导师风采
闻毅
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个人信息

Personal Information

  • 研究员
  • 导师类别:硕,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:医学院
  • 所属专业: 内科学
  • 邮箱 : 101012661@seu.edu.cn
  • 工作电话 : -

个人简介

Personal Profile

闻毅,东南大学医学博士,美国杜克大学博士后,东南大学医学院硕士生导师、博士生导师,东南大学附属中大医院研究员、肾内科医师。入选中国科协青年人才托举工程、中国生物物理学会代谢生物学分会青年委员、美国心脏病协会会员、Frontier in Physiology杂志编审。

主要研究方向为肾小管上皮细胞损伤和小管间质炎症细胞活化在急、慢性肾损伤中的作用机制。在国际学术期刊上发表SCI论文20余篇,其中在J Am Soc Nephrol,Kidney Int,Hypertension,Am J Pathol等高水平期刊发表SCI论文10余篇。


  • 研究方向Research Directions
炎症细胞在急性肾损伤中的作用机制,慢性肾脏病的发病机制和治疗研究
科研项目

国家自然科学基金面上项目

国家自然科学基金青年项目

中国科协青年人才托举工程

江苏省自然科学基金青年项目

东南大学特色医科攀升计划

东南大学国家“优青”培育计划


研究成果

1. Wen Y, Lu X, Ren J, Privratsky JR, Yang B, Rudemiller NP, Zhang J, Griffiths R, Jain MK, Nedospasov SA, Liu BC, Crowley SD*. KLF4 in macrophages attenuates TNFα-mediated kidney injury and fibrosis. J Am SocNephrol. 2019 Jul 23; 30(10):1925-1938. doi:10.1681/ASN.2019020111. 

2. Wen Y, Crowley SD.Connecting cytokines and cellular signals in the nephron during CKD and hypertension. Kidney Int. 2020 Apr;97(4):651-653.doi:10.1016/j.kint.2020.01.005.

3. Wen Y, Rudemiller NP, Zhang J, Lu X, Ren J, Privratsky JR, Griffiths R, Zhang JJ, Hammer GE, CrowleySD*. C-C motif chemokine receptor 7 exacerbates hypertension through effects on T lymphocyte trafficking. Hypertension. 2020 Jan 27; doi:10.1161/HYPERTENSIONAHA.119.14148. 

4. Wen Y,Yan HR, Wang B, Liu BC*. Macrophage Heterogeneity in Kidney Injury and fibrosis. Front Immunol. 2021 May 20; 12:681748.

5. Wen Y, Rudemiller NP, Zhang JD, Robinette T, Lu X, Ren J, Privratsky JR, Nedospasov SA, Crowley SD*. Tumor necrosis factor-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis. Am J Physiol Renal Physiol. 2019 Nov 18; doi:10.1152/ajprenal.00347.2019.

6. Wen Y, Rudemiller NP, Zhang J, Jeffs AD, Griffiths R, Lu X, Ren J, Privratsky J, Crowley SD*. Stimulating type 1 angiotensin receptors on T lymphocytes attenuates renal fibrosis. Am J Pathol. 2019May;189(5):981-988.

7. Wen Y, Pan MM, Lv LL,Tang TT, Zhou LT, Wang B, Liu H, Wang FM, Ma KL, Tang RN, Liu BC. Artemisininattenuates tubulointerstitial inflammation and fibrosis via the NF-κB/NLRP3pathway in rats with 5/6 subtotal nephrectomy. J Cell Biochem. 2019Mar;120(3):4291-4300. doi: 10.1002/jcb.27714. 

8. Wen Y, Liu YR, TangTT, Pan MM, Xu SC, Ma KL, Lv LL, Liu H, Liu BC. mROS-TXNIP axis activates NLRP3inflammasome to mediate renal injury during ischemic AKI. Int J Biochem CellBiol. 2018 May; 98:43-53. doi:10.1016/j.biocel. 

9. Wen Y, Crowley SD.Renal effects of cytokines in hypertension. Curr Opin Nephrol Hypertens. 2018Mar;27(2):70-76. doi: 10.1097/MNH.0000000000000385. 

10. Lu X, Rudemiller NP, Wen Y, Ren J, Hammer G, Griffiths R, Privratsky JR, Yang B, Sparks MA, Crowley SD*. A20 in myeloid cells protects against hypertension by inhibiting dendritic cell-mediated T cell activation. Circ Res. 2019 Oct 21; doi:10.1161/CIRCRESAHA.119.315343.

11. Lv LL, Feng Y, Wen Y, Wu WJ, Ni HF, Li ZL, Zhou LT, Wang B, Zhang JD, Crowley SD, Liu BC. Exosomal CCL2 from TubularEpithelial Cells Is Critical for Albumin-Induced TubulointerstitialInflammation. J Am Soc Nephrol. 2018 Mar;29(3):919-935. doi:10.1681/ASN.2017050523. 

12. Ren J, Zhang J, Rudemiller NP, Griffiths R, WenY, Lu X, Privratsky JR, Gunn MD, Crowley SD. Twist1 in InfiltratingMacrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13-MediatedMatrix Degradation. J Am Soc Nephrol. 2019 Sep;30(9):1674-1685. doi:10.1681/ASN.2018121253.

13.  Ren J, Rudemiller NP, Wen Y, Lu X, Privratsky JR, Crowley SD. The transcription factor Twist1 in the distal nephron but not in macrophages propagates aristolochic acid nephropathy. KidneyInt. 2020 Jan;97(1):119-129. doi: 10.1016/j.kint.2019.07.016.

14. Lu X, Rudemiller NP, Ren J, Wen Y, Yang B, Griffiths R, Privratsky JR, Madan B, Virshup DM, Crowley SD. Opposing actions of renal tubular- and myeloid-derived porcupine obstruction-induced kidney fibrosis. Kidney Int. 2019 Dec;96(6):1308-1319.doi: 10.1016/j.kint.2019.06.020.

15. Tang TT, Lv LL, Wang B, Cao JY, Feng Y, Li ZL, Wu M, Wang FM, Wen Y, Zhou LT, Ni HF, Chen PS, Gu N, Crowley SD, Liu BC. EmployingMacrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis.Theranostics. 2019 Jul 9;9(16):4740-4755. doi: 10.7150/thno.33520.

16. Lu X, Rudemiller NP, Privratsky JR, Ren J, WenY, Griffiths R, Crowley SD. Classical Dendritic Cells Mediate Hypertensionby Promoting Renal Oxidative Stress and Fluid Retention. Hypertension. 2020Jan;75(1):131-138. doi:10.1161/HYPERTENSIONAHA.119.13667. 

17. Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC. Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin-mediated NLRP3 inflammasome activation. Cell Death Dis. 2018 Mar 2;9(3):351. doi: 10.1038/s41419-018-0378-3.

18. Li ZL, Ji JL, Wen Y, Cao JY, Kharbuja N, Ni WJ, Yin D, Feng ST, Liu H, LvLL, Liu BC, Wang B. HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury. Am J Physiol Renal Physiol. 2021 Aug 1;321(2): F225-F235.

19. Li ZL, Wang B, Lv LL, Tang TT, Wen Y, Cao JY, Zhu XX, Feng ST, Crowley SD, Liu BC. FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling. Acta Pharmacol Sin.2021 Mar 3. doi: 10.1038/s41401-021-00617-4. 

20. Liu HF, Liu H, Lv LL, Ma KL, Wen Y, Chen L, Liu BC. CCN3 suppresses TGF-β1-induced extracellular matrix accumulation in human mesangial cells in vitro. Acta Pharmacol Sin. 2018 Feb;39(2):222-229.doi: 10.1038/aps.2017.87.

21. Wu Y, Ma KL, Zhang Y, Wen Y, Wang GH,Hu ZB, Liu L, Lu J, Chen PP, Ruan XZ, Liu BC. Lipid disorder and intrahepatic renin-angiotensin system activation synergistically contribute to non-alcoholic fatty liver disease. Liver Int. 2016 Oct;36(10):1525-34. doi:10.1111/liv.13131.

22. Zhu DD, Tang RN, Lv LL, Wen Y, Liu H, Zhang XL, Ma KL, Liu BC. Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells. Cardiovasc Diabetol.2016 Mar 5;15:42. doi: 10.1186/s12933-016-0358-9.

23. Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC. Megalin/Cubulin-Lysosome-mediated AlbuminReabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasomeand Tubulointerstitial Inflammation. J Biol Chem. 2015 Jul 17;290(29):18018-28.doi:10.1074/jbc.M115.662064.

24. Wang J, Wen Y, Lv LL, Liu H, Tang RN, Ma KL, Liu BC. Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro. Acta Pharmacol Sin. 2015 Jul;36(7):821-30. doi: 10.1038/aps.2015.21.

25. Xu M, Liu D, Ding LH, Ma KL, Wu M, Lv LL, Wen Y, Liu H, Tang RN, Liu BC. FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. Acta Pharmacol Sin. 2014 Dec;35(12):1537-45.doi: 10.1038/aps.2014.100.


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