本课题组致力于培养干细胞、组织工程和再生医学领域的相关研究人才。欢迎医学、生物学、生物医学工程、生物材料、生物信息学、药学等学生跨专业报考博士/硕士研究生，也欢迎本科生SRTP和毕业设计项目（已指导多项国家级、省级和校级本科生科研项目，本科生为第一作者发表SCI文章9篇，单篇最高影响因子29.4）。

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组织工程学（Tissue engineering），涉及到生物学、材料学和工程学等多学科，是指利用生物活性物质，通过体外培养或构建的方法，再造或者修复器官及组织的技术。

参考维基百科：https://zh.wikipedia.org/wiki/%E7%BB%84%E7%BB%87%E5%B7%A5%E7%A8%8B%E5%AD%A6

中国生物医学工程学会组织工程与再生医学分会委员

国际华人骨研学会（ICMRS）终身会员

中华医学会骨科学分会青年委员

中国医师协会骨科医师分会青年委员会骨科基础学组委员

中国骨科再生医学会（CORMed）成员

Discover AppliedSciences 期刊副主编

Biomimetics 期刊编委

Military Medical Research 期刊青年编委

Interdisciplinary Medicine 期刊青年编委

Biomedicines 期刊首席客座编辑（2023）

Stem Cells International 期刊客座编辑（2017-2018）

Applied Bionics and Biomechanics 期刊首席客座编辑（2017）

兼任数十本国际知名SCI期刊的审稿人，期刊包括 Advanced Materials, Advanced Functional Materials, Biomaterials,Bioactive Materials, Small, Military Medical Research 等

_____________________________________________________

目前作为 Biomedicines (IF=4.7) 期刊的首席客座编辑，负责Special Issue "Repair and Regeneration of Tendon, Cartilage and Cornea"。欢迎投稿！

网址：https://www.mdpi.com/journal/biomedicines/special_issues/15GO69A83E

奖励荣誉：

2024.01   2023年中华医学科技奖青年科技奖

2023.10   东南大学优秀本科生导师

2023.10   东南大学优秀导师（学习优秀生导师）

2023.01    东南大学2022年度校级优秀职工

2022.12    江苏省瑞华慈善基金会临床研究创新奖二等奖

2022.04    东大智能基金

2019.01    东南大学 至善青年学者

2018.04    浙江省医药卫生科技奖二等奖

2017.09    Travel grant from the Wallenberg Foundation, Sweden

2013.12    澳大利亚教育部2014 Endeavour Australia Cheung Kong ResearchFellowship（澳大利亚-长江研究学者奋进奖学金，全球所有Endeavour Research Fellowship 获奖者中的 Top 5）

2011         浙江大学医学部“杏林学术之星”

2010         浙江大学基础医学院POSTER作品竞赛二等奖

2009.11    第四届COA国际学术大会“优秀论文奖”

指导学生获奖：

2023.10  盛仁旺、陈祉璇、王铭悦、郑昊天、胡力之、池佳宇、刘佳、佟思齐，第十八届“挑战杯”全国大学生课外学术科技作品竞赛终审决赛，主赛道全国特等奖（第一指导教师）

2023.05  盛仁旺、王铭悦、郑昊天、陈祉璇、池佳宇、佟思齐、胡力之、刘佳，第十八届“挑战杯”全国大学生课外学术科技作品竞赛江苏省选拔赛，特等奖（第一指导教师）

2021.12，朱爱静、罗一帆、张艾妮、池佳宇、郑昊天，“第七届全国大学生基础医学创新研究暨实验设计论坛总决赛”，金奖+最佳学术奖（唯一指导教师）

国家重点研发计划，2024.01-2026.12，参与

横向项目，2022.04-2025.03，负责人

山东省重点研发计划，2022.01-2024.12，参与

国家自然科学基金--青年基金项目，2020.01-2022.12，负责人

江苏省自然科学基金--青年基金项目，2019.07-2022.06，负责人

东南大学“至善青年学者”支持计划资助，2019.01-2021.12，负责人

南京市留学人员科技创新项目择优资助A类，2020.09-2021.08，负责人

（省优势）新进教师人才引进启动费，2019.01-2020.12，负责人

东南大学基础科研扶持项目，2019.04-2019.12，负责人

东南大学中央高校建设一流大学（学科）和特色发展引导专项资金经费，2019

1.      SunYZ^#, Sheng RW^#, Cao ZC, Liu CQ, Li JX, Zhang P, Du Y, MoQY, Yao QQ*, Chen JL*, Zhang W*. Bioactive fiber-reinforcedhydrogel to tailor cellmicroenvironment for structural and functional regeneration of myotendinousjunction. Sci Adv. 2024, accepted(IF=13.6)

2.      Tong SQ^#, Sun YZ^#, Kuang BA, Wang MY, Chen ZX,Zhang W*, Chen JL*. A ComprehensiveReview of Muscle-tendon Junction: Structure, Function, Injury and Repair. Biomedicines. 2024, 12(2), 423 (IF=4.7)

3.      ZhuY^#, Chen JL^#, LiuHY^#, Zhang W*. Photocrosslinked Hydrogels for Cartilage andosteochondral Repair. ACS Biomater Sci Eng. 2023, 9(12), 6567-6585(IF=5.8)

4.      ShengRW^#, Liu J^#, Zhang W^#, Luo YF, Chen ZX, ChiJY, Mo QY, Wang MY, Sun YZ, Liu CQ, Zhang YN, Zhu Y, Kuang BA, Yan CG, Liu HY, Backman LJ, Chen JL*. MaterialStiffness in Cooperation with Macrophage Paracrine Signals Determines the Tenogenic Differentiation of Mesenchymal Stem Cells. AdvancedScience, 2023, 2206814 (IF=15.1)

5.      Chen JL*, Mo QY, Sheng RW, Long QZ, Chen ZX, Liu CQ, Zhang AN, Luo YF, Liu J, Zhang W*. Stiffness-dependent dynamic effect of inflammation on keratocyte phenotype and differentiation. Biomedical Materials, 2023, 18, 045001 (IF=4.0)

6.      Zhang YN^#, ShengRW^#, Chen JL^#, Wang HM^#, Zhu Y, Cao ZC, Zhao XY, Wang ZM, Liu CQ, Chen ZX, Zhang P, Kuang BA, Zheng HT, Shen CL, Yao QQ, Zhang W*. Silk Fibroin and SericinDifferentially Potentiate the Paracrine and Regenerative Functions of StemCells Through Multiomics Analysis. Adv Mater, 2023: e2210517 (IF=29.4)

7.      Chen JL#*, Mo QY#, Long QZ, Sheng RW, Chen ZX, LuoYF, Liu CQ, Backman LJ, Zhang YN, Zhang W*. Hydroxycamptothecin and substratum stiffness synergistically regulate fibrosis of human corneal fibroblasts. ACS Biomater Sci Eng, 2023,9(2), 959-967 (IF=5.8)

8.      Zhang P#, Chen JL#, Sun YZ, Cao ZC, Zhang YN, Mo QY, Yao QQ*, ZhangW*. 3D Multifunctional Bi-layer Scaffold to Regulate Stem Cell Behaviors and Promote Osteochondral Regeneration. Journal of Materials Chemistry B. 2023, 11(6), 1240-1261 (IF=7.0)

9.      Cao ZC#, Wang HM#, Chen JL#, Zhang YN, Mo QY, ZhangP, Wang MY, Liu HY, Bao XY, Sun YZ, Zhang W*, Yao QQ*. Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration. Bioact Mater. 2023;20:221-242. (IF=18.9)

10.      Chi JY#, Wang MY#, Chen JL#, Hu LZ, Chen ZX,Backman LJ, Zhang W*. Topographic Orientation of Scaffolds for TissueRegeneration: Recent Advances in Biomaterial Design and Applications. Biomimetics. 2022, 7, 131 (IF=4.5)

11.      Sheng RW#, Chen JL#, Wang HM#, Luo YF, Liu J, Chen ZX, MoQY, Chi JY, Ling C, Tan X, Yao QQ, Zhang W*. Nanosilicate-Reinforced SilkFibroin Hydrogel for Endogenous Regeneration of both Cartilage and Subchondral Bone. Adv Healthc Mater.2022:e2200602. (IF=10.0)

12.      Chen ZX#, Zhang W#, Wang MY, BackmanLJ, Chen JL*. Effects of zinc, magnesium and iron ions on bone tissue engineering. ACS Biomater Sci Eng,2022, 8(6), 2321-2335. (IF=5.8)

13.      Mo QY#, Zhang W#, Zhu AJ, BackmanLJ, Chen JL*. Regulation of osteogenic differentiation by the pro-inflammatory cytokines IL-1β and TNF-α: Current conclusions and controversies. Human Cell, 2022, 35(4), 957-971. (IF=4.3)

14.      Zhang W*, Zhang YN, Li XL, Cao ZC, Mo QY, Sheng RW, Ling C, Chi JY, Yao QQ*, Chen JL*, Wang HM*. Multifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects. Materials Today Bio, 2022,14:100251. (IF=8.2)

15.      Zhang AN#, Zhang W#, Backman LJ, Chen JL*. Advances in Regulatory Strategies of Differentiating StemCells towards Keratocytes. Stem Cells International 2022, 2022: 5403995 (IF=4.3)

16.   Chen JL*, Mo QY, Sheng RW, Zhu AJ, Ling C, Luo YF, Zhang AN, Chen ZX, Yao QQ, Cai ZY*, Zhang W*. The application of human periodontal ligament stem cells and biomimetic silk scaffold for in situ tendon regeneration. Stem Cell Res Ther 2021;12:596 (IF=7.5)

17.   Liu H#, Chen J#, Qiao S#,Zhang W*. Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: AReview. Acs Biomater Sci Eng 2021, 7:4718-4735. (IF=5.8)

18.   Zhang W*, Zhang YN, Zhang AN, Ling C, Sheng RW, Li XL, Yao QQ*, Chen JL*. Enzymatically Crosslinked Silk-NanosilicateReinforced Hydrogel with Dual-Lineage Bioactivity for Osteochondral Tissue Engineering. Mat Sci Eng C-Mater. 2021,127:112255. (IF=7.9)

19.   Zhang W*, Ling C, Li XL, Sheng RW, Liu HY, Zhang AN, Jiang YJ, Chen JL*, Yao QQ*. Cell-Free Biomimetic Scaffold with Cartilage Extracellular Matrix-Like Architectures for In Situ Inductive Regeneration of Osteochondral Defects. ACS Biomater Sci Eng 2020,6, 6917-6925. (IF=5.8)

20.   Sheng RW, Jiang YJ, Backman LJ, Zhang W*, Chen JL*. The application of mechanical stimulations in tendon tissue engineering. Stem Cells International 2020, 2020: 8824783. (IF=4.3)

21.   Chen J*, Backman LJ, Zhang W, Ling C, Danielson P*. Regulation of keratocyte phenotype and cell behavior by substrate stiffness. ACS Biomaterials Science & Engineering 2020. 6(9): 5162-5171. (IF=5.8)

22.   Zhang W*, Ling C, Zhang AN, Liu HY, Jiang YJ, Li XL, Sheng RW, Yao QQ*, Chen JL*. An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration. Bioactive Materials. 2020, 5:832-843. (IF=18.9)

23.   Zhang W*, Ling C, Liu HY, Zhang AN, Mao L, Wang J, Chao J, Backman L, Yao QQ*, Chen JL*. Tannic Acid-Mediated Dual Peptide-Functionalized Scaffolds to Direct Stem Cell Behavior and Osteochondral Regeneration. Chem Eng J. 2020, 396:125232. (IF=15.1)

24.   Chen J#, Zhang W#, Backman LJ, Kelk P, and Danielson P*. Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes. Br J Ophthalmol 2018; 102; 562-569 (IF=4.1)

25.   Chen J#, Zhang W#, Kelk P, Backman LJ, andDanielson P*. Substance P and Patterned Silk Biomaterial Stimulate PeriodontalLigament Stem Cells to Form Corneal Stroma in a Bioengineered 3D Model. Stem Cell Res Ther 2017;8:260 (IF=7.5)

26.   Chen J#, Zhang E#, Zhang W, Liu Z, Lu P, Zhu T, YinZ, Backman, LJ, Liu H, Chen X*, Ouyang HW*. Fos Promotes Early Stage Teno-Lineage Differentiation of Tendon Stem/Progenitor Cells in Tendon. Stem Cells Transl Med. 2017. 6(11): 2009-2019. (IF=6.0)

27.   Chen JL, Lan J, Liu DL, Backman LJ, Zhang W, Zhou QJ*, Danielson P*. Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/Progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea. Stem Cells Transl Med. 2017; 6(5): 1356-1365. (IF=6.0)

28.   Chen J, Chen P, Backman LJ, Zhou Q*, Danielson P*. Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt. Sci Rep 2016;6:25870. (IF=4.6)

29.   Chen JL, Zhang W, Liu ZY, Zhu T, Shen WL, Ran JS, Tang QM,Gong XN, Backman LJ, Chen X, Chen XW, Wen FQ*, Ouyang HW*. Characterization and comparison of post-natal rat Achilles tendon-derived stem cells at different development stages. Sci Rep 2016;6:22946. (IF=4.6)

30.   Chen JL, Zhang W, Liu ZY, Heng BC, Ouyang HW*, Dai XS*.Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction. Cell Tissue Res 2015. 360(2):195-207. (IF=3.6)

31.   Shen WL#, Chen JL#, Zhu T, Yin Z, Chen X, Chen LK, Fang Z, Heng BC, JiJF, Chen WS*, Ouyang HW*, Osteoarthritis prevention through meniscal regeneration induced by intra-articular injection of meniscus stem cells. Stem Cells Dev, 2013. 22(14): p. 2071-82. (封面文章, IF=4.0)

32.   Zhang W#, Chen JL#, Tao JD, Hu CC, Chen LK, Zhao HS, Xu GW, HengBC, Ouyang HW*. The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold. Biomaterials,2013. 34(25): p. 6046-57. (IF=14.0, 被引86次)

33.   Shen W#, Chen J#, Yin Z, Chen X, Liu H, Heng BC, Chen W*, OuyangHW*. Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair. Cell Transplant 2012;21(5):943-958. (IF=3.3, 被引121次)

34.   Chen JL#, Yin Z#, Shen WL, Chen X, Heng BC, Zou XH, Ouyang HW*. Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials 2010. 31(36):9438-9451. (IF=14.0, 被引250次)

35.   Li J, Zhou X, Chen J, Eliasson P, Kingham PJ, Backman LJ*. Secretome from myoblasts statically loaded at low intensity promotes tenocyte proliferation via the IGF-1 receptor pathway. FASEB J, 2023. 37(10): p. e23203. (IF=4.8)

36.   Wang YF#, Ling C#, Chen JL, Liu HY, Mo QY, Zhang W*, YaoQQ*. 3D-printed composite scaffold with gradient structure and programmed biomolecule delivery to guide stem cell behavior for osteochondral regeneration. Biomaterials Advances, 2022, 140: 213067. 

37.   Zhang W*, Chen JL, Qu ML, Backman J, Zhang AN, Liu HY, Zhang XP, Zhou QJ*, Danielson P*. Sustained release of TPCA-1 from silk fibroin hydrogels preserves keratocyte phenotype and promotes corneal regeneration by inhibiting interleukin-1β signaling. Adv Healthc Mater. 2020,9(17): e2000591. (IF=10.0)

38.   He SQ, Ruan DF, Chen YW, Ran JS, Chen X, Yin Z, TangCQ, Huang JY, Heng BC, Chen JL, Chen WS*, Shen WL*, Ouyang HW. Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages. Stem Cells Transl Med. 2019, 8:1318-1329. (IF=6.0)

39.   El-Habta R*, Chen JL, Pingel J, Backman LJ. Tendinosis-like changes in denervated rat Achilles tendon. BMC Musculoskelet Disord.2018, 19:426. (IF=2.3)

40.   Zhang W, Li Y, Jiang DM, Xie SJ, Zeng MF, Chen JL, Chen LK, Ouyang HW*, Zou XH*.Promotion of Hernia Repair with High-Strength, Flexible, and Bioresorbable SilkFibroin Mesh in a Large Abdominal Hernia Model. ACS Biomaterials Science & Engineering 2018 4 (6), 2067-2080. (IF=5.8)

41.   Spang C*, Backman LJ, Le RS, Chen J, Danielson P. Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells. BMC Musculoskelet Disord. 2017. 18(1): 218. (IF=2.3)

42.   Zhang W, Chen L, Chen J, Wang L, Gui X, Ran J, Xu G, Zhao H, Zeng M, Ji J, Qian L, Zhou J, Ouyang H*, Zou X*. Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial. Adv Healthc Mater 2017.6. (封面文章, IF=10.0)

43.   Zhang W, Chen J,Backman LJ, Malm AD, Danielson P*. Surface Topography and Mechanical StrainPromote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic3D Corneal Model. Adv Healthc Mater. 2017. 6(5). (封面文章, IF=10.0)

44.   Spang C*, ChenJ, Backman LJ. The tenocyte phenotype of human primary tendon cells in vitro is reduced by glucocorticoids. BMCMusculoskelet Disord. 2016;17:467.(IF=2.3)

45.   Yin Z#, Hu JJ#, Yang L, ZhengZF, An CR, Wu BB, Zhang C, Shen WL, Liu HH, Chen JL, Heng BC, Guo GJ, Chen X*, Ouyang HW*. Single-cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentiality. Science Advances, 2016. 2(11):e1600874-e1600874. (IF=13.6)

46.   Yin Z#, Chen X#, Song HX, Hu JJ,Tang QM, Zhu T, Shen WL, Chen JL,Liu H, Heng BC, Ouyang HW*. Electrospun scaffolds for multiple tissues regeneration in vivo through topography dependent induction of lineage specific differentiation. Biomaterials 2015;44:173-185. (IF=14.0)

47.   Tang QM, ChenJL, Shen WL, Yin Z, Liu HH, Fang Z, Heng BC, Ouyang HW*, Chen X*. Fetal and adult fibroblasts display intrinsic differences in tendon tissue engineering and regeneration. Sci Rep 2014;4:5515. (IF=4.6)

48.   Shen WL, Chen JL, Zhu T, Chen LK, Zhang W, Fang Z, Heng BC, Yin Z, Chen X, Ji JF, Chen WS*,Ouyang HW*. Intra-Articular Injection of Human Meniscus Stem/Progenitor CellsPromotes Meniscus Regeneration and Ameliorates Osteoarthritis Through StromalCell-Derived Factor-1/CXCR4-Mediated Homing. Stem Cells Transl Med, 2014.3(3): p. 387-94. (IF=6.0)

49.   Chen X#, Yin Z#, Chen JL, Liu HH, Shen WL, Fang Z, ZhuT, Ji JF, Ouyang HW, Zou XH*. Scleraxis-overexpressed human embryonic stemcell-derived mesenchymal stem cells for tendon tissue engineering with knitted silk-collagen scaffold. Tissue Eng Part A, 2014. 20(11-12): p. 1583-92. (IF=4.1)

50.   Fang Z, Zhu T, Shen WL, Tang QM, Chen JL, Yin Z, Ji JF, Heng BC, Ouyang HW, Chen X*. Transplantation of fetal instead of adult fibroblasts reduces the probability of ectopic ossification during tendon repair. TissueEng Part A, 2014. 20(13-14): p.1815-26. (IF=4.1)

51.   Shen W#, Chen X#, Hu Y, Yin Z,Zhu T, Hu J, Chen J, Zheng Z, ZhangW, Ran J, Heng BC, Ji J, Chen W*, Ouyang HW*. Long-term effects of knitted silk-collagen sponge scaffold on anterior cruciate ligament reconstruction and osteoarthritis prevention. Biomaterials 2014;35(28):8154-8163. (IF=14.0)

52.   Zhang W, Chen J, Tao J, Jiang Y, Hu C, Huang L, Ji JF*, Ouyang HW*. The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair. Biomaterials 2013;34(3):713-723. (IF=14.0)

53.   Chen X#, Yin Z#, Chen JL, Shen WL, Liu HH, Tang QM, FangZ, Lu LR, Ji JF*, Ouyang HW*. Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes. Sci Rep, 2012. 2: p.977. (IF=4.6)

54.   Zou XH, Jinag YZ, Chen JL, Chen X, Ouyang HW*. Tissue engineering for soft tissue regeneration. Science. 2012 April:(Suppl:regenerative medicine in China): 33-34. (Science专刊)

55.   Zhang W, Chen J, Zhang S, Ouyang HW*. Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair. Arthritis Res Ther 2012;14(4):221. (IF=4.9)

56.   Yin Z#, Chen X#, Chen JL, Shen WL, Hieu NT, Gao L, OuyangHW*. The regulation of tendon stem cell differentiation by the alignment of nanofibers. Biomaterials 2010;31(8):2163-2175. (IF=14.0)

57.   Shen W, Chen X, Chen J, Yin Z, Heng BC, Chen W*, Ouyang HW*. The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold on tendon regeneration. Biomaterials 2010;31(28):7239-7249. (IF=14.0)

58.   Yin Z#, Chen X#, Chen JL, Ouyang HW*. Stem cells for tendon tissue engineering and regeneration. ExpertOpin Biol Ther 2010;10(5):689-700. (IF=4.6)

注：上述标注均为2022年度影响因子：2022 JournalCitation Reports (Clarivate Analytics 2023)。

  《再生医学：基础与临床》 2013，人民卫生出版社

  《疫苗工程学》 2020，东南大学出版社

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