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1999年本科毕业于南京大学,2004年在南京大学获得博士学位,2004-2008年在美国马萨诸塞大学医学院进行博士后研究工作,2008年8月受聘东南大学任教授。现任东南大学生命科学与技术学院院长,兼任中国神经科学学会理事,中国细胞生物学学会理事,中国神经科学学会儿童认知与脑功能障碍分会秘书长,中国细胞生物学学会神经细胞分会副会长,江苏省细胞与发育生物学学会理事长,Neuroscience Bulletin、BMC Neuroscience编委。2015年入选“教育部长江学者奖励计划青年项目”。目前主要以果蝇和小鼠模型开展神经发育与孤独症致病机制的研究,获得了多项国家自然科学基金项目和科技部项目的资助;以第一作者或通讯作者在Cell、Neuron、Developmental Cell、Current Biology、PLoS Biology、EMBO J、JNs等杂志上发表论文多篇。
1. Jin X#, Tian Y#, Zhang ZC, GuP, Liu C, Han J* (2021). A subset ofDN1p neurons integrates thermosensory inputs to promote wakefulness via CNMasignaling. Curr Biol. Online, doi: 10.1016/j.cub.2021.02.048.
2. Shen Y#,Zhang ZC#,*, Cheng S#, Liu A, Zuo J, Xia S, Liu X, Liu W,Jia Z, Xie W, Han J* (2021). PQBP1promotes translational elongation and regulates hippocampal mGluR-LTD bysuppressing eEF2 phosphorylation. Mol Cell, online, doi: 10.1016/j.molcel.2021.01.032.
3. Wu J, Ji X, Gu Q, Liao B, Dong W*, HanJ* (2021). Parallel Synaptic Acetylcholine Signals Facilitate LargeMonopolar Cell Repolarization and Modulate Visual Behavior in Drosophila.JNeurosci. 41:2164-2176.
4. Gu Q#, Wu J#, TianY, Cheng S, Zhang ZC*, Han J* (2020). Gαq splice variants mediate phototransduction, rhodopsin synthesis, andretinal integrity in Drosophila. J Biol Chem. 295:5554-5563. (CoverStory).
5. Mu Y,Tian Y, Zhang ZC*, Han J* (2019). Metallophosphoesterase regulateslight-induced rhodopsin endocytosis by promoting an association betweenarrestin and the adaptor protein AP2. JBiol Chem. 294:12892-12900. (Cover Story).
6. Li Q#, Li Y#,Wang X#, Qi J, Jin X, Tong H, Zhou Z, Zhang ZC, Han J* (2017). Fbxl4Serves as a Clock Output Molecule that Regulates Sleep through Promotion ofRhythmic Degradation of the GABAA Receptor. Curr Biol. 27:3616-3625.
7. Liu L#, Tian Y#,Zhang XY, Zhang X, Li T, Xie W, Han J*(2017). NeurexinRestricts Axonal Branching in Columns by Promoting Ephrin Clustering. Dev Cell.41:94-106. (Cover Story)
8. Wang X#, Mu Y, Sun M, Han J* (2017). Bidirectionalregulation of fragile X mental retardation protein phosphorylation controls rhodopsinhomoeostasis. J Mol Cell Biol. 9:104-116.
9. Tong H#, Li Q, Zhang ZC, LiY, Han J* (2016). Neurexin regulates nighttime sleep by modulating synaptic transmission. Sci Rep. 6:38246.
10. Wan D#, Zhang ZC#, Zhang X,Li Q, Han J* (2015). X chromosome-linkedintellectual disability protein PQBP1 associates with and regulates thetranslation of specific mRNAs. Hum Mol Genet. 24:4599-614
11. Li T#, Tan Y, Li Q, Chen H, Lv H, Xie W,Han J* (2015). The Neurexin-NSF interactionregulates short-term synaptic depression. J Biol Chem. 290:17656-67. (Cover Story).
12. Hu W#, Wang T, Wang X, and Han J* (2015). Ih ChannelsControl Feedback Regulation from Amacrine Cells to Photoreceptors. PLoSBiology. 13:e1002115.
13. Li Y#, Zhou Z#, Zhang X, TongH, Li P, Zhang ZC, Jia Z, Xie W*, Han J*(2013). Drosophila Neuroligin 4 Regulates Sleep through Modulating GABATransmission. J Neurosci. 33:15545-54.
14. Tian Y#, Li T, Sun M, Wan D, Li Q, Li P,Zhang Z, Han J*, Wei Xie* (2013).Neurexin Regulates Visual Function via Mediating Retinoid Transport to PromoteRhodopsin Maturation. Neuron 77: 311-322.
15. Hu W#, Wan D, Yu X, Cao J, Guo P, Li HS,Han J* (2012). Protein Gq modulatestermination of phototransduction and prevents retinal degeneration. JBiol Chem 287:13911-8.
16. Cao J#, Li Y#, Xia W, ReddigK, Hu W, Xie W, Li HS*, Han J*(2011). A Drosophila metallophosphoesterase mediates deglycosylation ofrhodopsin. EMBO J 30: 3701-13.
17. Han J#, Reddig K and Li HS* (2007). Prolonged Gq activitytriggers fly rhodopsin endocytosis and degradation and reduces photoreceptorsensitivity. EMBO J 26:4966-73.
18. Han J#, Gong P#, Reddig K#, MitraM, Guo P and Li HS* (2006). The fly CAMTA transcription factor potentiatesdeactivation of the G protein-coupled light receptor rhodopsin. Cell127: 847-858.
研究方向:神经精神药物研发、兔单抗制备技术及应用、蛋白表达技术及应用。
校外合作导师:张闻,宁波瑞源生物科技有限公司,总经理,zhangwenn@163.com
娄阳,优睿赛思(武汉)生物科技有限公司,董事长,yang.lou@yurogen.com
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