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沈杨,男,医学博士,东南大学附属中大医院党委委员、副院长,东南大学妇产科学系主任,东南大学妇女生命健康研究所所长,女性盆底健康管理中心负责人,主任医师,东南大学教授、博士研究生导师,University of ArizonaMedical Center访问学者(2014-2015年),2020全国健康卫士(国家卫健委百姓健康频道),江苏省妇幼健康重点人才,江苏省333工程第二层次人才。
2012.06-2014.12生长抑素受体介导的靶向治疗对卵巢癌紫杉醇耐药的逆转作用及其机制研究 东南大学重大科研引导基金项目
2012.01-2014.12环境雌激素及雌激素代谢酶基因SNPs与子宫肌瘤易感性的研究,南京市科技基金项目,主持,5万
2013.01-2016.12环境雌激素暴露与其代谢酶遗传多态性对子宫肌瘤发病的影响 ,江苏省卫生厅青年基金项目,主持,3万
2014.01-2017.12酚类环境雌激素对子宫肌瘤影响的基础及临床研究,江苏省妇幼保健科研项目,主持,2万
2014.12-2017.12环境雌激素暴露及其相关代谢酶基因多态性与子宫肌瘤易感性的研究 ,东南大学科研研究项目,主持,2万
2017.01-2020.12酚类环境雌激素在子宫肌瘤发生发展中的作用和分子机制研究,国家自然科学基金面上项目,主持,55万
2020.07-2023.06基于微纳米流体的外泌体miRNA检测技术在卵巢癌早期诊断中的应用,江苏省重点研发计划,主持,50万
2021.01-2024.12盐诱导激酶2响应型多肽水凝胶的制备及其在卵巢癌腹腔灌注治疗中的应用,国家自然科学基金面上项目,主持,55万
2021.01-2023.12微纳流体传感器快速检测外泌体lncRNA在卵巢癌早期筛查中的应用,江苏省卫生厅重点 A 类项目 ,主持,20万
2023.10-2025.10 一种宫腔镜手术机器人及其控制系统的研发及转化应用 南京市重大科技专项(生命健康)项目,202305039,主持,30万
2024.01-2027.12 原位自组装AXL激酶抑制肽阻断GAS6-AXL结合抑制卵巢癌发展的机制研究,8237071954,国家自然科学基金项目,主持,48万
1.Zhang, X., Yu, H., Chen, K., Ding, B., & Shen, Y*. (2024). Definite Treatment Delay With Neoadjuvant Chemotherapy and Longitudinal Monitoring by Circulating Tumor DNA for Advanced Cervical Cancer During Pregnancy: A Case Series and Literature Review. Cancer Rep (Hoboken), 7(11), e70021.2.Zhu, M., Huang, F., Xu, J., Chen, W., Ding, B., & Shen, Y*. (2024). Risk factors and nomogram construction for predicting women with chronic pelvic pain:a cross-sectional population study. Heliyon, 10(14).
3.Liu, S., Ji, F., Ding, Y., Ding, B., Feng, S., Brennick, C., Lin, H., Zhang, T., & Shen, Y*. (2024). VISTA: A promising target for overcoming immune evasion in gyne-cologic cancers. International Immunopharmacology, 138.
4.Hua, Y., & Shen, Y*. (2024). Applications of self-assembled peptide hydrogels in anti-tumor therapy. Nanoscale Advances.
5.Yin, H., Hua, Y., Feng, S., Xu, Y., Ding, Y., Liu, S., Chen, D., Du, F., Liang, G., Zhan, W., & Shen, Y*. (2024). In Situ Nanofiber Formation Blocks AXL and GAS6 Binding to Suppress Ovarian Cancer Development. Advanced materials (Deerfield Beach, Fla.), e2308504.
6.Ding, B., Ye, Z., Yin, H., Hong, X.-Y., Feng, S.-w., Xu, J.-Y., & Shen, Y*. (2024). Comprehensive single-cell analysis reveals heterogeneity of fibroblast subpopulations in ovarian cancer tissue microenvironment. Heliyon, 10(6).
7.Ding, Y., Zhou, Q., Ding, B., Zhang, Y., & Shen, Y*. (2024). Transcriptome analysis reveals the clinical significance of CXCL13 in Pan-Gyn tumors. Journal of cancer research and clinical oncology, 150(3), 116.
8.Feng, S., Ding, B., Dai, Z., Yin, H., Ding, Y., Liu, S., Zhang, K., Lin, H., Xiao, Z., & Shen, Y*. (2024). Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter. Journal of translational medicine, 22(1), 280.
9.Ke Zhang, Songwei Feng, Yan Wang, Wen Feng, Yang Shen*. (2024). Significant Prognostic Factor at Age Cut-off of 73 Years for Advanced Ovarian Serous Cystadenocarcinoma Patients: Insights from Real-World Study.International Journal of Women’s Health 2024:16 203–218.
10.Jiang Y, Ding B, Huang H, Zhang C, Shen Y*. (2023). Application of transumbilical single port laparoscopic surgery for adnexal masses in pregnancy. Asian J Endosc Surg. 2023;1‐8.
11.Zhao, M., Qiu, S., Wu, X., Miao, P., Jiang, Z., Zhu, T., Xu, X., Zhu, Y., Zhang, B., Yuan, D., Zhang, Y., Sun, W., He, A., Zhao, M., Hou, W., Zhang, Y., Shao, Z., Jia, M., Li, M., Chen, J., Xu, J., Chen, B., Zhou, Y., & Shen, Y*. (2023). Efficacy and Safety of Niraparib as First-Line Maintenance Treatment for Patients with Advanced Ovarian Cancer: Real-World Data from a Multicenter Study in China. Target Oncol.
12.Xu, J. Y., Yu, T. X., Guan, X. M., Ding, B., Ren, M. L., & Shen, Y*. (2023). Long-term outcomes of vulvar or vaginal cancer patients undergoing laparoendoscopic single-site inguinal lymphadenectomy. Journal of minimal access surgery, 10.4103/jmas.jmas_268_22. Advance online publication.
13.Xu, J., Qian, Q., Ren, M., & Shen, Y*. (2023). Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases. Open Med (Wars), 18(1), 20230761.
14.Hong X, Qiu S, Wu X, Chen S, Chen X, Zhang B, He A, Xu Y, Wang J, Gao Y, Xu X, Sun L, Zhang Y, Xiang L, Zhou J, Guan Q, Zhu Y, Liu H, Xu H, Zhou Y, Chen B, Shen Y*. (2022). Efficacy and Safety of Anlotinib in Overall and Disease-Specific Advanced Gynecological Cancer: A Real-World Study. Drug Des Devel Ther. 2023 Jul 6;17:2025-2033.
15.Ding, B., Ye, Z., Yin, H., Hong, X. Y., Feng, S. W., Xu, J. Y., & Shen, Y*. (2023). Exosomes derived from ovarian cancer cells regulate proliferation and migration of cancer-associated fibroblasts. Genomics, 115(5), 110703.
16.Ye, Z., Li, S., Mi, X., Shao, B., Dai, Z., Ding, B., Feng, S., Sun, B., Shen, Y*., & Xiao, Z. (2023). STMHCpan, an accurate Star-Transformer-based extensible framework for predicting MHC I allele binding peptides. Brief Bioinform.
17.Ding, B., Yan, W., Shen, S., Meng, D., Chen, X., Wang, S., & Shen, Y*. (2023). Immune-Related Genes' Prognostic, Therapeutic and Diagnostic Value in Ovarian Cancer Immune-Related Gene Biomarker in Ovarian Cancer. Cancer Control, 30, 10732748231168756.
18.Si, K., Ye, Z., Ali, D. J., Ding, B., He, C., Dai, Z., Li, Z., Sun, B., Shen, Y*., & Xiao, Z. (2023). Co-delivery of PDL1-blocking scFv and chemotherapeutics using engineered exosomes for cancer therapy. Journal of Drug Delivery Science and Technology, 82.
19.Shen, Y*., Zha, Y.-J., Xu, J.-Y., Chen, M.-S., Ding, B., & Zhang, Q.-F. (2023). Restrictive Fluid Therapy for High-Complexity Advanced Ovarian Cancer Surgery: A Single-Center Retrospective Cohort Study. Clinical and Experimental Obstetrics & Gynecology, 50(1).
20.Si, K.; Dai, Z.; Li, Z.; Ye, Z.; Ding, B.; Feng, S.; Sun, B.; Shen, Y*.; Xiao, Z., Engineered exosome-mediated messenger RNA and single-chain variable fragment delivery for human chimeric antigen receptor T-cell engineering. Cytotherapy 2023.
21.Li, Z., Yin, H., Chen, K., Ding, B., Xu, J., Ren, M., Zhang, C., & Shen, Y*. (2022). Effects of bisphenol A on uterine leiomyoma: In vitro and in vivo evaluation with mechanistic insights related to XBP1. Ecotoxicology and environmental safety, 247, 114201
22.Hu, T., Wu, Z., Sang, W., Ding, B., Chen, K., Li, X., Shen, Y.*, & Ni, Z. (2022). A sensitive electrochemical platform integrated with a 3D graphene aerogel for point-of-care testing for tumor markers. Journal of materials chemistry.
23.Zhang, K., Feng, S., Ge, Y., Ding, B., & Shen, Y*. (2022). A Nomogram Based on SEER Database for Predicting Prognosis in Patients with Mucinous Ovarian Cancer: A Real-World Study. International Journal of Women's Health, Volume 14, 931-943.
24.Hong, X. Y., Ding, B., & Shen, Y*. (2022). Laparo-Endoscopic Single Site Combined With Hysteroscopy to Diagnose and Treat Robert's Uterine Malformation: A Case Report. Front Surg, 9, 926935.
25.Feng, S., Xu, Y., Dai, Z., Yin, H., Zhang, K., & Shen, Y*. (2022). Integrative Analysis From Multicenter Studies Identifies a WGCNA-Derived Cancer-Associated Fibroblast Signature for Ovarian Cancer. Frontiers in Immunology, 13.
26.Xu, J., Zhou, Z., Chen, K., Ding, Y., Hua, Y., Ren, M., & Shen, Y*. (2022). How to minimize the impact of COVID-19 on laparoendoscopic single-site surgery training? ANZ J Surg.
27.Hua, Y., Yin, H., Liu, X., Xie, J., Zhan, W*., Liang, G*., & Shen, Y*. (2022). Salt‐Inducible Kinase 2‐Triggered Release of Its Inhibitor from Hydrogel to Suppress Ovarian Cancer Metastasis. Advanced Science, e2202260.
28.Si, W., Yuan, R., Wu, G., Kan, Y., Sha, J., Chen, Y., Zhang, Y., & Shen, Y*. (2022). Navigated Delivery of Peptide to the Nanopore Using In-Plane Heterostructures of MoS2 and SnS2 for Protein Sequencing. The journal of physical chemistry letters, 13(17), 3863–3872.
29.Feng, S., Ge, Y., Ma, X., Zhang, K., Ge, M., Li, L., & Shen, Y*. (2022). The genomic landscape of invasive stratified mucin-producing carcinoma of the uterine cervix: the first description based on whole-exome sequencing. Journal of translational medicine, 20(1), 187.
30.Feng, S., Yin, H., Zhang, K., Shan, M., Ji, X., Luo, S., & Shen, Y*. (2022). Integrated clinical characteristics and omics analysis identifies a ferroptosis and iron-metabolism-related lncRNA signature for predicting prognosis and therapeutic responses in ovarian cancer. J Ovarian Res, 15(1), 10.
31.Feng, S., Xia, T., Ge, Y., Zhang, K., Ji, X., Luo, S., & Shen, Y*. (2022). Computed Tomography Imaging-Based Radiogenomics Analysis Reveals Hypoxia Patterns and Immunological Characteristics in Ovarian Cancer. Frontiers in Immunology, 13.
江苏省医学会妇产科分会副主任委员,中国临床肿瘤学会(CSCO)妇科肿瘤专业委员会常委,中国抗癌协会妇科肿瘤专委会委员,国家癌症中心卵巢癌质控专家委员会委员,中国研究型医院学会病毒肿瘤专委会常委,中国优生优育学会妇科肿瘤防治专委会常委,中国医师协会微无创分会单孔及经阴道腔镜学组委员,中国医师协会微无创分会生育力保护学组委员,江苏省研究型医院学会妇科人工智能与微无创专委会主任委员,江苏省妇幼保健研究会女性康复专委会副主任委员,江苏省医师协会妇产科学分会委员,江苏省妇产科学会腔镜学组委员,江苏省中西医结合学会妇产科学分会常委,江苏省抗癌协会妇科肿瘤专业委员会委员,江苏省预防医学会妇女保健专委会宫颈病防治学组委员,南京市医学会科学普及专科分会副主任委员,南京市妇产科学会腔镜学组副组长,世界中医药联合会盆底学组常务理事,世界华人妇产科学会NOTES学组委员。
承担国家自然科学基金两项,国家重点研发计划子项目一项,江苏省重点研发项目一项;获国家妇幼科技进步二等奖一项,省妇幼新技术引进一等奖两项和二等奖一项,省预防医学科技进步三等奖一项;承担省市级项目6项,发表论文60余篇,SCI收录40余篇。担任JCO中文版妇瘤专刊编委及国内外多个核心期刊审稿专家。
擅长妇科肿瘤的综合诊治,尤其是常规/单孔腹腔镜子宫内膜癌、宫颈癌、早期卵巢癌的手术治疗,晚期卵巢癌R0切除术,复发性宫颈癌盆腔廓清术;擅长女性盆底修复及尿失禁治疗。
从事妇产科教学工作18年,担任《妇产科学》的编委以及《妇产科学学习指导》副主编,历年作为骨干教师承担本科生(五年制和七年制)海外班《妇产科学》、硕士研究生《妇产科学进展》、《妇科肿瘤学》及博士研究生《妇产科学精要》(中文及全英文)等课程的教学任务,并在科室带教留学生、规范化培训医师。多次获得校级授课竞赛奖励、PBL教学案例奖及东南大学奖教金。注重科研与教学相结合的教学模式,曾在《江苏高教》撰文“试论研究型大学的学科建设及本科教育的研究型教学”,提出以研究为形式的教学,即以发现为本或研究为本的教学,提升本科生的创新品质和能力品质,为研究生教育建立基础。
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