
游均,博士,副研究员,硕士生导师,中国农业科学院油料作物研究所芝麻与特色油料遗传育种创新团队执行首席。主要从事芝麻品质和抗逆分子育种研究。具体研究方向包括:(1)芝麻种子发育与营养品质形成的遗传基础和调控网络研究;(2)芝麻非生物逆境抗性调控基因及其分子机制:(3)基于基因编辑技术的芝麻种质创制与分子育种。主持国家重点研发计划子课题、国家自然科学基金、湖北省重点研发计划等多个科研项目,初步揭示了芝麻油脂及其组分、功能活性成分芝麻素、褪黑素等含量变异的遗传基础;初步探明了芝麻抗旱、耐渍、耐盐的分子机制,全基因组解析了芝麻根系性状遗传基础,发掘出一批抗旱、耐渍和根系发育等性状基因位点;率先在芝麻中实现了CRISPR/Cas9介导的基因编辑;发表论文70余篇,其中以第一或通讯作者(含共同)在Plant Biotechnology Journal、Journal of Advanced Research、Plant Physiology、Journal of Experimental Botany等杂志发表SCI论文40余篇,单篇最高影响因子13.263;获授权发明专利12项,实用新型专利4项;参与育成芝麻新品种16个,发布行业标准1项。
1、国家重点研发计划项目子课题,多功能苏子、红花品种选育与示范应用,2025-2027,主持
2、湖北省国际合作项目,优质高产芝麻品种选育与示范,2024EHA055,2024-2026,主持
3、湖北省引进外国人才和智力项目(高端外国专家项目),芝麻现代育种关键种质创新与基因发掘,2024DJC011,2024,主持
4、湖北省重点研发计划(国际合作领域),高产抗旱适宜机械化芝麻品种选育及示范,2020BHB028,2020-2022,主持
5、农业部中央级公益性科研院所基本科研业务费专项,芝麻逆境应答基因网络构建及抗旱基因挖掘,1610172018007,2018-2020,主持
6、国家自然科学基金青年基金,水稻OsSRO1c基因在干旱胁迫诱导的叶片衰老中的功能研究,31500223,2016-2018,主持
第一或通讯作者论文
1. Kefale H†, Zhou R†, Luo Z, Dossou SSK, Berhe M, Wang L, Abbas AA, Zhang Y, Zhou T, You J*, Wang L*. Metabolomic and biochemical insights into bioactive compounds and antioxidant properties of black oilseed testa and peeled seeds. Curr Res Food Sci. 2025, 10:100939. https://doi.org/10.1016/j.crfs.2024.100939
2. Zhou J, Hu F, Berhe M, Zhou R, Li D, Li H, Yang L, Zhou T, Zhang Y, Wang L*, You J*. Genome-wide identification, classification, and expression profiling of LAC gene family in sesame. BMC Plant Biol. 2024, 24:1254. https://doi.org/10.1186/s12870-024-05982-w
3. Dossou SSK†, Luo Z†, Deng Q, Zhou R, Zhang Y, Li D, Li H, Tozo K, You J*, Wang L*. Biochemical and molecular insights into variation in sesame seed antioxidant capability as revealed by metabolomics and transcriptomics analysis. Antioxidants. 2024, 13(5):514. https://doi.org/10.3390/antiox13050514
4. Li H†, Hu F†, Zhou J, Yang L, Li D, Zhou R, Zhou T, Zhang Y, Wang L*, You J*. Genome-wide characterization of the DIR gene family in sesame reveals the function of SiDIR21 in lignan biosynthesis. Plant Physiol Biochem. 2024, 217:109282. https://doi.org/10.1016/j.plaphy.2024.109282
5. Song S†, Dossou SSK†, Meng M†, Sheng C, Li H, Zhou R, Li D, Xu P, You J*, Wang L*. Five improved sesame reference genomes and genome resequencing unveil the contribution of structural variants to genetic diversity and yield-related traits variation. Plant Biotechnol J. 2023, 21:1722-1724. https://dx.doi.org/10.1111/pbi.14092
6. Wang X†, Wang S†, Lin Q†, Lu J, Lv S, Zhang Y, Wang X, Fan W, Liu W, Zhang L*, Zhang X*, You J*, Cui P*, Li P*. The wild allotetraploid sesame genome provides novel insights into evolution and lignan biosynthesis. J Adv Res. 2023, 50:13-24. https://dx.doi.org/10.1016/j.jare.2022.10.004
7. Kefale H, Dossou SSK, Li F, Jiang N, Zhou R, Wang L, Zhang Y, Li D, You J*, Wang L*. Widely targeted metabolic profiling provides insights into variations in bioactive compounds and antioxidant activity of sesame, soybean, peanut, and perilla, Food Res Int. 2023, 174:113586. https://doi.org/10.1016/j.foodres.2023.113586
8. Sheng C, Song S, Zhou W, Dossou SSK, Zhou R, Zhang Y, Li D, You J*, Wang L*. Integrating transcriptome and phytohormones analysis provided insights into plant height development in sesame. Plant Physiol Biochem. 2023, 198:107695. https://dx.doi.org/10.1016/j.plaphy.2023.107695
9. Dossou SSK†, Song S†, Liu A, Li D, Zhou R, Berhe M, Zhang Y, Sheng C, Wang Z, You J*, Wang L*. Resequencing of 410 sesame accessions identifies SINST1 as the major underlying gene for lignans variation. Int J Mol Sci. 2023, 24:1055. https://dx.doi.org/10.3390/ijms24021055
10. Li H, Tahir Ul Qamar M, Yang L, Liang J, You J*, Wang L*. Current progress, applications and challenges of multi-omics approaches in sesame genetic improvement. Int J Mol Sci. 2023, 24:3105. https://dx.doi.org/10.3390/ijms24043105
11. Dossou SSK†, Luo Z†, Wang Z, Zhou W, Zhou R, Zhang Y, Li D, Liu A, Dossa K, You J*, Wang L*. The dark pigment in the sesame (Sesamum indicum L.) seed coat: isolation, characterization, and its potential precursors. Front Nutr. 2022, 9:858673. https://dx.doi.org/10.3389/fnut.2022.858673
12. You J*, Li D, Yang L, Dossou SSK, Zhou R, Zhang Y, Wang L*. CRISPR/Cas9-mediated efficient targeted mutagenesis in sesame (Sesamum indicum L.). Front Plant Sci. 2022, 13:935825. https://dx.doi.org/10.3389/fpls.2022.935825
13. Wang X†, You J†*, Liu A, Qi X, Li D, Zhao Y, Zhang Y, Zhang L*, Zhang X*, Li P*. Variation in melatonin contents and genetic dissection of melatonin biosynthesis in sesame. Plants (Basel). 2022, 11:2005. https://doi.org/10.3390/plants11152005
14. Zhou W†, Song S†, Dossou SSK, Zhou R, Wei X, Wang Z, Sheng C, Zhang Y, You J*, Wang L*. Genome-wide association analysis and transcriptome reveal novel loci and a candidate regulatory gene of fatty acid biosynthesis in sesame (Sesamum indicum L.). Plant Physiol Biochem. 2022, 186:220-231. https://dx.doi.org/10.1016/j.plaphy.2022.07.023
15. Su R, Dossou SSK, Dossa K, Zhou R, Liu A, Zhong Y, Fang S, Zhang X, Wu Z*, You J*. Genome-wide characterization and identification of candidate ERF genes involved in various abiotic stress responses in sesame (Sesamum indicum L.). BMC Plant Biol. 2022, 22: 256 http://dx.doi.org/10.1186/s12870-022-03632-7
16. Dossa K*, Zhou R, Li D, Liu A, Qin L, Mmadi MA, Su R, Zhang Y, Wang J, Gao Y, Zhang X*, You J*. A novel motif in the 5'-UTR of an orphan gene 'Big Root Biomass' modulates root biomass in sesame. Plant Biotechnol J. 2021, 19:1065-1079. https://dx.doi.org/10.1111/pbi.13531
17. Wang L†, Dossa K† You J†, Zhang Y, Li D, Zhou R, Yu J, Wei X, Zhu X, Jiang S, Gao Y, Mmadi MA, Zhang X*. High-resolution temporal transcriptome sequencing unravels ERF and WRKY as the master players in the regulatory networks underlying sesame responses to waterlogging and recovery. Genomics. 2021, 113:276-290. https://dx.doi.org/10.1016/j.ygeno.2020.11.022
18. Liu A, Wei M, Zhou Y, Li D, Zhou R, Zhang Y, Zhang X, Wang L*, You J*. Comprehensive analysis of SRO gene family in Sesamum indicum (L.) reveals its association with abiotic stress responses. Int J Mol Sci. 2021, 22:13048. https://doi.org/10.3390/ijms222313048
19. Zhang Y*, Gong H, Li D, Zhou R, Zhao F, Zhang X, You J*. Integrated small RNA and Degradome sequencing provide insights into salt tolerance in sesame (Sesamum indicum L.). BMC Genomics. 2020, 21: 494. https://doi.org/10.1186/s12864-020-06913-3
20. Dossa K†, You J†, Wang L†, Zhang Y, Li D, Zhou R, Yu J, Wei X, Zhu X, Jiang S, Gao Y, Mmadi MA, Zhang X*. Transcriptomic profiling of sesame during waterlogging and recovery. Sci Data. 2019, 6:204. https://dx.doi.org/10.1038/s41597-019-0226-z
21. You J, Zhang Y, Liu A, Li D, Wang X, Dossa K, Zhou R, Yu J, Zhang Y, Wang L, Zhang X*. Transcriptomic and metabolomic profiling of drought-tolerant and susceptible sesame genotypes in response to drought stress. BMC Plant Biol. 2019, 19:267. https://dx.doi.org/10.1186/s12870-019-1880-1
22. Zhang Y, Li D, Zhou R, Wang X, Dossa K, Wang L, Zhang Y, Yu J, Gong H, Zhang X*, You J*. Transcriptome and metabolome analyses of two contrasting sesame genotypes reveal the crucial biological pathways involved in rapid adaptive response to salt stress. BMC Plant Biol. 2019, 19:66. https://dx.doi.org/10.1186/s12870-019-1665-6
23. Zhang Y, Wei M, Liu A, Zhou R, Li D, Dossa K, Wang L, Zhang Y, Gong H, Zhang X*, You J*. Comparative proteomic analysis of two sesame genotypes with contrasting salinity tolerance in response to salt stress. J Proteomics. 2019, 201:73-83. https://dx.doi.org/10.1016/j.jprot.2019.04.017
24. Wei M, Liu A, Zhang Y, Zhou Y, Li D, Dossa K, Zhou R, Zhang X*, You J*. Genome-wide characterization and expression analysis of the HD-Zip gene family in response to drought and salinity stresses in sesame. BMC Genomics. 2019, 20:748. https://dx.doi.org/10.1186/s12864-019-6091-5
25. You J, Wang Y, Zhang Y, Dossa K, Li D, Zhou R, Wang L, Zhang X*. Genome-wide identification and expression analyses of genes involved in raffinose accumulation in sesame. Sci Rep. 2018, 8:4331. https://dx.doi.org/10.1038/s41598-018-22585-2
26. Wang Y, Zhang Y, Zhou R, Dossa K, Yu J, Li D, Liu A, Mmadi MA, Zhang X, You J*. Identification and characterization of the bZIP transcription factor family and its expression in response to abiotic stresses in sesame. PLoS One. 2018, 13:e0200850. https://dx.doi.org/10.1371/journal.pone.0200850
27. Zhang Y, Li D, Wang Y, Zhou R, Wang L, Zhang Y, Yu J, Gong H, You J*, Zhang X*. Genome-wide identification and comprehensive analysis of the NAC transcription factor family in Sesamum indicum. PLoS One. 2018, 13:e0199262. https://dx.doi.org/10.1371/journal.pone.0199262
28. You J and Chan Z*. ROS regulation during abiotic stress responses in crop plants. Front Plant Sci. 2015, 6:1092. https://doi.org/10.3389/fpls.2015.01092
29. You J, Zhang L, Song B, Qi X, Chan Z*. Systematic analysis and identification of stress-responsive genes of the NAC gene family in Brachypodium distachyon. PLoS ONE. 2015, 10(3):e0122027. http://dx.doi.org/10.1371/journal.pone.0122027
30. Zhang L†, You J†, Chan Z*. Identification and characterization of TIFY family genes in Brachypodium distachyon. J Plant Res. 2015, 128:995-1005. http://dx.doi.org/10.1007/s10265-015-0755-2
31. You J, Zong W, Hu H, Li X, Xiao J, Xiong L*. A STRESS-RESPONSIVE NAC1-regulated protein phosphatase gene rice protein phosphatase18 modulates drought and oxidative stress tolerance through abscisic acid-independent reactive oxygen species scavenging in rice. Plant Physiol. 2014, 166: 2100-2114. http://dx.doi.org/10.1104/pp.114.251116
32. You J, Zong W, Du H, Hu H, Xiong L*. A special member of the rice SRO family, OsSRO1c, mediates responses to multiple abiotic stresses through interaction with various transcription factors. Plant Mol Biol. 2014, 84: 693-705. http://dx.doi.org/10.1007/s11103-013-0163-8
33. You J, Zong W, Li X, Ning J, Hu H, Li X, Xiao J, Xiong L*. The SNAC1-targeted gene OsSRO1c modulates stomatal closure and oxidative stress tolerance by regulating hydrogen peroxide in rice. J Exp Bot. 2013, 64: 569-83. 5.36. http://dx.doi.org/10.1093/jxb/ers349
34. You J, Hu H, Xiong L*. An ornithine δ-aminotransferase gene OsOAT confers drought and oxidative stress tolerance in rice. Plant Sci. 2012, 197: 59-69. http://dx.doi.org/10.1016/j.plantsci.2012.09.002
35. Zhou W†, Sheng C†, Dossou SSK, Wang Z, Song S, You J*, Wang L*. Genome-wide identification of TPS genes in sesame and analysis of their expression in response to abiotic stresses. Oil Crop Science. 2023, 8:81-88. https://dx.doi.org/10.1016/j.ocsci.2023.03.004
36. Zhang Y, Li D, Zhou R, Liu A, Wang L, Zhang Y, Gong H, Zhang X*, You J*. A collection of transcriptomic and proteomic datasets from sesame in response to salt stress. Data Brief. 2020, 32:106096. https://dx.doi.org/10.1016/j.dib.2020.106096
37. You J, Li Q, Yue B, Xue WY, Luo LJ, Xiong LZ*. Identification of quantitative trait loci for ABA sensitivity at seed germination and seedling stages in rice. J Genet Genomics. 2006, 33:532-41. http://dx.doi.org/10.1016/S0379-4172(06)60082-6
38. 杨茜†, 游均†, 周瑢, 方圣, 张艳欣, 吴自明*, 王林海*. 芝麻籽粒植酸含量高通量检测方法的建立与低植酸种质的筛选. 中国农业科学. 2024, 57(12):2282-2294. https://doi.org/10.3864/j.issn.0578-1752.2024.12.002
39. 周江龙, 胡凤铎, 周瑢, 周王易, 王志坚, 黎冬华, 张艳欣, 王林海*, 游均*. 芝麻种质资源矿质元素含量和品质性状分析与综合评价. 中国油料作物学报. 2024. https://doi.org/10.19802/j.issn.1007-9084.2023322
40. 周江龙,胡凤铎,裴庆华,周瑢,韩亮,张艳欣,王林海*,游均*. 不同黑芝麻富硒能力及营养品质性状分析. 中国油料作物学报. 2024, 网络首发. https://doi.org/10.19802/j.issn.1007-9084.2024194
41. 苏如奇, 黎冬华, 吴自明, 王林海, 游均*. 芝麻非生物胁迫抗性研究进展. 中国油料作物学报. 2024, 网络首发. https://doi.org/10.19802/j.issn.1007-9084.2024041
42. 游均, 郭元章, 赵应忠, 王林海*. 栽培芝麻分布、起源与驯化. 中国油料作物学报. 2024, 46(5):959-968. https://doi.org/10.19802/j.issn.1007-9084.2023065
43. 张玉娟, 黎冬华, 宫慧慧, 崔新晓, 高春华, 张秀荣, 游均*, 赵军胜*. 芝麻NAC转录因子基因SiNAC77的克隆及耐盐功能分析. 生物技术通报. 2023, 39(11):308-317. https://doi.org/10.13560/j.cnki.biotech.bull.1985.2023-0096
44. 罗自舒, 王志坚, 周王易, Senouwa Segla Koffi Dossou, 周瑢, 张艳欣, 黎冬华, 游均*, 王林海*. 不同颜色芝麻营养品质性状遗传变异分析. 植物遗传资源学报. 2023, 24(2):365-375. https://doi.org/10.13430/j.cnki.jpgr.20220919001
45. 魏梦园, 刘爱丽, 黎冬华, 周瑢, 王林海, 张秀荣, 游均*. 芝麻CCCH锌指蛋白基因SiC3H1的克隆及表达分析. 分子植物育种. 2020, 18(24):7982-7988. https://doi.org/10.13271/j.mpb.018.007982
46. 刘爱丽, 魏梦园, 黎冬华, 周瑢, 张秀荣, 游均*. 芝麻肌醇半乳糖苷合成酶基因SiGolS6的克隆及功能分析. 中国农业科学. 2020, 53(17):3432-3442. https://doi.org/10.3864/j.issn.0578-1752.2020.17.002