脓毒症（Sepsis） 是宿主抗感染免疫失调所引起的危及生命的多器官功能障碍综合征， 是当前世界范围内感染致死的主要病因之一。  尽管近年来， 全球脓毒症联盟和世界卫生组织做出了大量努力以改善脓毒症的公众认知、临床诊治、 及科学研究，但由于脓毒症的发病机制复杂且尚未完全阐明，临床上针对脓毒症的治疗仍以抗菌药物、 液体复苏和器官功能支持等对症治疗为主，药物治疗并未取得突破性进展， 患者治疗过程漫长，预后差。 因此， 迫切需要深入了解脓毒症的发病机制， 以期发现脓毒症诊疗新靶标。本团队致力于挖掘脓毒症的新型诊疗生物标志物和治疗靶点，并阐述其免疫调控机制，近年来已发现CD5L、IL-34等多个脓毒症相关关键调控点。本团队拟进一步结合单细胞测序等手段深入挖掘脓毒症的发病机制，为其诊疗提供新靶点。

1.      Zhang C, Cai S, Li Y, Xu X, Liu Y, Qiao H, WongC-K, Wu G, Jin H, Gao X. Elevation of Metrnβ and Its Association withDisease Activity in Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2023; 24(17):13607.https://doi.org/10.3390/ijms241713607 

2.      Gao X, Chan PK, Wong KC, et al. Characterization of METRNbeta as a novel biomarker of Coronavirus disease 2019 severity and prognosis. FrontImmunol. 2023;14:1111920. Published 2023 Jan 31.doi:10.3389/fimmu.2023.1111920 

3.      Gao X, Wu G, Tsang MS, Huang D, Lam CW, Wong CK. Novelinsights into the role of anti-inflammatory IL-38 in immunity againstinfection. Cell Mol Immunol. 2022 Nov;19(11):1322-1324. doi:10.1038/s41423-022-00876-z. Epub 2022 Aug 16. PMID: 35974108; PMCID: PMC9379218. 

4.      Gao X, Leung TF, Wong GW, Ko WH, Cai M, He EJ, Chu IM,Tsang MS, Chan BC, Ling J, Fan X, Lu L, Lam CW, Wong CK. Meteorin-β/Meteorinlike/IL-41 attenuates airway inflammation in house dust mite-induced allergicasthma. Cell Mol Immunol. 2022 Feb;19(2):245-259. doi:10.1038/s41423-021-00803-8. 

5.      Gao X, Chan PKS, Lui GCY, et al. Interleukin-38ameliorates poly(I:C) induced lung inflammation: therapeutic implications inrespiratory viral infections. Cell Death Dis. 2021;12(1):53. Published2021 Jan 7. doi:10.1038/s41419-020-03283-2 

6.      Gao X, Liu Y, Xu F, Lin S, Song Z, Duan J, Yin Y, Cao J.Assessment of Apoptosis Inhibitor of Macrophage/CD5L as a Biomarker to PredictMortality in the Critically Ill With Sepsis. Chest. 2019Oct;156(4):696-705. (被《Chest》 作为必读文章推荐)

7.      Gao X, Yan X, Yin Y, Lin X, Zhang Q, Xia Y, Cao J.Therapeutic Targeting of Apoptosis Inhibitor of Macrophage/CD5L in Sepsis.Am J Respir Cell Mol Biol. 2019 Mar;60(3):323-334. (被《AmJ Respir Cell Mol Biol》作为当期亮点推荐并配发评论文章“AIMing immunomodulation therapy at sepsis” )

8.      Gao X, Yan X, Zhang Q, Yin Y, Cao J. CD5L contributes tothe pathogenesis of methicillin-resistant Staphylococcus aureus-inducedpneumonia. Int Immunopharmacol. 2019 Jul;72:40-47.