教师

  副教授-张伟，成于思，张昕昕

  讲   师-王静

  技术员-罗 薇

在读研究生

  博士生-刘亚萍，谢飞燕，王安澜，吴玲娜，徐可颖，王鹏皓，陈依春

  硕士生-邱晓宇，王子琪，徐安民，刘至宇，严丽娜

毕业研究生

  博   士-蒋荣，黄洁，王莎，陈梦灵，杨礼亮 

  硕   士-杨西月，郭会芳，陈露露，储汉，廖艳，杨富煌，丁嘉伟，印娟，史晓妮，周馨蓓，杨少奇，孙票票，孙玉恒，沙晓娟，张聪，王宇梦，任言晖，尉昕妍

实验室合影

肺部炎症及纤维化的基础与临床研究

   矽肺是由于长期吸入游离二氧化硅（SiO2）粉尘所引起的以肺组织持续慢性炎症、进行性肺纤维化为主，并伴有全身系统性炎症为特征的全身性疾病。矽肺一旦发生，肺损伤呈进行性发展，即使停止粉尘暴露，肺部病变依然进展，导致肺功能障碍，呼吸衰竭，甚至死亡。由于对矽肺的发病机制知之甚少，临床主要面临两个问题：（1）早期缺少筛检诊断方法，当经胸片确诊时，肺损伤已无逆转可能；（2）后期肺纤维化缺乏特效治疗措施，这是由于目前缺少肺纤维化进程评价指标，临床也无明确治疗靶标，因此发现矽肺早期诊断分子标志物以及干预肺纤维化进程的靶标已成为迫切需要解决的问题。

       本课题组着重于研究粉尘吸入引起肺部细胞激活，释放的细胞因子和化学趋化因子，参与炎症反应和肺纤维化的过程及其机制，进而为现有矽肺诊断和治疗提供新的理论依据，对临床治疗策略的选择和治疗药物靶标的遴选提供指导。

◆“矽肺中ECM力学时空动态演进操控效应细胞命运推动不可逆肺纤维化的机制”，国家自然科学基金委-面上项目，82574059，49万元，2026-2029，负责人

◆“肺细胞外基质“劫持”反向跨内皮中性粒细胞参与矽肺不可逆肺纤维化的机制研究”，国家自然科学基金委-面上项目，82373547，49万元，2024-2027，负责人

◆“急性肺损伤与肺外器官的交互机制及多维度治疗策略研究”，科学技术部-国家重点研发计划，2022YFC2504403，150万元，2023-2025，课题骨干

◆“环状RNA介导的失巢凋亡抵抗在矽肺中作用机制研究”，国家自然科学基金委-面上项目，81972987，55万元，2020-2023，负责人

◆“干细胞体内示踪的生物机制”，科学技术部-国家重点研发计划，2017YFA0104303，701万元，2017-2021，课题骨干

◆“ciR-0001544靶向调控ZC3H4在矽肺炎症和纤维化中的作用研究”，国家自然科学基金委-面上项目，81773796，50万元，2018-2021，负责人

◆“治疗矽肺炎性反应及肺纤维化的新靶点-MCPIP1 (ZC3H12A）的作用机制研究”，国家自然科学基金委-面上项目，81473263， 73万元，2015-2018，负责人

◆“矽肺炎症和纤维化治疗新靶点-MCPIP1的作用机制研究”，江苏省科技厅-面上项目，BK20141347，10万元，2014-2017，负责人

◆“p53/PUMA参与矽肺炎症和肺纤维化的作用机制研究”，江苏省卫生厅-江苏省“六大人才”高峰，3万元，2015，负责人

◆“矽肺炎症和纤维化治疗新靶点-MCPIP1 的作用机制研究”，中华人民共和国人力资源和社会保障部-留学人员科技活动项目，3万元，2015年，负责人

◆“肺缺氧致微循环炎症反应的机制研究”（Mechanisms of microvascularinflammation induced by alveolarhypoxia），美国心脏协会（American Heart Association, AH)，52000美元，2008-2010，负责人

2025

116. Chao J, Farkas L. Von Willebrand Factor: An Unhealthy Bond Between Lung Endothelium and Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2025 Jul 30. doi: 10.1165/rcmb.2025-0300ED. (SCI,IF:5.3, Q1) PubMed (Editorial) 

115. Wang J, Chao J#. Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets. Pharmaceuticals (Basel). 2025 May 28; 18(6): 812. (SCI,IF:4.8, Q1) PubMed T-58

114. Sun P, Yang L, Yu K, Wang J, Chao J#. Scaffold Proteins in Fibrotic Diseases of Visceral Organs. Biomolecules. 2025;15(3):420.(SCI,IF:4.8, Q1) T-57

113. Zhu XX, Li H, Zi SF, Tang Y, Liu N, Li KX, Geng SK, Lu HQ, Xie ZK, Xu XY, Wei YT, Wang LX, Liu T, Chao J, Yang Y, Qiu HB, Huang W#, Liu L#. tRF-5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome. Adv Sci (Weinh). 2025 Jun 20:e03014. (SCI, IF:14.1, Q1) PubMed

112. 任言晖，徐可颖，张伟，巢杰#．成纤维细胞来源半乳糖凝集素-3 通过细胞外基质蓄积促进矽肺纤维化[J/OL]．南京医科大学学报(自然科学版).

https://link.cnki.net/urlid/32.1442.R.20250508.1657.004 T-55

111. 王宇梦, 罗薇, 巢杰#. 基质金属蛋白酶3参与小鼠矽肺纤维化的机制研究[J]. 解放军医学杂志,2025,50(04):458-466. T-54

2024

110. Dai X, Cheng Y, Luo W, Wang J, Wang C, Zhang X, Zhang W#, Chao J#. m6A RNA methylation in fibrotic diseases of visceral organs. Small Sci. 2024, 5(2):2400308（Back-inside封面文章）. (ESCI, IF:8.3, Q1) T-53

109. Yang L*, Wei X*, Sun P, Wang J, Zhou X, Zhang X, Luo W, Zhou Y,Zhang W, Fang S#, Chao J#. Deciphering the spatial organization of fibrotic microenvironment in silica particles-induced pulmonary fibrosis. J Hazard Mater. 2024, 478:135540. (SCI,IF:11.3, Q1) PubMed T-52

108. Zi S*,Wu X*, Tang Y*, Liang Y, Liu X, Wang L, Li S, Wu C, Xu J, Liu T, Huang W, XieJ, Liu L, Chao J#. Qiu H#. Endothelialcell-derived extracellular vesicles promote aberrant neutrophil trafficking and subsequent remote lung injury. Adv Sci. 2024, 2400647.  (SCI, IF:14.1, Q1) PubMed WOS:001286563100001 T-51

107. Wang L*, Tang Y*, Tang J, Liu X, Zi S, Li S,Chen H, Liu A, Huang W, Xie J, Liu, L, Chao J#, Qiu H#. Endothelial cell-derived extracellular vesicles expressing surface VCAM1 promote sepsis-related acute lung injury by targeting and reprogramming monocytes. J Extracell Vesicles. 2024; 13:e12423.(SCI, IF:14.5,Q1) PubMed WOS:001185722000001 T-50

106. Zhou X*,Zhang C*, Yang S*, Yang L, Luo W, Zhang W, Zhang X, Chao J#. Macrophage-derived MMP12 promotes pulmonary fibrosis through sustained damage to endothelial cells in silicosis. J Hazard Mater. 2024, 461:132733. (SCI, IF:11.3, Q1) PubMed WOS:001099138000001 T-49

105. 张聪，罗薇，王莎，巢杰#.环状RNAhsa_circUCK2参与调控二氧化硅致肺纤维化进程[J]. 环境与职业医学，2024，41（4）：362-366，374. T-48

104. Zhang S,Huang W, Wu X, Chen H, Wang L, Chao J, Xie J, Qiu H. IBR1, a novel endogenous IFIH1‐binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS. Clin Transl Med. 2024;14(9):e70027(SCI,IF:6.8, Q1) PubMed

103. Hua X, Liang G, Chao J, Wang D. Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans. J Hazard Mater. 2024;472:134598. (SCI, IF:11.3, Q1) PubMed

102. Wu X, Tang Y, Lu X, Liu Y, Liu X, Sun Q, Wang L, Huang W, Liu A, Liu L, Chao J,Zhang X, Qiu H. Endothelialcell-derived extracellular vesicles modulate the therapeutic efficacy of mesenchymal stem cells through IDH2/TET pathway in ARDS. Cell Commun Signal. 2024;22(1):293.(SCI, IF:8.9, Q1) PubMed  WOS:00123340740000

101. Wang Y, Liang G, Chao J, Wang D#. Comparison of intestinal toxicity in enhancing intestinal permeability and incausing ROS production of six PPD quinones in Caenorhabditis elegans. Sci Total Environ. 2024, 927:172306.(SCI,IF:8, Q1) PubMed

100.  Wu Z, Liu X, Huang W, Chen J, Li S, Chao J, Xie J, Liu L, Yang Y, Wu X#, Qiu H#. CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis. Int Immunopharmacol. 2024, 132：111924. (SCI, IF:4.8, Q1) PubMed

99. He W, Chao J, Gu  A, Wang D#. Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics. Sci Total Environ.2024, 922:171220.(SCI,IF:8, Q1) PubMed

2023

98. Zhang X, Shi X, Xie F, Liu Y, Wei X, Cai Y, Chao J#. Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseases. Heliyon. 2023, 9:e19428. (SCI, IF:3.4, Q2) PubMed WOS:001069550200001 T-47 

97. Yang S*, Sun Y*,Long M*, Zhou X*, Yuan M, Yang L, Luo W, Cheng Y, Zhang X, Jiang W#, Chao J#. Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis. Part Fibre Toxicol. 2023, 20(1):29. (SCI, IF7.2, Q1)PubMed WOS:001029441200001 T-46 

96. Chen M*, Wang J*, Yuan M*, Long M, Sun Y, Wang S, Luo W, Zhou Y, Zhang W, Jiang W#, Chao J#. AT2 cell–derived IgA trapped by the extracellular matrix in silica-induced pulmonary fibrosis. Int Immunopharmacol. 2023, 122：110545. (SCI, IF:4.8,Q1) PubMed WOS:001030607200001 T-45 

95. Wang J, Zhang X, Long M, Yuan M, Yin J, Luo W, Wang S, Cai Y, Jiang W#, Chao J#. Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis. Commun Bio. 2023, 6:136. (SCI, IF:5.2, Q1) PubMed WOS:000925802900005 T-44 

94.Li B*, Xi W*,Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J#, Han B#, Yao H#. FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Nat Commun. 2023, 14(1):489. (SCI, IF:14.7, Q1) PubMed WOS:000955780200014 T-43 

93. Chen Z*, Huang J*, Zhang J*, Xu Z, LiQ, Ouyang J, Yan Y, Sun S, Ye H, Wang F, Zhu J, Wang Z, Chao J#, Pu Y#, Gu Z#. A storm in a teacup - A biomimetic lung microphysiological system in conjunction with a deep-learning algorithm tomonitor lung pathological and inflammatory reactions. Biosens Bioelectron. 2023,219:114772.(SCI, IF:10.7, Q1) PubMed WOS:000885971400004 T-42 

92. 王煜州，孙票票，孙玉恒，沙晓娟，巢杰#，王静#. 中性粒细胞与肺纤维化关系的研究进展. 东南大学学报(医学版). 2022; 42(1): 149-153. T-41 

91. Hua X, Feng X, Liang G, Chao J, Wang D#. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpseengulfment in Caenorhabditis elegans. J Hazard Mater. 2023, 454:131495 (SCI, IF:12.2, Q1) PubMed WOS:000991104000001

90. Hua X, Feng X, Liang G, Chao J, Wang D#. Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans. Environ Sci Technol. 2023,57(12):4940-4950. (SCI, IF:10.8, Q1) PubMed WOS:000953458700001

2022

88. Liu Y*, Zhang X*, Wang J*, Yang F*, Luo W, Huang J, Chen M, Wang S, Li C#, Zhang W#, Chao J#. ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10. Resp Res. 2022, 23：204.(SCI, IF:5.8, Q1) PubMed WOS:000840090800001

87. Shi X*, Wang J*, Zhang X*,Yang S, Luo W, Wang S, Huang J, Chen M, Cheng Y#, Chao J#. GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis. Cell Biosci. 2022, 12:123. (SCI, IF:7.5, Q1) PubMed WOS:00083677850000

86. Wang S*, Luo W*, Huang J, Chen M, Ding J, Cheng Y, Zhang W, Fang S, Wang J#, Chao J#.  The combined effects of circRNA methylation promote pulmonary fibrosis. Am J Resp Cell Mol Biol. 2022,66(5):510-523.(SCI, IF:6.4, Q1) PubMed (Highlighted Paper) WOS:000790563500010

85. Yin J*,Wang J*, Zhang X*, Liao Y*, Luo W, Ding J, Huang J, Chen M, Wang W#, Fang S#, Chao J#.  A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation. Cell Biosci. 2022,12:21. (SCI,IF:7.5, Q1) PubMed WOS:000769551500002

84. Ghafoor H, Chu H, Huang J, Chen M, Wang S, Wang J#, Chao J#. ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop. Toxicol Appl Pharmacol. 2022, 435,115856. (SCI,IF:3.8, Q1) PubMed WOS:000789925000001

83. Han B, Xi W, Hong Y, Gu L,Chao Y, Li L, Liu C, Yang L, Chao J#, Yao H#.  Mutual regulation of noncoding RNAs and RNA modifications in psychopathology: Potential therapeutic targets for psychiatricdisorders? Pharmacol Ther. 2022,108254.(SCI, IF:13.5, Q1) PubMed WOS:000843902000002

82. Li S#, Chen Z, Zhang W, WangT, Wang X, Wang C, Chao J#, Liu L#. Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression. Carcinogenesis. 2022, 43(11):1092-1102.(SCI, IF:4.7,Q2) PubMed WOS:000851216300001

81. Hua X, Feng X, Liang G, Chao J,Wang D. Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans. Sci Total Environ. 2022, 861:160591. (SCI, IF:9.8, Q1) PubMed

80. Yu X, Bai Y, Han B, Ju M, Tang T, Shen L, Li M, Yang L, Zhang Z, Hu G, Chao J, Zhang Y#, Yao H#. Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. J Extracell Vesicles. 2022 Jan;11(1):e12185. (SCI,IF:16, Q1) PubMed WOS:000742199800001

79. Wang L, Wen L, Zheng S, Tao F, Chao J, Wang F, Li C. Integrating peroxidase-mimicking NH2-MIL-101(Fe) with molecular imprinting forhigh-performance ratiometric fluorescence sensing of domoic acid. Sensor Actuat B-Chem. 2022, 361:131688.(SCI, IF:8.4, Q1) PubMed WOS:000782121600003

78. Wang L, Wen L, Zhao L, Chao J, Tao F, Wang F, Li C. Development of fluorescence sensor and test paper based on molecularlyimprinted carbon quantum dots for spiked detection of domoic acid in shellfishand lake water. Anal Chim Acta. 2022,1197,338515. (SCI,IF:6.2, Q1) PubMed WOS:000750845200011

77. LiuX, Wang F, Meng Y, Zhao L, Shi W, Wang X, He Z, Chao J, Li C. Electrochemical/visual microfluidic detection with a covalent organic framework supported platinum nanozyme-based device for early diagnosis of pheochromocytoma. Biosens Bioelectron. 2022 Mar 23;207:114208. (SCI, IF:12.6, Q1) PubMedWOS:000788141300001

76. 周馨蓓, 张伟, 巢杰#. 基于单细胞RNA 测序和空间转录组测序分析矽肺中巨噬细胞差异基因及其功能. 环境与职业医学. 2022, 39(12): 1350-1358.

75. 杨少奇, 史晓妮, 成于思, 巢杰#. 基于单细胞转录组测序探索FABP5在矽肺纤维化中II型肺泡上皮细胞的特异性表达. 环境与职业医学. 2022, 39(10):1089-1094.

74. 史晓妮，杨少奇，成于思，巢杰#. PPP2R3A通过调控p53的表达促进矽肺肺纤维化. 中国药科大学学报. 2022. 53(4):491 - 498

2021

73. Dai X, Cheng Y, Wang C, Huang J, Chao J#. Role of Circular RNAs in Visceral Organ Fibrosis. Food Chem Toxicol. 2021.150:112074.(SCI, IF:5.572, Q1) PubMed WOS:000632294100026

72. Jiang R#, Han L, Gao Q, Chao J#. ZC3H4 MediatesSilica-induced EndoMT via ER Stress and Autophagy. Environ Toxicol Pharmacol. 2021, 84:103605. (SCI, IF:5.785, Q2) PubMedWOS:000643672100005

71. 成于思，罗薇，沈灵，巢杰#。疫情背景下医学“生理学”课程思政的探索。科教文汇. 2021,517(1),54-58

70. 罗薇，王莎，李永琪，王静，杨少奇，巢杰#。矽肺早期炎症中环状RNA氮6-腺苷酸甲基化修饰差异。中华劳动卫生职业病杂志. 2021, 39(12), 899-902 MEDLINE:35164417

Before2020

69. Huang J, Huang J, Ning X, Luo W, Chen M, Wang Z, Zhang W, Zhang Z#, Chao J#. CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis. J Mater Chem B. 2020, 8 (8), 1713-1727. (SCI, IF:6.331, Q1) PubMed

68. Huang J, Huang, J, Bao H, Ning X, Yu C, Chen Z, Chao J#, Zhang Z#. CT/MR dual-Modal Imaging tracking of mesenchymalstem cells labeled with Au/GdNC@SiO2 nanotracer in pulmonary fibrosis. ACS Applied Bio Materials. 2020, 3,2489-2498.  ACS

67. Zhang W, Zhu T, Chen L, Luo W, Chao J#. MCP-1 mediates ischemia/reperfusion-induced cardiomyocyte apoptosis via MCPIP1and CaSR. Am J Physiol Heart Circ Physiol. 2020,318(1):H59-H71. (SCI, IF:4.733, Q1) PubMed

66. Chen L, Luo W, Zhang W, Chu H, Wang J, Dai X, Cheng Y, Zhu T#, Chao J#. circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cellsvia ER stress. RNA Biology. 2020, 17(2):240-253.(SCI, IF:4.652, Q1) PubMed  

65. Chu H, Wang W, Luo W, Zhang W, Cheng Y, Huang J, Wang J, Dai X, Fang S, Chao J#. circHECTD1mediates pulmonary fibroblast activation via HECTD1. Ther Adv Chronic Dis. 2019, Vol. 10: 1-18.(SCI, IF:4.257,Q1) PubMed

64. Jiang R, Liao Y, Yang F, Cheng Y, Dai X, Chao J#. SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO2. Exp Cell Res.2019, 383(1):111492. (SCI, IF:3.383, Q2) PubMed

63. Cheng Y, Luo W, Li Z, Cao M,Zhu Z, Han C, Dai X, Zhang W, Wang J, Yao H, Chao J#. CircRNA-012091/PPP1R13B-mediatedlung fibrotic response in silicosis via ER stress andaautophagy. AmJ Resp Cell Mol Biol. 2019, 61(3):380-391.(SCI, IF:5.373, Q1) PubMed

62. Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J#. The emerging roles of anovel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition. Toxicol Lett. 2019; 307:26-40. (SCI, IF:3.569, Q2) PubMed

61. Zhang Y, Huang R, Cheng M,Wang L, Chao J, Li J, Zheng P, Xie P, Zhang Z, Yao H. Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome. 2019; 7(1):116. (SCI, IF:11.607, Q1) PubMed

60. Cheng Y, Chao J, Chen C, Lv L,Han Y, Liu B#. The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role indiabetic nephropathy. J Pharm  Pharmacol.2019, 71(3):338-347. (SCI,IF:2.571, Q2) PubMed

59.Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H. Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis. Toxicol Lett. 2019; 301:53-63. (SCI, IF:3.569, Q2) PubMed

58. Zhao L, Du L, Zhang Y, Chao J, Duan M, Yao H, Shen C, Zhang Y. Role of PUMA in the methamphetamine-induced migration of microglia. Metab Brain Dis. 2019, 34(1):61-69.(SCI, IF:2.726, Q2) PubMed

57. Zhang Y, Du L, Bai Y, Han B,He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, Xie C, Zhang Z,Yao H. CircDYM ameliorates depressive-like behavior by targeting miR-9 toregulate microglial activation via HSP90 ubiquitination.  Mol Psychiatry. 2018 Nov 9. doi: 10.1038/s41380-018-0285-0. (SCI, IF:12.384, Q1) PubMed

56. Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W#, Chao J#. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Cell Death Dis. 2018;9(3):396. (SCI, IF:5.959, Q1)PubMed

55. Yang X*, Wang J*, Zhou Z*,Jiang R, Huang J, Chen L, Cao Z, Chu H, Han B, Cheng Y, Chao J#. Silica-induced initiation of circZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation. FASEB J. 2018, 32(6):3264-3277. (SCI, IF:5.391, Q1) PubMed

54. Zhou Z, Jiang R, Yang X, GuoH, Fang S, Zhang Y, Cheng Y, Wang J, Yao H, Chao J#. circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. Theranostics. 2018; 8:575-592. (SCI, IF:8.063, Q1) PubMed

53.Chao J#, LvY, Chen J, Wang J, Yao H. SiO2-induced release of sVEGFRs from pulmonary macrophages. Respir Physiol Neurobiol. 2018;247:1-8.(SCI, IF:1.582, Q3) PubMed

52. Xie X*, Zhu T*#, Chen L, Ding S, Chu H, Wang J, Yao H, Chao J#. MCPIP1-induced autophagy mediates ischemia/referfusion injury in endothlial cells via HMGB1 and CaSR. Sci Rep. 2018;8(1):1735. (SCI,IF:4.011, Q1) PubMed

51.Zhang Y, Shu G, Bai Y, Chao J, Chen X, Yao H. Effect of methamphetamine on the fasting blood glucose in methamphetamineabusers. Metab Brain Dis. 2018, 33(5):1585-1597. (SCI, IF:2.411, Q2) PubMed

50. Han B, Zhang Y, Zhang Y, BaiY, Chen X, Huang R, Wu F, Leng S, Chao J, Zhang JH, Hu G, Yao H. Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP:implications for cerebral ischemic stroke. Autophagy. 2018;14:1164-1184.(SCI, IF:11.059, Q1) PubMed

49. Han B, Chao J, Yao H. CircularRNA and its mechanisms in disease: From the bench to the clinic.Pharmacol Ther. 2018, 187:31-44. (SCI, IF:9.396, Q1) PubMed

48. Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F, Chao J, Liu P, Hu G, Zhang JH, Yao H.Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity. J Neurosci. 2018; 38:32-50. (SCI, IF:6.074, Q1) PubMed

47. Yang L, Han B, Zhang Y, BaiY, Chao J, HuG, Yao H. Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. Autophagy. 14(3):404-418. (SCI, IF:11.059, Q1) PubMed

46. Cao Z*, Xiao Q*, Dai X*, ZhouZ, Jiang R, Cheng Y, Yang X, Guo H, Wang J, Xi Z, Yao H, Chao J#. circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica. Cell Death Dis. 2017;8:3212. (SCI, IF:5.638, Q1) PubMed

45. Liu H, Cheng Y, Yang J, WangW, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J#, Liao H#: BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. Cell Death Dis. 2017; 8:e2657.(SCI,IF:5.638, Q1) PubMed

44. Chao J, Zhang Y, Du L, Zhou R, Wu X, Shen K, Yao H. Molecular mechanisms underlying the involvement of the sigma-1 receptor in methamphetamine-mediated microglial polarization.Sci Rep. 2017;7(1):11540. (SCI, IF:4.122, Q1)PubMed

43. Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZKindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress and Oxidative Damage. Front Cell Neurosci. 2017; 11:377.(SCI, IF:4.3,Q2) PubMed

42. Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior. Front Behav Neurosci. 2017; 11:203. (SCI,IF:3.138, Q2) PubMed

41. Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y, Chao J, Teng G, Yao H. An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017 26:1981-1987(SCI, IF:1.598, Q4) PubMed  

40. Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G, Chao J, Hu G, Yao H. Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy. 2017,13(10):1722-1741. (SCI, IF:11.1, Q1) PubMed

39. Casillan AJ, Chao J, Wood JG, Gonzalez NC. Acclimatization of the systemic microcirculation to alveolar hypoxia is mediated by iNOS-dependent increased nitric oxide availability. J Appl Physiol. 2017,123(4):974-982. (SCI, IF:3.256, Q2) PubMed  

38. Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X,Yao H. Involvement of PUMA in pericyte migration induced by methamphetamine. Exp Cell Res. 2017;356:28-39. (SCI, IF:3.309, Q2) PubMed

37. Zhu X, Dong J, Xia Z, Zhang A, Chao J, Yao H. Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress. Neurochem Int. 2017;110:25-37.(SCI,IF:3.603, Q2) PubMed  

36. Cheng Y, Chao J, Dai D, Dai Y,Zhu D, Liu B. AQP4-knockout aggravation of isoprenaline-induced myocardial injury is mediated by p66Shc and endoplasmic reticulum stress. Clin Exp Pharmacol Physiol. 2017;44:1106-1115. (SCI, IF:2.092, Q3) PubMed  47.794

35. Liu H, Fang S, Wang W, Cheng Y, Zhang Y, Liao H, Yao H#, Chao J#. Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. Part FibreToxicol. 2016; 13: 55.(SCI, IF:8.577, Q1) PubMed

34.Chao J*#, Wang X*, Zhang Y*, Zhu T, Zhang W, Zhou Z, Yang J, Han B, Cheng Y, Tu X, Yao H#. Role of MCPIP1 in the endothelial-mesenchymal transition induced by silica. Cell Physiol Biochem. 2016; 40:309-325.(SCI, IF:5.104, Q1) PubMed

33. Zhang W, Zhang M, Wang Z, Cheng Y, Liu H, Zhou Z, Han B, Chen B, Yao H#, Chao J#. Neogambogic Acid Prevents Silica-induced Fibrosis via Inhibition of High-mobility groupbox1 and MCP-1-induced protein 1. Toxicol Appl Pharmacol. 2016; 309:129-140. (SCI, IF:3.791, Q1) PubMed

32. Zhu T, Yao Q, Wang W, Yao H, Chao J#. iNOS induced vascular endothelial cell migration and apoptosis via autophagy in ischemia/reperfusion injury. Cell Physiol Biochem. 2016; 38: 1575-1588. (SCI,IF:5.104, Q1) PubMed

31. Wang X, Zhang Y, Zhang W, Liu H, Zhou Z, Dai X, Cheng Y, Fang S, Zhang Y, Yao H, Chao J#: MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica. Toxicol Sci. 151(1):126-38.   (SCI,IF:4.081, Q1) PubMed

30. Liu H, Dai X, Cheng Y, Fang S, Zhang Y, Wang X, Zhang W, Liao H, Yao H, Chao J#: MCPIP1 mediatessilica-induced cell migration in human pulmonary fibroblasts. Am J Physiol-Lung C. 2016; 310(2):L121-L132.(SCI, IF:4.281, Q1) PubMed

29. Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, Zhu X, Huang W, Chao J, Zhou R, Hu G,Yao H. Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse. Sci Rep. 2015; 6:35642.  (SCI,IF:4.259, Q1) PubMed

28. Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, YaoH. Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity. Autophagy. 2016,12(9):1538-59.(SCI, IF:8.593, Q1) PubMed

27. Zhu X, Shen K, Bai Y, Zhang A, Xia Z, Chao J, Yao H. NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy. Free Radic Biol Med. 2016; 94:230-242. (SCI, IF:5.606, Q1) PubMed

26. Zhu X, Dong J, Shen K, Bai Y, Chao J, Yao H. Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis. Brain Res Bull.2016. 121:138-47. (SCI,IF:3.033, Q3)PubMed 

25. Zhang Y, Huang R, Zhang Y, Yi H, Bai Y, Chao J, Yao H. IL-17 induces MIP-1α expression in primary mouse astrocytes via TRPC channel. Inflammopharmacology. 2016, 24(1):33-42.(SCI, IF:2.59, Q3) PubMed55.019

24. Wang W, Liu H, Dai X, Fang S,Wang X, Zhang Y, Yao H, Zhang X#, Chao J#:  p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis.Sci Rep. 2015; 5:16900. (SCI,IF:5.228, Q1)   PubMed

23. ZhuT, Yao Q, Hu X, Chen C, Yao H, Chao J#: The role of MCPIP1 in ischemia/reperfusion injury-induced HUVEC migration and apoptosis. Cell Physiol Biochem. 2015;37:577-591.(SCI,IF:4.652, Q1)   PubMed

22. Liu X, Fang S, Liu H, Wang X, Dai X, Yin Q, Yun T, Wang W, Zhang Y, Liao H, Zhang W, Yao H, Chao J#: Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. Toxicol Appl Pharmacol. 2015; 288:152-160.(SCI, IF:3.847, Q1)Global MedicalDiscoveryPubMed

21.Chao J, Dai X, Pena T, Doyle DA, Guenther TM, Carlson MA: MCPIP1 regulates fibroblast migration in 3-D collagen matrices downstream of MAP kinases and NF-kappa B. J Invest Dermatol. 2015;135:2944-54. (SCI,IF:6.915, Q1) PubMed

20. Bai Y*, Zhu X*, Chao J*, Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H: Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGFR expression: Implications for stroke. PLoS One. 2015;10:e0124362.(SCI,IF:3.057, Q1) PubMed

19. Zhang Y, Lv X, Bai Y, Zhu X,Wu X, Chao J, Duan M, Buch S, Chen L, Yao H: Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulationof its own expression. J Neuroinflammation. 2015;12:29. (SCI, IF:4.667, Q1) PubMed

18. Zhang Y, Zhu T, Zhang X, Chao J, Hu G, Yao H:Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes. J Neuroinflammation. 2015;12:156.(SCI,IF:4.667, Q2) PubMed

17.Zhu X, Dong J, Shen K, Bai Y, Zhang Y, Lv X, Chao J, Yao H: NMDA receptor NR2b subunits contribute to ptz-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015;114:70-78.(SCI, IF:2.572, Q3)  PubMed

16. Yi H, Bai Y, Zhu X, Lin L, Zhao L, Wu X, Buch S, Wang L, Chao J#, Yao H#: IL-17a induces MIP-1alpha expression in primary astrocytes via Src/MAPK/PI3K/NF-kB pathways:Implications for multiple sclerosis. J Neuroimmune Pharmacol.2014;9:629-641. (SCI, IF:4.11, Q2)  PubMed

15. Chao J*,Yang L*, Yao H, Buch S: Platelet-derived growth factor-bb restores HIV Tat-mediated impairment of neurogenesis: Role of GSK-3 beta/beta-catenin. J Neuroimmune Pharmacol. 2014;9:259-268. (SCI,IF:4.11, Q2)  PubMed

14. Chao J, Pena T, Heimann DG, Hansen C, Doyle DA, Yanala UR, Guenther TM, Carlson MA:Expression of green fluorescent protein in human foreskin fibroblasts for usein 2D and 3D culture models. Wound Repair Regen. 2014;22:134-140. (SCI, IF:2.768, Q1) Cover story MDLinxGlobal Medical DiscoveryPubMed

13. Chao J, Yang L, Buch S, Gao L: Angiotensin II increased neuronal stem cellproliferation: Role of AT2R. PLoS One. 2013;8:e63488.(SCI,IF:3.534) PubMed

12. Yang L*, Chao J*, Kook YH, GaoY, Yao H, Buch SJ: Involvement of mir-9/MCPIP1 axis in PDGF-bb-mediated neurogenesis in neuronal progenitor cells. Cell Death Dis.2013;4:e960.(SCI,IF:5.177) PubMed

11. Carlson MA, Smith LM, Cordes CM, Chao J, Eudy JD: Attachment-regulated signaling networks in the fibroblast-populated 3D collagen matrix. Sci Rep. 2013;3:1880.(SCI,IF:5.078)  PubMed

10. Chao J,Gao J, Parbhu KJ, Gao L: Angiotensin type 2 receptors in the intermediolateralcell column of the spinal cord: Negative regulation of sympathetic nerve activity and blood pressure. Int J Cardiol. 2013;168:4046-4055. (SCI, IF:6.175)  PubMed

9. Chao J, Viets Z, Donham P, Wood JG, Gonzalez NC: Dexamethasone blocks the systemic inflammation of alveolar hypoxia at several sites in the inflammatory cascade. Am J Physiol Heart Circ Physiol. 2012;303:H168-177. (SCI, IF:3.629) PubMed

8. Gao J, Chao J, Parbhu KJ, Yu L, Xiao L, Gao F, Gao L: Ontogeny of angiotensin type 2 and type1 receptor expression in mice. J Renin Angiotensin Aldosterone Syst. 2012;13:341-352.(SCI,IF:2.286)  PubMed

7. Chao J, Blanco G, Wood JG, Gonzalez NC: Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia. Am J Physiol Heart Circ Physiol. 2011;301:H2264-2270.(SCI,IF:3.708) PubMed

6. Chao J,Wood JG, Gonzalez NC: Alveolar macrophages initiate the systemic microvascular inflammatory response to alveolar hypoxia. Respir Physiol Neurobiol. 2011;178:439-448. (SCI, IF:2.242) PubMed

5. Gao J, Zhang H, Le KD, Chao J, Gao L:Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens. 2011;24:724-730.(SCI,IF:3.181) PubMed

4. Chao J, Donham P, van Rooijen N, Wood JG, Gonzalez NC: Monocyte chemoattractantprotein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. Am J Respir Cell Mol Biol.2011;45:53-61.(SCI,IF:5.125) PubMed

3. Chao J, Wood JG, Gonzalez NC: Alveolar hypoxia, alveolar macrophages, and systemic inflammation. Respir Res. 2009;10:54. (SCI, IF:3.36) PubMed

2.Chao J, WoodJG, Blanco VG, Gonzalez NC: The systemic inflammation of alveolar hypoxia is initiated by alveolar macrophage-borne mediator(s). Am J Respir Cell Mol Biol. 2009;41:573-582.(SCI, IF:5.125)PubMed

1.Meng X, Chao J, Xiang Y:Identification from diverse mammalian poxviruses of host-range regulatory genes functioning equivalently to vaccinia virus C7l. Virology. 2008;372:372-383.(SCI,IF:3.351) PubMed