主持的科研项目：

(1) 国家自然科学基金委员会，面上项目，82372024，联合PD-L1及miR-182的ROS响应光免疫探针用于调节乳腺癌免疫治疗耐药的分子影像研究，2024-01-01 至 2027-12-31，48万元，在研，主持

(2) 国家自然科学基金委员会，青年科学基金项目，81801759，乳腺癌转移相关FAP分子的靶向多模态成像及siRNA基因沉默诊疗一体化研究，2019-01-01 至 2021-12-31，22万元，结题，主持

(3) 江苏省自然科学基金委员会，江苏省基础研究计划（自然科学基金）-青年基金项目，BK20180375，基于FAP分子的乳腺癌多模态分子成像及其在siRNA基因 沉默疗效评价中的应用，2018-07 至 2021-06，20万元，结题，主持

(4) 南京医学会放射学分会医学影像人工智能专项，面上项目，基于影像组学和机器学习的三阴性乳腺癌复发转移及预后预测模型的研究，2023-06-01至2025-05-31，在研，主持

(5) 东南大学，东南大学“至善青年学者”B类人才科研资助，2242024RCB0056，2024-01-01至2026-12-31，20万元，在研，主持

(6) 中大医院-连云港市第一人民医院联合基金项目，面上项目，三阴性乳腺癌复发转移及预后预测模型的多组学研究，2024-07-01至2025-12-31，20万元，在研，主持

发表论文情况：

1）Chang D, Yang J, Li Y, Min S, Ma Y, Xu T, Zhang Z, Zhu X,Xu X, Lu C, Zhao B, Chen M, Xiao Z, Xie J, Ju S*. SpatiotemporallyControlled Nanomicelles for Synergistic Phototherapy and lmmune Reprogrammingin Triple-Negative Breast Cancer. ACS Nano. 2025;19(41):36323-36341. [IF: 16，独立一作]

2）Yang J#, Chang D#, Li Y, Xu Z, Li D, Xu X, Zhang Z, Li Y, Zhang J, Xie J, Xiao Z, Ju S*. Programmable nanomicelles rewire myeloid immunity for durable control of primary and metastatic breast cancer. Nature Communication. 2026 Accept. [IF: 15.7，共一第二]

3）Chang D, Wang YC, Xu TT, Peng XG, Cai Y, Wang L, Bai YY, Ju S*. Noninvasiveidentification of renal hypoxia in experimental myocardial infarctions ofdifferent sizes by using BOLD MR imaging in a mouse model. Radiology.2018;286(1):129-139. [IF: 15.2，独立一作]

4）Chang D, WangYC, Zhang SJ, Bai YY, Liu DF, Zang FC, Wang G, Wang B, Ju S*.Visualizing myocardial inflammation in a rat model of type 4 cardiorenalsyndrome by dual-modality molecular imaging. Biomaterials.2015;68:67-76. [IF: 12.9，独立一作]

5） Yuan M#, Chang D#, Lu W#, Ma K, Gu Y, Xia T, Peng J, Zhang Y, Fu L, Zhao B. Interpretable habitatand peritumoral radiomics from multiparametric MRI for preoperative high-riskprostate cancer prediction: a multi-institutional study. J Transl Med. 2026 Feb14. doi: 10.1186/s12967-026-07848-1. Epub ahead of print. [IF: 7.5，共一第二]

6）Lu CQ, Liu Y, Huang JR,Li MS, Wang YS, Gu Y*, Chang D*. Quantitativecomparison of CSVD imaging markers between patients with possible amyloid smallvessel disease and with non-amyloid small vessel disease. Neuroimage Clin.2024;44:103681. [IF: 3.6，末尾通讯]

7) Sun J#, Chang D#, Zhang H, Wen L, Liang X, Zhang Q, Ge N. Revolution APEX CT: preliminary assessment of its application value in pancreatic cancer T staging. BMC Med Imaging. 2026 Mar 18.  [IF: 3.2，共一第二]

8）Chang D, Xu TT, Zhang SJ, CaiY, Min SD, Zhao Z, Lu CQ, Wang YC, Ju S*. Telmisartan amelioratescardiac fibrosis and diastolic function in cardiorenal heart failure withpreserved ejection fraction. Exp Biol Med. 2021;15353702211035058. [IF: 2.7，独立一作]

9）Chang D#, Ma Y#, Xu X, Xie J*, Ju S*. Stimuli-Responsive PolymericNanoplatforms for Cancer Therapy. Front Bioeng Biotechnol.2021;9:707319. [IF: 4.8，共一第一]

10）Zhang SJ#, Chang D#, Jin JY, Wang YL, Wang L, Wang Z, Ju S*.Myocardial Extracellular Volume Fraction Measured by Cardiac Magnetic ResonanceImaging Negatively Correlates with Cardiomyocyte Breadth in a Healthy PorcineModel. Front Cardiovasc Med. 2022;9:791963. [IF: 2.9，共一第二]

11）Chang D, Wang YC, Bai YY, Lu CQ, Xu TT, Zhu L*, Ju S*.Role of p38 MAPK on MMP activity in photothrombotic stroke mice as measuredusing an ultrafast MMP activatable probe. Sci Rep. 2015;19;5:16951. [IF: 3.9，独立一作]

12）Zhou XY, Zheng XF, Zhang SJ, Ju S, Chang D*. Cardiac involvement in immune-mediated necrotizingmyopathy: a case report with insights from cardiac magnetic resonance imaging. EULARRheumatology Open. 2025 In Press. [独立通讯]

13）Feng J#, Chang D#, Wang Z*,Shen B, Yang J, Jiang Y, Ju S*, He N*. A FITC-dopedsilica coated gold nanocomposite for both in vivo X-ray CT and fluorescencedual modal imaging. RSC Advances.2014;4:51950-51959. [IF: 4.6，共一第二]

14）常娣，杨洁，李迎波，居胜红*. 氧化铁纳米颗粒在心血管MR分子影像中的研究进展，中华医学杂志，2025, 105(22): 1869-1874. [独立一作]

15）常娣，杨洁，李迎波，周昕宇，居胜红*. 肝癌分子影像诊疗现状及最新进展，中华肝脏病杂志，2024, 32(8): 688-694. [独立一作]

16）常娣，居胜红*. 腹腔局灶性脂肪坏死的典型影像学征象及其鉴别诊断，中华放射学杂志，2020, 54(1):79-81. [独立一作]

17）Bai Y, Chang D, Ren H, Ju M, Wang Y, Chen B, Li H, Liu X, Li D, Huo X, GuoX, Tong M, Tan Y, Yao H, Han B. Engagement of N6-methyladenisine methylation ofGng4 mRNA in astrocyte dysfunction regulated by CircHECW2. Acta Pharm Sin B.2024;14(4):1644-1660.

18)  Bai Y, Cai Y, Chang D, Li D, Huo X, Zhu T. Immunotherapy for depression:Recent insights and future targets. Pharmacol Ther. 2024;257:108624.

19）Xu X, Xu T, Liu D, Ding J, Chang D, Xie J, Ju S*. Dual-ModalityNanoprobe for Noninvasive Detection of Microthrombus after CerebralIschemia/Reperfusion. ACS Appl. Nano Mater. 2024, 7, 1, 292-305.

20) Chen Y, Chen Q, Ma Y, Zhang C, Xu J, Li K, Sun Y, Su X, Wei M, Bao R, Ding T, Tang L, Yu W, Ju S, Fan W. In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy. Nat Commun. 2026 Jan 21;17(1):1784.

21）Xu X, Zhang Z, Du J, Xue Y, Chen X, Zhang J, Yang X, Chang D, Xie J, Ju S*.Recruiting T-Cells toward the Brain for Enhanced Glioblastoma ImmunotherapeuticEfficacy by Co-Delivery of Cytokines and Immune Checkpoint Antibodies withMacrophage-Membrane-Camouflaged Nanovesicles. Adv Mater. 2023;35(25):e2209785.

22）Xu TT, Xu X, Liu D, Chang D, Li S, Sun Y, Xie J, Ju S*. VisualInvestigation of Tumor-Promoting Fibronectin Potentiated by Obesity inPancreatic Ductal Adenocarcinoma Using an MR/NIRF Dual-Modality DendrimerNanoprobe. Adv Healthc Mater. 2023;e2300787.

23）Min S, Chang D, Wang YC, Xu TT, Ge H, Zhang J, Wang B, Ju S*. Novelsmallmolecule compound VCP979 attenuates renal fibrosis in male rats withunilateral ureteral obstruction. Exp Biol Med (Maywood).2023;15353702221147569. 

24）Ma YY, Su Z, Zhou LM, He LC, Hou ZY, Zou JH, Cai Y, Chang D, Xie JB, Zhu C,Fan WP*, Chen XY*, Ju S*. BiodegradableMetal-Organic Framework-Gated Organosilica for Tumor Microenvironment-UnlockedGlutathione Depletion-Enhanced Synergistic Therapy. Adv Mater. 2022;34(12):e2107560.

25）CaiY, Leng S, Ma YY, Xu TT, Chang D, Ju S*. Dynamic change ofMMP-9 in diabetic stroke visualized by optical imaging and treated with CD28superagonist. Biomater Sci. 2021;9(7):2562-2570. 

26）Cai Y, Xu TT, Lu CQ, Ma YY, Chang D, Zhang Y, Gu XC, Ju S*. EndogenousRegulatory T Cells Promote M2 Macrophage Phenotype in Diabetic Stroke asVisualized by Optical Imaging. Transl Stroke Res. 2021;12(1):136-146.

27）Peng XG, Zhao Z, Chang D, Bai Y, Xu Q, Ju S*. Quantification of Fat Concentration andVascular Response in Brown and White Adipose Tissue of Rats by Spectral CTImaging. Korean J Radiol. 2020;21(2):248-56. 

28）Xu TT, Chang D,Cai Y, Min S, Ma Y, Mao H, Ju S*. Targeting of an antecedentproteinase by an activatable probe with deep tissue penetration facilitatesearly visualization and dynamic malignancy evaluation of orthotopic pancreaticductal adenocarcinoma (PDAC). Biomater Sci. 2019;7(8):3320-33. 

29）Wang YC, Chang D, Zhang SJ, Wang Q, Ju S*.The accuracy of renal function measurements in obstructive hydronephrosis usingdynamic contrast-enhanced MR renography. Am J Roentgenol 2019; 213:1-8. 

30）Gao Y, Wang YC, Lu CQ,Zeng C, Chang D, Ju S*. Correlations between the abdominal fat-relatedparameters and severity of coronary artery disease assessed by computedtomography. Quant Imaging Med Surg 2018;8(6):579-587. 

31）Wang YC, Tang A, Chang D, Lu CQ, Zhang SJ, Ju S*.Long-term adverse effects of low-osmolar compared with iso-osmolar contrastmedia after coronary angiography. Am J Cardiol. 2016;118(7):985-990. 

32）Wang W, Fang K, Li MC, Chang D, Shahzad KA, Xu T, Zhang L, GuN*, Shen CL*. A biodegradable killer microparticle toselectively deplete antigen-specific T cells in vitro and in vivo. Oncotarget.2016;7(11):12176-12190. 

33）Bai YY, Wang L, Chang D, Zhao Z, Lu CQ, Wang G, Ju S*.Synergistic effects of transplanted endothelial progenitor cells and RWJ 67657in diabetic ischemic stroke models. Stroke. 2015;46(7):1938-1946.

34）Bai YY, Wang L, Peng XG,Wang YC, Chang D, Zheng S, Ding J, Li C, Ju S*. Non-invasive monitoringof transplanted endothelial progenitor cells in diabetic ischemic strokemodels. Biomaterials. 2015;40:43-50. 

35）Zheng S#, BaiYY#, Liu Y, Gao X, Li Y, Changyi Y, Wang Y, Chang D, Ju S*, Li C*. Salvaging brainischemia by increasing neuroprotectant uptake via nanoagonist mediated bloodbrain barrier permeability enhancement. Biomaterials. 2015;66:9-20. 

36）Wang YC, Tang A, Chang D, Zhang SJ, Ju S*.Significant perturbation in renal functional magnetic resonance imagingparameters and contrast retention for iodixanol compared with iopromide: anexperimental study using blood-oxygen-level-dependent/diffusion-weightedmagnetic resonance imaging and computed tomography in rats. Invest Radiol.2014;49(11):699-706. 

37）Liu D, Qian C, An Y, Chang D, Ju S, Teng GJ*.Magnetic resonance imaging of post-ischemic blood-brain barrier damage withPEGylated iron oxide nanoparticles. Nanoscale. 2014;6(24):15161-15167.

38）Zhang SJ, Wang YX, YuanJ, Jin J, Wang YC, Chang D, Weng D,Greiser A, Ju S*. Time-efficient myocardial contrast partitioncoefficient measurement from early enhancement with magnetic resonance imaging.PLoS One. 2014;9(3):e93124. 

39）Bai YY, Gao X, Wang YC,Peng XG, Chang D, Zheng S, Li C*,Ju S*. Image-guided pro-angiogenic therapy in diabetic stroke mousemodels using a multi-modal nanoprobe. Theranostics. 2014;4(8):787-797.