【刘向东 导师】招生“生命科学与技术学院”研究生介绍
刘向东
教授
硕，博士生导师
男
生命科学与技术学院
生物与医药
,生物学
自身免疫疾病的发病机制,自身免疫疾病诊断方法学研究
xiangdongliu@seu.edu.cn
1985年毕业于厦门大学生物学系生化专业， 1991年毕业于协和医科大学研究生院和卫生部临床检验中心，获硕士学位， 1999年2月在丹麦奥尔胡斯大学（Aarhus University），公共卫生学院获分子医学博士学位。先后在丹麦肿瘤协会，加拿大病童医院（Sickkids）和安大略癌症研究所（OCI）从事科研和管理工作。 2012年2月至今任东南大学生命科学与技术学院特聘教授, 博士生导师。 2012年获江苏省高层次创新创业人才计划支持。主要从事原发性胆汁性胆管炎发病机制研究和自身抗体的检测方法学研究。 社会兼职包括江苏省遗传学会理事，江苏省免疫学会理事等。
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科研项目
研究成果
1. Xu Y, Yao Y, Ma M, Yang S, Jiang P, Wang J, Tsuneyama K, Wang C, Liu X, Li L, Lian Z. The pro-inflammatory cytokines IL-18, IL-21, and IFN-γ differentially regulate liver inflammation and antimitochondrial antibody level in a murine model of primary biliary cholangitis. Journal of Immunology Research, 2022 March 7; 2022:7111445.
2.Xu J, Zhang H, Wang C, Jiang P, Han C, Dai Y, Qiu F, Gong Y, Jiang Y, Xu P, Zhang M, Zhang L, Shi X, Chen S, Tian Y, Seldin MF, Gershwin ME, Liu X, Li L. Increased sensitivity of gp210 autoantibody detection using a newly designed gp210 antigen. Journal of Immunological methods, 2022 Feb; 501:113211.
3. Wang L, Li J, Chan Wang C, Tang R, Liang J, Gong Y, Dai Y, Ding N, Wu J, Dai N, Liu L, Zhao Y, Shao Y, Zhao W, Jiang P, Shi X, Chen W, Tian Y, Liu X, *, Ma X, * and Sun Z*. Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism. Journal of Genetics and Genomics, 2022, 49:145-54.
4. Wang C, Zheng X, Tang R, Han C, Jiang Y, Wu J, Shao Y, Gao Y, Yu J, Hu Z, Zang Z, Zhao Y, Dai N, Liu L, Wu X, Nie J, Jiang B, Lin M, Li L, Wei Y, Li Y, Gong Y, Dai Y, Wang L, Ding N, Xu P, Chen S, Jiang P, Wang L, Qiu F, Wu Q, Zhang M, Jawed R, Chen R, Zhang Y, Shi X, Zhu Z, Pei H, Huang L, Tian Y, Zhang K, Qiu H, Zhao W, Gershwin ME, Chen W, Seldin MF, Liu X, Ma X, Sun L. Fine Mapping of the MHC Region Identifies Major Independent Variants Associated with Han Chinese Primary Biliary Cholangitis. Journal of Autoimmunity, 2020 Feb; 107:102372.
5. Wang C, Zheng X, Jiang P, Tang R, Gong Y, Dai Y, Wang L, Xu P, Sun W, Wang L, Han C, Jiang Y, Wei Y, Zhang K, Wu J, Shao Y, Gao Y, Yu J, Hu Z, Zang Z, Zhao Y, Wu X, Dai N, Liu L, Nie J, Jiang B, Lin M, Li L, Li Y, Chen S, Shu L, Qiu F, Wu Q, Zhang M, Chen R, Jawed R, Zhang Y, Shi X, Zhu Z, Pei H, Huang L, Zhao W, Tian Y, Zhu X, Qiu H, Gershwin ME, Chen W, Seldin MF, Liu X, Sun L, Ma X. Genome Wide Association Studies of Specific Antinuclear Autoantibody Sub-phenotypes in Primary Biliary Cholangitis. Hepatology，2019; 70:294-307.
6. Qiu F, Tang R, Zuo X, Shi X, Wei Y, Zheng X, Dai Y, Gong Y, Wang L, Xu P, Zhu X, Wu J, Han C, Gao Y, Zhang K, Jiang Y, Zhou J, Shao Y, Hu Z, Tian Y, Zhang H, Dai N, Liu L, Wu X, Zhao W, Zhang X, Zang Z, Nie J, Sun W, Zhao Y, Mao Y, Jiang P, Ji H, Dong Q, Li J, Li Z, Bai X, Li L, Lin M, Dong M, Li J, Zhu P, Wang C, Zhang Y, Jiang P, Wang Y, Jawed R, Xu J, Zhang Y, Wang Q, Yang Y, Yang F, Lian M, Jiang X, Xiao X, Li Y, Fang J, Qiu D, Zhu Z, Qiu H, Zhang J, Tian W, Chen S, Jiang L, Ji B, Li P, Chen G, Wu T, Sun Y, Yu J, Tang H, He M, Xia M, Pei H, Huang L, Qing Z, Wu J, Huang Q, Han J, Xie W, Sun Z, Guo J, He G, Eric Gershwin M, Lian Z, Liu X, Seldin MF, Liu X, Chen W, Ma X. A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. Nat Commun. 2017 Apr 20; 8:14828.
7. Xu J, Li Z, Ren X, Dong M, Li J, Shi X, Zhang Y, Xie W, Sun Z, Liu X, Dai Q. Investigation of Pathogenic Genes in Chinese Sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing. Sci Rep. 2015 Nov 17; 5:16609.
8. Dong M, Li J, Tang R, Zhu P, Qiu F, Wang C, Qiu J, Wang L, Dai Y, Xu P, Gao Y, Han C, Wang Y, Wu J, Wu X, Zhang K, Dai N, Sun W, Zhou J, Hu Z, Liu L, Jiang Y, Nie J, Zhao Y, Gong Y, Tian Y, Ji H, Jiao Z, Jiang P, Shi X, Jawed R, Zhang Y, Huang Q, Li E, Wei Y, Xie W, Zhao W, Liu X, Zhu X, Qiu H, He G, Chen W, Seldin MF, Gershwin ME, Liu X, Ma X. Multiple genetic variants associated with primary biliary cirrhosis in a Han Chinese population. Clin Rev Allergy Immunol. 2015 Jun; 48(2-3):316-21. (original article)
9. Liu X, Invernizzi P, Lu Y, Kosoy R, Lu Y, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupoli S, Shigeta R, Ransom M, Lleo A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, Rosina F, Borghesio E, Floreani A, Lazzari R, Niro G, Andriulli A, Muratori L, Muratori P, Almasio PL, Andreone P, Margotti M, Brunetto M, Coco B, Alvaro D, Bragazzi MC, Marra F, Pisano A, Rigamonti C, Colombo M, Marzioni M, Benedetti A, Fabris L, Strazzabosco M, Portincasa P, Palmieri VO, Tiribelli C, Croce L, Bruno S, Rossi S, Vinci M, Prisco C, Mattalia A, Toniutto P, Picciotto A, Galli A, Ferrari C, Colombo S, Casella G, Morini L, Caporaso N, Colli A, Spinzi G, Montanari R, Gregersen PK, Heathcote EJ, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, Seldin MF. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet. 2010 Aug; 42(8):658-60.
10. Hirschfield GM, Liu X, Han Y, Gorlov IP, Lu Y, Xu C, Lu Y, Chen W, Juran BD, Coltescu C, Mason AL, Milkiewicz P, Myers RP, Odin JA, Luketic VA, Speiciene D, Vincent C, Levy C, Gregersen PK, Zhang J, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat Genet. 2010 Aug; 42(8):655-7.
11. Hirschfield GM*, Liu X*, Xu C, Lu Y, Xie G, Lu Y, Gu X, Walker EJ, Jing K, Juran BD, Mason AL, Myers RP, Peltekian KM, Ghent CN, Coltescu C, Atkinson EJ, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med. 2009 Jun 11; 360(24):2544-55.
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