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张莎莎,东南大学生命科学与技术学院副研究员,博士生导师。本科和博士均毕业于清华大学,师从李蓬院士。在东南大学先后任讲师、副研究员,主要从事内耳毛细胞保护和再生,及耳聋基因致聋机制等方面的研究。先后获得国自然面上、青年,江苏省优青、青年,江苏省333工程,东南大学至善青年学者等人才和基金项目的支持。研究成果已发表高水平SCI论文31篇,总影响因子232.59;其中第一作者和通讯作者12篇,一作和通讯总影响因子78.087(其中大于9分3篇,Faculty1000三星Exceptional推荐1篇,ESI高被引论文1篇);以副主编出版专著1部。现任中国生物物理学会听觉、语言和交流分会青年委员会委员,中国听力医学发展基金会专家指导委员会基础研究专家委员会委员,江苏省发育生物学会听觉专业委员会委员,江苏省医学会听力学分会委会会委员,以及Frontiers inCell and Developmental Biology杂志和Frontiers in Molecular Medicine杂志Review Editor。
属于东南大学生命科学与技术学院副院长、长江特聘学者柴人杰教授团队。本团队主要从事听力学相关研究,致力于耳蜗毛细胞的保护和再生,致聋机制的研究和毛细胞保护,遗传性耳聋的机制及基因治疗,螺旋神经元的保护和再生等研究方向。
国家自然科学基金面上项目(2020)
国家自然科学基金青年项目(2016)
江苏省科技厅优秀青年项目(2019)
江苏省科技厅青年项目(2015)
江苏省第六期“333高层次人才培养工程(2022)
东南大学至善青年学者人才计划(2019)
江苏省科协青年科技人才托举工程(2018)
科技部国家重点研发计划干细胞项目子课题三骨干(2017)
国家自然科学基金面上项目(2020)
国家自然科学基金青年项目(2016)
江苏省科技厅优秀青年项目(2019)
江苏省科技厅青年项目(2015)
江苏省第六期“333高层次人才培养工程(2022)
东南大学至善青年学者人才计划(2019)
江苏省科协青年科技人才托举工程(2018)
科技部国家重点研发计划干细胞项目子课题三骨干(2017)
1. PeiJiang#, Xiangyu Ma#, Shanying Han#, Leyao Ma#, Jingru Ai, Leilei Wu, YuanZhang, Hairong Xiao, Mengyao Tian, W.Andy Tao*, Shasha Zhang* (通讯作者),and Renjie Chai*, Characterization of the microRNA transcriptomes andproteomics of cochlear tissue-derived small extracellular vesicles from mice ofdifferent ages after birth. Cellular and MolecularLife Sciences, 2022. 79(3): p. 154.
2. Shasha Zhang#(第一作者),Ying Dong#, RuiyingQiang#, YuanZhang#, XiaoliZhang, Yin Chen, Pei Jiang, Xiangyu Ma, Leilei Wu, Jingru Ai, Xia Gao, PengjunWang*,Jie Chen*,and Renjie Chai*, Characterization of Strip1 Expression in MouseCochlear Hair Cells. Frontiers inGenetics, 12: p. 625867, 2021.
3. YinChen#,Ruiying Qiang#,Yuan Zhang#,Wei Cao#,Leilei Wu, Pei Jiang, Jingru Ai, Xiangyu Ma, Ying Dong, Xia Gao, He Li*, LingLu*, Shasha Zhang* (通讯作者) and RenjieChai*, The Expression and Roles of the Super Elongation Complex in Mouse CochlearLgr5+ Progenitor Cells. Frontiers inCellular Neuroscience, 5: p. 735723, 2021.
4. Shasha Zhang#(第一作者), Yuan Zhang, Lingna Guo,Zhong Zhang, Ying Dong, Buwei Shao, Jieyu Qi, Han Zhou, Weijie Zhu, XiaoqianYan, Guodong Hong, Liyan Zhang, Xiaoli Zhang, Mingliang Tang, Chunjie Zhao, XiaGao, Renjie Chai*. Knock-down of Foxg1 in Supporting Cells Increases theTransdifferentiation of Supporting Cells into Hair Cells in the Neonatal MouseCochlea. Cellular and Molecular LifeSciences, 77(7): 1401-1419, 2020
5. Yuan Zhang#, ShashaZhang#(共同第一作者), Zhonghong Zhang#, YingDong, Xiangyu Ma, Ruiying Qiang, Yin Chen, Xia Gao, Chunjie Zhao, Fangyi Chen,Shuangba He*, Renjie Chai*, Knockdown of Foxg1 in Sox9+ supporting cellsincreases the trans-differentiation of supporting cells into hair cells in theneonatal mouse utricle. Aging-US, 12(20): p. 19834-19851,2020
6. Pei Jiang#, ShashaZhang#(共同第一作者), Cheng Cheng, Song Gao,Mingliang Tang, Ling Lu, Guang Yang, and Renjie Chai, The Roles of Exosomes inVisual and Auditory Systems. Frontiers inBioengineering and Biotechnology, 8: p. 525, 2020
7. Shasha Zhang#(第一作者), Dingding Liu, Zhong Zhang, YuanZhang, Ying Dong, Han Zhou, Lingna Guo, Jieyu Qi, Ruiying Qiang, MingliangTang, Xia Gao, Chunjie Zhao, Xiaoyun Chen*, Xiaoyun Qian*, Renjie Chai*.Frizzled-9+ supporting cells are inner ear progenitors for the generation ofhair cells in the postnatal mouse cochlea. Frontiersin Molecular Neuroscience, 12:184, 2019
8. Shasha Zhang#(第一作者), Yuan Zhang, Pengfei Yu, Yao Hu, HanZhou, Lingna Guo, Xiaochen Xu, Xiaocheng Zhu, Muhammad Waqas, Jieyu Qi, XiaoliZhang, Xiaoyun Qian, Fangyi Chen,Mingliang Tang, Yan Liu, Haibo Shi*, XiaGao*,Renjie Chai*.Characterization of Lgr5+ progenitor cell transcriptomesafter neomycin injury in the neonatal mouse cochleae. Frontiers in Molecular Neuroscience, 10:213, 2017
9. Rongrong Guo#, ShashaZhang#(共同第一作者), Miao Xiao#, Fuping Qian, Zuhong He, Dan Li, XiaoliZhang, Huawei Li, Xiaowei Yang, MingWang, Renjie Chai*, Mingliang Tang*. Accelerating bioelectric functionaldevelopment of neural stem cells by graphene coupling: Implications for neuralinterfacing with conductive materials.Biomaterials, 106:193-204. 2016
10. Zhuhong He#, Shasha Zhang#(共同第一作者), Qin Song#, Wenyan Li, Dong Liu,Huawei Li, Mingliang Tang*, Renjie Chai*. Thestructural development of primary cultured hippocampal neurons on a graphenesubstrate. Colloids and surfaces B:Biointerfaces, 146:442-451, 2016
11. Muhammad Waqas#, Shasha Zhang#(共同第一作者), Zuhong He#, Mingliang Tang*, RenjieChai*. Role of Wnt and Notch signaling in regulating hair cell regeneration inthe cochlea. Frontiers of Medicine, 10(3): 237–249, 2016
12. Shasha Zhang#(第一作者), Guanghou Shui, GuanqunWang, Chao Wang, Shuhong Sun, Christos C. Zouboulis, Ran Xiao, Jing Ye, Wei Liand Peng Li*. Cidea Control of Lipid Storage and Secretion in Mouse and HumanSebaceous Glands. Molecular and CellularBiology, 34(10): 1827-1838,2014
合作校外导师简介:
殷潇,现任江南大学附属医院耳鼻咽喉头颈外科主任医师。本科毕业于苏州医学院临床医学专业,后在江南大学附属医院(原无锡市第四人民医院、无锡市肿瘤医院)耳鼻咽喉头颈外科先后任医师、主治医师、副主任医师、主任医师。主要研究方向是耳鼻咽喉头颈肿瘤的基础和临床研究、阻塞性睡眠呼吸暂停综合征、内镜下的微创手术。
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