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陈辉,东南大学附属中大医院重症医学科副主任医师、江苏省重症医学重点实验室PI、硕士生导师。主要从事急性呼吸窘迫综合征精准治疗的临床和基础研究,主持国家自然科学基金青年基金等多个重点课题,近5年以第一和通讯作者发表SCI论文20余篇,包括Am J Resp Crit Care Med,Intensive Care Med,CHEST(2篇),EClinicalMedicine,Crit Care(6篇),BMC Medicine,Annals Intensive Care等本领域高影响力期刊,相关成果获得2024年江苏省新技术引进奖一等奖(排一)。担任江苏省医学会重症医学分会青年学组副组长,江苏省医师协会重症医师分会委员,江苏省病理生理学会危重症医学专业委员会委员。
东南大学附属中大医院重症医学科是国家重点临床专科,国家重症医学质控中心,是江苏第一个重症医学硕士、博士学位授予点,国家疑难重症提升工程中江苏唯一重症医学专业,在2019年复旦专科排名中排名第一,具有丰富的重症医学临床诊疗以及科学研究基础。江苏省重症医学重点实验室是依托东南大学和东南大学附属中大医院重症医学科,由江苏省科学技术厅批复成立的省级学科重点实验室。实验室围绕重症医学未来的发展趋势和突发公共事件对重症医学发展的重大需求,重点开展重症感染等多种原因导致的多脏器功能障碍的临床流行病学、生物学标志物、发病机制、免疫调控、器官间交互作用及精准化治疗研究,拟通过医工结合,建设集科学研究、技术创新、人才培养、成果转化于一体的重症医学研究平台,实现重症医学领域的重大科技创新,打造具有国际竞争力的重症医学创新型研究平台。
国家自然科学基金青年科学基金项目,82402565,基于单细胞免疫图谱解析低密度中性粒细胞介导ARDS器官损伤表型发生的作用机制,2025/01-2027/12,30万元,主持,在研
1. Hu Z, Pu X, Tang R, Zhou M, Liu W, Li J, Cui M, Zhu Y, Yu T, Yu J, Ma X, Ge H, Xu Q, Wang Y, Ou J, Guan Z, Chen T, Yuan X, Zheng M, Wang H, Yang Y, Qiu H, Chen H(共同通讯), Liu L; Chi-ARDS Net; Chinese ARDS Research Network. Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients with Impaired Consciousness: A Multicenter Randomized Controlled Trial. Chest. 2025 Sep 20:S0012-3692(25)05263-8. doi: 10.1016/j.chest.2025.08.040. Epub ahead of print. PMID: 40983167
2. Lou X*, Chen H*, Shi N, Yu R, Li S, Yang Y, Liu S, Xie J, Qiu H. Treatment effects of Xuebijing injection in patients with sepsis by clinical phenotype: a post hoc analysis of the EXIT-SEP trial. EClinicalMedicine. 2025 Jul 9;86:103341. doi: 10.1016/j.eclinm.2025.103341.
3. Chen H, Qiu H. Acute respiratory distress syndrome: Rethinking and research priorities. Chin Med J (Engl). 2025 Jun 5.
4. Sun Q, Zhang R, Zhang J, Xie J, Huang Y, Yang Y, Qiu H, Liu L, Chen H(最后通讯); Chi-ARDS Net (Chinese ARDS Research Network). Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial. Ann Intensive Care. 2025 Jun 23;15(1):84
5. Xie Y, Yan Y, Hong Q, Zheng H, Cao L, Li X, Liu S, Chen H(最后通讯). Heterogeneous treatment effects of stress ulcer prophylaxis among ICU patients at risk for gastrointestinal bleeding. BMC Med. 2025 Apr 7;23(1):206
6. Yang M, Zhuang J, Hu W, Li J, Wang Y, Zhang Z, Liu C, Chen H(最后通讯). Enhancing Patient Selection in Sepsis Clinical Trials Design Through an AI Enrichment Strategy: Algorithm Development and Validation. J Med Internet Res. 2024 Sep 4;26:e54621. doi: 10.2196/54621.
7. Chen H*, Liang M*, He Y*, Teboul JL, Sun Q, Xie J, Yang Y, Qiu H, Liu L. Inspiratory effort impacts the accuracy of pulse pressure variations for fluid responsiveness prediction in mechanically ventilated patients with spontaneous breathing activity: a prospective cohort study. Ann Intensive Care. 2023 Aug 17;13(1):72.
8. Hu W*, Chen H*, Ma C, Sun Q, Yang M, Wang H, Peng Q, Wang J, Zhang C, Huang W, Xie J, Huang Y. Identification of indications for albumin administration in septic patients with liver cirrhosis. Crit Care. 2023 Jul 28;27(1):300.
9. Chen H*, Sun Q*, Chao Y*, Liu Y, Yu Q, Xie J, Pan C, Liu L, Yang Y, Qiu H. Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome. Crit Care. 2023 Feb 13;27(1):59.
10. Chen H*, Yu Q*, Xie J, Liu S, Pan C, Liu L, Huang Y, Guo F, Qiu H, Yang Y. Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study. Crit Care. 2022 Nov 4;26(1):340
11. Zhu Z, Zhou M, Wei Y, Chen H(最后通讯). Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation. Crit Care. 2022;26(1):239.
12. Chen H*, Xie J*, Su N*, Wang J*, Sun Q*, Li S, Jin J, Zhou J, Mo M, Wei Y, Chao Y, Hu W, Du B, Qiu H. Corticosteroid Therapy Is AssociatedWith Improved Outcome in Critically Ill Patients With COVID-19 With Hyperinflammatory Phenotype. Chest. 2021 May;159(5):1793-1802
13. Chen H*#, Zhu Z*, Su N, Wang J, Gu J, Lu S, Zhang L, Chen X, Xu L, Shao X, Yin J, Yang J, Sun B, Li Y. Identification and Prediction of Novel Clinical Phenotypes for Intensive Care Patients With SARS-CoV-2 Pneumonia: An Observational Cohort Study. Front Med (Lausanne). 2021 Jun 4;8:681336.
14. Liu L, Xie J, Wu W, Chen H, Li S, He H, Yu Y, Hu M, Li J, Zheng R, Li X, Qiu H, Tong Z, Du B, Fan E, Yang Y, Slutsky AS. A simple nomogram for predicting failure of non-invasive respiratory strategies in adults with COVID-19: a retrospective multicentre study. Lancet Digit Health. 2021Mar;3(3):e166-e174.
15. Chen H*, Wang J, Su N, Bao X, Li Y, Jin J. Simplified immune-dysregulation index: a novel marker predicts 28-day mortality of intensive care patientswith COVID-19. Intensive Care Med. 2020;1-3.
16. Chen H*, Zhu Z*, Zhao C, et al. Central venous pressure measurement is associated with improved outcomes in septic patients: an analysis of the MIMIC-III database. Crit Care. 2020;24(1):433.
17. Zhao C, Wei Y, Chen D, Jin J, Chen H(最后通讯). Prognostic value of an inflammatory biomarker-based clinical algorithm in septic patients in the emergencydepartment: An observational study. Int Immunopharmacol. 2020; 80:106145.
18. Wang Y*, Lu X*, Li Y*, Chen H*, Chen T*, Su N*, Huang F, Zhou J, Zhang B, Yan F, Wang J. Clinical Course and Outcomes of 344 Intensive Care Patients with COVID-19. Am J Respir Crit Care Med. 2020 Jun 1;201(11):1430-1434.
19. Lai T*, Xiang F*, Zeng J*, Huang Y*, Jia L*, Chen H*, Wu J, Xie J, Liu S, Deng W, Zheng W, Huang Y, Zhang Q, Luo Q, Mo F, Long L, Zhang W, Chen W, Han H. Reliability of induced sputum test is greater than that of throat swab test for detecting SARS-CoV-2 in patients with COVID-19: A multi-center cross-sectional study. Virulence. 2020 Dec;11(1):1394-1401
20. Wu Y*, Chen H*, Liu X, et al. A new nomogram for individualized prediction of the probability of hemorrhagic transformation after intravenousthrombolysis for ischemic stroke patients. BMC Neurol. 2020;20(1):426.
21. Chen H*, Zhao C*, Wei Y, Jin J. Early lactate measurement is associated with better outcomes in septic patients with an elevated serum lactate level. Crit Care. 2019;23(1):351
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