江苏省生物材料与器件重点实验室纳米研究组

https://lbmd.seu.edu.cn/nano/

焦真研究组

生物医用微纳材料制备：开发面向临床诊疗的微纳气泡、铁基磁性材料等生物医用材料。

基于超临界流体制备微纳材料技术：利用超临界二氧化碳技术制备微纳材料，目前的主要工作包括两亲嵌段聚合物在超临界流体中的自组装；超临界技术制备用于食品和医药的脂质体等。

CFD技术在半导体制造装备结构优化、过程开发等应用：利用计算流体力学模拟技术优化半导体晶圆清洗、晶圆电镀等装置结构；模拟微化工设备内和生物体内的流体流动及相关的研究开发等

高附加值精细化学品研制：针对企业技术需求，开发高附加值精细化学品生产工艺，协助企业完成工业化生产。

在研科研项目：

1. 1. 国家自然科学基金重点项目，面向间歇缺氧致脑损伤诊治一体化的纳米磁基元脂质序构体材料，92163213，2022.1-2025.12，合作单位负责人
2. 2. 国家重点研发计划课题，外场响应性磁基元及组装材料研究，2024YFF0508601，2024.12-2029.11，子课题负责人
3. 3. 苏州市关键核心技术“揭榜挂帅”攻关项目，45-14nm制程的铜互连电镀设备关键技术研发，SYG202411，2024.11-2027.12，技术单位负责人
4. 4. 江苏省重点研发计划产业前瞻与核心技术项目，基于微纳气泡强化的集成电路14nm先进制程单片清洗设备研发，BE2023066，2023.9-2026.9
5. 5. 苏州市前沿技术研究项目，用于MPI成像的高性能铁基磁性纳米微球材料研发，SYG202318，2023.11-2026.12，技术单位负责人
6. 6. 曹传欣校友发展研究基金，基于微气泡的气-液-固反应体系强化及其用于醇胺氧化耦合反应制备亚胺的研究，2023.7-2025.6，负责人
7. 7. 苏州市产业前瞻与关键核心技术项目，面向药物递送的功能纳米磁基元脂质序构微球材料研发，SYC2022099，2022.11-2025.10，技术单位负责人
8. 8. 苏州市产业前瞻与关键核心技术项目，面向集成电路28nm先进制程的单片清洗设备关键技术研发，SYC2022050，2022.11-2025.10，技术单位负责人

1. 发表的论文：
2. [43] Kailin Wang#, Mengnan Zhang#, Zejin Geng, Shuo Zhang, Zhuang Deng, Jin Tan, Qiang Zhang, ZhenJiao*, Ning Gu*, One-Step Preparation of Magnetic Lipid Bubbles:Magnetothermal Effect Induces the Simultaneous Formation of Gas Nuclei and Self-Assemblyof Phospholipids, ACS Applied Materials & Interfaces, 2024, 16, 30755-30765
3. [42] Shuo Zhang,Zhuang Deng, Bingxu Yao, Jingyi Wu, Zhen Jiao*, Ning Gu*, Polyhedral MagneticNanoparticles of High Magnetization Synthesized by Hydrocooling andMagnetically Internal Heating Co-precipitation: Implications for MagneticResonance Imaging, Journal: ACS Applied Nano Materials, 2024, 7, 10377–10386
4. [41] Jingyi Wu#,Qianqian Wang#,Zhuang Deng,Shuo Zhang,Zhen Jiao*,A Novel Design of Superparamagnetic Iron Oxide-based Metal-Organic Frameworkfor SSI-assisted Drug Delivery System, New Journal of Chemistry, 2024, 48,4118 - 4125
5. [40]Zhen Jiao*, Zhuang Deng, Yi Zhang, Jinjing Wang, Fabrication Magnetic Composite Scaffolds with Multi-Modal Cell Structurefor Enhanced Properties Using Supercritical CO2 Two-stepDepressurization Foaming Process, Polymer Bulletin, 2024, 81: 5627–5652
6. [39] Tao Du, Peng Zhang*, Zhen Jiao*, Jiancheng Zhou*,Yuxiao Ding*, Homogeneous and Heterogeneous Frustrated Lewis Pairs for the Activationand Transformation of CO2, Chemistry-A Asian Journal, 2024, e202400208
7. [38] Zhen Jiao*, Shuo Zhang, Jinjing Wang, YiZhang, Preparation of magnetic scaffolds via supercritical carbon dioxide foamingprocess using iron oxide nanoparticles coated with CO2-philicmaterials as nucleating agents, Journal of Applied Polymer Science, 2024
8. [37] Jingyi Wu#, Qianqian Wang#,Kailin Wang, Zejin Geng, Yadong Shao, Zhen Jiao*, Synthesis andcharacterization of Fe3O4@MIL-100 nanoparticles as an SSI-assisted drugcarrier, Materials Letters, 2024, 137473
9. [36] Zhuang Deng#, Yu Wang#,Shuo Zhang, Jingyi Wu, Shuning Wei, Zhen Jiao*, Ion-Doped Iron-Based Nanoparticleswith Enhanced Magnetic Properties: Synthesis and Formation Mechanism viaCoprecipitation, Journal of Magnetism and Magnetic Materials, 2024, 611, 172588
10. [35] Qianqian Wang, Shuo Zhang, Zhuang Deng,Yi Zhang, Zhen Jiao*, Preparation of curcumol-loaded magnetic metal- organicframework using supercritical solution impregnation process, Microporous andMesoporous Materials, 2023, 357, 112612
11. [34]Ruan Nningjie, Jiao Zhen*,Tang Linglong, Response surface methodology to optimizesupercritical carbon dioxide extraction of Polygonum Cuspidatum, Journal of AOAC international，2022,105(1): 272–281
12. [33] Wang Jinjing, Zhang Yi, Sun Jianfei*, Jiao Zhen*, Controllablefabrication of multi-modal porous PLGA scaffolds with different sizes of SPIONsusing supercritical CO2 foaming, Journal of Applied Polymer Science, 2022, 139:e52287
13. [32] Xu Qianrui, Gao Pengchao, Wang Yang, Jiang Wenjie,Wang Zhifei, Jiang Yong*, Jiao Zhen*, Using supercritical carbon dioxide tosynthesize polymer nanospheres with an open hole on the surface and theapplication of spatially structured PS/P(DVB-co-MAA)@Fe3O4/TA@Ag nanocomposites,The Journal of Supercritical Fluids, 2022, 184, 105561.  
14. [31] Zhang Yi, Wang Jinjing, Zhou Jiancheng, Sun Jianfei*,Jiao Zhen*, Multi-modal cell structure formation of poly (lactic-co-glycolicacid) /superparamagnetic iron oxide nanoparticles composite scaffolds bysupercritical CO2 varying-temperature foaming, Polymers for AdvancedTechnologies, 2022, 33:1906–1915.
15. [30] Jiao Zhen*, Zhang Mengnan, Yang Lixia, Wang Yuxuan,Fu Jiajie, Liquid−Liquid Equilibrium for the Ternary System Water +1‑Methylimidazole + Ionic Liquid ([Hmim][PF6], [Omim][PF6], or [Omim][BF4]) at303.15K, Journal of Chemical & Engineering Data, 2022, 67, 6, 1474–1480
16. [29] Zhong Qiuwen#, Jiao Zhen#,*,Nie Wenhui, Li Yan, Gu Ning*, Numerical investigation of mass transfer behaviorof a gas–liquid two‐phase Taylor flow in a microchannel by a volume‐of‐fluidmultiphase flow system, International Journal of Mechanical System Dynamics,2022, 2, 253–264
17. [28] Wang Jiada#, Guo Ying#, JiaoZhen*, Tan Jin. Zhang Mengnan, Zhang Qiang*, Gu Ning*, Generation of micro-nanobubbles by magneto induced internal heat for protecting cells from intermittenthypoxic damage, Colloids and Surfaces A: Physicochemical and EngineeringAspects, 2022, 655, 130289
18. [27] Yang L, Han Y, Jiao Z*, Measurementand Correlation of Liquid−Liquid Equilibria of Water (1) + 1‑Methylimidazole (2) + [Bmim][PF6](3) Ternary Systems between303.15 and 323.15 K, Journal of Chemical & Engineering Data, 2021, 66, 2134−2142
19. [26]Han Y, Cheng J, Ruan N, Jiao Z*, Preparation of liposomes composed ofsupercritical carbon dioxide-philic phospholipids using the rapid expansion ofsupercritical solution process, Journal of Drug Delivery Science and Technology,2021, 64, 102568
20. [25] Jiao Z*, Ruan N, Wang W, Guo M, HanS, Cheng J, Supercritical carbon dioxide co-extraction of perilla seeds andperilla leaves: experiments and optimization, Separation Science and Technology,2021, 56(3): 617-630
21. [24] Jiao Z*, Han S, Wang W, Song J, ChengJ, Preparation and optimization of Vitamin E acetate liposomes using a modifiedRESS process combined with response surface methodology, Particulate Scienceand Technology,2020, 38(7):863-875
22. [23]Song J, Jiao Z*, Cheng J, Ruan N., Yang L, Synthesis of Supercritical CarbonDioxide-philic Phospholipids and Determination of their Solubility, PolymerEngineering & Science, 2020, 60: 2333–2346
23. [22]Jiao Z*, Han S, Wang W, Cheng J, Song J, Response surface optimization ofcatechin liposomes preparation using the rapid expansion of supercriticalsolution process, Journal of Nanoscience and Nanotechnology, 2020, 20(12):7583-7592
24. [21] ZhaX, Han S, Wang W, Jiao Z*, Experimental measurement and correlation ofsolubility of ethosuximide in supercritical carbon dioxide, The Journal ofChemical Thermodynamics, 2019, 131: 104–110
25. [20] JiaoZ*, Zha X, Wang Z, Wang X, Fan W, Response surface modeling of drug-loadedmicelles preparation by supercritical carbon dioxide evaporation method usingBox-Behnken experimental design, Journal of Nanoscience and Nanotechnology, 2019,19(6): 3616-3620
26. [19] JiaoZ*, Wang X, Han S, Zha X, Xia J, Preparation of vitamin C liposomes by rapidexpansion of supercritical solution process: Experiments and optimization, Journalof Drug Delivery Science and Technology, 2019, 51, 1-6
27. [18] Wang W, Han S, Zha X, Cheng J, Song J, Jiao Z*, ResponseSurface Optimization of Supercritical Carbon Dioxide Extraction of TeaPolyphenols from Green Tea Scraps, Journal of AOAC International，2019, 102(2), 451-456
28. [17] Jiao Z*, Wang X, Yin Y, Xia J, Preparation andevaluation of vitamin C and folic acid co-loaded antioxidant liposomes,Particulate Science and Technology, 2019, 37(4), 449-455
29. [16] JiaoZ*, Song J, Fan W, Wang X, Wang Z, Synthesis of poly (vinyl acetate) oligomerand their phase behavior in supercritical carbon dioxide, Journal of SoutheastUniversity(English Edition), 2019, 35(2) :264-268
30. [15]Wang W, Han S, Jiao Z*, Cheng J, Song J, Antioxidant activity and totalpolyphenols content of camellia oil extracted by optimized supercritical carbondioxide, Journal of the American Oil Chemists' Society, 2019, 96(11): 1275–1289
31. [14] Jiao Z*, ChengJ, Guo M, Han S, Measurement and Correlation of Paeonol Solubility inSupercritical Carbon Dioxide, Journal ofChemical & Engineering Data, 2019, 64(10): 4424−4429
32. [13] JiaoZ*, Fan W, Wang X, Wang Z, Synthesis of CO2-philic amphiphilic block copolymersby RAFT polymerization and its application on forming drug-loaded micelles usingScCO2 evaporation method, Journal of Drug Delivery Science and Technology, 2018,44:13-18
33. [12]  Jiao Z*, Wang C, Yang Q, Wang X, Preparationand characterization of UV-curable urethane acrylate oligomers modified with cycloaliphaticepoxide resin，Journalof Coatings Technology and Research, 2018, 15(2): 251-258
34. [11] JiaoZ*, Wang Z., Wang X., Fan W., Effects of Processing Parameters on theProperties of Amphiphilic Block Copolymer Micelles Prepared by SupercriticalCarbon Dioxide Evaporation Method, Polish Journal of Chemical Technology, 2018， 20(1): 81-86.
35. [10] JiaoZ*, Wang X, Yin Y, Wang Z, Mei Y, Xia J, Preparation and evaluation of achitosan-coated antioxidant liposome containing vitamin C and folic acid, Journalof Microencapsulation, 2018, 35(3): 272-280.
36. [9]Cheng J, Han S, Song Junying, Wang W, Jiao Z*, Solubility of Vitamin E Acetatein Supercritical Carbon Dioxide with Ethanol as Cosolvent, Journal of Chemical & EngineeringData, 2018, 63(11): 4248–4255
37. [8] WangX, Wang C, Zha X, Mei Y, Xia J, Jiao Z*, Supercritical carbon dioxideextraction of β-carotene and α-tocopherol from pumpkin :A Box-Behnken designfor extraction variables, Analytical Methods, 2017, 9(2): 294-303
38. [7] JiaoZ*, Wang X, Yang Q, Wang C, Modification and characterization of urethaneacrylate oligomers used for UV-curable coatings, Polymer Bulletin, 2017， 74(7), 2497-2511
39. [6] JiaoZ*, Yang Q, Wang X, Wang C, UV-curable hyperbranched urethane acrylateoligomers modified with different fatty acids, Polymer Bulletin, 2017，74(12),5049-5063
40. [4] Han S, Wang W, Jiao Z*; Wei X, Solubility of Vitamin Eacetate in supercritical carbon dioxide: Measurement and Correlation. Journalof Chemical & Engineering Data, 2017, 62(11), 3854–3860
41. [4] Jiao Z*, Sun Y, Yang Q, Wang X, Activitycoefficients at infinite dilution of organic solutes in the ionic liquid ethyl(2-hydroxyethyl)dimethyl-ammoniumdiethylphosphate using gas–liquid chromatography, Fluid Phase Equilibria, 2012,325: 15–19
42. [3] Jiao Z, Liu N, Chen Z*, Selectionsuitable solvents to prepare paclitaxel-loaded micelles by solvent evaporationmethod, Pharmaceutical Development and Technology, 2012, 17(2): 164-169
43. [2] Jiao Z, Wang X, Chen Z*,Folate-conjugated methoxy poly (ethylene glycol)/poly(L-Alanine) amphiphilicblock copolymeric  micelles for targeteddelivery of paclitaxel, Drug Delivery, 2011, 18(7): 478–484.
44. [1] Jiao Z*, Chen Z, Wu Y, Ma S,Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz CrystalMicrobalance, Chinese Journal of Chemical Engineering, 2011,19(2): 227-231
45.  

1. 专利:
2. [16] 焦真，吴婧怡，一种用于二氧化碳光催化还原的光磁耦合反应装置，2024100874466
3. [15] 焦真，王凯麟，顾宁，一种测定微纳气泡溶液中气泡含气量的方法, 2024100938260
4. [14] 焦真，邓壮，崔婧璇，一种磁性微气泡催化剂及其在醇胺耦合氧化反应中的应用，202410614594.9
5. [13] 焦真，韦淑宁，董歌，施晶晶，一种基于共沉淀法制备磁性纳米颗粒的装置和方法，202411145100.3
6. [12] 焦真，张硕，顾宁，张梦楠，陈怡，一种磁性脂质微纳气泡的连续制备装置及方法，202211229704.7
7. [11] 焦真，张梦楠，顾宁，杨芳，孙剑飞，陈怡，一种基于磁热效应诱导界面自组装制备磁性脂质气泡的方法，ZL202110606441.6
8. [10] 焦真， 王倩倩，李乃旭，顾宁，一种基于超临界浸渍制备磁性MOF载药系统的方法，ZL202210458332.9
9. [9] 焦真，王甲妲，顾宁，孙剑飞，陈怡，一种微纳气泡的制备方法，ZL 202010912586.4
10. [8] 焦真，张溢，孙剑飞，周建成，一种利用超临界流体发泡技术制备骨组织工程支架的方法，ZL202010155938.6
11. [7] 焦真，王卫芳，程江瑞，宋俊颖，韩赛，一种改进的超临界抗溶剂法制备聚合物载药颗粒装置，ZL 201810554543.6
12. [6] 焦真，阚道琴，李乃旭，马全红，周建成，一种基于Radziszewski反应法制备的简单咪唑类化合物的分离工艺，ZL 201910348491.1
13. [5] 焦真，宋俊颖，程江瑞，韩赛，王卫芳，查贤君, 一种具有亲超临界二氧化碳性能的合成磷脂及其制备方法, ZL 201810337209.5
14. [4] 焦真，樊文景，王梓屹，王秀东；一种两亲嵌段聚合物及其制备方法；ZL 201510121569.8
15. [3] 焦真，王秀东，王梓屹，查闲君，王晨，殷玉婷；一种从天然物中提取营养素并制剂的系统，ZL 201610072488.8
16. [2] 焦真，王晨晨，杨前前，王献伟；脂环族环氧聚氨酯丙烯酸酯紫外光固化涂料及其制备方法；ZL 201410212211.1
17. [1] 焦真，樊文景，王秀东，王梓屹；天然物中脂性药物的超临界萃取/胶束化一体装置；ZL 201510186337.0