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何志辉,现任东南大学研究员、博士生导师。 本科毕业于北京师范大学生命科学学院,博士毕业于中国科学院上海生命科学研究院。2016年-2024年先后在美国宾州州立大学和圣路易斯华盛顿大学医学院从事博士后/研究科学家工作,长期从事大孔径Pannexin离子通道、线粒体MRS2通道及离子通道型神经递质受体门控调节机制及其介导生理病理功能研究,并针对这些靶点开发疾病治疗药物。作为核心骨干,参与多项美国国立卫生研究院(NIH)资助的R01和R35项目。近年来以第一作者(含共一)在Nature Structural & Molecular Biology,Nature Communications 等杂志发表学术论文10余篇, 获批上海市海外高层次青年人才计划。 目前担任Frontiers in Molecular Biosciences, International Immunopharmacology青年编委,Vascular Pharmacology,International Journal of Molecular Sciences,Pharmaceutics等多个杂志审稿人。
欢迎具有结构生物学、生物化学、免疫学、生物信息学及药学等相关背景的同学申请硕士、博士研究生和博士后。
1. 东南大学新进教师启动经费,主持,2025-2028
2. 上海市海外高层次人才计划,主持,2024-2027
3. 上海市“扬帆”计划,主持,2016-2019
4. NIH/NIGMS, R35GM149287,Neurosteroid and Cholesterol Binding to Integral Membrane Proteins,参与,2023-2028
5. NIH/NINDS, R01NS099341,Structure and Mechanism of a Polymodal TRP Ion Channel,参与,2017-2022
6. NIH/NINDS, R01NS109307,Molecular Mechanisms of Copper Transport, 参与,2018-2024
1. He, Z.#, Tu, Y.C. #, Tsai, C.W., Mount, J., Zhang, J.,Tsai, M.F., Yuan, P. (2025) Structure and function of the human mitochondrial MRS2 channel. Nature Structural & Molecular Biology 32: 459-468.
2. Koyama, S., He, Z., Bracamontes J.R., AKK, G., Evers, A.S.(2025) Differential binding and action of neurosteroids in β3-homopentameric GABAA receptor. Biophysical Journal 124(3), 457a.
3. He, Z.#, Zhao, Y.#, Rau, M., Fitzpatrick, J.A.J., Sah,R., Hu, H., Yuan, P. (2023) Structural and functional analysis of human pannexin 2 channel. Nature communications 14, 1712.
4. Deng, Z#, He,Z.#, Maksaev, G., Bitter, R.M., Rau, M., Fitzpatrick, J.A.J.,Yuan, P. (2020) Cryo-EM structures of the ATP release channel pannexin 1. Nature Structural & Molecular Biology 27: 373-381.
5. He, Z., Ferlez, B.H., Kurashov,V., Tank, M., Golbeck, J.H., Bryant, D.A. (2019) Reaction centers of the thermophilic microaerophile, Chloracidobacterium thermophilum (Acidobacteria) I: biochemical and biophysical characterization. Photosynthesis Research 142: 87-103.
6. He, Z., Xu, M., Wu, Y., Lv. J., Fu, P., and Mi, H. (2016) NdhM subunit is required for the stability and the function of NAD(P)H dehydrogenase complexes involved in CO2 uptake in Synechocystis sp. strain PCC 6803. Journal of Biological Chemistry 291: 5902-5912.
7. He, Z., Zheng, F., Wu, Y., Li, Q.,Lv, J., Fu, P., and Mi, H. (2015) NDH-1L interacts with ferredoxin via the subunit NdhS in Thermosynechococcus elongatus. Photosynthesis Research 126: 341-349.
8. Chen,X., He, Z., Xu, M., Peng, L., and Mi, H. (2016) NdhV subunit regulatesthe activity of type-1 NAD(P)H dehydrogenase under high light conditions in cyanobacterium Synechocystis sp. PCC 6803. Scientific Reports 6: 28361.
9. Charles, P., Kalendra, V., He,Z., Khatami, M.H., Golbeck, J.H., van der Est, A., Lakshmi, K.V., Byrant,D.A. (2020) Two-dimensional 67Zn HYSCORE spectroscopy reveals that a Zn-bacteriochlorophyll aP′ dimer is the primary donor (P840) in the type-1 reaction centers of Chloracidobacterium thermophilum. Physical Chemistry Chemical Physics 22: 6457-6467.
10. Zill, J.C., He, Z., Tank, M., Ferlez, B.H., Canniffe, D.P., Lahav, Y., Bellstedt, P., Alia, A., Schapiro, I., Golbeck, J.H., Bryant, D.A., and Matysik, J. (2018) 15N photo-CIDNP MAS NMR analysis of reaction centers of Chloracidobacterium thermophilum. Photosynthesis Research 137: 295-305.
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