导师风采
王适之
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个人信息

Personal Information

  • 副教授
  • 导师类别:硕,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:公共卫生学院
  • 所属专业: 公共卫生与预防医学  、 公共卫生
  • 邮箱 : shizhiwang2009@seu.edu.cn
  • 工作电话 : 025-83272566

个人简介

Personal Profile

博士生导师,东南大学“仲英青年学者”。主要致力于探索以生物标志物为基础的环境污染物致疾病和器官毒性的分子流行病学与机制研究。主持完成国家(81302502)和江苏省自然科学基金青年基金(BK20130641)各1项、教育部博士点专项科研基金1项(20130092120063),目前主持在研国家(81872684)和江苏省自然科学基金面上基金项目(BK20171367)各1项,东南大学“仲英青年学者”项目一项。近年来在环境与肿瘤/职业病领域形成了以环境、遗传/表遗传与肿瘤/职业病发生发展及其机制为稳定的研究方向,较系统地开展了多种肿瘤及职业病如噪声聋的遗传易感性及其分子机制研究,形成了人群生物标志物与机制研究密切结合的特色,研究成果发表在《International Journal of Cancer》、《MolecularCarcinogenesis》、《Carcinogenesis》等专业期刊杂志上。目前共发表学术论文50余篇,其中第一作者(通讯作者)SCI收录论文20余篇。相关研究成果获江苏省抗癌协会“江苏肿瘤医学科学技术奖励”三等奖。获聘南京预防医学会“环境卫生专业委员会”委员、江苏省抗癌协会“第一届肿瘤病因学及流行病学委员会”青年委员、中国毒理学会毒理学替代法与转化毒理学专业委员会青年委员、《中华疾病控制杂志》第五届编委会青年委员。


  • 研究方向Research Directions
环境与肿瘤,职业病发病机制
科研项目

1.       东南大学“仲英青年学者”,2020/01-2022/12,30万元,在研,主持

2.       国家自然科学基金面上项目,81872684,MiR-143/145宿主基因CARMN低表达参与宫颈癌遗传易感及其机制研究,2019/01-2022/12,57万元,在研,主持

3.       江苏省自然科学基金面上项目,BK20171367,LncRNAMIR143HG及其遗传变异与宫颈癌易感性的机制研究,2017/07-2020/06,10万元,结题,主持

4.       国家自然科学青年基金项目,81302502,miR-143基因启动子区遗传变异影响基因转录调控机制及与宫颈癌发生危险性的研究,2014/01-2016/12,23万元,已结题,主持

5.       江苏省自然科学青年基金项目,BK20130641,miR-21基因启动子区多态变异与宫颈癌遗传易感性及其机制探讨,2013/07-2016/6,20万元,已结题,主持

6.       教育部博士点基金(新教师类),20130092120063,miR-143基因启动子区多态变异与宫颈癌遗传易感性的研究,2014/01-2016/12,4万元,已结题,主持


研究成果

1.        Wang Shizhi*, Ding Bo, Cui Mengjing, Yan Wenjing, Xia Qianqian, Meng Dan, Shen Siyuan,Xie Shuqian, Jin Hua, Zhang Xing*. Fanconi Anemia Pathway Genes Advance Cervical Cancer via ImmuneRegulation and Cell Adhesion. Front Cell Dev Biol. doi.org/10.3389/fgene.2021.707299. Online. 

2.        Zhu Chuanhui#, Xia Qianqian#, Gu Bin, Cui Mengjing, Zhang Xing, Yan Wenjing, Meng Dan, Shen Siyuan,Xie Shuqian, Li Xueliang*, Jin Hua*, Wang Shizhi*. Esophageal Cancer Associated Immune Genes asBiomarkers for Predicting Outcome in Upper Gastrointestinal Tumors. FrontGenet. 2021 Jul 19;12:707299.

3.        Meng Dan#, Jin Hua#, Zhang Xing, Yan Wenjing, Xia Qianqian, Shen Siyuan, Xie Shuqian, CuiMengjing, Ding Bo, Gu Yun*, Wang Shizhi*. Identification of autophagy-related risksignatures for the prognosis, diagnosis, and targeted therapy in cervicalcancer. Cancer Cell Int. 2021 Jul 8;21(1):362.

4.        Yan Wenjing#, Jin Hua#, Zhang Xing, Long Sigui, Xia Qianqian, Meng Dan, Ding Bo, Li Dake,Ma Jingru, Cao Jian*, and WangShizhi*. Identification of an immune signature topredict poor clinical outcome in cervical cancer. Epigenomics. 2021Jun;13(11):891-907.

5.        Xia Qianqian#, Jin Hua #, Zhang Xing, Yan Wenjing, Meng Dan, Ding Bo, Cao Jian, Li Dake*, WangShizhi*. Prognosis prediction signature of sevenimmune genes based on HPV status in cervical cancer. InternationalImmunopharmacology. 2020; 88:106935

6.        Zhang Yan, Zhang Xing, Zhu Haixia, Liu Yang, Cao Jian, Li Dake,Ding Bo, Yan Wenjing, Jin Hua*, Wang Shizhi*. Identification of Potential Prognostic LongNon-Coding RNA Biomarkers for Predicting Recurrence in Patients with CervicalCancer. CancerManagement and Research.2020;12: 719-730.

7.        Wang Shizhi*, Zhu Haixia, Ding Bo, Feng Xinrui, Zhao Wenxuan, Cui Mengjing, XuYuling, Shi Minxing, Chen Jian, Jin Hua*. Genetic variants in microRNAs are associated with cervical cancerrisk. Mutagenesis. 2019 May 29;34(2):127-133.

8.        Gu Bin, Li Meng, Zhang Yan, Li Lingyun, Yao Kun, Wang Shizhi*. DR7 encoded by human herpesvirus 6 promotesglioma development and progression. Cancer Management and Research. 2019 Mar12;11:2109-2118.

9.        Li Xiuting, Dong Qiu, Wang Boshen, Song Haiyan, Wang Shizhi*, Zhu Baoli*. The Influence of Occupational Noise Exposure on Cardiovascularand Hearing Conditions among Industrial Workers. Scientific Reports.2019;9:11524

10.     Gu Bin, Li Lingyun, Li Meng, Wang Jinfeng,Zhang Guofeng, Yao Kun, Wang Shizhi*. U94/rep of human herpesvirus 6 inhibitsproliferation, invasion, and angiogenesis of glioma. Cancer Management and Research.2018 Nov 20;10:5991-6001.

11.     Jin Hua#, Lu Xiaoyun#, Ni Jing#, Sun Jinfang, Gu Bin, Ding Bo, Zhu Haixia, Ma Chao, Cui Mengjing,Xu Yuling, Zhang Zhengdong, Lercher Martin, Chen Jian*, Gao Na*, Wang Shizhi*, HOTAIR rs7958904 polymorphism is associatedwith increased cervical cancer risk in a Chinese population [J]. Scientific Reports.2017, 7(1):3144.

12.     Meng Qingtao#, Wang Shizhi#, Tang Weiyan#, Wu Shenshen, Gao Nao, Zhang Chengcheng, Cao Xiaoli, Li Xiaobo,Zhang Zhengdong, Aschner Michael, Jin Hua*, Huang Yue*, Chen Rui*. XRCC1 mediated the development of cervival cancer through a novelSp1/Krox-20 swich. Oncotarget. 2017 Sep 16;8(49):86217-86226.

13.     Wu Shenshen#, Wang Shizhi#, Fu You, Tang Weiyan, Jin Hua, Meng Qingtao,Zhang Chengcheng, Cui Mengjing, Cao Xiaoli, Li Xiaobo, Zhang Zhengdong, Chen Rui*, A novel mechanism of rs763110 polymorphismcontributing to cervical cancer risk by affecting the binding affinity ofC/EBPbeta and OCT1 complex to chromatin [J]. International Journal of Cancer,2017, 140(4): 756-763.

14.     Wang Shizhi#, Ma Gaoxiang#, Zhu Haixia#, Lv Chunye#, Chu Haiyan, Tong Na, Wu Dongmei, Qiang Fulin,Gong Weida, Zhao Qinghong, Tao Guoquan, Zhou Jianwei, Zhang Zhengdong*, Wang Meilin*, miR-107 regulates tumor progression by targeting NF1 in gastriccancer [J]. Scientific Reports, 2016, 6: 36531.

15.     Wang Shizhi*, Cao Xiaoli, Ding Bo, Chen Jinfeng, Cui Mengjing, Xu Yuling, LuXiaoyun, Zhang Zhengdong, He Aiqin, Jin Hua*, The rs767649 polymorphism in the promoter of miR-155 contributesto the decreased risk for cervical cancer in a Chinese population [J]. Gene,2016, 595(1): 109-114.

16.     Wang Shizhi, Wu Shenshen, Zhu Haixia, Ding Bo, Cai Yunlang, Ni Jing, Wu Qiang,Meng Qingtao, Zhang Xin, Zhang Chengcheng, Li Xiaobo, Wang Meilin, Chen Rui*, Jin Hua*, Zhang Zhengdong*, PSCA rs2294008 polymorphism contributes to the decreased risk forcervical cancer in a Chinese population [J]. Scientific Reports, 2016, 6:23465.

17.     Wang Shizhi, Wu Shenshen, Meng Qingtao, Li Xiaobo, Zhang Jinchun, Chen Rui*, Wang Meilin*, FAS rs2234767 and rs1800682 polymorphisms jointly contributed torisk of colorectal cancer by affecting SP1/STAT1 complex recruitment tochromatin, Scientific Reports, 2016, 6: 19229.

18.     Wang Shizhi, Lv Chunye, Jin Hua, Xu Ming, Kang Meiyun, Chu Haiyan, Tong Na, WuDongmei, Zhu Haixia, Gong Weida, Zhao Qinghong, Tao Guoquan, Zhou Jianwei,Zhang Zhengdong*, Wang Meilin, A common genetic variation inthe promoter of miR-107 is associated with gastric adenocarcinomasusceptibility and survival, Mutation Research, 2014, 769: 35-41.

19.     Wang Shizhi, Chen Lulu, Zhao Qinghong, Rong Huan, Wang Meilin, Gong Weida, ZhouJianwei, Wu Dongmei, Zhang Zhengdong*, Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survivalof gastric cancer among patients who receiving 5-fluorouracil-basedpostoperative adjuvant chemotherapy, Cancer Chemother Pharmacol, 2013, 71(4):1073-1082.

20.     Wang Shizhi, Tao Guoquan, Wu Dongmei, Zhu Haixia, Gao Yan, Tan Yongfei, WangMeilin, Gong Weida, Zhou Yan, Zhou Jianwei, Zhang Zhengdong*, A functional polymorphism in MIR196A2 isassociated with risk and prognosis of gastric cancer, Mol Carcinog, 2013, 52Suppl 1: E87-95.

21.     Shi Danni#, Wang Shizhi#, Gu Dongying#, Wu Dongmei, Wang Meilin, Chu Haiyan, Tong Na, Ma Lan, ZhongDongyan, Zhang Zhengdong*, The PSCA polymorphisms derived fromgenome-wide association study are associated with risk of gastric cancer: ameta-analysis, J Cancer Res Clin Oncol, 2012, 138(8): 1339-1345.

22.     Wang Shizhi, Tian Yuanyuan, Wu Dongmei, Zhu Haixia, Luo Dewei, Gong Weida,Zhou Yan, Zhou Jianwei, Zhang Zhengdong*, Genetic variation of CTNNB1 gene is associated withsusceptibility and prognosis of gastric cancer in a Chinese population,Mutagenesis, 2012, 27(6): 623-630.

23.     Wang Shizhi, Tang Jialin, Wang Meilin, Yuan Lin, Zhang Zhengdong*, Genetic variation in PSCA and bladder cancersusceptibility in a Chinese population, Carcinogenesis, 2010, 31(4): 621-624.

# & * indicate co-first authorand co-corresponding author, respectively.


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