1. 
   
2. 1. 国家自然科学基金面上项目： DNMTs 在肝癌发生发展中的作用及其表遗传机制的研究  （2005,1-- 2007,12） 
3. 
   
4. 2. 国家自然科学基金面上项目： 肝细胞癌中HBx调控DNMTs影响抑癌基因表达的机制研究 （2010,1-- 2012,12） 
5. 
   
6. 3. 国家自然科学基金面上项目： DNMT3A 基因variantrs在胃癌发生重生物学作用及表观遗传调控机制的研（2012,1-- 2015,12） 
7.  
8. 4. 国家自然科学基金重大研究计划（培育项目）：乙肝病毒X 蛋白激活调控LncRNA在介导慢性肝炎恶性转化中的作用研究 （2013,1--2015,12） 
9. 
   

1. 5. 国家自然科学基金面上项目：DNMT3A2通过lncRNA-TRERNA1-E-cadherin轴在胃癌侵袭转移中作用机制研究 （2017,1-- 2020,12）
2.   
3. 6. 国家自然科学基金面上项目：TRERNA1通过抑制Wnt通路拮抗分子表达降低肝癌细胞索拉菲尼敏感性的作用机制研究（2020,1--2023,12）
4. 
   
5. 7. 江苏省自然科学基金面上项目：HBx介导染色质可及性激活ETV4/G6PD轴促进肝癌生长作用机制研究 （2023，9--2026，8）  

已发表的科学研究论文

(1)  Su H, Shu S, Tang W, Zheng C, Zhao L, Fan H*. ETV4 facilitates angiogenesis in hepatocellular carcinoma by upregulating MMP14 expression. Biochem Biophys Res Commun. 2023 Dec 3;684:149137.

(2) Jiang P, Wang C, Zhang M, Tian Y, Zhao W, Xin J, Huang Y, Zhao Z, Sun W, Long J, Tang R, Qiu F, Shi X, Zhao Y, Zhu L, Dai N, Liu L, Wu X, Nie J, Jiang B, Shao Y, Gao Y, Yu J, Hu Z, Zang Z, Gong Y, Dai Y, Wang L, Ding N, Xu P, Chen S, Wang L, Xu J, Zhang L, Hong J, Qian R, Li H, Jiang X, Chen C, Tian W, Wu J, Jiang Y, Han C, Zhang K, Qiu H, Li L, Fan H, Chen L, Zhang J, Sun Z, Han X, Dai Z, Li E, Gershwin ME, Lian Z, Ma X, Seldin MF, Chen W, Wang M, Liu X. Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis. J Genet Genomics. 2023 Jun 20:S1673-8527(23)00140-6.

 (3) Zhou M, Yu S, Liu Y, Shu S, Xu Y, Liu M, Ge Y, Fan H*. H3K27me3 Inactivates SFRP1 to Promote Cell Proliferation via Wnt/β-Catenin Signaling Pathway in Esophageal Squamous Cell Carcinoma. Dig Dis Sci. 2023 Jun;68(6):2463-2473.

(4) Zheng C, Liu M, Ge Y, Qian Y, Fan H*. HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression. Cell Death Dis. 2022 Feb 4;13(2):116. 

(5) Qian Y, Su H, Ge Y, Lei K, Li Y, Fan H*. Prognostic value of PD-L1 expression combined with hypoxia-associated immunosuppression in hepatocellular carcinoma. Biomark Med. 2022 Apr;16(6):435-448. 

(6) Song W, Zheng C, Liu M, Xu Y, Qian Y, Zhang Z, Su H, Li X, Wu H, Gong P, Li Y, Fan H*. TRERNA1 upregulation mediated by HBx promotes sorafenib resistance and cell proliferation in HCC via targeting NRAS by sponging miR-22-3p. Mol Ther. 2021 Aug 4;29(8):2601-2616. 

(7) Shen X, Li Y, Xu Y, Liu M, Zhang Q, Yin R, Zhou M, Lin S, Fan H*. Hypoxia-inducible factor-1α cooperates with histone Lys methylation to predict prognosis in esophageal squamous cell carcinoma. Biomark Med. 2021 May;15(7):509-522.

(8) Qian Y, Li Y, Ge Y, Song W, Fan H*. Elevated LncRNA TRERNA1 correlated with activation of HIF-1α predicts poor prognosis in hepatocellular carcinoma. Pathol Res Pract. 2021 Nov;227:153612.

(9) Gong P, Xu Y, Liu M, Shen X, Mao Y, Li Y, Zhang K, Yu S, Fan H*. Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells. Oncol Lett. 2021 Jul;22(1):557. 

(10) Zheng C, Liu M, Fan H*. Targeting complexes of super-enhancers is a promising strategy for cancer therapy. Oncol Lett. 2020 Sep;20(3):2557-2566. 

(11) Chen P, Qian Q, Zhu Z, Shen X, Yu S, Yu Z, Sun R, Li Y, Guo D, Fan H*. Increased expression of EHMT2 associated with H3K9me2 level contributes to the poor prognosis of gastric cancer. Oncol Lett. 2020 Aug;20(2):1734-1742. 

(12) Zhou M, Mao Y, Yu S, Li Y, Yin R, Zhang Q, Lu T, Sun R, Lin S, Qian Y, Xu Y, Fan H*. LINC00673 Represses CDKN2C and Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells by EZH2-Mediated H3K27 Trimethylation. Front Oncol. 2020 Aug 18;10:1546. 

(13)  Qian Y, Li Y, Zheng C, Lu T, Sun R, MaoY, Yu S, Fan H*, Zhang Z*. High methylation levels of histone H3 lysine 9associated with activation of hypoxia-inducible factor 1α (HIF-1α) predictpatients' worse prognosis in human hepatocellular carcinomas. Cancer Genet.2020;245:17-26.

(14)  Lin S, Zhou M, Li Y, Chen Y, Xu W, Xia W,Wang S, Yin R, Zhang Q, Xu L*, Fan H*. H3K27 trimethylation and H3K9dimethylation as poor prognostic markers for patients with esophageal squamouscell carcinoma. Int J Clin Exp Pathol. 2019; 12:2657-2664.

(15)  Song W, Gu Y, Lu S, Wu H, Cheng Z, Hu J,Qian Y, Zheng Y, Fan H*. LncRNA TRERNA1 facilitates hepatocellular carcinomametastasis by dimethylating H3K9 in the CDH1 promoter region via the recruitmentof the EHMT2/SNAI1 complex. Cell Prolif. 2019; 52(4):e12621.

(16)  Shen X, Gu Y, Yu S, Gong P, Mao Y, Li Y,Zheng Y, Qiao F, Zhao Z, Fan H*. Silenced PITX1 promotes chemotherapeuticresistance to 5-fluorocytosine and cisplatin in gastric cancer cells. Exp TherMed. 2019;17:4046-4054.

(17)  Zhou M, Li Y, Lin S, Chen Y, Qian Y, ZhaoZ, Fan H*. H3K9me3, H3K36me3, and H4K20me3 Expression Correlates withPatient Outcome in Esophageal Squamous Cell Carcinoma as Epigenetic Markers.Dig Dis Sci. 2019,64:2147-2157.

(18)  Lin S, Zhou M, Li Y, Chen Y, Xu W, Xia W, Wang S, Yin R, Zhang Q, Xu L, Fan H*. H3K27 trimethylation and H3K9 dimethylation as poor prognostic markers for patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2019 Jul 1;12(7):2657-2664. 

(19)  GongP, Qiao F, Wu H, Cui H, Li Y, ZhengY, Zhou M, Fan H*. LncRNA UCA1 promotes tumor metastasis by inducing miR-203/ZEB2axis in gastric cancer. Cell Death Dis. 2018; 9:1158.

(20)  Li Y, Guo D, Sun R, Chen P, Qian Q, Fan H*. Methylation Patterns ofLys9 and Lys27 on Histone H3 Correlate with PatientOutcome in Gastric Cancer. Dig Dis Sci.2018; 22. 5341-8.

(21)  Wu H, Liu X, Gong P, Song W, Zhou M, LiY, Zhao Z, Fan H*. Elevated TFAP4 regulates lncRNA TRERNA1 to promote cellmigration and invasion in gastric cancer. Oncol Rep. 2018;40:923-931. 

(22)  Qiao F, Gong P, Song Y, Shen X, Su X, LiY, Wu H, Zhao Z, Fan H*. Downregulated PITX1modulated by miR-19a-3ppromotes cell malignancy and predicts a poor prognosis of gastric cancer byaffecting transcriptionally activated PDCD5. Cell Physiol Biochem. 2018;46:2215-2231. 

(23)  Cui H, Hu Y, Guo D, Zhang A, Gu Y, ZhangS, Zhao C, Gong P, Shen X, Li Y, Wu H, Wang L, Zhao Z, Fan H*. DNA methyltransferase3A isoform b contributes to repressing E-cadherin through cooperation of DNAmethylation and H3K27/H3K9 methylation in EMT-related metastasis of gastriccancer. Oncogene.2018;37:4358-4371. 

(24)  Wu H，Hu Y, Liu X, Song W, Gong P, Zhang K,Chen Z, Zhou M, Shen X, Qian Y, Fan H*.  LncRNATRERNA1 function as anenhancer of SNAI1 promotes gastric cancer metastasis by regulatingepithelial-mesenchymal transition. Mol Ther Nucleic Acids. 2017;8:291-299.

(25)   Zhao Z, Hu Y, Shen X, Lao Y, Zhang L, Qiu X,Hu J, Gong P, Cui H, Lu S, Zheng Y, Zhou M, Fan H*.  HBx repressesRIZ1expression by DNA methyltransferase 1 involved in decreased miR-152inhepatocellular carcinoma. Oncol Rep. 2017；21:2811-2818.

(26)  Hu J, Song W, Zhang S, Shen X, Qiu X, WuH, Gong P, Lu S, Zhao Z, He M, Fan H*.  HBx-upregulated lncRNA UCA1promotes cell growth and tumorigenesis by recruiting EZH2 and repressingp27Kip1/CDK2signaling. Sci Rep. 2016; 6:23521.

(27)  Fan H*, Zhao Z, Cheng Y, Cui H, Qiao F,Wang L, Hu J, Wu H, Song W. Genome-wide profiling of DNA methylation revealspreferred sequences of DNMTs in hepatocellular carcinoma cells. Tumor Bio.2016; 37:877-85.

(28)  Cui H, Zhao C, Gong P, Wang L, Wu H,Zhang K, Zhou R, Wang L, Zhang T, Zhong S, Fan H*. DNA methyltransferase 3Apromotes cell proliferation by silencing CDK inhibitor p18(INK4C) in gastric carcinogenesis. Sci Rep. 2015; 5:13781.

(29)  Zhao Z, Wang L, Song W, Cui H, Chen G,Qiao F, Hu J, Zhou R, Fan H*. Reduced miR-29a-3pexpression is linked to thecell proliferation and cell migration in gastric cancer. World J Surg Oncol.2015; 13:101.

(30)  Cui H, Wang L, Gong P, Zhao C, Zhang S,Zhang K, Zhou R, Zhao Z, Fan H*. Deregulation betweenmiR-29b/c and DNMT3A is associatedwith epigenetic silencing of the CDH1 gene affecting cell migration and invasionin gastric cancer. PLoS One. 2015;10:e0123926.

(31)  Wu H, Zhang K, Gong P, Qiao F, Wang L,Cui H, Sui X, Gao J, Fan H*.  A novel functional tagSNP rs7560488 in theDNMT3A1 promoter is associated with susceptibility to gastric cancer bymodulating promoter activity. PLoS One. 2014；25：9:e92911.

(32)  Qiao F, Zhang K, Gong P, Wang L, Hu J, LuS, Fan H*. Decreased miR-30b-5p expression by DNMT1 methylation regulationinvolved in gastric cancer metastasis. Mol Biol Rep. 2014; 41:5693-700.

(33)  Qiu X, Zhang L, Lu S, Song Y, Lao Y, Hu J,Fan H*. Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expressionindependent of DNA methylation. Oncol Rep. 2014；31: 202-208.

(34)  Lao Y, Wu H, Zhao C, Wu Q, Qiao F, Fan H*. Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellularcarcinoma. Bio medical Reports. 2013;1: 771-775.

(35)  Zhao C, Yan F, Wu H, Qiao F, Qiu X, Fan H*. DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.Bio medical Reports. 2013; 1:664-668.

(36)  Qiu X, Dong S, Qiao F, Lu S, Song Y, Lao Y,Li Y, Zeng T, Hu J, Zhang L, Zhang L, Fan H*. HBx-mediated miR-21 upregulationrepresses tumor-suppressor function of PDCD4 in hepatocellular carcinoma.Oncogene. 2013; 32, 3296– 3305.

(37)  Chen H, Pan Y, Cheng Z, Wang Z, Liu Y, ZhaoZ, Fan H.  Hypermethylation and clinic pathological significance of RASAL1gene in gastric cancer. Asian Pac J Cancer Prev. 2013;14:6261-5.

(38)  Wu Q, Lu S, Wang L, Hu J, Qiao F, Qiu X, ZhaoC, Lao Y, Song Y, Fan H*. DNMT3A rs36012910 A>G polymorphism and gastriccancer susceptibility in a Chinese population. Mol Biol Rep. 2012; 39:10949-55.

(39)  Fan H*, Chen L, Zhang F, Quan Y, Su X,Qiu X, Zhao Z, Kong K, Dong S, Song Y, Chan T, Guan X. MTSS1, a novel target ofDNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.Oncogene. 2012; 31:2298-308.

(40)  Qiao F, Su X, QiuX, Qian D, Peng X, ChenH, Zhao Z, Fan H*. Enforced expression of RASAL1 suppresses cell proliferationand the transformation ability of gastric cancer cells. Oncol Rep.2012;28:1475-81.

(41)  Zhao Z, Li C, Song Y, Wu Q, Qiao F, Fan H*. Association of theDNMT3A -448A>G polymorphism with geneticsusceptibility to colorectal cancer. Oncol Lett. 2012; 3:450-454.

(42)  Liu H, Jiao Y, Guan Y, Lao Y, Zhao C, Fan H*. The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer. ExpTher Med. 2012;3:525-529.

(43)  Huang H, Wei X, Su X, QiaoF, Xu Z, Gu D, Fan H, Chen J. Clinical significance ofexpression of Hint1 and potential epigenetic mechanism in gastric cancer.Int J Oncol. 2011; 38:1557-64.

(44)  Yang J, Wei X, Wu Q, Xu Z, Gu D, Jin Y,Shen Y, Huang H, Fan H, Chen J.   Clinical significance of theexpression of DNA methyltransferase proteins in gastric cancer. Mol Med Rep.2011; 4:1139-43. 

(45)  Zhao Z, Wu Q, Chen J, Qiu X, Zhang J, Fan H*. Depletion of DNMT3A suppressed cell proliferation and restored PTEN inhepatocellular carcinoma cells. J Biomed Biotech. 2010; 2010:737535.

(46)  Fan H*, Liu D, Qiu X, Qiao F, Wu Q, Su X,Zhang F, Song Y, Zhao Z, Xie W. A functional polymorphism in the DNA methyltransferase3A promoter modifies the susceptibility in gastric cancer but not in esophagealcarcinoma. BMC Medicine. 2010；8:12

(47)  Su X, Lv C, Qiao F, Qiu X, Huang W, Wu Q,Zhao Z, Fan H*. Expression pattern and clinical significance of DNA methyltransferase3B variants in gastric carcinoma. Oncol Rep. 2010; 23:819-26.

(48)  Yang X, Lee Y, Fan H, Sun X, Lussier Y. Identification of common microRNA-mRNA regulatory biomodules in humanepithelial cancers. Chin Sci Bull. 2010; 55:3576-3589.

(49)  Hu J, Fan H*, Liu D, Zhang S, Zhang F, XuH. DNMT3B promoter polymorphism and risk of gastric cancer. Dig Dis Sci. 2010;55:1011-6.

(50)  Qiu X, Qiao F, Su X, Zhao Z, Fan H*. Epigeneticactivation of E-cadherin is a candidate therapeutic target in human hepatocellularcarcinoma. Exp. Ther. Med. 2010; 1: 519-523.

(51)  Fan H*, Zhao Z, Cheng J, Su X, Wu Q, ShanY. Overexpression of DNA methyltransferase 1 and its biological significance inprimary hepatocellular carcinoma. World J Gastroenterol. 2009;15:2020-6.

(52)  Fan H*, Liu D, Zhang S, Hu J, Zhang F,Zhao Z. The DNMT3B G>T promoter Polymorphism and the Risk of EsophagusCarcinoma in a Chinese Population. World J Gastroenterol. 2008;14:2230-4.

(53)  Fan H*, Zhang F, Hu J, Liu D, Zhao Z.Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese:a case-control study. J Exp Clin Cancer Res. 2008; 27:24.

(54)  Fan H*, Cheng J, Zhao Z.  Inhibitionof de novo DNA Methyltransferase3B is a Potential. Therapy for HepatocellularCarcinoma. Gastroen Res. 2008;1:33-39.

(55)  Fan H*, Zhao Z, Quan Y, Xu J, Zhang J,Xie W.  DNA methyltransferase 1 knock down induces silenced CDH1 genere-expression by demethylation of methylated CpG in HCC cell line SMMC-7721.Eur J Gastroenterol Hepatol. 2007; 19:952-61.

(56)   Fan H*, Zhao Z, Cheng Y, ShanY, Lu Z, Zhang J, Xie W.  Analysisof gene induction and apoptosis in human hapetocellular carcinoma cellsSMMC-7721 exposed to the methylation inhibitor 5-Aza-2’-deoxycytidine. Chin Med J (Engl). 2007; 120:1626-31.

(57)  Xu W, Fan H*, He X. LOI of IGF2 isassociated with esophageal cancer and linked to methylation status ofIGF2 DMR.J Exp Clin Cancer Res. 2006; 25: 543-7.

(58)  Fan H*, Xu J, Zhao Z, Zhang J, Xie W.Construction of DNMT1 siRNA stable expressing construct and evaluation of itssilenced efficiency in blocking gene expression.  Chin J Med Genet, 2005;22:142-145.

(59)  李默怡, 罗卓娟, 樊红*. 东南大学遗传学学科发展回顾与展望——纪念江苏省遗传学会成立40周年[J].遗传, 2021, 43(5): 390-392.

(60)  刘敏，樊红*。肿瘤超级增强子的作用及其临床意义的研究进展. 东南大学学报(医学版). 2020;39:1-3 （综述）

(61)  刘秀芳，郭迪迪，郑颖，吴华彰，樊红*.  Linc00651对胃癌细胞增殖与迁移侵袭能力影响的研究,基因组学与应用生物学,2020;39(4):1905-1910

(62)  孙瑞，樊红*. 组蛋白赖氨酸甲基化修饰与胃癌发病机制相关性的研究进展. 东南大学学报(医学版). 2019;38:536 – 540 （综述）

(63)  王琼，陆向东，李懿萍，王楠瑶，黄娴婷，樊红*。 TRDMT1 蛋白在胃癌组织中的表达及其临床意义。 临床肿瘤学杂志， 2018；23（6）：524-527 (北图核心期刊)

(64)  宋蕴薇，仇雪梅，陆森，樊红*. HBx抑制RASSF1A表达参与肝细胞癌发生的可能机制。东南大学学报(医学版)，2018；37（3）：401-406 （综述）

(65)  吴华彰, 公丕海, 吴涛, 赵云利, 汤必奎, 陈文静, 刘牧林, 樊红*. 转录因子AP-4 基因真核表达载体构建及表达分析. 基因组学与应用生物学. 2018;38（5）

(66)  陈雨朦，刘琳，樊红*。 LncRNA UCA1表达水平与常见肿瘤患者预后关系的研究进展。现代肿瘤医学杂志，2018；7：1135-1138 （综述）

(67)  黄珊，于天源，樊红* 。胃癌转移相关lncRNA的研究进展。东南大学学报（医学版） 2017；36: 1-4 （综述）

(68)  宋伟，樊红*。胃癌中LncRNA的研究进展。 国际遗传学杂志  2014；37:189-193（综述）

(69)  张少丹，樊红*。组蛋白甲基化与lncRNAs的表达调控国际遗传学杂志 2014；37:236-235（综述）

(70)  杨华，樊红*.基于分子结构的lncRNA分子功能的研究进展。东南大学学报（医学版）2013；33：99-102 （综述）

(71)  石明，仇雪梅，樊红*. 血浆miRNA检测在肿瘤临床应用的研究进展. 东南大学学报（医学版）。2012；31：122-125 （综述）

(72)  崔鹤, 樊红* .DNMT3A在肿瘤发生中表遗传调控作用的研究进展. 东南大学学报（医学版）。2012；31：508-511 （综述）

(73)  吴华彰, 樊红*.TagSNPs在鉴定肿瘤易感性基因研究中的应用. 东南大学学报(医学版)   2013;31: 247-250 （综述）

(74)  刘东声,张淑红,胡嘉波,张凤,赵主江, 樊红*. DNMT3B基因启动子C46359T多态性与食管癌易感性的关联分析 东南大学学报 (医学版) 2008; 27: 319-323

(75)  单云峰，樊红*，赵主江. DNMT3B 基因异常表达与肝癌发生的相关性研究. 临床检验杂志 2008；26：27-30

(76)  赵主江，樊红*，单云峰等. DNA甲基转移酶3A siRNA真核表达载体的构建和鉴定. 东南大学学报（医学版）2008；27;1-5

已授权的发明专利

（1）樊红;刘敏;钱言言;李懿萍. 检测转录因子MAX基因表达量在肝癌c-MYC靶向治疗预后评估试剂盒中的应用,发明专利（授权）。专利号:ZL202110901877.8 

（2）樊红;周梦晗;李懿萍;徐颖.  检测linc00673表达量在食管癌靶向治疗预后评估试剂盒中的应用,发明专利（授权）。专利号:ZL2020 1 0100207.1

（3）樊红;钱言言;李懿萍;郑楚骞;刘敏. 检测H3K9甲基化和E-cadherin表达量试剂在制备肝癌预后评估试剂盒的应用,发明专利（授权）。专利号:ZL2019 1 0497621.8

（4）樊红;李懿萍;郭迪迪;刘东声;陈平;钱琦;周梦晗. 检测H3K9me2和H3K36me3表达量的试剂在制备胃癌预后评估试剂盒中的应用，发明专利（授权）。专利号:ZL201810744519.9

（5）樊红;许林;张勤;李懿萍;尹荣;周梦晗;虞慎玲;林邵峰;刘秀芳. H4K20、H3K9及H3K36三甲基化量检测试剂在食管癌预后评估中的应用，发明专利（授权）。专利号:ZL201810861814.2

（6）樊红;宋伟;辜跃俊;陆森;李懿萍;钱言言.TRERNA1基因在预测、提高肝癌药物索拉菲尼敏感性中的应用,发明专利（授权）。专利号: ZL201810863020.X

（7）樊红;乔凤昌;沈小慧;李懿萍. 检测PITX1表达量的试剂在制备胃癌预后评估试剂盒中的应用，发明专利（授权）。 专利号：ZL201710216328.0

编写论著与教材

1. 《临床遗传学》人民卫生出版社  编委，2017年

2. 《医学遗传学》国家十二五规划教材  北京大学医学出版社  编委，2013年

3. 《医学遗传学》国家十一五规划教材  北京大学医学出版社  编委，2009年

4.  《医学遗传学实验》 人民卫生出版社 副主编， 2007年

5. 《肿瘤表观遗传学》 科学出版社  编委， 2005年

6. 《分子诊断学-基础与临床》   科学出版社   编委，2003年