
方可,男,生物化学与分子生物学博士,博士毕业于中山大学生命科学学院,现为东南大学生命科学与技术学院讲师。东南大学至善青年学者。研究方向为癌症和发育相关的遗传学和分子生物学。在国际著名杂志Genome biology, Molecular Cell, Blood, J Hematology&Oncology,Clinical and Translational medcine,Cell death and Differentiation 等发表发表论文18篇,其中13篇IF>10。其中以第一/通讯作者发表论文5篇。目前,作为负责人主持国家自然基金青年项目一项。
发表文章(*第一作者;#通讯作者):
2022:
Han C, Sun LY, Luo XQ, Pan Q, Sun YM, Zeng ZC, Chen TQ, Huang W, Fang K, Wang WT, Chen YQ. Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex. CELL REP 2022, 38(13): 110421.(中科院一区;IF=9.4,五年IF=10.4)
2021:
Huang W, Zeng ZC, Wang WT, Sun YM, Chen YQ, Luo XQ, Fang K#. A CRISPR/CAS9-based strategy targets the personalized chimeric neosequence in fusion-driven cancer genome for precision medicine. Clin Transl Med 2021, 11(3): e355.(中科院一区;IF=11.4,五年IF=8.6)
Huang W, Chen TQ, Fang K, Zeng ZC, Ye H, Chen YQ. N6-methyladenosine methyltransferases: functions, regulation, and clinical potential. J HEMATOL ONCOL 2021, 14(1): 117. (中科院一区;IF=17.4,五年IF=12.6)
Sun L, Wang W, Han C, Huang W, Sun Y, Fang K, Zeng Z, Yang Q, Pan Q, Chen T, Luo X, Chen Y. The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation. MOL CELL 2021, 81(21): 4493-4508. (中科院一区;IF=18.0,五年IF=19.6)
2020:
Fang K*, Huang W*, Sun YM, Chen TQ, Zeng ZC, Yang QQ, Pan Q, Han C, Sun LY, Luo XQ, Wang WT, Chen YQ. Cis-acting lnc-eRNA SEELA directly binds histone H4 to promote histone recognition and leukemia progression. GENOME BIOL 2020, 21(1): 269. (中科院一区;IF=13.6,五年IF=17.4)
Chen ZH, Chen TQ, Zeng ZC, Wang D, Han C, Sun YM, Huang W, Sun LY, Fang K, Chen YQ, Luo XQ, Wang WT. Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies. CELL DEATH DIS 2020, 11(7): 566. (中科院一区;IF=8.5,五年IF=8.7)
Wang WT, Chen TQ, Zeng ZC, Pan Q, Huang W, Han C, Fang K, Sun LY, Yang QQ, Wang D, Luo XQ, Sun YM, Chen YQ. The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. J HEMATOL ONCOL 2020, 13(1): 78. (中科院一区;IF=17.4,五年IF=12.6)
2019:
Huang W*, Fang K*, Chen TQ, Zeng ZC, Sun YM, Han C, Sun LY, Chen ZH, Yang QQ, Pan Q, Luo XQ, Wang WT, Chen YQ. circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression. J HEMATOL ONCOL 2019, 12(1): 103. (中科院一区;IF=17.4,五年IF=12.6)
Sun YM, Wang WT, Zeng ZC, Chen TQ, Han C, Pan Q, Huang W, Fang K, Sun LY, Zhou YF, Luo XQ, Luo C, Du X, Chen YQ. circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression. BLOOD 2019, 134(18): 1533-1546. (中科院一区;IF=20.6,五年IF=20.1)
Wang WT, Han C, Sun YM, Chen ZH, Fang K, Huang W, Sun LY, Zeng ZC, Luo XQ, Chen YQ. Activation of the Lysosome-Associated Membrane Protein LAMP5 by DOT1L Serves as a Bodyguard for MLL Fusion Oncoproteins to Evade Degradation in Leukemia. CLIN CANCER RES 2019, 25(9): 2795-2808. (中科院一区;IF=12.5,五年IF=12.8)
2019年前:
Sun LY, Li XJ, Sun YM, Huang W, Fang K, Han C, Chen ZH, Luo XQ, Chen YQ, Wang WT. LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1. MOL CANCER 2018, 17(1): 127.
Huang W, Wang WT, Fang K, Chen ZH, Sun YM, Han C, Sun LY, Luo XQ, Chen YQ. MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47. MOL CANCER 2018, 17(1): Chen ZH, Wang WT, Huang W, Fang K, Sun YM, Liu SR, Luo XQ, Chen YQ. The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway. CELL DEATH DIFFER 2017, 24(2): 212-224.
Fang K*, Han BW*, Chen ZH, Lin KY, Zeng CW, Li XJ, Li JH, Luo XQ, Chen YQ. A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target. HUM MOL GENET 2014, 23(12): 3278-3288.
Duan FT, Qian F, Fang K, Lin KY, Wang WT, Chen YQ. miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. MOL CANCER 2013, 12: 164.