule Hao, Christian Luebbert, Gabriele Sadowski. Insights into influence mechanism of polymeric excipient on drug dissolution: theoretical model analysis and prediction[J]. AIChE Journal, 2021, e17372.

[2] Qiao Chen, Yuanhui Ji*, Kai Ge. Influence of excipients on thermodynamic phase behavior ofpharmaceutical/solvent systems: molecular thermodynamic model prediction[J]. Chemical Engineering Science, 2021, 244: 116798.

[3] Long Cheng, Yuanhui Ji*, Xiaomin Liu, Liwen Mu, Jiahua Zhu. Sorption mechanism of organic dyes on a novel self-nitrogen-doped porous graphite biochar: Coupling DFT calculations with experiments[J]. Chemical Engineering Science, 2021, 242: 116739.

[4] Long Cheng, Yuanhui Ji*, Xiaomin Liu. Insights into interfacial interaction mechanism of dyes sorption on a novel hydrochar:Experimental and DFT study[J]. Chemical Engineering Science, 2021, 233: 116432.

[5] Kai Ge, Yuanhui Ji*. A novel computational approach by combining machine learning with molecular thermodynamics for predicting drug solubility in solvents[J]. Industrial & Engineering Chemistry Research, 2021, 60(25): 9259-9268.

[6] Weikang Fan, Yuanhui Ji*. A novel theoretical strategy for modeling viscosity of polymer melts: modified friction theory with PC-SAFT[J]. Fluid Phase Equilibria, 2021, Accept.

[7] Zheng Zhang, Yuanhui Ji*, Chengqi Lin, Li Tao. Thermosensitive hydrogel-functionalized gold nanorod/mesoporous MnO2 nanoparticles for tumor cell-triggered drug delivery[J]. Materials Science and Engineering: C, 2021, in press, DOI: https://doi.org/10.1016/j.msec.2021.112504.

[8] Yu Cheng, Yuanhui Ji*, Defang Ouyang. FC-BBR/IND induced glucose oxidase nanodrugs for targeted combination therapy[J]. International Journal of Pharmaceutics, 2021, Accept.

[9] Yang Zhang, Yuanhui Ji*, Hongliang Qian*, Progress in thermodynamic simulation and system optimization of thermochemical conversion process of biomass[J].Green Chemical Engineering, 2021, 2 (3): 266-283.

[10] Dule Hao, Zheng Zhang, Yuanhui Ji*. Responsive polymeric drug delivery systems forcombination anticancer therapy: experimental design and computational insights[J]. The International Journal of Polymeric Materials and Polymeric Biomaterials, 2021, Accept.

[11] 吉远辉*, 黄谊平，张茂，程龙. 布洛芬-乙醇-水混合物相分离机制的分子模拟研究[J]. 中国科学 化学，2021，Accept.

[12] Wenbo Kang, Yuanhui Ji*,Yu Cheng. Van der Waals force-driven indomethacin-ss-paclitaxel nanodrugs forreversing multidrug resistance and enhancing NSCLC therapy[J]. International Journal of Pharmaceutics, 2021, 603: 120691.

[13] Long Cheng, Yuanhui Ji*, Qing Shao. Facile modification of hydrochar derived from cotton straw with excellent sorptionperformance for antibiotics: Coupling DFT simulations with experiments[J]. Science of  The Total Environment, 2021, 760: 144124.

[14] 吉远辉*，陈俏，翁靖云. 聚合物辅料对阿司匹林结晶动力学影响机制的非平衡热力学建模及预测[J]. 化工学报，2021,72(1): 508-520.

[15] Kai Ge, Yuanhui Ji*, Xiaohua Lu. A novel interfacial thermodynamic model for predicting solubility of nanoparticles coated by stabilizers[J]. Chinese Journal of Chemical Engineering, 2021, 31: 103-112.

[16] Yongming Tu*, RongjiaWen, Qian Yu, Jie Cao, Yuanhui Ji, Gabriel Sas, Lennart Elfgren. Molecular dynamics study on coupled ion transportin aluminum-doped cement-based materials[J]. Construction and Building Materials, 2021, 295: 123645.

[17] Yiping Huang, Yuanhui Ji*, Mao Zhang, Defang Ouyang. How imidazolium-based ionic liquids solubilize the poorly soluble ibuprofen? A theoretical study[J]. AIChE Journal, 2020, 66(5): e16940.

[18] Shuai Tang, Yuanhui Ji*, Kai Ge. Crystallization kinetics and mechanisms of calcium sulfate dihydrate: Experimental investigation and theoretical analysis[J]. Industrial & Engineering Chemistry Research, 2020, 59(50): 21676-21684.

[19] Kai Ge, Yuanhui Ji*, Shuai Tang. Crystallization kinetics and mechanism of magnesiumammonium phosphate hexahydrate: experimental investigation and chemicalpotential gradient model analysis and prediction[J]. Industrial & Engineering Chemistry Research, 2020, 59(30): 13799-13809.

[20] Yu Cheng, Yuanhui Ji*, Jiwei Tong. Triplestimuli-responsive supramolecular nanoassembly with mitochondrial targetabilityfor chemophotothermal therapy[J]. Journal of Controlled Release, 2020, 327: 35-49.

[21] Zheng Zhang, Yuanhui Ji*. Nanostructured manganese dioxide for anticancer applications:preparation, diagnosis, and therapy[J]. Nanoscale, 2020,12: 17982-18003.

[22] Mao Zhang, Yiping Huang, Dule Hao, Yuanhui Ji*, Defang Ouyang. Solvation structure and molecular interactions of ibuprofen with ethanol and water: A theoretical study[J]. Fluid Phase Equilibria, 2020, 510: 112454.

[23] Dongxu Wu, Yuanhui Ji*. Influence of Polymeric Excipients on the Solubility of Aspirin:Experimental Measurement and Model Prediction[J]. Fluid Phase Equilibria, 2020, 508: 112450.

[24] Zheng Zhang, Yuanhui Ji*, Wei Chen. Hollow MnO2/GNPs serving as a multiresponsivenanocarrier for controlled drug release[J]. Chinese Journal of Chemical Engineering, 2020, 28: 1405-1414.（国内科技期刊）

[25] Raj Schneider, Lütfi Taspinar, Yuanhui Ji, Gabriele Sadowski. The influence of polymericexcipients on desupersaturation profiles of active pharmaceutical ingredients.1: Polyethylene glycol[J]. International Journal of Pharmaceutics, 2020, 582: 119317.

[26] Jingyun Weng, Yiping Huang, Dule Hao, Yuanhui Ji*. Recent advances ofpharmaceutical crystallization theories[J]. Chinese Journal of Chemical Engineering, 2020, 28: 935-948.（国内科技期刊）

[27] Yu Cheng, Yuanhui Ji*. Mitochondria-targeting nanomedicine self-assembled from GSH-responsive paclitaxel-ss-berberine conjugate for synergetic cancertreatment with enhanced cytotoxicity[J]. Journal of Controlled Release，2020, 318: 38-49.

[28] Run Han, Tianhe Huang, Xinyang Liu, Xunqing Yin, Haifeng Li, Jiahong Lu, Yuanhui Ji, Huimin Sun, and Defang Ouyang. Insight into the dissolution molecular mechanism of ternary solid dispersions by combined experiments and molecular simulations[J]. AAPS PharmSciTech, 2019, 20(274):1-14.

[29] Zheng Zhang, Yuanhui Ji*. Mesoporous manganese dioxide coated gold nanorods as amultiresponsive nanoplatform for drug delivery[J]. Industrial &Engineering Chemistry Research, 2019, 58(8): 2991-2999.

[30] Yu Cheng, Yuanhui Ji*. RGD-modified polymer and liposome nanovehicles: Recent researchprogress for drug delivery in cancer therapeutics[J]. European Journal of Pharmaceutical Sciences, 2019, 128: 8-17.

[31] Jinglu Zhang, Run Han, Weijie Chen, Weixiang Zhang,Ying Li*, Yuanhui Ji, Lijiang Chen, Hao Pan, Xinggang Yang, Weisan Pan, Defang Ouyang*. Analysis of theLiterature and Patents on Solid Dispersions from 1980 to 2015[J]. Molecules, 2018, 23, 1697-1716.

[32] Yuanhui Ji*,Max Lemberg, Anke Prudic, Raphael Paus, Gabriele Sadowski. Modeling andanalysis of dissolution of paracetamol/Eudragit® formulations[J]. Chemical Engineering Research and Design, 2017, 121: 22-31.

[33] Yiping Huang, Zheng Wan, Zhen Yang*, Yuanhui Ji*, Li Li, DeshuaiYang, Meihua Zhu, Xiangshu Chen*. Concentration-dependent hydrogen bondbehavior of ethylammonium nitrate protic ionic liquid−water mixtures exploredby molecular dynamics simulations[J]. Journal of Chemical & Engineering Data, 2017, 62: 2340-2349.

[34] Yuanhui Ji*, Anna Katharina Lesniak, Anke Prudic, Raphael Paus, Gabriele Sadowski. Drug release kinetics and mechanism from PLGA formulations[J]. AIChE Journal, 2016, 62(11): 4055-4065.

[35] Yuanhui Ji*,Raphael Paus, Anke Prudic, Christian Lübbert, GabrieleSadowski. A novel approach for analyzing the dissolution mechanism of solid dispersions[J]. Pharmaceutical Research, 2015, 32(8): 2559-2578.

[36] Raphael Paus, Yuanhui Ji*. Modeling and predicting the influence of variable factors ondissolution of crystalline pharmaceuticals[J]. Chemical Engineering Science, 2016, 145: 10-20.

[37] Raphael Paus, Elena Hart, Yuanhui Ji*. A novel approach for predicting the dissolutionprofiles of pharmaceutical tablets[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2015, 96: 53-64.

[38] Raphael Paus, Anke Prudic, Yuanhui Ji*. Influence of excipients on solubility anddissolution of pharmaceuticals[J]. International Journal of Pharmaceutics, 2015, 485(1-2): 277-287.

[39] Raphael Paus, Yuanhui Ji, Lisa Vahle, Gabriele Sadowski*. Predicting the solubility advantageof amorphous pharmaceuticals: a novel thermodynamic approach[J]. Molecular Pharmaceutics, 2015, 12: 2823-2833.

[40] Raphael Paus, Elena Hart, Yuanhui Ji, Gabriele Sadowski*. Solubility and caloricproperties of cinnarizine[J]. Journal of Chemical & Engineering Data, 2015, 60: 2256-2261.

[41] Raphael Paus, Yuanhui Ji, Florian Braak, Gabriele Sadowski*. Dissolution of crystallinepharmaceuticals: experimental investigation and thermodynamic modeling[J]. Industrial & Engineering Chemistry Research, 2015, 54(2): 731-742.

[42] Anke Prudic, Yuanhui Ji, Christian Luebbert, Gabriele Sadowski*. Influence of humidity onthe phase behavior of API/polymer formulations[J]. European Journalof Pharmaceutics and Biopharmaceutics, 2015, 94: 352-362.

[43] Anke Prudic, Anna-Katharina Lesniak, Yuanhui Ji, Gabriele Sadowski*.Thermodynamic phase behaviour of indomethacin/PLGA formulations[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2015, 93: 88-94.

[44] Anke Prudic, Tobias Kleetz, Marcel Korf, Yuanhui Ji, Gabriele Sadowski*.Influence of copolymer composition on the phase behavior of solid dispersions[J]. Molecular Pharmaceutics, 2014, 11(11): 4189-4198.

[45] Anke Prudic, Yuanhui Ji, Gabriele Sadowski*. Thermodynamic phase behavior of API/polymersolid dispersions[J]. Molecular Pharmaceutics,2014, 11(7): 2294-304.

[46] Yuanhui Ji, Xiaoyan Ji, Xiaohua Lu*, Yongming Tu. Modeling mass transfer of CO2 in brine at high pressures by chemical potential gradient[J]. Science China Chemistry, 2013, 56(6): 821-830.

[47] Xiaohua Lu*, Yuanhui Ji, Xin Feng, Xiaoyan Ji. Methodology of non-equilibrium thermodynamics for kinetics research of CO2 capture by ionic liquids[J]. Science China Chemistry, 2012, 55(6): 1079-1091.

[48] Yuanhui Ji,Wenjuan Huang, Xiaohua Lu*, Zhuhong Yang, Xin Feng. Theoretical limitingconcentration for mineralization of trichloromethane and dichloromethane inaqueous solutions by AOPs[J]. Science China Chemistry, 2011, 54(3): 559-564.

[49] Xiaohua Lu*, Yuanhui Ji, Honglai Liu. Non-equilibrium thermodynamics analysis and itsapplication in interfacial mass transfer[J]. Science China Chemistry, 2011, 54(10): 1659-1666.

[50] Yuanhui Ji, Xiaoyan Ji, Chang Liu, Xin Feng, Xiaohua Lu*. Modelling of mass transfer coupling with crystallization kinetics in microscale[J]. Chemical Engineering Science, 2010, 65: 2649-2655.