导师风采
严春光
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个人信息

Personal Information

  • 教授
  • 导师类别:硕,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:医学院
  • 所属专业: 基础医学
  • 邮箱 : ycgagcy@163.com
  • 工作电话 : -

个人简介

Personal Profile

受教育经历:

2012/12 - 2013/04,哈佛大学医学院,博士后

2007/08 - 2012/11,北达科他大学医学院/哈佛大学医学院,博士

2004/09 - 2007/06,南京大学,生命科学学院,硕士

1999/09 - 2003/06,南京农业大学,资源与环境科学学院,学士

 

工作经历:

2022/04 - 至今 东南大学,医学院,教授

2021/03 - 至今 东南大学,医学院,副院长

2020/11 - 至今 东南大学,医学院,党委委员

2019/06 - 2021/03东南大学,医学院,行政助理

2013/09 - 2022/04 东南大学,医学院,副研究员


  • 研究方向Research Directions
探讨ARDS和肿瘤发生发展的免疫学机制,从免疫学角度寻找治疗ARDS和肿瘤的靶点
科研项目



研究成果

发表论文:

1. Sun, X.#, Wang, X.#Yan, C.#, Zheng, S.#, Gao, R., Huang, F., Wei, Y., Wen, Z., Chen, Y., Zhou, X., Liu, X., Chen, B., Shen, Y., Cai, Y., Pan, N.*, Wang, L.* Tumor cell-released LC3-positive EVs promote lung metastasis of breast cancer through enhancing premetastatic niche formation. Cancer Sci. 2022; 113(10): 3405-3416. 

2. Wei, Y.#, Wang, X.#, Yan, C.#, Huang, F., Zhang, Y., Liu, X., Wen, Z., Sun, X., Zhang, Y., Chen, Y., Gao, R., Pan, N., Wang, L.* Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis. Cancer Res. 2022; 82:1991-2002.

3. Yan, C.*, Chen, L., Ding, Y., Zhou, Z., Li, B., Deng, C., Yuan, D., Zhang, Q., Wang, X.* The crucial role of PPARγ-Egr-1-pro-inflammatory mediators axis in IgG immune complex-induced acute lung injury. Front Immunol. 2021; 12: 634889.

4. Yan, C.*, Zhang, L., Yang, L., Zhang, Q., Wang, X.* C/EBPγ is a critical negative regulator of LPS-/IgG immune complex-induced acute lung injury through the downregulation of C/EBPβ-/C/EBPδ-dependent C/EBP transcription activation. FASEB J. 2020; 34: 13696-13710.

5. Yan, C.*, Li, B., Liu, X., Deng, C., Cai, R., Shen, Y., Tang, H. Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells. Mol Immunol. 2019; 111:95-105.

6. Yan C.*, Deng C., Liu X., Chen Y., Ye J., Cai R., Shen Y., Tang H. TNF-α induction of IL-6 in alveolar type II epithelial cells: Contributions of JNK/c-Jun/AP-1 element, C/EBPδ/C/EBP binding site and IKK/NF-κB p65/κB site. Mol Immunol. 2018; 101:585-596.

7. Wang X., Song S., Hu Z., Zhang Z., Li Y., Yan C.Li Z., Tang H. Activation of Epac alleviates inflammation and vascular leakage in LPS-induced acute murine lung injury. Biomed Pharmacother. 2017;96:1127-1136.

8. Yan C.*, Shen Y., Sun Q., Yuan D., Tang H., Gao H. 2-Methoxyestradiol protects against IgG immune complex-induced acute lung injury by blocking NF-kappaB and CCAAT/enhancer-binding protein beta activities. Mol Immunol. 2017; 85:89-99. 

9. Yan C.*, Guan F., Shen Y., Tang H., Yuan D., Gao H., Feng X. Bigelovii A protects against lipopolysaccharide-induced acute lung injury by blocking NF-κB and CCAAT/Enhancer-binding protein δ pathways. Mediators Inflamm. 2016; 2016: 9201604.

10. Yan C.*, Wang X., Liu Y., Abdulnour RE., Wu M., Gao H. Protective role of Rho guanosine diphosphate dissociation inhibitor, Ly-GDI, in pulmonary alveolitis. PLoS One 2015; Oct 15;10(10):e0140804.

11. Zhao, F., He, X., Sun, J., Wu, D., Pan, M., Li, M., Wu, S., Zhang, R., Yan, C., Dou, J. Cancer stem cell vaccine expressing ESAT-6-gpi and IL-21 inhibits melanoma growth and metastases. Am J Transl Res. 2015; 7(10):1870-82. 

12. Wu, D., Wang, J., Cai, Y., Ren, M., Zhang, Y., Shi, F., Zhao, F., He, X., Pan, M., Yan, C.Dou, J. Effect of targeted ovarian cancer immunotherapy using ovarian cancer stem cell vaccine. J Ovarian Res. 2015; 24(8):68. 

13. Yan C.Liu Y., Gao H., Wang X. Suppressor of cytokine signaling 3 is essential for FcγR-mediated inflammatory response via enhancing CCAAT/enhancer-binding protein δ transcriptional activity in macrophages. Exp Cell Res. 2015; 337(1):120-7.

14. Yan, C., Ward, PA., Wang, X., Gao H. Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein δ pathway. FASEB J. 2013; 27(8):2967-76. 

15. Yan, C., Johnson, PF., Tang, H., Wu, M., Gao, H. CCAAT/enhancer-binding protein d is a critical mediator of lipopolysaccharide-induced lung injury. Am J Pathol. 2013; 182(2):420-30.

16. Yan, C.Tang H., Gao H., Johnson PF., Ye Y., Wu M. CCAAT/Enhancer-Binding protein δ multifaceted regulator in respiratory disease. Am J Pathol. 2013; 182(4):1459-60. 

17. Yan, C., Wu, M., Cao, J., Tang, H., Zhu, M., Johnson, PF., Gao, H. Critical role for CCAAT/enhancer-binding protein β in immune complex-induced acute lung injury. J. Immunol. 2012; 189(3):1480-90. 

18. Yan, C., Zhu, M., Staiger, J., Johnson, PF., Gao, H. C5a-regulated CCAAT/enhancer-binding Proteins β and δ are essential in Fcγ receptor-mediated inflammatory cytokine and chemokine production in macrophages. J. Biol. Chem. 2012; 287(5):3217-30. 

19. Yan, C., Wang, X., Cao, J., Wu, M., Gao, H. CCAAT/enhancer-binding protein γ is a critical regulator of IL-1β-induced IL-6 production in alveolar epithelial cells. PLoS One 2012; 7(4):e35492. 

20. Yan, C., Gao, H. New insights for C5a and C5a receptors in sepsis. Front Immunol. 2012; 3:368.

21. Yan, C., Cao, J., Wu, M., Zhang, W., Jiang, T., Yoshimura, A., Gao, H.   Suppressor of cytokine signaling 3 inhibits LPS-Induced IL-6 expression by suppressing CCAAT/Enhancer-Binding protein β activity. J. Biol. Chem. 2010; 285(48):37227-39.

22. Tang H., Liu Y., Yan C.Petasis NA., Serhan CN., Gao H. Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl-ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. J. Immunol. 2014; 193(7):3769-78.

23. Li, G., Yuan, K., Yan, C., Fox, J 3rd., Gaid, M., Breitwieser, W., Bansal, AK., Zeng, H., Gao, H., Wu, M. 8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice. Free Radic. Biol. Med. 2012; 52(2):392-401. 


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