1、国家自然科学基金面上项目，81872846 “海马犬尿氨酸代谢失衡在颞叶癫痫中的作用及其机制研究”，2019/01-2022/12，在研，主持。

2、国家自然科学基金面上项目，81673413 “miR-23a靶向调控ADAM10基因在颞叶癫痫中的作用及其机制研究”，2017/01-2018/12，已结题，主持。

3、教育部留学回国人员科研启动基金“NMDA受体通过转录因子CREB调控癫痫发生的作用及其细胞分子机制研究”第49批，2015/03-2018/6，已结题、主持。

4、江苏省自然科学基金面上项目，BK20141335、“NMDA受体通过转录因子CREB调控癫痫发生及其分子机制研究”  2014/07-2017/06，已结题、主持。

5、高等学校博士学科点专项科研基金项目，20130092120043、“NMDA受体NR2B亚基调控癫痫发生的作用及其分子细胞机制研究”，

  2014/01-2016/12，已结题、主持。

研究论文：

(1) Zhu X*, Yao Y, Yang J, Zhang C, Li X, Zhang A, Liu X,Zhang C, Gan G. Valproic acid suppresses cuprizone-induced hippocampal demyelination andanxiety-like behavior by promoting cholesterol biosynthesis. Neurobiol Dis. 2021;158:105489.

(2) Zhu X*, Yao Y, Yang J, ZhangC, Li X, Zhang A, Liu X, Zhang C, Gan G.  ADAM10 suppresses demyelination and reducesseizure susceptibility in cuprizone-induced demyelination model. Free Radic Biol Med. 2021;171:26-41.

(3) Zhu X*, Yao Y, Yang J, ZhengxieJ, Li X, Hu S, Zhang A, Dong J, Zhang C, Gan G. COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injuryand cognitive impairment in PTZ-kindled epilepsy mice. International Immunopharmacology. 2020, 87:106801.

(4) Zhu X*, Yao Y, Yang J, Ge Q, Niu D, Liu X, Zhang C, GanG, Zhang A, Yao H. Seizure-induced neuroinflammation contributes to ectopic neurogenesis andaggressive behavior in pilocarpine-induced status epilepticus mice. Neuropharmacology. 2020, 170:108044.

(5) Zhu X*, Zhang A, Dong J, Yao Y, Zhu M, Xu K, AlHamda MH. MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory impairment in an experimental model oftemporal lobe epilepsy. BrainRes Bull. 2019, 152:175-183.

(6) Zhu X*, Yao Y, Liu Y, Zhou R, Zhang W, Hu Q, Liu H, Al HamdaMH1, Zhang A. Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. Front Cell Neurosci. 2019, 30; 13: 180.

(7) Zhu X*, Yao Y,Li X, Dong J, Zhang A. Alteration of GABAergic signaling is associated withanxiety-like behavior in temporal lobe epilepsy mice. Prog Neuropsychopharmacol Biol Psychiatry. 2019; 93:141-148

(8) ZhuX*, Li X, Zhu M, Xu K, Yang L, Han B, Huang R, Zhang A, Yao H.,Metalloprotease Adam10 suppresses epilepsy through repression of hippocampalneuroinflammation. J Neuroinflammation. 2018;15 (1):221.

(9)   ZhuX*,Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H., Neuronal nitric oxide synthase contributes to PTZ kindling epilepsy-induced hippocampal endoplasmic reticulum stress andoxidative damage. Front Cell Neurosci. 2017;11:377.

(10)  ZhuX*,Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H., Neuronal nitric oxide synthase contributes toPTZ kindling-induced cognitive impairment and depressive-like behavior. Front Behav Neurosci. 2017;11:203.

(11)   Zhu X*, Dong J,Xia Z, Zhang A, Chao J, Yao H., Repeated restraint stress increases seizure susceptibility by activation hippocampal endoplasmic reticulum stress. Neurochem Int. 2017;110:25-37.

(12)   杨展能, 姜靓婧，顾仕红，陈磊，黎虹薇，朱新建*.  NMDA受体在匹罗卡品癫痫小鼠海马星形胶质细胞活化中的作用. 东南大学学报（医学版）. 2017,36(2):129-136.

(13)   Zhu X*, ShenK, Bai Y, Zhang A, Xia Z, Chao J, Yao H., NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy. Free Radic Biol Med. 2016;94:230-42.

(14)  Zhu X*, DongJ, Shen K, Bai Y, Chao J, Yao H., Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis. Brain Res Bull. 2016, 24 (1), 33-42.

(15)  Zhu X, Dubey D, Bermudez C, Porter BE*., Suppressing cAMP response element-bindingprotein transcription shortens the duration of status epilepticus and decreasesthe number of spontaneous seizures in the pilocarpine model of epilepsy. Epilepsia. 2015, 56(12):1870-1078

(16)  Zhu X*, Dong J, Shen K, Bai Y, Zhang Y, Lv X, Chao J, Yao H., NMDA receptor NR2B subunits contributeto PTZ-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015, 114:70-78.

(17)  Bai Y#, Zhu X#, Chao J#,Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, YaoH*.,  Pericytes Contribute to the Disruption of theCerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke, PLoS One, 2015; 10(4): e0124362

(18)  Zhu XJ, Han X, Blendy, JA, Porter BE*. Decreased CREB levels suppress epilepsy. Neurobiol Dis. 2012,253-263.

(19)   Luo CX#, Zhu XJ#, Zhou QG#, Wang B, Wang W, Cai HH, Sun YJ, HuM, Jiang J, Hua Y, Han X, Zhu DY*. Reduced neuronal nitric oxidesynthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem. 2007, 103:1872-1882.

(20)  Zhu XJ, Hua Y, Jiang J, Zhou QG, Luo CX,Han X, Lu YM, Zhu DY*., Neuronal nitric oxide synthase-derived nitricoxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation. Neuroscience.2006 , 141(2):827-836.

(21)  Luo CX#, Zhu XJ#, Zhang AX#, Wang W, Yang XM, Liu SH, Han X,Sun J, Zhang SG, Lu Y, Zhu DY*., Blockade of L-typevoltage-gated Ca channel inhibits ischemia-induced neurogenesis by down-regulating iNOS expression in adult mouse. J Neurochem. 2005,94(4):1077-1086.

(22)  Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, ZhuX, Huang W, Chao J, Zhou R, Hu G, Yao H*., Silencing microRNA-143 protects the integrity of the blood-brain barrier:implications for methamphetamine abuse. Sci Rep. 2016, 6:35642.

(23)  Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J,Duan M, Buch S, Chen L, Yao H*., Involvementof sigma-1 receptor in astrocyte activation induced by methamphetamine viaup-regulation of its own expression. J Neuroinflammation. 201512:29.

(24)   Yi H,Bai Y, Zhu X, Lin L, Zhao L, Wu X,Buch S, Wang L, Chao J, Yao H*., IL-17Ainduces MIP-1α expression in primary astrocytes via Src/MAPK/PI3K/NF-kBpathways: implications for multiple sclerosis. J Neuroimmune Pharmacol. 2014, 9(5):629-641.

(25)   Wang IT, Allen M, GoffinD, Zhu X, Fairless AH, Brodkin ES, Siegel SJ, Marsh ED, Blendy JA, ZhouZ*.(2012) Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A, 2012, 109:21516-21521.

(26)   Varodayan FP, Zhu XJ, Cui XN, Porter BE*. Seizures increasecell proliferation in the dentate gyrus by shortening progenitor cell-cyclelength. Epilepsia, 2009,50: 2638-2647.

(27)   ZhouQG, Hu Y, Hua Y, Hu M, Luo CX, Han X, ZhuXJ, Wang B, Xu JS, Zhu DY*.,Neuronal nitric oxide synthase contributes to chronic stress-induced depressionby suppressing hippocampal neurogenesis.J Neurochem. 2007, 103(5):1843-54.

(28)   Lin X,Zhang Y*, Dong J, Zhu X, Ye M, ShiJ, Lu J, Di Q, Shi J, Liu W., GM-CSF enhances neural differentiation of bonemarrow stromal cells., Neuroreport. 2007:18(11):1113-1117.

(29) Xin Jian Zhu, You Ming Lu, Dong Ya Zhu.Neuronal selfrepair following ischemic insults.Central nervous system Agents in Medicinal  Chemistry. 2007,7:79-84.

(30)  Luo CX, Zhu XJ, Zhou QG et al. Reduced neuronal nitric oxide synthase is involved inischemia-induced hippocampal neurogenesis by up- regulating inducible nitricoxide synthase expression. J Neurochem. 2007,103:1872-1882.

(31)  Luo CX, Jiang J, Zhou QG, Zhu XJ, Wang W et al. Voluntary exercise-induced neurogenesis in thepostischemic dentate gyrus is associated with spatial memory recovery fromstroke. J Neurosci Res. 2007, 85:1637-1646. 

(32)   Lin X, Zhang Y, Dong J, Zhu X, Ye M et al. GM-CSF enhances neural differentiation of bone marrowstromal cells.Neuroreport. 2007, 16:1113-1117. 

(33)  Zhou QG, Hu Y,Hua Y, Hu M, Luo CX, Han X, Zhu XJ et al. Neuronalnitric oxide synthase contributes to chronic stress-induced depression bysuppressing hippocampal neurogenesis.J Neurochem. 2007,103:1843-1854. 

(34)  Zhu XJ, Hua Y, Jiang J et al. Neuronal NOS-derived NO inhibits neurogenesis in the adult DG by down- regulating CREB phosphorylation. Neuroscience. 2006,141:827-836. 

(35)  Luo CX, Zhu XJ, Zhang AX et al. Blockade of L-type voltage-gated Ca2+channel inhibits ischemia-induced neurogenesis by down-regulating iNOS expression in adult mouse. J Neurochem. 2005, 94:1077-1086. 

国际会议论文 

(1)  X. ZHU*."Neuronalnitric oxide synthase contributes to PTZ kindling-induced cognitive impairmentand depressive-like behavior by activation of hippocampal endoplasmic reticulumstress. 47th Annualmeeting of the Society for Neuroscience, Washington, DC, USA,Nov 11-15, 2017.

(2)  X. ZHU*.,Neuronal nitric oxide synthase contributes to pentylenetetrazole kindling-inducedhippocampal neurogenesis. 45th Annual meeting of the Society for Neuroscience,Chicago, IL, USA, Oct 17-22, 2015

(3)  X.ZHU*, J.DONG. NMDA receptor blockade suppresses pentylenetetrazole- inducedacute seizure and kindling by down-regulation of CREB phosphorylation. 44thAnnual meeting of the Society for Neuroscience, Washington, DC, USA, Nov 11-15,2014

(4)  X. ZHU,J. BLENDY, B. PORTER*. Effect of inducible repression of CREB on thedevelopment of epilepsy. 41th Annual meeting of the Society for Neuroscience,Washington, DC, USA, Nov 12-16, 2011

(5)  Zhu X., Han X., Blendy J.A., Porter B.E*. CREB deficiency suppressesthe development of epilepsy. 39th Annual meeting of the Society forNeuroscience, Chicago, IL, USA, Nov 17-21, 2009