【王彬导师】招生“医学院”研究生介绍
王彬
副教授
硕，博士生导师
男
医学院
急慢性肾脏病及其并发症的临床和基础研究,肾脏罕见病的分子诊断和治疗
wangbinhewei@126.com
东南大学青年首席教授，附属中大医院肾脏科副主任医师，东南大学肾脏病研究所副所长，博士生导师。
教育部“长江学者”青年学者，东南大学“至善学者”。主持国家自然科学基金3项、江苏省重点研发计划社会发展项目1项、江苏省自然科学基金面上项目1项等课题。
现任中国生物医学工程学会人工器官分会委员兼学术秘书，中华医学会肾脏病学分会青年委员（第十二届），江苏省中西医结合学会第八届肾病委员会青年副主委，江苏省医学会肾脏病学分会青年委员。
第10届意大利国际肌肉减少症-恶病质-消耗性疾病学会（SCWD）获得“青年研究者奖”。以第一作者或通讯作者身份（含共同）在J Am Soc Nephrol, Sci Adv, Diabetes, JACC Basic Transl Sci, Theranostics, Mol Ther, Kidney Int Rep, Human Gene Therapy 等杂志发表SCI论文50余篇。
主要研究方向：CKD相关肌少症及疑难罕见肾脏病的分子诊断和治疗策略研究。
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科研项目
CDK12-HNF4A轴调控AKI肾小管损伤及机制研究，国家自然科学基金专项项目，2023.01- 2025.12，在研，主持，排1
巨噬细胞源性外泌体miR-155调控肾小管上皮细胞衰老的机制研究，国家自然科学基金面上项目，2021.01- 2024.12，在研，主持，排1
罕见肾脏病多维度筛诊体系建设与推广，江苏省科技计划专项项目，2023.07-2026.06，在研，主持，排1
东南大学“至善青年项目”，东南大学，2022年，在研，主持，排1
托伐普坦在肾病患者容量管理中的精准应用，中国心血管健康联盟诺创高血压科研创新基金，2022-01-2024-01，在研，主持，排1
RVG修饰外泌体运载miR-26a对尿毒症心肌损害的治疗作用研究，江苏省自然科学基金面上项目，2018-07-01-2020-06-3010，结题，主持，排1
醛固酮诱导TIF新机制：FOXO1/Rab7轴对miR-26a表达调控的研究，国家自然科学基金青年项目，2017-08-06-2020-12-31，结题，主持，排1
成纤维细胞生长因子21与血液透析患者血管钙化的相关性研究和机制初探，中华医学会临床医学科研专项资金项目，2020-03-31-2022-03-31，结题，主持，排1
血液透析患者膈肌功能障碍的临床研究，江苏省“六大人才”高峰项目C类一项，2018-06-01-2020-12-31，结题，主持，排1
醛固酮诱导TIF新机制：FOXO1/Rab7轴.miR-26a表达调控的研究，东南大学高水平论文扶持项目，2018-01-01-2019-12-31，结题，主持，排1
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研究成果
1.Wang B, Wang Y, Wen Y, Zhang YL, Ni WJ, Tang TT, et al. Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene. Mol Ther. 2022;30:3300-12.
2.Wang B, Qian JY, Tang TT, Lin LL, Yu N, Guo HL, et al. VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy. Diabetes. 2021;70:2639-51.
3.Wang B, Wang ZM, Ji JL, Gan W, Zhang A, Shi HJ, et al. Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy. JACC Basic Transl Sci. 2020;5:148-66.
4.Tang TT#, Wang B#, Wu M, Li ZL, Feng Y, Cao JY, et al. Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI. Sci Adv. 2020;6:z748.
5.Wang B, Zhang C, Zhang A, Cai H, Price SR, Wang XH. MicroRNA-23a and MicroRNA-27a Mimic Exercise by Ameliorating CKD-Induced Muscle Atrophy. J Am Soc Nephrol. 2017;28:2631-40.
6.Tang TT#, Wang B#, Li ZL, Wen Y, Feng ST, Wu M, et al. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI. J Am Soc Nephrol. 2021;32:2467-83.
7.Yin Q, Zhao YJ, Ni WJ, Tang TT, Wang Y, Cao JY, et al, Liu BC*, Wang B*. MiR-155 deficiency protects renal tubular epithelial cells from telomeric and genomic DNA damage in cisplatin-induced acute kidney injury. Theranostics. 2022;12:4753-66.
8.Ni WJ#, Li ZL#, Wen XL, Ji JJ, Liu H, Yin Q, et al, Liu BC*, Wang B*. HIF-1α and adaptor protein LIM and senescent cell antigen-like domains protein 1 axis promotes tubulointerstitial fibrosis by interacting with vimentin in angiotensin II-induced hypertension. Br J Pharmacol. 2024 May 3.（Online ahead of print）.
9.Zhang YL, Tang TT, Ni WJ, Li ZT, Jiang LYZ, Wang Y, et al, Liu BC*, Wang B*. Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects. Int J Biol Sci. 2024;12;20:1669-87.
10.Ni WJ, Zhao YJ, Shen jx, Yin Q, Wang Y, Li ZL, et al, Wang B*, Liu BC*. Therapeutic role of miR-26a on cardiaorenal injury in mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway. Chin Med J (Engl). 2024 Mar 6.（Online ahead of print）.
11.Sheng MJ, Cao JY, Hou SM, Li M, Wang Y, Fang Q, et al, Wang B*. Computed tomography-determined skeletal muscle density predicts 3-year mortality in initial-dialysis patients in China. J Cachexia Sarcopenia Muscle. 2023;14:2569-78.
12.Yin D, Cao JY, Yang Y, Li ZT, Liu H, Tang TT, et al, Liu BC*, Wang B*. Quercetin alleviates tubulointerstitial inflammation by inhibiting exosomes-mediated crosstalk between tubular epithelial cells and macrophages. Inflamm Res. 2023;72:1051-67.
13.Ji JJ, Shi HM, Li ZL, Jin R, Qu GT, Zheng H, et al, Wang B*, Zhang AQ*. Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy. Acta Pharmacol Sin. 202;44:2455-68.
14.Zheng J, Yin Q, Wang SY, Wang YY, Xiao JJ, Tang TT, et al, Liu BC*, Wang B*. Ultrasound-assessed diaphragm dysfunction predicts clinical outcomes in hemodialysis patients. Sci Rep. 2022;12:16550.
15.Gao YM, Feng ST, Wen Y, Tang TT, Wang B*, Liu BC*. Cardiorenal protection of SGLT2 inhibitors-Perspectives from metabolic reprogramming. EBioMedicine. 2022;83:104215.
16.Wang B, Li ZL, Zhang YL, Wen Y, Gao YM, Liu BC. Hypoxia and chronic kidney disease. EBioMedicine. 2022;77:103942.
17.Ni HF, Yang Y, Li CQ, Zhou TZ, Liu BC, Wang B*. Myeloid bodies caused by COQ2 mutation: a case of concurrent COQ2 nephropathy and IgA nephropathy. Clin Kidney J. 2021;14:1697-700.
18.Wang FM, Yang Y, Zhang XL, Wang YL, Tu Y, Liu BC, Wang B*. Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report. Frontiers in Genetics. 2021;12:690952.
19. Li ZL, Wang B*, Wen Y, Wu QL, Lv LL, Liu BC*. Disturbance of Hypoxia Response and Its Implications in Kidney Diseases. Antioxid Redox Signal. 2022 Nov;37:936-55.
20.Li ZL, Ji JL, Wen Y, Cao JY, Kharbuja N, Ni WJ, et al, Liu BC*, Wang B*. HIF-1alpha is transcriptionally regulated by NF-kappaB in acute kidney injury. Am J Physiol Renal Physiol. 2021;321:F225-35.
21.Li ZL, Wang B*, Lv LL, Tang TT, Wen Y, Cao JY, et al, Liu BC*. FIH-1-modulated HIF-1alpha C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling. Acta Pharmacol Sin. 2021;42:2106-19. doi: 10.1038/s41401-021-00617-4.
22. Wang H#, Wang B#, Zhang A, Hassounah F, Seow Y, Wood M, et al. Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice. Mol Ther. 2019;27:571-83.
23. Wang B, Zhang A, Wang H, Klein JD, Tan L, Wang ZM, et al. miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease. Theranostics. 2019;9:1864-77.
24. Cao JY#, Wang B#, Tang TT#, Wen Y, Li ZL, Feng ST, et al. Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics. 2021;11:5248-66.
25. Wang B, Wang J, He W, Zhao Y, Zhang A, Liu Y, et al. Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice. Hum Gene Ther. 2020;31:367-75.
26. Wang B, Yin Q, Wang YY, Tu Y, Han Y, Gao M, et al. Diaphragmatic dysfunction associates with dyspnoea, fatigue, and hiccup in haemodialysis patients: a cross-sectional study. Sci Rep. 2019;9:19382.
27. Qian FY, Li ZL, Guo YD, Gao HC, Gu LH, Le K, et al, Wang B*，Zhang Z J*. Hypoxia-inducible factor-prolyl hydroxylase inhibitor ameliorates myopathy in a mouse model of chronic kidney disease. Am J Physiol Renal Physiol. 2019;317:F1265-73.
28. Tu Y, Sheng MJ, Wang YL, Wang ZJ, Zhang XL, Liu BC, Wang B*. A Woman With "Polycystic Kidney Disease". Kidney Int Rep. 2020;5:1367-70.
29. Jiang L, Yin Q, Yang M, Li M, Pan M, Han Y, et al, Wang B*. Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients. Kidney Dis (Basel). 2021;7:227-40.
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