
张昌明,女,东部战区总医院肾脏科副主任医师,副教授,硕士生导师。主要研究方向为自身免疫性肾脏病的基因组变异解析,发病机制及靶向干预。在JASN, CJASN等杂志发表SCI论文10余篇,主持国家自然科学基金2项。获江苏省科学技术奖,江苏省医学引进新技术奖共3项。
(1)国家自然科学基金青年科学基金项目,81700628,足细胞来源外泌体介导miR-1246调控肾小管上皮细胞损伤的机制研究,2018/01-2020/12,20万元,已结题,主持;
(2)国家自然科学基金面上项目,82170739,从基因组层面解析特殊类型狼疮性肾炎发病机制,2022/01-2025/12,68万元,在研,主持。
发表的论文
1. Zhang Changming; Han Xu; Jin Ying; Chen Xiang; Gong Cheng; Peng Jiahui; Wang Yusha; Luo Xiaoxin; Yang Zhaohui; Zhang Yangyang; Wan Weiguo; Liu Xiaohui; Mao Jianhua; Yu Haiguo; Li Jingyi; Liu Li; Sun Li; Yang Sirui; An Yu; Liu Zhengzhao; Gao Erzhi; Zhu Honghao; Chen Yinghua; Yu Xiaomin; Zhou Qing; Liu Zhihong. Pathogenic Gene Spectrum and Clinical Implication in Chinese Patients with Lupus Nephritis. Clin J Am Soc Nephrol,18(7): 869-880, 2023 Apr 25. doi: 10.2215/CJN.0000000000000185. IF=10.61
2. Jiahui Peng#, Yusha Wang#, Xu Han#, Changming Zhang#, Xiang Chen, Ying Jin, Zhaohui Yang, Yu An, Jiahui Zhang, Zhengzhao Liu, Yinghua Chen, Erzhi Gao, Yangyang Zhang, Feng Xu, Chunxia Zheng, Qing Zhou*, Zhihong Liu*. Clinical Implications of a New DDX58 Pathogenic Variant That Causes Lupus Nephritis due to RIG-I Hyperactivation. J Am Soc Nephrol, 2023; 34 (2): 258-272 IF=14.978
3. Changming Zhang#, Xu Han#, Li Sun, Sirui Yang, Jiahui Peng, Yinghua Chen, Ying Jin, Feng Xu, Zhihong Liu*, Qing Zhou*. Novel loss-of-function mutations in TNFAIP3 gene in patients with lupus nephritis. Clinical Kidney Journal; 2022; 15 (11): 2027-2038, https://doi.org/10.1093/ckj/sfac130. November 2022 IF=5.860
4. Jiahui Zhang#, Changming Zhang#, Erzhi Gao, Qing Zhou. Next-Generation Sequencing-Based Genetic Diagnostic Strategies of Inherited Kidney Diseases. Kidney Dis; 2021;7 (6):425–437. IF =3.700
5. Changming Zhang, Mingchao Zhang, Dacheng Chen, Qiang Ren, Weiwei Xu,Caihong Zeng, Weisong Qin, Zhihong Liu*. Features of phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A in malignancy-associated membranous nephropathy. J Clin Pathol, 2019 Oct;72(10):705-711. doi: 10.1136/jclinpath-2019-205852. Epub 2019 Jun 26. IF=4.463
6. Zhang Changming#; Liang Shaoshan#; ChengShuiqin; Li Wei; WangXia; Zheng Chunxia; Zeng Caihong; Shi Shaolin; Xie Lu; Zen Ke*; Liu Zhihong*. Urinary miR-196a predicts disease progression in patients with chronic kidney disease.J Transl Med, 2018 Apr 10;16(1):91. doi: 10.1186/s12967-018-1470-2.IF=8.440
7. An Yu#;Zhang Changming#; Xu Feng; Li Wei; Zeng Caihong; Xie Lu; Liu Zhihong*. Increased urinary miR-196a level predicts the progression of renal injury in patients with diabetic nephropathy. Nephrol Dial Transplant, 2020 Jun 1;35(6):1009-1016. doi: 10.1093/ndt/gfy326. IF=7.186
8. Zhang Changming#; Zhang Wanfen; Chen Hui-Mei; Liu Chunbei; Wu Junnan; Shi Shaolin*; Liu Zhi-Hong*. Plasma MicroRNA-186 and Proteinuria in Focal Segmental Glomerulosclerosis. Am J Kidney Dis, 2015, 65(2), pp 223-232. IF=11.072
9. Changming Zhang; Jiahui Peng; Zhihong Liu; Qing Zhou. Kidney Involvement in Autoinflammatory Diseases. Kidney Dis (2023) 9 (3): 157-172. https://doi.org/10.1159/000529917 IF=3.700
10. 张洋洋, 金英, 梁丹丹, 涂远茂, 刘志红, 张昌明*. DNASE1L3基因变异致狼疮性肾炎的临床及遗传学分析——附1例病例报道及文献复习.肾脏病与透析肾移植杂志2023, 32 (2) :133-139.
11. 金英, 罗晓鑫, 梁丹丹, 彭嘉惠, 张洋洋, 涂远茂, 刘志红, 张昌明*. 3 例伴 G6PD 基因变异狼疮肾炎患者的临床病理特征及基因分析.肾脏病与透析肾移植杂志2023, 32 (3) :207-213.
12. 彭嘉惠,张昌明,刘志红.特殊类型系统性红斑狼疮致病基因研究.肾脏病与透析肾移植杂志.2021; 30(5) pp451-458
13. 张思盼#;张昌明#;吴俊男;赵越;徐孝东;郎月;朱小东;刘志红*,T细胞来源的细胞外囊泡通过miR-193a诱导足细胞损伤,肾脏病与透析肾移植杂志,2018,27(2),pp 124-129
获得的奖励
(1)2020年度江苏省医学新技术引进二等奖 慢性肾脏病尿液新型生物标志物的临床应用 第1名 江苏省卫生健康委员会 2020-2-256-1
(2)2016年度江苏省科学技术奖一等奖 足细胞损伤机制及临床转化研究 第7名 江苏省人民政府 2016-1-26-R7
(3)2015年度江苏省医学新技术引进一等奖 SuPAR检测在临床FSGS患者中的应用 第2名 江苏省卫生与计划生育委员会 2015-74-2