导师风采
周雯
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个人信息

Personal Information

  • 副研究员
  • 导师类别:硕士生导师
  • 性别: 女
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:化学化工学院
  • 所属专业: 化学
  • 邮箱 : wzhou@seu.edu.cn
  • 工作电话 : -

个人简介

Personal Profile

周雯,女,硕士生导师

主要从事化学生物学与药物化学学科领域内心血管药物的设计、生物活性评价以及药理研究


  • 研究方向Research Directions
化学生物学,药物化学
科研项目
主持科研基金项目:
1.国家自然科学基金:缺氧促发型碳酸酐酶9抑制剂的设计合成及其抗心肌缺氧损伤研究,22207016,30万,2023.1–2025.12.
2.江苏省自然科学基金:线粒体靶向性琥珀酸脱氢酶抑制剂的分子设计与抗心肌缺血再灌注损伤研究,BK20180570,20万,2018.7–2021.12.


研究成果

1. Wanxing Yang#, Wen Zhou#,Shaohua Gou*. Hypoxia Activated Nitric OxideDonor Compounds for the Prevention and Treatment of Myocardial Hypoxia-InducedInjury. Journal of Medicinal Chemistry, 2025, 68, 491.

2. Wen Zhou,Wanxing Yang, Ping Jiang, Shaohua Gou*. A Lysosome-Targeting hNEU1 Inhibitor TreatsMyocardial Infarction: A Potential Therapeutic Breakthrough, Journal of MedicinalChemistry, 2024, 67, 16899.

3. Wen Zhou, PingJiang, Chunping Wang, Shaohua Gou*. Discovery of the Synergy between Sulindacand NO Expands the Application of NSAIDs in Cardiac Complications, Bioorganic& Medicinal Chemistry, 2024, 116, 117991.

4. 周 雯,江 萍,杨万祥,苟少华*。基于协同分析设计的阿司匹林衍生物在抗冠心病缺氧损伤中的应用研究,药学学报,2024,59,2800。

5. 一种以阿司匹林或其缺氧促发型衍生物为配体的镁配合物、制备方法及应用。周雯,江萍,杨万祥,苟少华。202410734714.9,2024.09. (发明专利)

6. Wanxing Yang#, Wen Zhou#, Shaohua Gou*. Discoveryof Efficient Hypoxia-Targeted NO Donor Compounds to Alleviate Hypoxia Cardiac Disease.Journal of Medicinal Chemistry, 2023, 66, 15977.

7. Wen Zhou, Chunping Wang, Bin Zhang, ShaohuaGou*. Hybrids of Carbonic Anhydrase and Cyclooxygenase Inhibitors Attenuate CardiacHypoxic Inflammatory Injuries. European Journal of Pharmacology, 2023, 950,175751.

8. Wen Zhou, Wanxiang Yang, Keyu Fan, WuyangHua and Shaohua Gou*. A Hypoxia-Activated NO Donor for the Treatment of MyocardialHypoxia Injury. Chemical Science, 2022, 13, 3549.

9. Wen Zhou,Chunping Wang, Zhikun Liu, Shaohua Gou*. Hypoxia-Activated Prodrugs with DualCOX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia. Journalof Medicinal Chemistry, 2022, 65, 13436.

10. Wen Zhou,Keyu Fan, Xiaojian Yin, Yuxuan Wang, Shaohua Gou*. A Tanshinone IIA Derivative Designedto Target Mitochondria Inhibit Myocardial Ischemia/Reperfusion Injury invivo in a GUF1 Dependent-Pathway. Pharmacological Research–ModernChinese Medicine. 2022, 2, 100066.

11. Bin Zhang#,Zichen Xu#, Wen Zhou, Zhikun Liu, Jian Zhao, Shaohua Gou*. A Light-ControlledMulti-Step Drug Release Nanosystem Targeting Tumor Hypoxia for Synergistic CancerTherapy. Chemical Science. 2021, 12, 11810.

12. Wen Zhou,Bin Zhang, Keyu Fan, Xiaojian Yin, jinfeng Liu, Shaohua Gou*. An Original Aspirin-ContainingCarbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhancethe Efficacy of Myocardial Protection. Cardiovascular Drugs and Therapy.2021, 36, 605.

13. 乙酰唑胺衍生物及其制备方法和在制备治疗冠心病药物中的应用。苟少华,周雯,张斌。CN111961043A,2020.11.(发明专利)

14. Fei Wang,Qingqing Peng, Jingfeng Liu, R.N. Alolga, Wen Zhou*. A Novel Ferulic AcidDerivative Attenuates Myocardial Cell Hypoxia Reoxygenation Injury through a SuccinateDehydrogenase Dependent Antioxidant Mechanism. European Journal ofPharmacology, 2019, 856, 172417.

15. Yunpeng Zhao,Fei Wang, Wei Jiang, Jinfeng Liu, Baolin Liu, Lianwen Qi, Wen Zhou*. A Mitochondrion-TargetingTanshinone IIA Derivative Attenuates Myocardial Hypoxia Reoxygenation Injurythrough a SDH-Dependent Antioxidant Mechanism. Journal of Drug Targeting,2019, 11, 1.

16. Lanzhu Li,Guoxiu Zhou, Jia Li, Wei Jiang, Baolin Liu, Wen Zhou*. Compounds ContainingTrace Element Copper or Zinc Exhibit as Potent Hyperuricemia Inhibitors viaXanthine Oxidase Inactivation. Journal of Trace Elements in Medicine andBiology, 2018, 49, 72.


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