导师风采
庞力智
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个人信息

Personal Information

  • 研究员
  • 导师类别:硕,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:医学院
  • 所属专业: 基础医学
  • 邮箱 : panglizhi@seu.edu.cn
  • 工作电话 : -

个人简介

Personal Profile

庞力智,现任东南大学研究员、博士生导师,小米青年学者,入选国家高层次青年人才项目(海外)。


博士毕业于美国北达科他州立大学,先后在美国西北大学(Northwestern University)和克利夫兰医学中心(Cleveland Clinic)进行博士后研究,致力于探索重大脑疾病如胶质母细胞瘤、卒中等免疫微环境形成机制和相关免疫治疗策略的开发,作为主要成员,参与多项美国国立卫生研究院(NIH)R01、R15及美国国防部(DoD)科研项目,以第一/通讯作者在Nature Immunology(封面论文)、Journal of Clinical Investigation(三篇)、Cell Reports MedicineCell ReportsTrends in Cancer(封面论文,两篇)、Cancer Research等发表多篇论文,主导研发的药物与爱尔兰药企DSBiopharma签订共同开发协议。


欢迎具有免疫学、分子生物学、药学、及生物信息学等相关背景和热爱科研的同学申报硕士、博士研究生。


  • 研究方向Research Directions
脑肿瘤免疫微环境,卒中免疫和治疗
科研项目


国家自然科学基金优秀青年科学基金项目(海外)


江苏省基础研究计划青年基金项目


研究成果


Lizhi Pang, Songlin Guo, Yuyun Huang, Fatima Khan, etc  Targeting legumain-mediated cell-cell interaction sensitizes glioblastoma to immunotherapy in preclinical models, 2025, Journal of Clinical Investigation, 135(10):e186034. (IF13.3)


Lizhi Pang*, Yuyun Huang*, Jean Huang-Gao, and Peiwen Chen  Protease regulation of tumor-immune cell symbiosis, 2025, Trends in Cancer,11(6):560-574  (IF 14.3)


Lizhi Pang*, Fei Zhou*, Yang Liu, Heba Ali,etc. Epigenetic regulation of tumor immunity, 2024, Journal of Clinical Investigation, 134(12):e178540  (IF 13.3)


Lizhi Pang, Fei Zhou, and Peiwen Chen. Lipid-laden macrophages recycle myelin to feed glioblastoma. 2024, Cancer Research, 84.22: 3712-3714. (IF 12.5)


Lizhi Pang*, Songlin Guo*, Fatima Khan*, Madeline Dunterman, etc  Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma, Cell Reports Medicine, 2023, 4,101238  (IF 11.7)


Lizhi Pang*, Madeline Dunterman*, Songlin Guo, Fatima Khan, etc  Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma, 2023, Nature Immunology, 1-17  (封面文章) (IF 27.7)

10


Lizhi Pang*, Madeline Dunterman*, Wenjing Xuan, Annette Gonzalez, etc. Circadian Regulator CLOCK Promotes Tumor Angiogenesis inGlioblastoma, 2023, Cell Reports, 42, 112127. (IF 7.5)


Lizhi Pang, Fatima Khan, Amy B. Heimberger, and Peiwen Chen. Mechanism and therapeutic potential of tumor-immune symbiosis in glioblastoma, 2022, Trends in Cancer, 8; 10: 839-854  (封面文章) (IF 14.3)

cover


Lizhi Pang, Fatima Khan, Madeline Dunterman, and Peiwen Chen  Pharmacological targeting of the tumor–immune symbiosis in glioblastoma, 2022, Trends in Pharmacological Sciences, 43; 8: 686-700  (IF 13.9)


Lizhi Pang, Harshit Shah, Steven Qian, and Venkatachalem Sathish  Iminodibenzyredirected cyclooxygenase-2-2 catalyzed DGLA peroxidation pattern in lung cancer via suppressing delta-5-desaturase, 2021, Free Radical Biology &Medicine, 172, 167-180  (IF 7.1)


FatimaKhan*, Lizhi Pang*, Madeline Dunterman, Maciej S.Lesniak, Amy B. Heimberger, and Peiwen Chen. Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy, 2023, Journal of Clinical Investigation, 133(1):e163446  (*These authors contributed equally to this work.) (IF 13.3)


Fatima Khan, Yang Liu, Donovan Whitfield, Lizhi Pang, Heba Ali, Yuyun Huang,Fei Zhou et al. Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis, 2025, Proceedings of the National Academy of Sciences, 122, 34 (2025): e2420793122  (IF 8.9)


Yang Liu, Junyan Wu, Hinda Najem, Yiyun Lin, Lizhi Pang, etc. Dual-targeting macrophages and microglia is a therapeutic vulnerability in models of PTEN-deficient glioblastoma, 2024, Journal of Clinical Investigation, 15;134(22)  (IF 13.3)


Fatima Khan, Yiyun Lin, Heba Ali, Lizhi Pang, etc  Lactate dehydrogenase regulates tumor-macrophage symbiosis to promote glioblastoma progression, 2024, Nature Communications, 15;1:1987  (IF 14.7)


Yang Liu, Heba Ali, Fatima Khan, Lizhi Pang, etc. Epigenetic regulation of tumor-immune symbiosis in glioma, 2024, Trends in Molecular Medicine, 30:5: 429-442  (IF 12.8)


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