主持的科研项目：

(1) 国家自然科学基金委员会，面上项目，82372024，联合PD-L1及miR-182的ROS响应光免疫探针用于调节乳腺癌免疫治疗耐药的分子影像研究，2024-01-01 至 2027-12-31，48万元，在研，主持

(2) 国家自然科学基金委员会，青年科学基金项目，81801759，乳腺癌转移相关FAP分子的靶向多模态成像及siRNA基因沉默诊疗一体化研究，2019-01-01 至 2021-12-31，22万元，结题，主持

(3) 江苏省自然科学基金委员会，江苏省基础研究计划（自然科学基金）-青年基金项目，BK20180375，基于FAP分子的乳腺癌多模态分子成像及其在siRNA基因 沉默疗效评价中的应用，2018-07 至 2021-06，20万元，结题，主持

(4) 南京医学会放射学分会医学影像人工智能专项，面上项目，基于影像组学和机器学习的三阴性乳腺癌复发转移及预后预测模型的研究，2023-06-01至2025-05-31，在研，主持

(5) 东南大学，东南大学“至善青年学者”B类人才科研资助，2242024RCB0056，2024-01-01至2026-12-31，20万元，在研，主持

(6) 中大医院-连云港市第一人民医院联合基金项目，面上项目，三阴性乳腺癌复发转移及预后预测模型的多组学研究，2024-07-01至2025-12-31，20万元，在研，主持

1.第一作者/通讯作者（含共同）论文

(1)  LuCQ, Liu Y, Huang JR, Li MS, Wang YS, Gu Y*, Chang D*.Quantitative comparison of CSVD imaging markers between patients with possibleamyloid small vessel disease and with non-amyloid small vessel disease.Neuroimage Clin. 2024;44:103681.

(2)  Chang D, Wang YC, Xu TT, PengXG, Cai Y, Wang L, Bai YY, Ju S*. Noninvasiveidentification of renal hypoxia in experimental myocardial infarctions ofdifferent sizes by using BOLD MR imaging in a mouse model. Radiology.2018;286(1):129-139. 

(3)  Chang D,Wang YC, Zhang SJ, Bai YY, Liu DF, Zang FC, Wang G, Wang B, Ju S*.Visualizing myocardial inflammation in a rat model of type 4 cardiorenalsyndrome by dual-modality molecular imaging. Biomaterials.2015;68:67-76. 

(4)  ZhangSJ#, Chang D#, Jin JY, Wang YL, Wang L, Wang Z, JuS*. Myocardial Extracellular Volume Fraction Measured by CardiacMagnetic Resonance Imaging Negatively Correlates with Cardiomyocyte Breadth ina Healthy Porcine Model. Frontiers in Cardiovascular Medicine. 2022;9:791963.

(5)  ChangD, Xu TT, Zhang SJ, Cai Y, Min SD,Zhao Z, Lu CQ, Wang YC, Ju S*. Telmisartan ameliorates cardiacfibrosis and diastolic function in cardiorenal heart failure with preservedejection fraction. Exp Biol Med (Maywood). 2021;15353702211035058.

(6)  ChangD#,Ma Y#, Xu X, Xie J*, Ju S*. Stimuli-ResponsivePolymeric Nanoplatforms for Cancer Therapy. Front Bioeng Biotechnol. 2021;9:707319.

(7)  Chang D,Wang YC, Bai YY, Lu CQ, Xu TT, Zhu L*, Ju S*. Role of p38MAPK on MMP activity in photothrombotic stroke mice as measured using anultrafast MMP activatable probe. Sci Rep. 2015;19;5:16951.

(8)  FengJ#, Chang D#,Wang Z*, Shen B, Yang J, Jiang Y, Ju S*, He N*.A FITC-doped silica coated gold nanocomposite for both in vivo X-ray CT and fluorescencedual modal imaging. RSC Advances. 2014;4:51950-51959.

(9)  常娣，杨洁，李迎波，周昕宇，居胜红*. 肝癌分子影像诊疗现状及最新进展，中华肝脏病杂志，2024,32(8): 688-694.

(10)常娣，居胜红*. 腹腔局灶性脂肪坏死的典型影像学征象及其鉴别诊断，中华放射学杂志，2020,54(1):79-81.

2. 既非第一作者又非通讯作者论文

(1)    BaiY, Chang D, Ren H, Ju M, Wang Y, Chen B, Li H, Liu X, Li D, Huo X, GuoX, Tong M, Tan Y, Yao H, Han B. Engagement of N6-methyladenisine methylation ofGng4 mRNA in astrocyte dysfunction regulated by CircHECW2. Acta Pharm Sin B.2024;14(4):1644-1660.

(2)    BaiY, Cai Y, Chang D, Li D, Huo X, Zhu T. Immunotherapy for depression:Recent insights and future targets. Pharmacol Ther. 2024;257:108624.

(3)    XuX, Xu T, Liu D, Ding J, Chang D, Xie J, Ju S*. Dual-ModalityNanoprobe for Noninvasive Detection of Microthrombus after CerebralIschemia/Reperfusion. ACS Appl. Nano Mater. 2024, 7, 1, 292-305.

(4)    XuX, Zhang Z, Du J, Xue Y, Chen X, Zhang J, Yang X, Chang D, Xie J, Ju S*.Recruiting T-Cells toward the Brain for Enhanced Glioblastoma ImmunotherapeuticEfficacy by Co-Delivery of Cytokines and Immune Checkpoint Antibodies withMacrophage-Membrane-Camouflaged Nanovesicles. Adv Mater. 2023;35(25):e2209785.

(5)    XuTT, Xu X, Liu D, Chang D, Li S, Sun Y, Xie J, Ju S*. VisualInvestigation of Tumor-Promoting Fibronectin Potentiated by Obesity inPancreatic Ductal Adenocarcinoma Using an MR/NIRF Dual-Modality DendrimerNanoprobe. Adv Healthc Mater. 2023;e2300787.

(6)    MinS, Chang D, Wang YC, Xu TT, Ge H, Zhang J, Wang B, Ju S*. Novelsmallmolecule compound VCP979 attenuates renal fibrosis in male rats withunilateral ureteral obstruction. Exp Biol Med (Maywood).2023;15353702221147569. 

(7)    MaYY, Su Z, Zhou LM, He LC, Hou ZY, Zou JH, Cai Y, Chang D, Xie JB, Zhu C,Fan WP*, Chen XY*, Ju S*. BiodegradableMetal-Organic Framework-Gated Organosilica for Tumor Microenvironment-UnlockedGlutathione Depletion-Enhanced Synergistic Therapy. Adv Mater. 2022;34(12):e2107560.

(8)    CaiY, Leng S, Ma YY, Xu TT, Chang D, Ju S*. Dynamic change ofMMP-9 in diabetic stroke visualized by optical imaging and treated with CD28superagonist. Biomater Sci. 2021;9(7):2562-2570. 

(9)    CaiY, Xu TT, Lu CQ, Ma YY, Chang D, Zhang Y, Gu XC, Ju S*. EndogenousRegulatory T Cells Promote M2 Macrophage Phenotype in Diabetic Stroke asVisualized by Optical Imaging. Transl Stroke Res. 2021;12(1):136-146.

(10)  Peng XG, Zhao Z, ChangD, Bai Y, Xu Q, Ju S*. Quantification of Fat Concentration andVascular Response in Brown and White Adipose Tissue of Rats by Spectral CTImaging. Korean J Radiol. 2020;21(2):248-56. 

(11)  Xu TT, Chang D,Cai Y, Min S, Ma Y, Mao H, Ju S*. Targeting of an antecedentproteinase by an activatable probe with deep tissue penetration facilitatesearly visualization and dynamic malignancy evaluation of orthotopic pancreaticductal adenocarcinoma (PDAC). Biomater Sci. 2019;7(8):3320-33. 

(12)  Wang YC, Chang D, Zhang SJ, Wang Q, Ju S*.The accuracy of renal function measurements in obstructive hydronephrosis usingdynamic contrast-enhanced MR renography. Am J Roentgenol 2019; 213:1-8. 

(13)  Gao Y, Wang YC, Lu CQ,Zeng C, Chang D, Ju S*. Correlations between the abdominal fat-relatedparameters and severity of coronary artery disease assessed by computedtomography. Quant Imaging Med Surg 2018;8(6):579-587. 

(14)  Wang YC, Tang A, Chang D, Lu CQ, Zhang SJ, Ju S*.Long-term adverse effects of low-osmolar compared with iso-osmolar contrastmedia after coronary angiography. Am J Cardiol. 2016;118(7):985-990. 

(15)  Wang W, Fang K, Li MC, Chang D, Shahzad KA, Xu T, Zhang L, GuN*, Shen CL*. A biodegradable killer microparticle toselectively deplete antigen-specific T cells in vitro and in vivo. Oncotarget.2016;7(11):12176-12190. 

(16)  Bai YY, Wang L, Chang D, Zhao Z, Lu CQ, Wang G, Ju S*.Synergistic effects of transplanted endothelial progenitor cells and RWJ 67657in diabetic ischemic stroke models. Stroke. 2015;46(7):1938-1946.

(17)  Bai YY, Wang L, Peng XG,Wang YC, Chang D, Zheng S, Ding J, Li C, Ju S*. Non-invasive monitoringof transplanted endothelial progenitor cells in diabetic ischemic strokemodels. Biomaterials. 2015;40:43-50. 

(18)  Zheng S#, BaiYY#, Liu Y, Gao X, Li Y, Changyi Y, Wang Y, Chang D, Ju S*, Li C*. Salvaging brainischemia by increasing neuroprotectant uptake via nanoagonist mediated bloodbrain barrier permeability enhancement. Biomaterials. 2015;66:9-20. 

(19)  Wang YC, Tang A, Chang D, Zhang SJ, Ju S*.Significant perturbation in renal functional magnetic resonance imagingparameters and contrast retention for iodixanol compared with iopromide: anexperimental study using blood-oxygen-level-dependent/diffusion-weightedmagnetic resonance imaging and computed tomography in rats. Invest Radiol.2014;49(11):699-706. 

(20)  Liu D, Qian C, An Y, Chang D, Ju S, Teng GJ*.Magnetic resonance imaging of post-ischemic blood-brain barrier damage withPEGylated iron oxide nanoparticles. Nanoscale. 2014;6(24):15161-15167.

(21)  Bai YY, Gao X, Wang YC,Peng XG, Chang D, Zheng S, Li C*,Ju S*. Image-guided pro-angiogenic therapy in diabetic stroke mousemodels using a multi-modal nanoprobe. Theranostics. 2014;4(8):787-797. 

(22)  Zhang SJ, Wang YX, YuanJ, Jin J, Wang YC, Chang D, Weng D,Greiser A, Ju S*. Time-efficient myocardial contrast partitioncoefficient measurement from early enhancement with magnetic resonance imaging.PLoS One. 2014;9(3):e93124.