1. 国家自然科学基金面上项目，81870568，：O-GlcNAc糖基化修饰途径介导葡萄糖毒性致tau蛋白过度磷酸化的分子机制及其神经网络特征，2019/01-2022/12，57万元，在研，主持。2. 国家自然科学基金面上项目，81570732，BDNF（Val66Met）多态性及其神经网络特征对T2DM患者认知障碍进展预测价值的前瞻性研究，2016/01-2019/12，58万元，已结题，主持。3. 国家自然科学基金面上项目，81370921，糖尿病认知障碍机制初探：糖基化终产物致糖尿病认知障碍: BDNF-TrkB-CREB信号介导的海马重塑神经网络机制研究，2014/01-2014/12，16万元，已结题，主持。4. 江苏省科技计划项目，SBE201170735，合并高危因素的妊娠糖尿病患者早期筛查和胰岛素强化干预的前瞻性研究，2011/01-2014/12，30万元，已结题，主持。5. 国家自然科学基金面上项目，81070638，糖尿病认知障碍机制初探：PPAR-γ 介导糖基化终产物致海马重塑障碍的机制研究，2011/01-2013/12，36万元，已结题，主持。6. 国家自然科学基金面上项目，30870870，γ－分泌酶介导Notch 通路参与脑卒中后抑郁海马重塑障碍的机制研究，2009/01-2011/12，28万元，已结题，主持。7. 江苏自然科学基金面上项目，BK2008302，γ－分泌酶介导Notch 通路参与脑卒中后抑郁海马重塑障碍的机制研究，2008/09-2010/12，8万元，已结题，主持。

[1]. Sai Tian, Rong Huang, Dan Guo, Hongyan Lin, Jiaqi Wang, Ke An, Shaohua Wang*. Associations of Plasma BACE1 Level and BACE1 C786G Gene Polymorphism with Cognitive Functions in Patients with Type 2 Diabetes: A Cross- Sectional Study[J]. Current Alzheimer Research,2020,17(4).

[2]. Haoqiang Zhang, Rong Huang, Sai Tian, Ke An, Wenwen Zhu, Jijing Shi, Wuyou Cao, Shaohua Wang*, Margaret A. Niznikiewicz. The CC Genotype of Insulin-Induced Gene 2 rs7566605 Is a Protective Factor of Hypercholesteremia Susceptible to Mild Cognitive Impairment, Especially to the Executive Function of Patients with Type 2 Diabetes Mellitus[J]. BioMed Research International,2020,2020.

[3]. Wang Chenchen, Huang Xi, Tian Sai, Huang Rong, Guo Dan, Lin Hongyan, Wang Jiaqi, Wang Shaohua*. High Plasma Resistin Levels Portend the Insulin Resistance-Associated Susceptibility to Early Cognitive Decline in Patients with Type 2 Diabetes Mellitus.[J]. Journal of Alzheimer's disease : JAD,2020,75(3).

[4]. Rong Huang, Sai Tian, Haoqiang Zhang, Wenwen Zhu, Shaohua Wang*. Chronic hyperglycemia induces tau hyperphosphorylation by downregulating OGT-involved O-GlcNAcylation in vivo and in vitro[J]. Brain Research Bulletin,2020,156.

[5]. Lin H, Yuan Y, Tian S, Han J, Huang R, Guo D, Wang J, Wang S*. In Addition to Poor Glycemic Control, a High Level of Irisin in the Plasma Portends Early Cognitive Deficits Clinically in Chinese Patients With Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne). 2019;10:634.

[6]. Guo D, Yuan Y, Huang R, Tian S, Wang J, Lin H, An K, Han J, Wang S*. Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study. BMC Endocr Disord. 2019;19(1):108.

[7]. Huang X, Wang C, Tian S, Huang R, Guo D, Zhang H, Shi J, Wang S*. Higher Plasma Level of Nampt Presaging Memory Dysfunction in Chinese Type 2 Diabetes Patients with Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. 2019.

[8]. An K, Huang R, Tian S, Guo D, Wang J, Lin H, Wang S*. Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis. Lipids in health and disease. 2019;18(1):121.

[9]. Huang R, Tian S, Han J, Cai R, Lin H, Guo D, Wang J, Wang S*. Increased Ratio of Global -GlcNAcylation to Tau Phosphorylation at Thr212 Site Is Associated With Better Memory Function in Patients With Type 2 Diabetes. Frontiers in physiology. 2019; 10: 110

[10]. Huang R, Tian S, Han J, Lin H, Guo D, Wang J, Wang S*. U-Shaped Association Between Serum Uric Acid Levels and Cognitive Functions in Patients with Type 2 Diabetes: A Cross-Sectional Study.  Journal of Alzheimer's disease : JAD. 2019;69(1):135-44.

[11]. Wang J, Huang R, Tian S, Lin H, Guo D, An K, Wang S*. Elevated Plasma Level of D-dimer Predicts the High Risk of Early Cognitive Impairment in Type 2 Diabetic Patients as Carotid Artery Plaques become Vulnerable or Get Aggravated. Current Alzheimer research. 2019;16(5):396-404.

[12]. Huang R, Tian S, Cai R, Sun J, Shen Y, Wang S*. Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis. Frontiers in genetics. 2018;9:541.

[13]. Tian S, Huang R, Han J, Cai R, Guo D, Lin H, Wang J, Wang S*. Increased plasma Interleukin-1beta level is associated with memory deficits in type 2 diabetic patients with mild cognitive impairment. Psychoneuroendocrinology. 2018;96:148-54.

[14]. Yin H, Tian S, Huang R, Cai R, Guo D, Lin H, Wang J, Wang S*. Low Plasma Leptin and High Soluble Leptin Receptor Levels Are Associated With Mild Cognitive Impairment in Type 2 Diabetic Patients. Frontiers in aging neuroscience. 2018;10:132.

[15]. Wang J, Yuan Y, Cai R, Huang R, Tian S*, Lin H, Guo D, Wang S*. Association between Plasma Levels of PAI-1, tPA/PAI-1 Molar Ratio, and Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes Mellitus. Journal of Alzheimer's disease : JAD. 2018;63(2):835-45.