教师

  副教授-张伟，成于思，张昕昕

  讲   师-王静

  技术员-罗 薇

在读研究生

  博士生-杨礼亮，刘亚萍，谢飞燕，王安澜，吴玲娜，徐可颖

  硕士生-孙票票，孙玉恒，沙晓娟，张聪，王宇梦，任言晖，蔚昕妍，邱晓宇，王子琪

毕业研究生

  博   士-蒋荣，黄洁，王莎，陈梦灵    

  硕   士-杨西月，郭会芳，陈露露，储汉，廖艳，杨富煌，丁嘉伟，印娟，史晓妮，周馨蓓，杨少奇，

实验室合影

肺部炎症及纤维化的基础与临床研究

   矽肺是由于长期吸入游离二氧化硅（SiO2）粉尘所引起的以肺组织持续慢性炎症、进行性肺纤维化为主，并伴有全身系统性炎症为特征的全身性疾病。矽肺一旦发生，肺损伤呈进行性发展，即使停止粉尘暴露，肺部病变依然进展，导致肺功能障碍，呼吸衰竭，甚至死亡。由于对矽肺的发病机制知之甚少，临床主要面临两个问题：（1）早期缺少筛检诊断方法，当经胸片确诊时，肺损伤已无逆转可能；（2）后期肺纤维化缺乏特效治疗措施，这是由于目前缺少肺纤维化进程评价指标，临床也无明确治疗靶标，因此发现矽肺早期诊断分子标志物以及干预肺纤维化进程的靶标已成为迫切需要解决的问题。

       本课题组着重于研究粉尘吸入引起肺部细胞激活，释放的细胞因子和化学趋化因子，参与炎症反应和肺纤维化的过程及其机制，进而为现有矽肺诊断和治疗提供新的理论依据，对临床治疗策略的选择和治疗药物靶标的遴选提供指导。

◆“肺细胞外基质“劫持”反向跨内皮中性粒细胞参与矽肺不可逆肺纤维化的机制研究”，国家自然科学基金委-面上项目，82373547，49万元，2024-2027，负责人

◆“急性肺损伤与肺外器官的交互机制及多维度治疗策略研究”，科学技术部-国家重点研发计划，2022YFC2504403，150万元，2023-2025，课题骨干

◆“环状RNA介导的失巢凋亡抵抗在矽肺中作用机制研究”，国家自然科学基金委-面上项目，81972987，55万元，2020-2023，负责人

◆“干细胞体内示踪的生物机制”，科学技术部-国家重点研发计划，2017YFA0104303，701万元，2017-2021，课题骨干

◆“ciR-0001544靶向调控ZC3H4在矽肺炎症和纤维化中的作用研究”，国家自然科学基金委-面上项目，81773796，50万元，2018-2021，负责人

◆“治疗矽肺炎性反应及肺纤维化的新靶点-MCPIP1 (ZC3H12A）的作用机制研究”，国家自然科学基金委-面上项目，81473263， 73万元，2015-2018，负责人

◆“矽肺炎症和纤维化治疗新靶点-MCPIP1的作用机制研究”，江苏省科技厅-面上项目，BK20141347，10万元，2014-2017，负责人

◆“p53/PUMA参与矽肺炎症和肺纤维化的作用机制研究”，江苏省卫生厅-江苏省“六大人才”高峰，3万元，2015，负责人

◆“矽肺炎症和纤维化治疗新靶点-MCPIP1 的作用机制研究”，中华人民共和国人力资源和社会保障部-留学人员科技活动项目，3万元，2015年，负责人

◆“肺缺氧致微循环炎症反应的机制研究”（Mechanisms of microvascularinflammation induced by alveolarhypoxia），美国心脏协会（American Heart Association, AH)，52000美元，2008-2010，负责人

2024

101. Wang L, Tang Y, Tang J, Liu X, Zi S, Li S, Chen H, Liu A, Huang W, Xie J, Liu, L, Chao J#, Qiu H#.  Endothelial cell-derived  extracellular  vesicles  expressing surface VCAM1 promote sepsis-related acute lung  injury  by  targeting  and  reprogramming  monocytes.  J  Extracell  Vesicles.  2024, 13:e12423. (SCI, IF:16, Q1) PubMed PDF

100. Zhou X*, Zhang C*, Yang S*, Yang L, Luo W, Zhang W, Zhang X, Chao J#. Macrophage-derived MMP12 promotes pulmonary fibrosis through sustained damage to endothelial cells in silicosis. J Hazard Mater. 2024, 461:132733. (SCI, IF:13.6, Q1) PubMedPDF WOS:001099138000001

99. He W, Chao J, Gu  A, Wang D#. Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics. Sci Total Environ. 2024, 922:171220. (SCI, IF:9.8, Q1)PubMed PPDF

2023

98. Zhang X, Shi X, Xie F, Liu Y, Wei X, Cai Y, Chao J#. Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseases. Heliyon. 2023, 9:e19428. (SCI, IF:4, Q2) PubMedPDF WOS:001069550200001

97. Yang S*, Sun Y*, Long M*, Zhou X*, Yuan M, Yang L， Luo W, Cheng Y, Zhang X, Jiang W#, Chao J#. Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis. Part Fibre Toxicol. 2023, 20(1):29. (SCI, IF:10, Q1) PubMedPDF WOS:001029441200001

96. Chen M*, Wang J*, Yuan M*, Long M, Sun Y, Wang S, Luo W, Zhou Y, Zhang W, Jiang W#, Chao J#. AT2 cell–derived IgA trapped by the extracellular matrix in silica-induced pulmonary fibrosis. Int Immunopharmacol. 2023, 122：110545. (SCI, IF:5.6, Q1) PubMedPDF WOS:001030607200001

95. Wang J, Zhang X, Long M, Yuan M, Yin J, Luo W, Wang S, Cai Y, Jiang W#, Chao J#. Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis. Commun Bio. 2023, 6:136. (SCI, IF:5.9, Q1) PubMedPDF WOS:000925802900005

94.Li B*, Xi W*, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J#, Han B#, Yao H#. FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Nat Commun. 2023, 14(1):489. (SCI, IF:16.6, Q1) PubMedPDF WOS:000955780200014

93. Chen Z*, Huang J*, Zhang J*, Xu Z, Li Q, Ouyang J, Yan Y, Sun S, Ye H, Wang F, Zhu J, Wang Z, Chao J#, Pu Y#, Gu Z#. A storm in a teacup - A biomimetic lung microphysiological system in conjunction with a deep-learning algorithm to monitor lung pathological and inflammatory reactions. Biosens Bioelectron. 2023, 219:114772. (SCI, IF:12.6, Q1) PubMedPDF WOS:000885971400004

92. Hua X, Feng X, Liang G, Chao J, Wang D#. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpse engulfment in Caenorhabditis elegans. J Hazard Mater. 2023, 454:131495 (SCI, IF:13.6, Q1) PubMedPDF WOS:000991104000001

91. Hua X, Feng X, Liang G, Chao J, Wang D#. Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans. Environ Sci Technol.2023, 57(12):4940-4950. (SCI, IF:11.4, Q1) PubMedPDF WOS:000953458700001

90.王煜州，孙票票，孙玉恒，沙晓娟，巢杰#，王静#. 中性粒细胞与肺纤维化关系的研究进展. 东南大学学报(医学版). 2022; 42(1): 149-153. PDF

89. Liu Y*, Zhang X*, Wang J*, Yang F*, Luo W, Huang J, Chen M, Wang S, Li C#, Zhang W#, Chao J#. ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10. Resp Res. 2022, 23：204.(SCI, IF:5.8, Q1) PubMedPDF WOS:000840090800001

88. Shi X*, Wang J*, Zhang X*, Yang S, Luo W, Wang S, Huang J, Chen M, Cheng Y#, Chao J#. GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis. Cell Biosci. 2022, 12:123. (SCI, IF:7.5, Q1) PubMedPDF WOS:00083677850000

87. Wang S*, Luo W*, Huang J, Chen M, Ding J, Cheng Y, Zhang W, Fang S, Wang J#, Chao J#.  The combined effects of circRNA methylation promote pulmonary fibrosis. Am J Resp Cell Mol Biol. 2022,66(5):510-523.(SCI, IF:6.4, Q1) PubMed PDF (Highlighted Paper,Editorial) WOS:000790563500010

86. Yin J*, Wang J*, Zhang X*, Liao Y*, Luo W, Ding J, Huang J, Chen M, Wang W#, Fang S#, Chao J#.  A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation. Cell Biosci. 2022,12:21. (SCI, IF:7.5, Q1) PubMedPDF WOS:000769551500002

85. Ghafoor H, Chu H, Huang J, Chen M, Wang S, Wang J#, Chao J#. ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop. Toxicol Appl Pharmacol. 2022, 435,115856. (SCI, IF:3.8, Q1) PubMedPDF WOS:000789925000001

84. Han B, Xi W, Hong Y, Gu L, Chao Y, Li L, Liu C, Yang L, Chao J#, Yao H#.  Mutual regulation of noncoding RNAs and RNA modifications in psychopathology: Potential therapeutic targets for psychiatric disorders? Pharmacol Ther. 2022,108254.(SCI, IF:13.5, Q1) PubMedPDF WOS:000843902000002

83. Li S#, Chen Z, Zhang W, Wang T, Wang X, Wang C, Chao J#, Liu L#. Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression. Carcinogenesis. 2022, 43(11):1092-1102. (SCI, IF:4.7, Q2) PubMedPDF WOS:000851216300001

82. Hua X, Feng X, Liang G, Chao J, Wang D. Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans. Sci Total Environ. 2022, 861:160591. (SCI, IF:9.8, Q1) PubMedPDF

81. Yu X, Bai Y, Han B, Ju M, Tang T, Shen L, Li M, Yang L, Zhang Z, Hu G, Chao J, Zhang Y#, Yao H#. Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. J Extracell Vesicles. 2022 Jan;11(1):e12185. (SCI, IF:16, Q1) PubMedPDF WOS:000742199800001

80.Wang L, Wen L, Zheng S, Tao F, Chao J, Wang F, Li C. Integrating peroxidase-mimicking NH2-MIL-101(Fe) with molecular imprinting for high-performance ratiometric fluorescence sensing of domoic acid. Sensor Actuat B-Chem. 2022, 361:131688.(SCI, IF:8.4, Q1) PubMed PDF WOS:000782121600003

79. Wang L, Wen L, Zhao L, Chao J, Tao F, Wang F, Li C. Development of fluorescence sensor and test paper based on molecularly imprinted carbon quantum dots for spiked detection of domoic acid in shellfish and lake water. Anal Chim Acta. 2022, 1197,338515. (SCI, IF:6.2, Q1) PubMedPDF WOS:000750845200011

78. Liu X, Wang F, Meng Y, Zhao L, Shi W, Wang X, He Z, Chao J, Li C.Electrochemical/visual microfluidic detection with a covalent organic framework supported platinum nanozyme-based device for early diagnosis of pheochromocytoma. Biosens Bioelectron. 2022 Mar 23;207:114208. (SCI, IF:12.6, Q1) PubMedPDF WOS:000788141300001

77. 丁旭，张浩天，杨凯哲，王哲，张宇，成于思#，巢杰#.外泌体在肺相关疾病中的诊治作用及其分子机制研究进展. 东南大学学报(医学版). 2022; 41(5): 725-730.PDF

76. 周馨蓓, 张伟, 巢杰#. 基于单细胞RNA 测序和空间转录组测序分析矽肺中巨噬细胞差异基因及其功能.环境与职业医学.2022, 39(12): 1350-1358. PDF

75. 杨少奇, 史晓妮, 成于思, 巢杰#. 基于单细胞转录组测序探索FABP5在矽肺纤维化中II型肺泡上皮细胞的特异性表达. 环境与职业医学. 2022, 39(10):1089-1094. PDF

74. 史晓妮，杨少奇，成于思，巢杰#. PPP2R3A通过调控p53的表达促进矽肺肺纤维化. 中国药科大学学报. 2022. 53(4):491 - 498

2021

73.Dai X, Cheng Y, Wang C, Huang J, Chao J#. Role of Circular RNAs in Visceral Organ Fibrosis. Food Chem Toxicol. 2021.150:112074.(SCI, IF:5.572, Q1) PubMedPDF WOS:000632294100026

72.Jiang R#, Han L, Gao Q, Chao J#. ZC3H4 Mediates Silica-induced EndoMT via ER Stress and Autophagy. Environ Toxicol Pharmacol. 2021, 84:103605. (SCI, IF:5.785, Q2) PubMedPDF WOS:000643672100005

71.成于思，罗薇，沈灵，巢杰#。疫情背景下医学“生理学”课程思政的探索。科教文汇. 2021,517(1),54-58PDF

70. 罗薇，王莎，李永琪，王静，杨少奇，巢杰#。矽肺早期炎症中环状RNA氮6-腺苷酸甲基化修饰差异。中华劳动卫生职业病杂志. 2021, 39(12), 899-902 PDF MEDLINE:35164417

Before 2020

69.Huang J, Huang J, Ning X, Luo W, Chen M, Wang Z, Zhang W, Zhang Z#, Chao J#. CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis. J Mater Chem B. 2020, 8 (8), 1713-1727. (SCI, IF:6.331, Q1) PubMedPDF

68.Huang J, Huang, J, Bao H, Ning X, Yu C, Chen Z, Chao J#, Zhang Z#. CT/MR dual-Modal Imaging tracking of mesenchymal stem cells labeled with Au/GdNC@SiO2 nanotracer in pulmonary fibrosis. ACS Applied Bio Materials. 2020, 3, 2489-2498.  ACSPDF

67.Zhang W, Zhu T, Chen L, Luo W, Chao J#. MCP-1 mediates ischemia/reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR. Am J Physiol Heart Circ Physiol. 2020,318(1):H59-H71. (SCI, IF:4.733, Q1) PubMedPDF

66.Chen L, Luo W, Zhang W, Chu H, Wang J, Dai X, Cheng Y, Zhu T#, Chao J#. circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress. RNA Biology. 2020, 17(2):240-253.(SCI, IF:4.652, Q1) PubMed PDF

65.Chu H, Wang W, Luo W, Zhang W, Cheng Y, Huang J, Wang J, Dai X, Fang S, Chao J#. circHECTD1 mediates pulmonary fibroblast activation via HECTD1. Ther Adv Chronic Dis. 2019, Vol. 10: 1-18.(SCI, IF:4.257,Q1) PubMedPDF

64.Jiang R, Liao Y, Yang F, Cheng Y, Dai X, Chao J#. SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO2. Exp Cell Res.2019, 383(1):111492. (SCI, IF:3.383, Q2) PubMedPDF

63.Cheng Y, Luo W, Li Z, Cao M, Zhu Z, Han C, Dai X, Zhang W, Wang J, Yao H, Chao J#. CircRNA-012091/PPP1R13B-mediated lung fibrotic response in silicosis via ER stress andaautophagy. Am J Resp Cell Mol Biol. 2019, 61(3):380-391. (SCI, IF:5.373, Q1) PubMedPDF

62.Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J#. The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial tomesenchymal transition. Toxicol Lett. 2019; 307:26-40. (SCI, IF:3.569, Q2) PubMedPDF

61.Zhang Y, Huang R, Cheng M, Wang L, Chao J, Li J, Zheng P, Xie P, Zhang Z, Yao H. Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome. 2019; 7(1):116. (SCI, IF:11.607, Q1) PubMedPDF

60.Cheng Y, Chao J, Chen C, Lv L, Han Y, Liu B#. The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy. J Pharm  Pharmacol. 2019, 71(3):338-347. (SCI, IF:2.571, Q2) PubMedPDF

59.Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H. Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis. Toxicol Lett. 2019; 301:53-63. (SCI, IF:3.569, Q2) PubMedPDF

58.Zhao L, Du L, Zhang Y, Chao J, Duan M, Yao H, Shen C, Zhang Y. Role of PUMA in the methamphetamine-induced migration of microglia. Metab Brain Dis. 2019, 34(1):61-69.(SCI, IF:2.726, Q2) PubMedPDF

57.Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, Xie C, Zhang Z, Yao H. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination.  Mol Psychiatry. 2018,25(6):1175-1190. (SCI, IF:12.384, Q1) PubMedPDF

56.Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W#, Chao J#. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Cell Death Dis. 2018;9(3):396. (SCI, IF:5.959, Q1)PubMedPDF

55.Yang X*, Wang J*, Zhou Z*, Jiang R, Huang J, Chen L, Cao Z, Chu H, Han B, Cheng Y, Chao J#. Silica-induced initiation of circZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation. FASEB J. 2018, 32(6):3264-3277. (SCI, IF:5.391, Q1) PubMedPDF

54.Zhou Z, Jiang R, Yang X, Guo H, Fang S, Zhang Y, Cheng Y, Wang J, Yao H, Chao J#. circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. Theranostics. 2018; 8:575-592. (SCI, IF:8.063, Q1) PubMedPDF

53.Chao J#, Lv Y, Chen J, Wang J, Yao H. SiO2-induced release of sVEGFRs from pulmonary macrophages. Respir Physiol Neurobiol. 2018; 247:1-8. (SCI, IF:1.582, Q3) PubMedPDF

52.Xie X*, Zhu T*#, Chen L, Ding S, Chu H, Wang J, Yao H, Chao J#. MCPIP1-induced autophagy mediates ischemia/referfusion injury in endothlial cells via HMGB1 and CaSR. Sci Rep. 2018; 8(1):1735. (SCI, IF:4.011, Q1) PubMedPDF

51.Zhang Y, Shu G, Bai Y, Chao J, Chen X, Yao H. Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers. Metab Brain Dis. 2018, 33(5):1585-1597. (SCI, IF:2.411, Q2) PubMedPDF

50.Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, Wu F, Leng S, Chao J, Zhang JH, Hu G, Yao H. Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. Autophagy. 2018;14:1164-1184. (SCI, IF:11.059, Q1) PubMedPDF

49.Han B, Chao J, Yao H. Circular RNA andits mechanisms in disease: From the bench to the clinic.Pharmacol Ther. 2018, 187:31-44. (SCI, IF:9.396, Q1) PubMedPDF

48.Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F, Chao J, Liu P, Hu G, Zhang JH, Yao H.Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity. J Neurosci.2018; 38:32-50. (SCI, IF:6.074, Q1) PubMedPDF

47.Yang L, Han B, Zhang Y, Bai Y, Chao J, Hu G, Yao H. Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. Autophagy. 14(3):404-418. (SCI, IF:11.059, Q1) PubMedPDF    65.005

46.Cao Z*, Xiao Q*, Dai X*, Zhou Z, Jiang R, Cheng Y, Yang X, Guo H, Wang J, Xi Z, Yao H, Chao J#. circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica. Cell Death Dis. 2017; 8:3212. (SCI, IF:5.638, Q1) PubMedPDF

45.Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J#, Liao H#: BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. Cell Death Dis. 2017; 8:e2657. (SCI, IF:5.638, Q1) PubMedPDF

44.Chao J, Zhang Y, Du L, Zhou R, Wu X, Shen K, Yao H. Molecular mechanisms underlying the involvement of the sigma-1 receptor in methamphetamine-mediated microglial polarization.Sci Rep. 2017; 7(1):11540. (SCI, IF:4.122, Q1)PubMedPDF

43.Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress and Oxidative Damage. Front Cell Neurosci. 2017; 11:377. (SCI, IF:4.3, Q2) PubMedPDF

42.Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior. Front Behav Neurosci. 2017; 11:203. (SCI, IF:3.138, Q2) PubMedPDF

41.Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y, Chao J, Teng G, Yao H. An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017 26:1981-1987(SCI, IF:1.598, Q4) PubMed PDF

40.Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G, Chao J, Hu G, Yao H. Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy. 2017,13(10):1722-1741. (SCI, IF:11.1, Q1) PubMedPDF

39.Casillan AJ, Chao J, Wood JG, Gonzalez NC. Acclimatization of the systemic microcirculation to alveolar hypoxia is mediated by iNOS-dependent increased nitric oxide availability. J Appl Physiol. 2017,123(4):974-982. (SCI, IF:3.256, Q2) PubMed PDF

38.Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, Yao H. Involvement of PUMA in pericyte migration induced by methamphetamine. Exp Cell Res. 2017;356:28-39. (SCI, IF:3.309, Q2) PubMedPDF

37.Zhu X, Dong J, Xia Z, Zhang A, Chao J, Yao H. Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress. Neurochem Int. 2017;110:25-37. (SCI, IF:3.603, Q2) PubMed PDF

36.Cheng Y, Chao J, Dai D, Dai Y, Zhu D, Liu B. AQP4-knockout aggravation of isoprenaline-induced myocardial injury is mediated by p66Shc and endoplasmic reticulum stress. Clin Exp Pharmacol Physiol. 2017; 44:1106-1115. (SCI, IF:2.092, Q3) PubMed PDF 47.794

35.Liu H, Fang S, Wang W, Cheng Y, Zhang Y, Liao H, Yao H#, Chao J#. Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. Part Fibre Toxicol. 2016; 13: 55. (SCI, IF:8.577, Q1) PubMedPDF

34.Chao J*#, Wang X*, Zhang Y*, Zhu T, Zhang W, Zhou Z, Yang J, Han B, Cheng Y, Tu X, Yao H#. Role of MCPIP1 in the endothelial-mesenchymaltransition induced by silica. Cell Physiol Biochem. 2016; 40:309-325. (SCI, IF:5.104, Q1) PubMedPDF

33.Zhang W, Zhang M, Wang Z, Cheng Y, Liu H, Zhou Z, Han B, Chen B, Yao H#, Chao J#. Neogambogic Acid Prevents Silica-induced Fibrosis via Inhibition of High-mobility group box1 and MCP-1-induced protein 1. Toxicol Appl Pharmacol. 2016; 309:129-140.  (SCI, IF:3.791, Q1) PubMedPDF

32.Zhu T, Yao Q, Wang W, Yao H, Chao J#. iNOS induced vascular endothelial cell migration andapoptosis via autophagy in ischemia/reperfusion injury. Cell Physiol Biochem. 2016; 38: 1575-1588. (SCI, IF:5.104, Q1) PubMedPDF

31.Wang X, Zhang Y, Zhang W, Liu H, Zhou Z, Dai X, Cheng Y, Fang S, Zhang Y, Yao H, Chao J#: MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica. Toxicol Sci. 151(1):126-38.   (SCI, IF:4.081, Q1) PubMedPDF

30.Liu H, Dai X, Cheng Y, Fang S,Zhang Y, Wang X, Zhang W, Liao H, Yao H, Chao J#: MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol-Lung C. 2016; 310(2):L121-L132. (SCI, IF:4.281, Q1) PubMedPDF

29.Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, Zhu X, Huang W, Chao J, Zhou R, Hu G, Yao H. Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse. Sci Rep. 2015; 6:35642.  (SCI, IF:4.259, Q1) PubMedPDF

28.Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H.Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis andautophagy: Implications for methamphetamine-mediated neurotoxicity. Autophagy. 2016,12(9):1538-59. (SCI, IF:8.593, Q1) PubMedPDF

27.Zhu X, Shen K, Bai Y, Zhang A, Xia Z, Chao J, Yao H.NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy. Free Radic Biol Med. 2016; 94:230-242. (SCI, IF:5.606, Q1) PubMedPDF

26.Zhu X, Dong J, Shen K, Bai Y, Chao J, Yao H. Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.Brain Res Bull. 2016. 121:138-47. (SCI, IF:3.033, Q3) PubMed PDF

25.Zhang Y, Huang R, Zhang Y, Yi H, Bai Y, Chao J, Yao H. IL-17 induces MIP-1α expression in primary mouse astrocytes via TRPC channel. Inflammopharmacology. 2016, 24(1):33-42. (SCI, IF:2.59, Q3) PubMed 55.019

24.Wang W, Liu H, Dai X, Fang S, Wang X, Zhang Y, Yao H, Zhang X#, Chao J#:  p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis.Sci Rep. 2015; 5:16900.  (SCI, IF:5.228, Q1)   PubMedPDF

23.Zhu T, Yao Q, Hu X, Chen C, Yao H, Chao J#: The role of MCPIP1 in ischemia/reperfusion injury-induced HUVEC migration and apoptosis. Cell Physiol Biochem. 2015;37:577-591.(SCI, IF:4.652, Q1)   PubMedPDF

22.Liu X, Fang S, Liu H, Wang X, Dai X, Yin Q, Yun T, Wang W, Zhang Y, Liao H, Zhang W, Yao H, Chao J#: Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. Toxicol Appl Pharmacol. 2015; 288:152-160. (SCI, IF:3.847, Q1) Global Medical DiscoveryPubMedPDF

21.Chao J, Dai X, Pena T, Doyle DA, Guenther TM, Carlson MA: MCPIP1 regulates fibroblast migration in 3-D collagen matrices downstream of MAP kinases and NF-kappa B. J Invest Dermatol. 2015; 135:2944-54.  (SCI, IF:6.915, Q1) PubMedPDF

20.Bai Y*, Zhu X*, Chao J*, Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H: Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGFR expression: Implications for stroke. PLoS One. 2015;10:e0124362. (SCI, IF:3.057, Q1) PubMedPDF

19.Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J, Duan M, Buch S, Chen L, Yao H: Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulationof its own expression. J Neuroinflammation. 2015;12:29. (SCI, IF:4.667, Q1) PubMedPDF

18.Zhang Y, Zhu T, Zhang X, Chao J, Hu G, Yao H: Role of high-mobility group box 1 inmethamphetamine-induced activation and migration of astrocytes. J Neuroinflammation.2015;12:156. (SCI, IF:4.667, Q2) PubMedPDF

17.Zhu X, Dong J, Shen K, Bai Y, Zhang Y, Lv X, Chao J, Yao H: NMDA receptor NR2b subunits contribute to ptz-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015;114:70-78.(SCI, IF:2.572, Q3)  PubMedPDF 35.605

16.Yi H, Bai Y, Zhu X, Lin L, Zhao L, Wu X, Buch S, Wang L, Chao J#, Yao H#: IL-17a induces MIP-1alpha expression in primary astrocytes via Src/MAPK/PI3K/NF-kB pathways:Implications for multiple sclerosis. J Neuroimmune Pharmacol.2014;9:629-641. (SCI, IF:4.11, Q2)  PubMedPDF

15.Chao J*, Yang L*, Yao H, Buch S: Platelet-derived growth factor-bb restores HIV Tat -mediated impairment of neurogenesis: Role of GSK-3beta/beta-catenin. J Neuroimmune Pharmacol.2014;9:259-268.  (SCI, IF:4.11, Q2)  PubMedPDF

14.Chao J, Pena T, Heimann DG, Hansen C, Doyle DA, Yanala UR, Guenther TM, Carlson MA: Expression of green fluorescent protein in human foreskin fibroblasts for use in 2D and 3D culture models. Wound Repair Regen.2014;22:134-140. (SCI, IF:2.768, Q1) Cover story MDLinxGlobal Medical DiscoveryPubMedPDF

13.Chao J, Yang L, Buch S, Gao L: Angiotensin II increased neuronal stem cell proliferation: Role of AT2R. PLoS One.2013;8:e63488. (SCI, IF:3.534) PubMedPDF

12.Yang L*, Chao J*, Kook YH, Gao Y, Yao H, Buch SJ: Involvement of mir-9/MCPIP1 axis in PDGF-bb-mediated neurogenesis in neuronal progenitor cells. Cell Death Dis.2013;4:e960. (SCI, IF:5.177) PubMedPDF

11.Carlson MA, Smith LM, Cordes CM, Chao J, Eudy JD: Attachment-regulated signaling networks in the fibroblast-populated 3D collagen matrix. Sci Rep.2013;3:1880. (SCI, IF:5.078)  PubMedPDF

10.Chao J, Gao J, Parbhu KJ, Gao L: Angiotensin type 2 receptors in the intermediolateral cell column of the spinal cord: Negative regulation of sympathetic nerve activity and blood pressure. Int J Cardiol. 2013;168:4046-4055. (SCI, IF:6.175)  PubMedPDF

9.Chao J, Viets Z, Donham P, Wood JG, Gonzalez NC: Dexamethasone blocks the systemic inflammation of alveolar hypoxia at several sites in the inflammatory cascade. Am J Physiol Heart Circ Physiol.2012;303:H168-177. (SCI, IF:3.629) PubMedPDF

8.Gao J, Chao J, Parbhu KJ, Yu L, Xiao L, Gao F, Gao L: Ontogeny of angiotensin type 2 and type1 receptor expression in mice. J Renin Angiotensin Aldosterone Syst.2012;13:341-352. (SCI, IF:2.286)  PubMedPDF

7. Chao J, Blanco G, Wood JG, Gonzalez NC: Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia. Am J Physiol Heart Circ Physiol.2011;301:H2264-2270. (SCI, IF:3.708) PubMedPDF-6

6.Chao J, Wood JG, Gonzalez NC: Alveolar macrophages initiate the systemic microvascular inflammatory response to alveolar hypoxia. Respir Physiol Neurobiol.2011;178:439-448. (SCI, IF:2.242) PubMedPDF

5.Gao J, Zhang H, Le KD, Chao J, Gao L: Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens.2011;24:724-730. (SCI, IF:3.181) PubMedPDF

4.Chao J, Donham P, van Rooijen N, Wood JG, Gonzalez NC: Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. Am J Respir Cell Mol Biol.2011;45:53-61. (SCI, IF:5.125) PubMedPDF

3.Chao J, Wood JG, Gonzalez NC: Alveolar hypoxia, alveolar macrophages, and systemic inflammation. Respir Res.2009;10:54. (SCI, IF:3.36) PubMedPDF

2.Chao J, Wood JG, Blanco VG, Gonzalez NC: The systemic inflammation of alveolar hypoxia is initiated by alveolar macrophage-borne mediator(s). Am J Respir Cell Mol Biol. 2009;41:573-582. (SCI, IF:5.125) PubMedPDF

1.Meng X, Chao J, Xiang Y: Identification from diversemammalian poxviruses of host-range regulatory genes functioning equivalently tovaccinia virus C7l. Virology.2008;372:372-383. (SCI, IF:3.351) PubMedPDF 51.971