导师风采
王彬
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个人信息

Personal Information

  • 副教授
  • 导师类别:硕,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

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  • 所属院系:医学院
  • 所属专业:
  • 邮箱 : wangbinhewei@126.com
  • 工作电话 : -

个人简介

Personal Profile

        东南大学青年首席教授,附属中大医院肾脏科副主任医师,东南大学肾脏病研究所副所长,博士生导师。

        教育部“长江学者”青年学者,东南大学“至善学者”。主持国家自然科学基金3项、江苏省重点研发计划社会发展项目1项、江苏省自然科学基金面上项目1项等课题。

        现任中国生物医学工程学会人工器官分会委员兼学术秘书,中华医学会肾脏病学分会青年委员(第十二届),江苏省中西医结合学会第八届肾病委员会青年副主委,江苏省医学会肾脏病学分会青年委员。

        第10届意大利国际肌肉减少症-恶病质-消耗性疾病学会(SCWD)获得“青年研究者奖”。以第一作者或通讯作者身份(含共同)在JAm Soc Nephrol, Sci Adv, Diabetes,JACCBasic Transl Sci, Theranostics, Mol Ther, Kidney Int Rep, Human Gene Therapy等杂志发表SCI论文50余篇。

        主要研究方向:CKD相关肌少症及疑难罕见肾脏病的分子诊断和治疗策略研究。


  • 研究方向Research Directions
急慢性肾脏病及其并发症的临床和基础研究,肾脏罕见病的分子诊断和治疗
项目情况

CDK12-HNF4A轴调控AKI肾小管损伤及机制研究,国家自然科学基金专项项目,2023.01- 2025.12,在研,主持,排1


巨噬细胞源性外泌体miR-155调控肾小管上皮细胞衰老的机制研究,国家自然科学基金面上项目,2021.01- 2024.12,在研,主持,排1


罕见肾脏病多维度筛诊体系建设与推广,江苏省科技计划专项项目,2023.07-2026.06,在研,主持,排1


东南大学“至善青年项目”,东南大学,2022年,在研,主持,排1


托伐普坦在肾病患者容量管理中的精准应用,中国心血管健康联盟诺创高血压科研创新基金,2022-01-2024-01,在研,主持,排1


RVG修饰外泌体运载miR-26a对尿毒症心肌损害的治疗作用研究,江苏省自然科学基金面上项目,2018-07-01-2020-06-3010,结题,主持,排1


醛固酮诱导TIF新机制:FOXO1/Rab7轴对miR-26a表达调控的研究,国家自然科学基金青年项目,2017-08-06-2020-12-31,结题,主持,排1


成纤维细胞生长因子21与血液透析患者血管钙化的相关性研究和机制初探,中华医学会临床医学科研专项资金项目,2020-03-31-2022-03-31,结题,主持,排1


血液透析患者膈肌功能障碍的临床研究,江苏省“六大人才”高峰项目C类一项,2018-06-01-2020-12-31,结题,主持,排1


醛固酮诱导TIF新机制:FOXO1/Rab7轴.miR-26a表达调控的研究,东南大学高水平论文扶持项目,2018-01-01-2019-12-31,结题,主持,排1


科研项目

CDK12-HNF4A轴调控AKI肾小管损伤及机制研究,国家自然科学基金专项项目,2023.01- 2025.12,在研,主持,排1


巨噬细胞源性外泌体miR-155调控肾小管上皮细胞衰老的机制研究,国家自然科学基金面上项目,2021.01- 2024.12,在研,主持,排1


罕见肾脏病多维度筛诊体系建设与推广,江苏省科技计划专项项目,2023.07-2026.06,在研,主持,排1


东南大学“至善青年项目”,东南大学,2022年,在研,主持,排1


托伐普坦在肾病患者容量管理中的精准应用,中国心血管健康联盟诺创高血压科研创新基金,2022-01-2024-01,在研,主持,排1


RVG修饰外泌体运载miR-26a对尿毒症心肌损害的治疗作用研究,江苏省自然科学基金面上项目,2018-07-01-2020-06-3010,结题,主持,排1


醛固酮诱导TIF新机制:FOXO1/Rab7轴对miR-26a表达调控的研究,国家自然科学基金青年项目,2017-08-06-2020-12-31,结题,主持,排1


成纤维细胞生长因子21与血液透析患者血管钙化的相关性研究和机制初探,中华医学会临床医学科研专项资金项目,2020-03-31-2022-03-31,结题,主持,排1


血液透析患者膈肌功能障碍的临床研究,江苏省“六大人才”高峰项目C类一项,2018-06-01-2020-12-31,结题,主持,排1


醛固酮诱导TIF新机制:FOXO1/Rab7轴.miR-26a表达调控的研究,东南大学高水平论文扶持项目,2018-01-01-2019-12-31,结题,主持,排1


研究成果


1.Wang B, Wang Y, Wen Y, Zhang YL, Ni WJ, TangTT, et al. Tubular-specific CDK12 knockout causes a defect in urineconcentration due to premature cleavage of the slc12a1 gene. Mol Ther.2022;30:3300-12.

 

2.Wang B, Qian JY, Tang TT, Lin LL, Yu N, GuoHL, et al. VDR/Atg3 axis regulates slit diaphragm to tight junction transitionvia p62-mediated autophagy pathway in diabetic nephropathy. Diabetes.2021;70:2639-51.

 

3.Wang B, Wang ZM, Ji JL, Gan W, Zhang A, ShiHJ, et al. Macrophage-Derived Exosomal Mir-155 Regulating CardiomyocytePyroptosis and Hypertrophy in Uremic Cardiomyopathy. JACC Basic Transl Sci.2020;5:148-66.

 

4.Tang TT#, Wang B#, Wu M, Li ZL, Feng Y, CaoJY, et al. Extracellular vesicle-encapsulated IL-10 as novel nanotherapeuticsagainst ischemic AKI. Sci Adv. 2020;6:z748.

 

5.Wang B, Zhang C, Zhang A, Cai H, Price SR,Wang XH. MicroRNA-23a and MicroRNA-27a Mimic Exercise by AmelioratingCKD-Induced Muscle Atrophy. J Am Soc Nephrol. 2017;28:2631-40.

 

6.Tang TT#, Wang B#, Li ZL, Wen Y, Feng ST, WuM, et al. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform forRNAi to Treat AKI. J Am Soc Nephrol. 2021;32:2467-83.

 

7.Yin Q, Zhao YJ, Ni WJ, Tang TT, Wang Y, CaoJY, et al, Liu BC*, Wang B*. MiR-155 deficiency protects renal tubularepithelial cells from telomeric and genomic DNA damage in cisplatin-inducedacute kidney injury. Theranostics. 2022;12:4753-66.

 

8.Ni WJ#, Li ZL#, Wen XL, Ji JJ, Liu H, Yin Q,et al, Liu BC*, Wang B*. HIF-1α and adaptor protein LIM and senescent cellantigen-like domains protein 1 axis promotes tubulointerstitial fibrosis byinteracting with vimentin in angiotensin II-induced hypertension. Br JPharmacol. 2024 May 3.(Onlineahead of print).

 

9.Zhang YL, Tang TT, Ni WJ, Li ZT, Jiang LYZ,Wang Y, et al, Liu BC*, Wang B*. Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidneyinjury through transcriptional elongation defects. Int J Biol Sci.2024;12;20:1669-87.

 

10.Ni WJ, Zhao YJ, Shen jx, Yin Q, Wang Y, LiZL, et al, Wang B*, Liu BC*. Therapeutic role of miR-26a on cardiaorenal injuryin mice model of angiotensin-II induced chronic kidney disease throughinhibition of LIMS1/ILK pathway. Chin Med J (Engl). 2024 Mar 6.(Onlineahead of print).

 

11.Sheng MJ, Cao JY, Hou SM, Li M, Wang Y, FangQ, et al, Wang B*.  Computedtomography-determined skeletal muscle density predicts 3-year mortality ininitial-dialysis patients in China. J Cachexia Sarcopenia Muscle.2023;14:2569-78. 

 

12.Yin D, Cao JY, Yang Y, Li ZT,  Liu H, Tang TT, et al, Liu BC*, Wang B*. Quercetin alleviatestubulointerstitial inflammation by inhibiting exosomes-mediated crosstalkbetween tubular epithelial cells and macrophages. Inflamm Res.2023;72:1051-67. 

 

13.Ji JJ, Shi HM, Li ZL, Jin R, Qu GT, Zheng H,et al, Wang B*, Zhang AQ*. Satellite cell-derived exosome-mediated delivery ofmicroRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosisin mouse diabetic nephropathy. Acta Pharmacol Sin. 202;44:2455-68. 

 

14.Zheng J, Yin Q, Wang SY, Wang YY, Xiao JJ,Tang TT, et al, Liu BC*, Wang B*. Ultrasound-assessed diaphragm dysfunctionpredicts clinical outcomes in hemodialysis patients. Sci Rep. 2022;12:16550.

 

15.Gao YM, Feng ST, Wen Y, Tang TT, Wang B*,Liu BC*. Cardiorenal protection of SGLT2 inhibitors-Perspectives from metabolicreprogramming. EBioMedicine. 2022;83:104215.

 

16.Wang B, Li ZL, Zhang YL, Wen Y, Gao YM, LiuBC. Hypoxia and chronic kidney disease. EBioMedicine. 2022;77:103942.

 

17.Ni HF, Yang Y, Li CQ, Zhou TZ, Liu BC, WangB*. Myeloid bodies caused by COQ2 mutation: a case of concurrent COQ2nephropathy and IgA nephropathy. Clin Kidney J. 2021;14:1697-700.

 

18.Wang FM, Yang Y, Zhang XL, Wang YL, Tu Y,Liu BC, Wang B*. Combination of a Novel Genetic Variant in CFB Gene and aPathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report.Frontiers in Genetics. 2021;12:690952.

 

19. Li ZL, Wang B*, Wen Y, Wu QL, Lv LL, LiuBC*. Disturbance of Hypoxia Response and Its Implications in Kidney Diseases.Antioxid Redox Signal. 2022 Nov;37:936-55.

 

20.Li ZL, Ji JL, Wen Y, Cao JY, Kharbuja N,Ni WJ, et al, Liu BC*, Wang B*. HIF-1alpha is transcriptionally regulated byNF-kappaB in acute kidney injury. Am J Physiol Renal Physiol. 2021;321:F225-35.


21.Li ZL, Wang B*, Lv LL, Tang TT, Wen Y, CaoJY, et al, Liu BC*. FIH-1-modulated HIF-1alpha C-TAD promotes acute kidneyinjury to chronic kidney disease progression via regulating KLF5 signaling.Acta Pharmacol Sin. 2021;42:2106-19. doi: 10.1038/s41401-021-00617-4.


22. Wang H#, Wang B#, Zhang A, Hassounah F,Seow Y, Wood M, et al. Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophyand Kidney Fibrosis in Mice. Mol Ther. 2019;27:571-83.

 

23. Wang B, Zhang A, Wang H, Klein JD, Tan L,Wang ZM, et al. miR-26a Limits Muscle Wasting and Cardiac Fibrosis throughExosome-Mediated microRNA Transfer in Chronic Kidney Disease. Theranostics.2019;9:1864-77.

 

24. Cao JY#, Wang B#, Tang TT#, Wen Y, Li ZL,Feng ST, et al. Exosomal miR-125b-5p deriving from mesenchymal stem cellspromotes tubular repair by suppression of p53 in ischemic acute kidney injury.Theranostics. 2021;11:5248-66.

 

25. Wang B, Wang J, He W, Zhao Y, Zhang A, LiuY, et al. Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis inUnilateral Ureteral Obstruction Mice. Hum Gene Ther. 2020;31:367-75.

 

26. Wang B, Yin Q, Wang YY, Tu Y, Han Y, Gao M,et al. Diaphragmatic dysfunction associates with dyspnoea, fatigue, and hiccupin haemodialysis patients: a cross-sectional study. Sci Rep. 2019;9:19382.

 

27. Qian FY, Li ZL, Guo YD, Gao HC, Gu LH, LeK, et al, Wang B*,ZhangZ J*. Hypoxia-inducible factor-prolyl hydroxylase inhibitor amelioratesmyopathy in a mouse model of chronic kidney disease. Am J Physiol RenalPhysiol. 2019;317:F1265-73.

 

28. Tu Y, Sheng MJ, Wang YL, Wang ZJ, Zhang XL,Liu BC, Wang B*. A Woman With "Polycystic Kidney Disease". Kidney IntRep. 2020;5:1367-70.

 

29. Jiang L, Yin Q, Yang M, Li M, Pan M, Han Y,et al, Wang B*. Fibroblast Growth Factor 21 Predicts and Promotes VascularCalcification in Haemodialysis Patients. Kidney Dis (Basel). 2021;7:227-40.


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