【周志新导师】招生“化学化工学院”研究生介绍
周志新
教授
硕，博士生导师
男
化学化工学院
化学
分析化学,电分析化学,DNA纳米技术,疾病标志物检测分析
zhixin.zhou@seu.edu.cn
教育背景
• 2007.09-2011.06 南京工业大学，化学，理学学士
• 2011.09-2017.03 东南大学，材料物理与化学，硕博连读（导师：张袁健教授）
工作经历
• 2017.03-2021.03 以色列耶路撒冷希伯来大学，化学系，博士后（导师：Itamar Willner教授）
• 2021.05至今 东南大学化学化工学院，教授
• 2025.01至今 东南大学，青年特聘教授
研究兴趣
以“基于生物反应网络的高性能生物传感应用”为主题，以生物分子为基本结构工具，结合分子工程技术和生物传感技术，构建了系列生物反应网络，并将其应用于高性能生物传感器的设计和活细胞内精准化学测量，开展了系列创新性研究：（1）构建了系列生物反应网络体系，揭示细胞内复杂分子网络的作用机制，进而建立基于生物反应网络的多元组分识别、多信号协同响应和时间选择性传感新原理；（2）发展基于空间限域效应的生物反应网络生物传感探针，通过提高局域浓度显著提高了生物传感的灵敏度、响应速度和选择性；（3）将新型生物传感器应用于活细胞内的精准测量，实现活细胞微环境，脑疾病相关分子智能检测和精准成像分析，为科学研究和临床诊断提供新的工具。围绕上述研究开展了系统工作，取得了阶段性成果，并产生第一作者/通讯作者（含共同）论文25篇，包括J. Am. Chem. Soc. 6篇、ACS Nano 5篇、Nano Lett. 1篇、Chem. Sci. 1篇、Anal. Chem. 3篇、Chem. Soc. Rev. 2篇。研究成果受到国内外同行广泛关注，被Nat. Chem.和Nat. Catal.等期刊正面引用或大篇幅重点介绍2900余次。作为项目负责人承担国家省部级项目3项，曾获得江苏省优秀博士学位论文奖和江苏省材料学会优秀教学成果一等奖（排4），受聘《中国化学快报》青年编委。
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科研项目
1. 国家自然科学基金面上项目，2026.01-2029.12，主持；
2. 国家自然科学基金青年项目，2024.01-2026.12，主持；
3. 国家重点研发计划，2024.12-2026.11，项目骨干
4. 国家重点研发计划，2024.12-2027.11，子课题负责人
5. 江苏省自然科学基金青年项目，2022.06-2025.06，主持；
6. 江苏省双创博士，2022-2024，主持
7. 东南大学院系联合基金项目，2024，主持
8. 东南大学科研启动经费，2021-2024，主持；
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研究成果
课题组网页：https://carbosensing.group/zh.htm
加入东南大学之后代表性论文：
1. Nina Lin‡, Yu Ouyang‡, Yunlong Qin, Songqin Liu, Itamar Willner*, Yuanjian Zhang, and Zhixin Zhou*, J. Am. Chem. Soc. 2025, Accepted.
2. Zhixin Zhou‡, Bing Han‡, Yu Wang, Nina Lin, Zhongqiu Zhou, Yuan Zhang, Ying Bai, Ling Shen, Yanfei Shen, Yuanjian Zhang*, and Honghong Yao*, Fast and Sensitive Multivalent Spatial Pattern-Recognition for Circular RNA Detection, Nature Communications, 2024, 15, 10900
3. Nina Lin, Yu Ouyang, Yunlong Qin, Ola Karmi, Yang Sung Sohn, Songqin Liu, Rachel Nechushtai, Yuanjian Zhang*, Itamar Willner*, and Zhixin Zhou*, “Spatially Localized Entropy-Driven Evolution of Nucleic Acid-Based Constitutional Dynamic Networks for Intracellular Imaging and Spatiotemporal Programmable Gene Therapy”, J. Am. Chem. Soc. 2024, 146, 20685
4. Zhixin Zhou*‡, Nina Lin‡, Yu Ouyang, Songqin Liu, Yuanjian Zhang*, and Itamar Willner*, “Cascaded, Feedback-Driven, and Spatially Localized Emergence of Constitutional Dynamic Networks Driven by Enzyme-Free Catalytic DNA Circuits”, J. Am. Chem. Soc. 2023, 145, 12617–12629.
5. Yanfeng Fang, Zhixin Zhou*, Yuhua Hou, Chenchen Wang, Xuwen Cao, Songqin Liu, Yanfei Shen*, and Yuanjian Zhang*, “Highly Efficient Wavelength-Resolved Electrochemiluminescence of Carbon Nitride Films for Ultrasensitive Multiplex MicroRNA Detection”, Anal. Chem. 2023, 95, 16, 6620–6628
加入东南大学之前代表性论文：
1. Zhixin Zhou, Yu Ouyang, Jianbang Wang, and Itamar Willner*, Dissipative Gated and Cascaded DNA Networks, J. Am. Chem. Soc. 2021, 143, 5071–5079
2. Zhixin Zhou, Jianbang Wang, and Itamar Willner*, Dictated Emergence of Nucleic Acid-Based Constitutional Dynamic Networks by DNA Replication Machineries, J. Am. Chem. Soc. 2021, 143, 241–251
3. Zhixin Zhou, Liang Yue, Shan Wang, Jean-Marie Lehn, and Itamar Willner*, DNA-Based Multiconstituent Dynamic Networks: Hierarchical Adaptive Control over the Composition and Cooperative Catalytic Functions of the Systems, J. Am. Chem. Soc. 2018, 140, 12077-12089
4. Zhixin Zhou, Jianhai Wang, Jiachao Yu, Yanfei Shen, Ying Li, Anran Liu, Songqin Liu, and Yuanjian Zhang*, Dissolution and Liquid Crystals Phase of 2D Polymeric Carbon Nitride, J. Am. Chem. Soc. 2015, 137, 2179-2182
5. Zhixin Zhou, Jianbang Wang, R. D. Levine, Francoise Remacle and Itamar Willner*, DNA-Based Constitutional Dynamic Networks as Functional Modules for Logic Gates and Computing Circuit Operations, Chem. Sci. 2021, 12, 5473-5483
6. Zhixin Zhou, Yang Sung Sohn, Rachel Nechushtai, and Itamar Willner*, DNA Tetrahedra Modules as Versatile Optical Sensing Platforms for Multiplexed Analysis of miRNAs, Endonucleases, and Aptamer–Ligand Complexes, ACS Nano, 2020, 14, 9021–9031
7. Zhixin Zhou, Daoqing Fan, and Itamar Willner*, Modeling Gene Expression Instability by Programmed and Switchable Polymerization/Nicking DNA Nanomachineries, ACS Nano, 2020, 14, 5046-5052
8. Zhixin Zhou, Pu Zhang, Liang Yue, and Itamar Willner*, Triggered Interconversion of Dynamic Networks Composed of DNA-Tetrahedra Nanostructures, Nano Lett. 2019, 19, 7540-7547
9. Zhixin Zhou, Xia Liu, Liang Yue, and Itamar Willner*, Controlling the Catalytic and Optical Properties of Aggregated Nanoparticles or Semiconductor Quantum Dots Using DNA-Based Constitutional Dynamic Networks, ACS Nano, 2018, 12, 10725-10735
10. Zhixin Zhou, Qiuwei Shang, Yanfei Shen, Linqun Zhang, Yuye Zhang, Yanqin Lv, Ying Li, Songqin Liu and Yuanjian Zhang*, Chemically Modulated Carbon Nitride Nanosheets for Highly Selective Electrochemiluminescent Detection of Multiple Metal-ions, Anal. Chem., 2016, 88, 6004-6010
11. Zhixin Zhou, Yanfei Shen, Ying Li, Anran Liu, Songqin Liu, and Yuanjian Zhang*, Chemical Cleavage of Layered Carbon Nitride with Enhanced Photoluminescent Performances and Photoconduction, ACS Nano, 2015, 9, 12480-12487
12. Zhixin Zhou, Margarita Vázquez-González, and Itamar Willner*, Stimuli-Responsive Metal-Organic Framework Nanoparticles for Controlled Drug Delivery and Medical Applications, Chem. Soc. Rev. 2021, 50, 4541-4563
13. Zhixin Zhou, Yuye Zhang, Yanfei Shen, Songqin Liu, and Yuanjian Zhang*, Molecular engineering of polymeric carbon nitride: advancing applications from photocatalysis to biosensing and more, Chem. Soc. Rev. 2018, 47, 2298-2321
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