1. 1、国家重点研发项目：胚胎心脏前体细胞的精确定位与命运决定机制，2372万，首席科学家）；
2. 2、国家自然基金委：原创项目（调控染色体倍性的新型特化细胞器的鉴定与功能研究，300万，主持）、重点项目（早期胚胎发育的转录调控，287万，主持）、面上项目；

1. 3、江苏省杰出青年基金和江苏省“双创人才”；
2. 4、新加坡国家医学研究理事会(NMRC)转化与临床研究（500万）；
3. 5、新加坡卫生部物医药研究理事会(BMRC)项目（150万）

1.        Guo C, Si S, FangH, Shuai S, Zhang Y, Du X, Duan B, Wu J, Yao H, Ge Z, Lin C†,Luo Z†. LEDGF/p75 promotes transcriptional pausing throughpreventing SPT5 phosphorylation. Sci Adv. 2025 Jan17;11(3):eadr2131.

2.        Zhu S, Xie P,Yang Y, Wang Y, Zhang C, Zhang Y, Si S, Zhang J, He J, Si H, Fang K, Ma B,Jiang X, Huang L, Li J, Min T, Zheng B, Da L, Lin D, Gao K, Li Y, Huang M, QiaoF, Huo H, Feng H, Zhao H, Chen Z, Xu Z, Xie J, Cao H, Liu J, Yao X, Xie W, SunY, Wu K, Xiong B, Hu P, Luo Z†, Lin C†.Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage. Nat Struct MolBiol. 2025 Jan 16.

3.        She P, Gao B, LiD, Wu C, Zhu X, He Y, Mo F, Qi Y, Jin D, Chen Y, Zhao X, Lin J, Hu H, Li J,Zhang B, Xie P, Lin C, Christoffels VM, Wu Y, Zhu P, ZhongTP. The transcriptional repressor HEY2 regulates mitochondrial oxidativerespiration to maintain cardiac homeostasis. NatCommun. 2025 Jan 2;16(1):232.

4.        Liao X, Kang L,Peng Y, Chai X, Xie P, Lin C, Ji H, Jiao Y, Liu J. Multivariatestochastic modeling for transcriptional dynamics with cell-specific latent timeusing SDEvelo. Nat Commun. 2024 Dec 30;15(1):10849.

5.        Xie P,  ZhuS,  Zhang J,  Wang X,  Jiang X, Xiong F, ChenL, Fang K, Ji Y, Zheng B, Da L, Cao H, Sun Y†, LuoZ†,  Lin C†.4D live tracing reveals distinct movementtrajectories of meiotic chromosomes. LifeMedicine, 2024 Nov. lnae038

6.        Mao G, Yang Y, Luo Z†, Lin C†, Xie P†.SpatialQC: automated quality control for spatial transcriptome data. Bioinformatics. 2024 Aug 2;40(8):btae458.

7.        Xie P, Jiang X,Pan Q, He J, Yang X, Che Z, Fang, K, Si S, Gao K, Zhong T, Yang Z, Wei K, Xie W,Jing N, Luo Z†, Lin C†. Epigenetic delineation of the earliest cardiac lineagesegregation by single cell multi-omics. 2024 eLife

8.        Meng S, Liu X,Zhu S, Xie P, Fang H, Pan Q, Fang K, Li F, Zhang J, Che Z, Zhang Q, Mao G, WangY, Hu P, Chen K, Sun F, Xie W, Luo Z†, Lin C†.Young LINE-1 transposon 5’UTRs marked by elongation factor ELL3 function asenhancers to regulate naïve pluripotency in embryonic stem cells. Nat Cell Biol. 2023 Aug 17（封面文章，同期杂志述评）

9.        Che Z, Liu X, DaiQ, Fang K, Guo C, Yue J, Fang H, Xie P, Luo Z†, LinC†. Distinct roles of the two SEC scaffold proteins, AFF1and AFF4, in regulating RNA Pol II transcription elongation. J Mol CellBiol. 2023 Aug 1:mjad049.

10.      Zhao X, Fang K, Liu X, Yao R, Wang M, Li F, Hao S, HeJ, Wang Y, Fan M, Huang W, Li Y, Gao C, Lin C†, Luo Z†. QSER1 preserves the suppressive status of thepro-apoptotic genes to prevent apoptosis. Cell Death Differ. 2023Mar;30(3):779-793. 

11.      Guo C, Zhang Y, Shuai S, Sigbessia A, Hao S, Xie P, JiangX, Luo Z†, Lin C†. The super elongationcomplex (SEC) mediates phase transition of SPT5 during transcriptional pauserelease. EMBO Rep. 2023 Jan 11:e55699. （同期杂志述评）

12.     Guo C, Luo Z†, LinC†. Phase Separation Properties in TranscriptionalOrganization. Biochemistry. 2022 Nov 15;61(22):2456-2460. 

13.      Wang Y, Ma B, Liu X, Gao G, Che Z, Fan M, Meng S, ZhaoX, Sugimura R, Cao H, Zhou Z, Xie J, Lin C†, Luo Z†.ZFP281-BRCA2 prevents R-loop accumulation during DNA replication. NatCommun. 2022 Jun 17;13(1):3493.

14.      Guo C, Luo Z, Lin C. Phaseseparation, transcriptional elongation control, and human diseases. J MolCell Biol. 2021 Aug 4;13(4):314-318. （封面文章）

15.      Yue J, Dai Q, Hao S, Zhu S, Liu X, Tang Z, Li M, FangH, Lin C, Luo Z. Suppression of the NTS-CPS1 regulatory axisby AFF1 in lung adenocarcinoma cells. J Biol Chem. 2021 Jan-Jun;296:100319.

16.      Du H, Chen C, Wang Y, Yang Y, Che Z, Liu X, Meng S,Guo C, Xu M, Fang H, Wang F, Lin C†, Luo Z†. RNF219 interacts withCCR4-NOT in regulating stem cell differentiation. J Mol Cell Biol.2020 Oct 26;12(11):894-905. 

17.      Han Z, Cui K, Placek K, Hong N, Lin C,Chen W, Zhao K, Jin W. Diploid genome architecture revealed by multi-omic dataof hybrid mice. Genome Res. 2020 Aug; 30(8):1097-1106.

18.      Guo C, Che Z, Yue J, Xie P, Hao S, Xie W, Luo Z†, Lin C†. ENL initiatesmultivalent phase separation of the super elongation complex (SEC) incontrolling rapid transcriptional activation. Sci Adv. 2020 Apr 1;6(14):eaay4858.

19.      Luo Z, Liu X, Xie H, Wang Y, Lin C †. ZFP281 recruits MYCto active promoters in regulating transcriptional initiation and elongation. MolCell Biol. 2019 Sep 30. pii: MCB.00329-19.

20.      Zhang Y, Wang C, Liu X, Yang Q, Ji H, Yang M, Xu M,Zhou Y, Xie W, Luo Z, Lin C†. AFF3-DNA methylation interplay in maintaining the mono-allelicexpression pattern of XIST in terminally differentiated cells. J Mol CellBiol. 2018 Dec 7. （同期杂志述评）

21.      Wu J, Tao N, Tian Y, Xing G, Lv H, Han J, Lin C, Xie W. Proteolyticmaturation of Drosophila Neuroligin 3 by tumor necrosis factor α-convertingenzyme in the nervous system. Biochim Biophys Acta. 2017 Oct 28.Pii: S0304-4165(17)30350-1.

22.      Dai Q, Shen Y, Wang Y, Wang X, Francisco JC, Luo Z, Lin C †. Striking abalance: regulation of transposable elements by Zfp281 and Mll2 in mouseembryonic stem cells. Nucleic Acids Res. 2017 Sep 25.

23.      Francisco JC, Dai Q, Luo Z, Wang Y, Chong RH, Tan YJ,Xie W, Lee GH, Lin C †.Transcriptional elongation control of the HBV cccDNA transcription by SuperElongation Complex (SEC) and BRD4. Mol Cell Biol. 2017 Jul 10. pii:MCB.00040-17.（封面文章）

24.      Wang Y, Shen Y, Dai Q, Yang Q, Zhang Y, Wang X, Xie W,Luo Z†, Lin C †.A permissive chromatin state regulated by ZFP281-AFF3 in controlling theimprinted Meg3 polycistron. Nucleic Acids Res.2017 Feb 17;45(3):1177-1185.

25.      Luo Z, Lin C†.Enhancer, epigenetics and human diseases. Curr Opin Genet Dev.2016 Apr 21;36:27-33.

26.      Luo Z, Lin C,Ashley RW, Bartom E, Gao X, Smith E, and Shilatifard A. Regulation of imprintedgene expression by allele-specific enhancer activity. GenesDev. 2016 Jan 1;30(1):92-101.

27.      De Kumar B, Parrish ME, Slaughter BD, Unruh JR, GogolM, Seidel C, Paulson A, Li H, Gaudenz K, Peak A, McDowell W, Fleharty B, Ahn Y,Lin C, Smith E, ShilatifardA, Krumlauf R. Analysis of dynamic changes in retinoid-induced transcriptionand epigenetic profiles of murine Hox clusters in ES cells. GenomeRes. 2015 Aug;25(8):1229-43.

28.      Luo Z, Gao X, LinC, Smith ER, Marshall SA, Swanson SK, Florens L, Washburn MP,Shilatifard A. Zic2 is an enhancer-binding factor required for embryonic stemcell specification. Mol Cell. 2015 Feb 19;57(4):685-94.

29.      Hu D, Smith ER, Garruss AS, Mohaghegh N, Varberg JM, Lin C, Jackson J, Gao X, SarafA, Florens L, Washburn MP, Eissenberg JC, Shilatifard A. The little elongationcomplex functions at initiation and elongation phases of snRNA gene transcription.MolCell. 2013 Aug 22;51(4):493-505.

30.      Lin C, Garrus AS, Luo Z, Guo F, Shilatifard A. The RNA PolII elongation factor Ell3 marks enhancers in ES cells and primes future geneactivation. Cell. 2013 Jan 17;152(1-2):144-56.

31.      Luo Z, Lin C,Shilatifard A. The super elongation complex (SEC) family in transcriptional control.NatRev Mol Cell Biol. 2012 Aug 16;13(9):543-7.

32.      Luo Z, Lin C,Guest E, Garrett AS, Mohaghegh N, Swanson S, Marshall S, Florens L, WashburnMP, Shilatifard A. The super elongation complex family of RNA polymerase IIelongation factors: gene target specificity and transcriptional output. MolCell Biol. 2012 Jul;32(13):2608-17.

33.      Smith ER, LinC, Garrett AS, Thornton J, Mohaghegh N, Hu D, Jackson J, Saraf A,Swanson SK, Seidel C, Florens L, Washburn MP, Eissenberg JC, Shilatifard A. Thelittle elongation complex regulates small nuclear RNA transcription. MolCell. 2011 Dec 23;44(6):954-65.

34.      Lin C, Garrett AS, De Kumar B, Smith ER, Gogol M, Seidel C,Krumlauf R, Shilatifard A. Dynamic transcriptional events in embryonic stemcells mediated by the super elongation complex (SEC). Genes Dev. 2011 Jul15;25(14):1486-98. （封面亮点文章介绍）

35.      Takahashi H, Parmely TJ, Sato S, Tomomori-Sato C,Banks CA, Kong SE, Szutorisz H, Swanson SK, Martin-Brown S, Washburn MP,Florens L, Seidel CW, Lin C,Smith ER, Shilatifard A, Conaway RC, Conaway JW. Human mediator subunit MED26functions as a docking site for transcription elongation factors. Cell.2011 Jul 8;146(1):92-104.

36.      Smith E, LinC, Shilatifard A. The super elongation complex (SEC) and MLL indevelopment and disease. Genes Dev. 2011 Apr 1;25(7):661-72.

37.      Mohan M, LinC, Guest E, Shilatifard A. Licensed to elongate: a molecular mechanismfor MLL-based leukaemogenesis. Nat Rev Cancer. 2010 Oct;10(10):721-8.

38.      Mohan M, Herz HM, Takahashi YH, Lin C, Lai KC, Zhang Y, Washburn MP, Florens L, ShilatifardA. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containingcomplex (DotCom). Genes Dev. 2010 Mar 15;24(6):574-89. （封面亮点文章介绍）

39.      Lin C, Smith ER, Takahashi H, Lai KC, Martin-Brown S,Florens L, Washburn MP, Conaway JW, Conaway RC, Shilatifard A. AFF4, acomponent of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras,can link transcription elongation to leukemia. Mol Cell. 2010 Feb12;37(3):429-37. （同期杂志述评）(Recommendedby the Faculty of 1000)

40.      Wang P, LinC, Smith ER, Guo H, Sanderson BW, Wu M, Gogol M, Alexander T, Seidel C,Wiedemann LM, Ge K, Krumlauf R, Shilatifard A. Global analysis of H3K4 methylationdefines MLL family member targets and points to a role for MLL1-mediated H3K4methylation in the regulation of transcriptional initiation by RNA polymeraseII. MolCell Biol. 2009 Nov;29(22):6074-85

41.      Lin C, Yuan YA. Structural insights into histone H3 lysine56 acetylation by Rtt109. Structure. 2008 Oct8;16(10):1503-10. （封面文章）

42.      Chen HY, Yang J, LinC, Yuan YA. Structural basis for RNA-silencing suppression by Tomatoaspermy virus protein 2b. EMBO Rep. 2008 Aug;9(8):754-60.

肿瘤发病机理与靶向治疗，生殖与出生缺陷