1、国家自然科学基金面上项目，82471486 “Tak1调控小胶质细胞嘌呤核苷酸代谢重编程在颞叶癫痫中的作用及其机制研究”，2025/01-2028/12，在研，主持。

2、国家自然科学基金面上项目，81872846 “海马犬尿氨酸代谢失衡在颞叶癫痫中的作用及其机制研究”，2019/01-2022/12，已结题，主持。

3、国家自然科学基金面上项目，81673413 “miR-23a靶向调控ADAM10基因在颞叶癫痫中的作用及其机制研究”，2017/01-2018/12，已结题，主持。

4、教育部留学回国人员科研启动基金“NMDA受体通过转录因子CREB调控癫痫发生的作用及其细胞分子机制研究”第49批，2015/03-2018/6，已结题、主持。

5、江苏省自然科学基金面上项目，BK20141335、“NMDA受体通过转录因子CREB调控癫痫发生及其分子机制研究”  2014/07-2017/06，已结题、主持。

6、高等学校博士学科点专项科研基金项目，20130092120043、“NMDA受体NR2B亚基调控癫痫发生的作用及其分子细胞机制研究”，

  2014/01-2016/12，已结题、主持。

研究论文：

（1） Li J, Qi H, Chen Y, ZhuX*. Epilepsy and demyelination:towards a bidirectional relationship. Prog Neurobiol. 2024,18: 102588.

（2）Xu F, Wang Y, Zhu X*. The Safety and Efficacy ofAbaloparatide on Postmenopausal Osteoporosis: A Systematic Review and Meta-Analysis. Clin Ther. 2024, S0149-2918 (24) 00004-3.

（3）Hu Y, Yao Y, Qi H, Yang J, Zhang C, Zhang A, Liu X, Zhang C,Gang G, Zhu X*. Microglia sense and suppress epileptic neuronalhyperexcitability. Pharmacol Res. 2023,195: 106881.

（4）Yang L, Yao Y, Yang J, Cheng H*, Zhu X*, Zhang Z*.Sphingosine 1-phosphate receptor 1 regulates blood brain barrierpermeability in epileptic mice. Neural Regen Res. 2023, 18(8): 1763-9.

（5） Yao Y, Hu Y, Yang J, Zhang C, He Y, Qi H, Zeng Y, Zhang A,Liu X, Zhu X*. Inhibition of neuronal nitricoxide synthase protects against hippocampal neuronal injuries by increasingneuropeptide Y expression in temporal lobe epilepsy mice. Free Radic Biol Med. 2022 Aug 1;188:45-61.

（6）Zhu Y, Yang J, Zhu X*.Combined effects of levetiracetam and sodium valproate on paediatric patientswith epilepsy: a systematic review and meta-analysis. Seizure. 2022 Feb; 95:17-25.

   (7)  Zhu X*, Yao Y, Yang J, Zhang C, Li X, Zhang A, Liu X,Zhang C, Gan G. Valproic acid suppresses cuprizone-induced hippocampal demyelination andanxiety-like behavior by promoting cholesterol biosynthesis. Neurobiol Dis. 2021;158:105489.

   (8)  Zhu X*, Yao Y, Yang J, ZhangC, Li X, Zhang A, Liu X, Zhang C, Gan G.  ADAM10 suppresses demyelination and reducesseizure susceptibility in cuprizone-induced demyelination model. Free Radic Biol Med. 2021;171:26-41.

   (9) Zhu X*, Yao Y, Yang J, ZhengxieJ, Li X, Hu S, Zhang A, Dong J, Zhang C, Gan G. COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injuryand cognitive impairment in PTZ-kindled epilepsy mice. International Immunopharmacology. 2020, 87:106801.

   (10) Zhu X*, Yao Y, Yang J, Ge Q, Niu D, Liu X, Zhang C, GanG, Zhang A, Yao H. Seizure-induced neuroinflammation contributes to ectopic neurogenesis andaggressive behavior in pilocarpine-induced status epilepticus mice. Neuropharmacology. 2020, 170:108044.

   (11)  Zhu X*, Zhang A, Dong J, Yao Y, Zhu M, Xu K, AlHamda MH. MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory impairment in an experimental model oftemporal lobe epilepsy. BrainRes Bull. 2019, 152:175-183.

   (12) Zhu X*, Yao Y, Liu Y, Zhou R, Zhang W, Hu Q, Liu H, Al HamdaMH1, Zhang A. Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. Front Cell Neurosci. 2019, 30; 13: 180.

   (13) Zhu X*, Yao Y,Li X, Dong J, Zhang A. Alteration of GABAergic signaling is associated withanxiety-like behavior in temporal lobe epilepsy mice. Prog Neuropsychopharmacol Biol Psychiatry. 2019; 93:141-148

   (14) ZhuX*, Li X, Zhu M, Xu K, Yang L, Han B, Huang R, Zhang A, Yao H.,Metalloprotease Adam10 suppresses epilepsy through repression of hippocampalneuroinflammation. J Neuroinflammation. 2018;15 (1):221.

   (15)   ZhuX*,Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H., Neuronal nitric oxide synthase contributes to PTZ kindling epilepsy-induced hippocampal endoplasmic reticulum stress andoxidative damage. Front Cell Neurosci. 2017;11:377.

   (16)  Zhu X*,Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H., Neuronal nitric oxide synthase contributes toPTZ kindling-induced cognitive impairment and depressive-like behavior. Front Behav Neurosci. 2017;11:203.

    (17)   Zhu X*, Dong J,Xia Z, Zhang A, Chao J, Yao H., Repeated restraint stress increases seizure susceptibility by activation hippocampal endoplasmic reticulum stress. Neurochem Int. 2017;110:25-37.

    (18)   杨展能, 姜靓婧，顾仕红，陈磊，黎虹薇，朱新建*.  NMDA受体在匹罗卡品癫痫小鼠海马星形胶质细胞活化中的作用. 东南大学学报（医学版）. 2017,36(2):129-136.

    (19)   Zhu X*, ShenK, Bai Y, Zhang A, Xia Z, Chao J, Yao H., NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy. Free Radic Biol Med. 2016;94:230-42.

    (20)  Zhu X*, DongJ, Shen K, Bai Y, Chao J, Yao H., Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis. Brain Res Bull. 2016, 24 (1), 33-42.

    (21)  Zhu X, Dubey D, Bermudez C, Porter BE*., Suppressing cAMP response element-bindingprotein transcription shortens the duration of status epilepticus and decreasesthe number of spontaneous seizures in the pilocarpine model of epilepsy. Epilepsia. 2015, 56(12):1870-1078

    (22)  Zhu X*, Dong J, Shen K, Bai Y, Zhang Y, Lv X, Chao J, Yao H., NMDA receptor NR2B subunits contributeto PTZ-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015, 114:70-78.

   (23)  Bai Y#, Zhu X#, Chao J#,Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, YaoH*.,  Pericytes Contribute to the Disruption of theCerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke, PLoS One, 2015; 10(4): e0124362

  (24)  Zhu XJ, Han X, Blendy, JA, Porter BE*. Decreased CREB levels suppress epilepsy. Neurobiol Dis. 2012,253-263.

  (25)   Luo CX#, Zhu XJ#, Zhou QG#, Wang B, Wang W, Cai HH, Sun YJ, HuM, Jiang J, Hua Y, Han X, Zhu DY*. Reduced neuronal nitric oxidesynthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem. 2007, 103:1872-1882.

  (26)  Zhu XJ, Hua Y, Jiang J, Zhou QG, Luo CX,Han X, Lu YM, Zhu DY*., Neuronal nitric oxide synthase-derived nitricoxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation. Neuroscience.2006 , 141(2):827-836.

  (27)  Luo CX#, Zhu XJ#, Zhang AX#, Wang W, Yang XM, Liu SH, Han X,Sun J, Zhang SG, Lu Y, Zhu DY*., Blockade of L-typevoltage-gated Ca channel inhibits ischemia-induced neurogenesis by down-regulating iNOS expression in adult mouse. J Neurochem. 2005,94(4):1077-1086.

  (28)  Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, Zhu X, Huang W, Chao J, Zhou R, Hu G, Yao H*., Silencing microRNA-143 protects the integrity of the blood-brain barrier:implications for methamphetamine abuse. Sci Rep. 2016, 6:35642.

  (29)  Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J,Duan M, Buch S, Chen L, Yao H*., Involvementof sigma-1 receptor in astrocyte activation induced by methamphetamine viaup-regulation of its own expression. J Neuroinflammation. 201512:29.

  (30)   Yi H,Bai Y, Zhu X, Lin L, Zhao L, Wu X,Buch S, Wang L, Chao J, Yao H*., IL-17Ainduces MIP-1α expression in primary astrocytes via Src/MAPK/PI3K/NF-kBpathways: implications for multiple sclerosis. J Neuroimmune Pharmacol. 2014, 9(5):629-641.

  (31)   Wang IT, Allen M, GoffinD, Zhu X, Fairless AH, Brodkin ES, Siegel SJ, Marsh ED, Blendy JA, ZhouZ*.(2012) Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A, 2012, 109:21516-21521.

  (32)   Varodayan FP, Zhu XJ, Cui XN, Porter BE*. Seizures increasecell proliferation in the dentate gyrus by shortening progenitor cell-cyclelength. Epilepsia, 2009,50: 2638-2647.

  (33)   ZhouQG, Hu Y, Hua Y, Hu M, Luo CX, Han X, ZhuXJ, Wang B, Xu JS, Zhu DY*.,Neuronal nitric oxide synthase contributes to chronic stress-induced depressionby suppressing hippocampal neurogenesis.J Neurochem. 2007, 103(5):1843-54.

  (34)   Lin X,Zhang Y*, Dong J, Zhu X, Ye M, ShiJ, Lu J, Di Q, Shi J, Liu W., GM-CSF enhances neural differentiation of bonemarrow stromal cells., Neuroreport. 2007:18(11):1113-1117.

 (35) Xin Jian Zhu, You Ming Lu, Dong Ya Zhu.Neuronal selfrepair following ischemic insults. Central nervous system Agents in Medicinal  Chemistry. 2007,7:79-84.

(36)  Luo CX, Zhu XJ, Zhou QG et al. Reduced neuronal nitric oxide synthase is involved inischemia-induced hippocampal neurogenesis by up- regulating inducible nitricoxide synthase expression. J Neurochem. 2007,103:1872-1882.

(37)  Luo CX, Jiang J, Zhou QG, Zhu XJ, Wang W et al. Voluntary exercise-induced neurogenesis in thepostischemic dentate gyrus is associated with spatial memory recovery fromstroke. J Neurosci Res. 2007, 85:1637-1646. 

国际会议论文 

(1)  X. ZHU*."Neuronalnitric oxide synthase contributes to PTZ kindling-induced cognitive impairmentand depressive-like behavior by activation of hippocampal endoplasmic reticulumstress. 47th Annualmeeting of the Society for Neuroscience, Washington, DC, USA,Nov 11-15, 2017.

(2)  X. ZHU*.,Neuronal nitric oxide synthase contributes to pentylenetetrazole kindling-inducedhippocampal neurogenesis. 45th Annual meeting of the Society for Neuroscience,Chicago, IL, USA, Oct 17-22, 2015

(3)  X.ZHU*, J.DONG. NMDA receptor blockade suppresses pentylenetetrazole- inducedacute seizure and kindling by down-regulation of CREB phosphorylation. 44thAnnual meeting of the Society for Neuroscience, Washington, DC, USA, Nov 11-15,2014

(4)  X. ZHU,J. BLENDY, B. PORTER*. Effect of inducible repression of CREB on thedevelopment of epilepsy. 41th Annual meeting of the Society for Neuroscience,Washington, DC, USA, Nov 12-16, 2011

(5)  Zhu X., Han X., Blendy J.A., Porter B.E*. CREB deficiency suppressesthe development of epilepsy. 39th Annual meeting of the Society forNeuroscience, Chicago, IL, USA, Nov 17-21, 2009