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从事内分泌疾病和糖尿病临床、教学和科研工作二十多年。培养研究生40余人。在 《 Diabetes》《 Diabetologia 》等杂志发表SCI论文及核心期刊论文40余篇。主持国家自然科学基金和省自然科学基金面上项目,对糖尿病胰岛功能损伤的分子机制和肥胖、内分泌代谢病发病理论有较深入的研究和临床经验。
1. 国家重点研发计划,《糖尿病防诊治协同服务模式与传播体系研究及示范应用》
2. 国家自然科学基金面上项目,《CASK在2型糖尿病胰岛β细胞胰岛素囊泡转运及分泌障碍中的作用及其机制研究》
3. 江苏省自然科学基金面上项目,《CASK基因在FoxO1介导的胰岛β细胞损伤中的作用》
1、 Liu X, Sun P, Yuan Q, Xie J, Xiao T, Zhang K, Chen X, Wang Y*, Yuan L, Han X. Specific Deletion of CASK in Pancreatic βCells Affects Glucose Homeostasis and Improves Insulin Sensitivity in ObeseMice by Reducing Hyperinsulinemia Running Title: β Cell CASK Deletion ReducesHyperinsulinemia. Diabetes. 2021 Oct 21:db201208.
2、Qian J, Chen C, Wang X, Tan Y, Yang J, Yuan Y, Chen J,Guo H, Wang B, Sun Z, Wang Y*. HbA1c combinedwith glycated albumin or 1,5-anhydroglucitol improves the efficiency ofdiabetes screening in a Chinese population. Diabet Med. 2021 Sep 2:e14685.
3、 An L, Wang Y*.Potential Roles of miRNA-1245a Regulatory Networks in Sarcopenia. Int J GenMed. 2021 Oct 14;14:6807-6813.
4、 Yuan Y, Cheng J, Chen C, Wang Y*.Combining serum 1,5-anhydroglucitol with fasting plasma glucose to detectdiabetes mellitus in a community-based population with hypertension. AnnPalliat Med. 2021 Aug;10(8):8746-8752.
5、 Zhang K, Zhang Y, Chen C, Yuan Y, Jiang X, Yuan X, Wang Y*. miR-139-5p mediates the palmitate-inducedinhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1cells. Acta Biochim Biophys Sin (Shanghai). 2021 Jul28;53(8):1017-1026.
6、 Tianyuan Wang, Xingjing Liu, Jinyang Xie, Qingzhao Yuan, YaoWang*. Cask methylation involved in theinjury of insulin secretion function caused by interleukin1-β. J Cell Mol Med.2020 Nov 14;24(24):14247–14256.
7、 Kai Zhang, Tianyuan Wang, Xingjing Liu, Qingzhao Yuan, TingXiao, Xiangjiang Yuan, Yijian Zhang, Li Yuan, Yao Wang*. CASK, APBA1,and STXBP1 collaborate during insulin secretion. Mol Cell Endocrinol. 2021 Jan15;520:111076.
8、Cheng Chen, Xiaohang Wang, Yuanyuan Tan, JiaoYang, Yuexing Yuan, Juan Chen, Haijian Guo, Bei Wang, Zilin Sun, Yao Wang*.Reference intervals for serum 1,5-anhydroglucitol of a population with normalglucose tolerance in Jiangsu Province. J Diabetes. 2020 Jun;12(6):447-454.
9、 Ting Lu, Yao Wang*, Ting Dou, Bizhen Xue, Yuanyuan Tan, Jiao Yang. Pancreaticfat content is associated with beta-cell function and insulin resistance inChinese type 2 diabetes subjects. Endocrine journal. 2019;66(3):265-270.
10、 Kai Zhang, Bizhen Xue, Yuexing Yuan, Yao Wang*. Correlation of Serum 1,5-AG with Uric Acid inType 2 Diabetes Mellitus with Different Renal Functions. 2019;2019:4353075.
11、 Kai Zhang, Qingzhao Yuan, Jinyang Xie, LiYuan, Yao Wang*. PPAR-γ activation increases insulin secretion independent of CASK inINS-1 cells, Acta Biochim Biophys Sin 2019.
12、 YaoWang, Yuexing Yuan, Chenhao Lei, Yi Zhou, JiajiaHe, Zilin Sun. Serum 1,5-anhydroglucitol level as a screening tool for diabetesmellitus in a community-based population at high risk of diabetes. Actadiabetologica. 2017;54(5):425-431.
13、 YaoWang*, Nana Hao, Haiyan Lin, Tianyuan Wang, JinyangXie, Yuexing Yuan. Down-regulation of CASK in glucotoxicity-induced insulindysfunction in pancreatic beta cells. Acta biochimica et biophysica Sinica.2018;50(3):281-287.
14、YaoWang , Haiyan Lin , Nana Hao, Zhengqiu Zhu, DongWang, Yuan Li, Hong Chen, Yunxia Zhu, Xiao Han; Forkhead box O1 mediatesdefects in palmitate-induced insulin granule exocytosis by downregulation ofcalcium/calmodulin-dependent serine protein kinase expression in INS-1 cells. Diabetologia.2015;58(6):1272-1281.
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