【张磊导师】招生“医学院”研究生介绍
张磊
硕士生导师
男
医学院
外科学
急慢性肾脏损伤及保护
lei198711@163.com
张磊，医学博士，东南大学附属中大医院泌尿外科 主治医师，东南大学硕士研究生导师。国家公派美国Mayo Clinic联合培养博士、德国汉堡大学Eppendorf医院（UKE）访问学者。主要从事肾脏损伤修复以及泌尿系肿瘤的基础研究和临床诊治工作。主持国自然青年基金1项，江苏省自然青年基金1项，参与国家及省部级科研课题多项，发表SCI论文10余篇。
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科研项目
Principal Investigator:
Natural Science Foundation of China (82100732): Hypoxia preconditioned renal tubular epithelial cell-derived extracellular vesicles protect against renal ischaemia-reperfusion injury by transferring DRD4 mRNA.
Date:01/01/2022-12/31/2024
Natural Science Foundation of Jiangsu Province of China (BK20200360): Mechanism research on the role of extracellular vesicle-encapsulated miR-125b regulated by HIF-1α/SP1 in protection of remote ischemic preconditioning on renal ischemia-reperfusion injury.
Date: 07/01/2020-06/31/2023
Postgraduate Research & Practice Innovation Program of Jiangsu Province(KYCX17_0180): HIF-1α-Rabs-EVs: a new mechanism of remote ischemic precondition for protecting renal ischemia-reperfusion injury.
Date: 07/10/2017-05/01/2019
Co-Investigator：
Natural Science Foundation of China (81871157): Adipose derived stem cells improve penile erectile function in type 2 diabetic rats through adiponectin pathway.
PI: Chao Sun.
Date: 01/01/2019-12/31/2022.
Natural Science Foundation of China (82070773): A novel compounds combination maintaining Foxp3-CNS2 demethylation for generation of stable iTreg cells via inhibition of STAT6 induces immune tolerance in mouse kidney transplantation.
PI: Shuqiu Chen.
Date: 01/01/2021-12/31/2024.
Natural Science Foundation of China (82170703): Mechanism of apoptosis related vesicles loaded with MIF protein involved in the protective effect of remote ischemic preconditioning on kidney injury.
PI: Guangyuan Zhang.
Date: 01/01/2022-12/31/2025.
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研究成果
1.Zhang L, Zhu XY*, Zhao Y, Eirin A, Liu L, Fergusom CM, Tang H, Lerman A, Lerman LO*. Selective intrarenal delivery of mesenchymal stem cell‑derived extracellular vesicles attenuates myocardial injury in experimental metabolic renovascular disease. Basic Res Cardiol. 2020; 115(2):16.
2.Zhang L, Liu H, Xu K, Ling Z, Huang Y, Lu K, Liu C, Wang Y, Liu N, Zhang X, Xu B, Wu J, Chen S, Zhang G*, Chen M*. Hypoxia preconditioned renal tubular epithelial cell-derived extracellular vesicles alleviate renal ischaemia-reperfusion injury mediated by the HIF-1α/Rab22 pathway and potentially affected by microRNAs. Int J Biol Sci. 2019; 15(6): 1161-1176.
3.Zhang L, Zhang X, Liu C, Lu K, Huang Y, Wang Y, Xing L, Zhang L, Liu N, Jiang H, Sun C, Yang Y, Chen S, Chen M, Xu B. MiR-30a functions as a tumor suppressor by downregulating CCNE2 expression in castration-resistant prostate cancer. Mol. Med. Rep. 2016, 14(3): 2077-2084.
4.Zhang L, Xu B, Wang Y, Liu C, Lu K, Huang Y, Liu N, Zhang X, Chen S, Chen M. Advanced renal cell carcinoma in a patient with de novo von Hippel–Lindau disease: case report and review of the literature. Oncol Lett. 2015, 10(2): 1087-1090.
5.Zhang L, Xu B, Chen S, Lu K, Liu C, Wang Y, Zhao Y, Zhang X, Liu D, Chen M. The complex roles of microRNAs in the metastasis of renal cell carcinoma. J Nanosce Nanotechno, 2013, 13(5):3195-3203.
6.Mao W, Zhang L(equally contributing), Sun S, Wu J, Zou X, Zhang G, Chen M. Physical Activity Reduces the Effect of High Body Mass Index on Kidney Stones in Diabetes Participants From the 2007-2018 NHANES Cycles: A Cross-Sectional Study. Front Public Health.2022;10, 936552.
7.Ling Z, Wang X, Tao T, Zhang L(equally contributing), Guan H, You Z, Lu K, Zhang G, Chen S, Wu J, Qian J, Liu H, Xu B, Chen M. Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer. J Exp Clin Cancer Res.2017 15;36(1):159.
8.Liu C, Zhang L(equally contributing), Huang Y, Lu K, Tao T, Chen S, Zhang X, Guan H, Chen M, Xu B. MicroRNA-328 directly targets p21-activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity. Mol. Med. Rep. 2015, 12(5): 7389-7395.
9.Wang Y, Qu H, Zhang L(equally contributing), Chen S, Xu B, Lu K, Liu C, Tao T, Yang Y, Chen M. Safety and postoperative outcomes of regional versus global ischemia for partial nephrectomy: a systematic review and meta-analysis. Urol Int. 2015, 94(4): 428-435.
10.Sun S, Mao W, Wan L, Pan K, Deng L, Zhang L*, Zhang G*, Chen M*. Metastatic Immune-Related Genes for Affecting Prognosis and Immune Response in Renal Clear Cell Carcinoma. Front Mol Biosci. 2022; 8:794326.
11.Mao W, Chen S, Zhang L, Li T, Sun S, Xu B, Zhu W, Zhang G, Zhang L*, Wu J*, Chen M*. Robot-Assisted Laparoscopic Radical Cystectomy and Modified Y-Shaped Ileal Orthotopic Neobladder Reconstruction. Front Surg.2022; 9, 889536.
12.Zhang G, Zhang L, Sun S, Chen M. Identification of a Novel Defined Immune-Autophagy-Related Gene Signature Associated With Clinical and Prognostic Features of Kidney Renal Clear Cell Carcinoma. Front Mol Biosci. 2021; 8:790804.
13.Liu L, Xu Q, Zhang L, Sun H, Ding F, Li Y*, Chen P*. Fe3O4 magnetic nanoparticles ameliorate albumin-induced tubulointerstitial fibrosis by autophagy related to Rab7. Colloids Surf B Biointerfaces. 2020 Nov 15;111470. (doi: 10.1016/j.colsurfb.2020.111470. Online ahead of print).
14.Zhao Y, Zhu X, Zhang L, Ferguson CM, Song T, Jiang K, Conley SM, Krier JD, Tang H, Saadiq I, Jordan KL, Lerman A, Lerman LO*. Mesenchymal Stem/Stromal Cells and their Extracellular Vesicle Progeny Decrease Injury in Poststenotic Swine Kidney Through Different Mechanisms. Stem Cells Dev. 2020;29:1190-200.
15.Qian S, Sun S, Zhang L, Tian S, Xu K, Zhang G*, Chen M*. Integrative Analysis of DNA Methylation Identified 12 Signature Genes Specific to Metastatic ccRCC. Front Oncol. 2020, 10:556018.
16.Zhao Y, Zhu XY, Song T, Zhang L, Eirin A, Conley S, Tang H, Saadiq I, Jordan K, Lerman A Lerman LO. Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching. AJP-Renal Physiology. 2021, 320(3): F454-F463.
17.Zhang G, Yang Y, Huang Y, Zhang L, Ling Z, Zhu Y, Wang F, Zou X, Chen M. Hypoxia-induced extracellular vesicles mediate protection of remote ischemic preconditioning for renal ischemia-reperfusion injury. Biomed Pharmacother. 2017, 90: 473-478.
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