教师

  副教授 - 成于思，张昕昕，黄洁

  讲    师 - 王静

  技术员 - 罗薇

  博士后 - 谢天（2025）

在读研究生

  博士生-谢飞燕（2022），刘亚萍（2023），王安澜（2024），徐可颖（2024），吴玲娜（2024），王鹏皓（2025），陈依春（2025）

  硕士生-邱晓宇，王子琪（2023），徐安民，刘至宇（2024），严丽娜（2025）

毕业研究生

  博   士-蒋荣（2019），黄洁（2020），王莎（2023），陈梦灵（2023），杨礼亮（2025）  

  硕   士-杨西月，郭会芳（2018），陈露露，储汉（2019），廖艳，杨富煌（2020），丁嘉伟（2021），刘亚萍，印娟，史晓妮（2022），周馨蓓，杨少奇（2023），孙票票，孙玉恒，沙晓娟，张聪（2024），王宇梦，任言晖，尉昕妍（2025）

实验室合影

肺部炎症及纤维化的基础与临床研究

   矽肺是由于长期吸入游离二氧化硅（SiO2）粉尘所引起的以肺组织持续慢性炎症、进行性肺纤维化为主，并伴有全身系统性炎症为特征的全身性疾病。矽肺一旦发生，肺损伤呈进行性发展，即使停止粉尘暴露，肺部病变依然进展，导致肺功能障碍，呼吸衰竭，甚至死亡。由于对矽肺的发病机制知之甚少，临床主要面临两个问题：（1）早期缺少筛检诊断方法，当经胸片确诊时，肺损伤已无逆转可能；（2）后期肺纤维化缺乏特效治疗措施，这是由于目前缺少肺纤维化进程评价指标，临床也无明确治疗靶标，因此发现矽肺早期诊断分子标志物以及干预肺纤维化进程的靶标已成为迫切需要解决的问题。

       本课题组着重于研究粉尘吸入引起肺部细胞激活，释放的细胞因子和化学趋化因子，参与炎症反应和肺纤维化的过程及其机制，进而为现有矽肺诊断和治疗提供新的理论依据，对临床治疗策略的选择和治疗药物靶标的遴选提供指导。

◆国家自然科学基金委-面上项目，“矽肺中ECM力学时空动态演进操控效应细胞命运推动不可逆肺纤维化的机制”，82574059，49万元，2026-2029，负责人

◆江苏省基础研究计划-重点项目，“肺纤维化机制引导的干细胞体内命运和赋能研究”，BK20253013，500万元，2025/09-2028/08，负责人

◆江苏省科技厅-前沿技术研发计划，“急性肺损伤精准治疗的间充质干细胞定制技术研发”，BF2024054，50万元，2024/07-2027/06，课题骨干

◆国家自然科学基金委-面上项目，“肺细胞外基质“劫持”反向跨内皮中性粒细胞参与矽肺不可逆肺纤维化的机制研究”，82373547，49万元，2024-2027，负责人

◆科学技术部-国家重点研发计划，“急性肺损伤与肺外器官的交互机制及多维度治疗策略研究”，2022YFC2504403，50万元，2023-2025，课题骨干

◆国家自然科学基金委-面上项目，“环状RNA介导的失巢凋亡抵抗在矽肺中作用机制研究”，81972987，55万元，2020-2023，负责人

◆科学技术部-国家重点研发计划，“干细胞体内示踪的生物机制”，2017YFA0104303，701万元，2017-2021，课题骨干

◆国家自然科学基金委-面上项目，“ciR-0001544靶向调控ZC3H4在矽肺炎症和纤维化中的作用研究”，81773796，50万元，2018-2021，负责人

◆国家自然科学基金委-面上项目，“治疗矽肺炎性反应及肺纤维化的新靶点-MCPIP1 (ZC3H12A）的作用机制研究”，81473263， 73万元，2015-2018，负责人

◆江苏省科技厅-面上项目，“矽肺炎症和纤维化治疗新靶点-MCPIP1的作用机制研究”，BK20141347，10万元，2014-2017，负责人

◆江苏省卫生厅-江苏省“六大人才”高峰，“p53/PUMA参与矽肺炎症和肺纤维化的作用机制研究”，3万元，2015，负责人

◆中华人民共和国人力资源和社会保障部-留学人员科技活动项目，“矽肺炎症和纤维化治疗新靶点-MCPIP1 的作用机制研究”，3万元，2015年，负责人

◆美国心脏协会（American Heart Association, AH)，“肺缺氧致微循环炎症反应的机制研究”（Mechanisms of microvascularinflammation induced by alveolarhypoxia），52000美元，2008-2010，负责人

2026

124. Liu X, Huang W, Zhang X, Li S, Wang H, Wu Z, Zi S, Wang L, Liu L, Yang Y, Xie J#, Zheng M#, Chao J#, Qiu H#. Endothelium-Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome. J Extracell Vesicles. 2026 Feb;15(2):e70235. (SCI, IF:14.5, Q1). PubMed T-64

123. Xie F, Sun Y, Wang J, Luo W, Zhang X, Cheng Y, Chao J#. The Extracellular Matrix and the Immune System in Acute Lung Injury: Partners in Damage and Repair. Biomedicines. 2026, 14(1), 57 (SCI, IF:3.9, Q1). PubMed Review T-63

122. 王子琪，成于思，沙晓娟，巢杰#. 巨噬细胞囊泡中补体成分1r诱导矽肺小鼠成纤维细胞活化. 环境与职业医学，2026, 43(1):28-34. T-62

2025

121.  Yang L*, Sun P*, Wang J*, Xu M, Zhu B, Yu K, Rong Y, Mao R, Zi S, Liu C, Huang J, Ma J, Chen H, Luo W, Zhang W, Zhang X, Fang S#, Chao J#. Extracellular matrix anchored neutrophils drive pulmonary fibrosis in mice. Nat Commun. 2025, 16:11655. (SCI, IF:15.7, Q1) PubMed T-61

120. Gao C, Lu X, Jiang Y, Tang Y, Ni Y, Chen H, Wu X, Zhou X, Yang Y, Liu L, Chao J#, Xie J#, Qiu H. Development of a Gene Panel for Immune Status Assessment in Sepsis. Ann Intensive Care. 2025,15:170. (SCI, IF:5.5, Q1) PubMed T-60

119. Wang J, Chao J#.  Alveolar Epithelial Cell Dysfunction in Acute Respiratory Distress Syndrome: Mechanistic Insights and Targeted Interventions.  Biomedicines. 2025, 13:2299. (SCI, IF:3.9, Q1) PubMed Review T-59

118. Chao J, Farkas L. Von Willebrand Factor: An Unhealthy Bond Between Lung Endothelium and Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2025 73(6):825-827. (SCI,IF:5.3, Q1) PubMed Editorial

117. Chen H, Xu A, Qiu H#, Chao J#. Single-Cell Sequencing Redefines Immune Heterogeneity and Communication Networks in ARDS: Toward Precision Therapeutics. Int J Genomics. 2025 Oct 21:2025:9902676. (SCI, IF:1.9, Q3) PubMed Review T-58

116. Wang J, Chao J#. Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets. Pharmaceuticals (Basel). 2025 May 28; 18(6): 812. (SCI,IF:4.8, Q1) PubMed Review WOS:001514957400001 T-57

115. Sun P, Yang L, Yu K, Wang J, Chao J#. Scaffold Proteins in Fibrotic Diseases of Visceral Organs. Biomolecules. 2025;15(3):420.(SCI,IF:4.8, Q1) PubMed Review WOS:001452843200001 T-56

114. 任言晖，徐可颖，张伟，巢杰#．成纤维细胞来源半乳糖凝集素-3 通过细胞外基质蓄积促进矽肺纤维化[J/OL]．南京医科大学学报(自然科学版).   2025, 45(10):1427-1434 T-55

113. 王宇梦, 罗薇, 巢杰#. 基质金属蛋白酶3参与小鼠矽肺纤维化的机制研究[J]. 解放军医学杂志, 2025,50(04):458-466. T-54

112. Zhou Z, Ding J, Han S, Duan Y, Chao J, Huang J#. Enhanced therapeutic efficacy of repeated bone marrow-derived MSC administration in a murine model of pulmonary fibrosis.  Stem Cell Res Ther.  DOI: 10.1186/s13287-025-04859-5. (SCI, IF:7.3, Q1) PubMed

111. Zhu XX, Li H, Zi SF, Tang Y, Liu N, Li KX, Geng SK, Lu HQ, Xie ZK, Xu XY, Wei YT, Wang LX, Liu T, Chao J, Yang Y, Qiu HB, Huang W#, Liu L#. tRF-5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome. Adv Sci (Weinh). 2025 Jun 20:e03014. (SCI, IF:14.1, Q1) PubMed

2024

110. Dai X, Cheng Y, Luo W, Wang J, Wang C, Zhang X, Zhang W#, Chao J#. m6A RNA methylation in fibrotic diseases of visceral organs. Small Sci. 2024, 5(2):2400308 (Back-inside 封面文章). (ESCI, IF:8.3, Q1)  Review  WOS:001359827600001 T-53

109. Yang L*, Wei X*, Sun P, Wang J, Zhou X, Zhang X, Luo W, Zhou Y,Zhang W, Fang S#, Chao J#. Deciphering the spatial organization of fibrotic microenvironment in silica particles-induced pulmonary fibrosis. J Hazard Mater. 2024, 478:135540. (SCI,IF:11.3, Q1) PubMed WOS:001306241100001 T-52

108. Zi S*,Wu X*, Tang Y*, Liang Y, Liu X, Wang L, Li S, Wu C, Xu J, Liu T, Huang W, XieJ, Liu L, Chao J#. Qiu H#. Endothelialcell-derived extracellular vesicles promote aberrant neutrophil trafficking and subsequent remote lung injury. Adv Sci. 2024, 2400647.  (SCI, IF:14.1, Q1) PubMed WOS:001286563100001 T-51

107. Wang L*, Tang Y*, Tang J, Liu X, Zi S, Li S,Chen H, Liu A, Huang W, Xie J, Liu, L, Chao J#, Qiu H#. Endothelial cell-derived extracellular  vesicles expressing surface VCAM1 promote sepsis-related acute lung injury by targeting and reprogramming monocytes. J Extracell Vesicles. 2024; 13:e12423.(SCI, IF:14.5,Q1) PubMed WOS:001185722000001 T-50

106. Zhou X*,Zhang C*, Yang S*, Yang L, Luo W, Zhang W, Zhang X, Chao J#. Macrophage-derived MMP12 promotes pulmonary fibrosis through sustained damage to endothelial cells in silicosis. J Hazard Mater. 2024, 461:132733. (SCI, IF:11.3, Q1) PubMed WOS:001099138000001 T-49

105. 张聪，罗薇，王莎，巢杰#.环状RNAhsa_circUCK2参与调控二氧化硅致肺纤维化进程[J]. 环境与职业医学，2024, 41(4):362-366, 374. T-48

104. Zhang S, Huang W, Wu X, Chen H, Wang L, Chao J, Xie J, Qiu H. IBR1, a novel endogenous IFIH1‐binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS. Clin Transl Med. 2024;14(9):e70027(SCI,IF:6.8, Q1) PubMed

103. Hua X, Liang G, Chao J, Wang D. Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans. J Hazard Mater. 2024;472:134598. (SCI, IF:11.3, Q1) PubMed

102. Wu X, Tang Y, Lu X, Liu Y, Liu X, Sun Q, Wang L, Huang W, Liu A, Liu L, Chao J, Zhang X, Qiu H. Endothelialcell-derived extracellular vesicles modulate the therapeutic efficacy of mesenchymal stem cells through IDH2/TET pathway in ARDS. Cell Commun Signal. 2024;22(1):293.(SCI, IF:8.9, Q1) PubMed  WOS:00123340740000

101. Wang Y, Liang G, Chao J, Wang D#. Comparison of intestinal toxicity in enhancing intestinal permeability and incausing ROS production of six PPD quinones in Caenorhabditis elegans. Sci Total Environ. 2024, 927:172306.(SCI,IF:8, Q1) PubMed

100.  Wu Z, Liu X, Huang W, Chen J, Li S, Chao J, Xie J, Liu L, Yang Y, Wu X#, Qiu H#. CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis. Int Immunopharmacol. 2024, 132：111924. (SCI, IF:4.8, Q1) PubMed

99. He W, Chao J, Gu  A, Wang D#. Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics. Sci Total Environ.2024, 922:171220.(SCI,IF:8, Q1) PubMed

2023

98. Zhang X, Shi X, Xie F, Liu Y, Wei X, Cai Y, Chao J#. Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseases. Heliyon. 2023, 9:e19428. (SCI, IF:3.4, Q2) PubMed Review WOS:001069550200001 T-47 

97. Yang S*, Sun Y*,Long M*, Zhou X*, Yuan M, Yang L, Luo W, Cheng Y, Zhang X, Jiang W#, Chao J#. Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis. Part Fibre Toxicol. 2023, 20(1):29. (SCI, IF7.2, Q1)PubMed WOS:001029441200001 T-46 

96. Chen M*, Wang J*, Yuan M*, Long M, Sun Y, Wang S, Luo W, Zhou Y, Zhang W, Jiang W#, Chao J#. AT2 cell–derived IgA trapped by the extracellular matrix in silica-induced pulmonary fibrosis. Int Immunopharmacol. 2023, 122：110545. (SCI, IF:4.8,Q1) PubMed WOS:001030607200001 T-45 

95. Wang J, Zhang X, Long M, Yuan M, Yin J, Luo W, Wang S, Cai Y, Jiang W#, Chao J#. Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis. Commun Bio. 2023, 6:136. (SCI, IF:5.2, Q1) PubMed WOS:000925802900005 T-44 

94.Li B*, Xi W*,Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J#, Han B#, Yao H#. FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Nat Commun. 2023, 14(1):489. (SCI, IF:14.7, Q1) PubMed WOS:000955780200014 T-43 

93. Chen Z*, Huang J*, Zhang J*, Xu Z, LiQ, Ouyang J, Yan Y, Sun S, Ye H, Wang F, Zhu J, Wang Z, Chao J#, Pu Y#, Gu Z#. A storm in a teacup - A biomimetic lung microphysiological system in conjunction with a deep-learning algorithm tomonitor lung pathological and inflammatory reactions. Biosens Bioelectron. 2023,219:114772.(SCI, IF:10.7, Q1) PubMed WOS:000885971400004 T-42 

92. 王煜州，孙票票，孙玉恒，沙晓娟，巢杰#，王静#. 中性粒细胞与肺纤维化关系的研究进展. 东南大学学报(医学版). 2022; 42(1): 149-153. T-41 

91. Hua X, Feng X, Liang G, Chao J, Wang D#. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpseengulfment in Caenorhabditis elegans. J Hazard Mater. 2023, 454:131495 (SCI, IF:12.2, Q1) PubMed WOS:000991104000001

90. Hua X, Feng X, Liang G, Chao J, Wang D#. Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans. Environ Sci Technol. 2023,57(12):4940-4950. (SCI, IF:10.8, Q1) PubMed WOS:000953458700001

2022

88. Liu Y*, Zhang X*, Wang J*, Yang F*, Luo W, Huang J, Chen M, Wang S, Li C#, Zhang W#, Chao J#. ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10. Resp Res. 2022, 23：204.(SCI, IF:5.8, Q1) PubMed WOS:000840090800001 T-39

87. Shi X*, Wang J*, Zhang X*,Yang S, Luo W, Wang S, Huang J, Chen M, Cheng Y#, Chao J#. GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis. Cell Biosci. 2022, 12:123. (SCI, IF:7.5, Q1) PubMed WOS:00083677850000 T-38

86. Wang S*, Luo W*, Huang J, Chen M, Ding J, Cheng Y, Zhang W, Fang S, Wang J#, Chao J#.  The combined effects of circRNA methylation promote pulmonary fibrosis. Am J Resp Cell Mol Biol. 2022,66(5):510-523.(SCI, IF:6.4, Q1) PubMed (Highlighted Paper) WOS:000790563500010 T-37

85. Yin J*,Wang J*, Zhang X*, Liao Y*, Luo W, Ding J, Huang J, Chen M, Wang W#, Fang S#, Chao J#.  A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation. Cell Biosci. 2022,12:21. (SCI,IF:7.5, Q1) PubMed WOS:000769551500002 T-36

84. Ghafoor H, Chu H, Huang J, Chen M, Wang S, Wang J#, Chao J#. ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop. Toxicol Appl Pharmacol. 2022, 435,115856. (SCI,IF:3.8, Q1) PubMed WOS:000789925000001 T-35

83. Han B, Xi W, Hong Y, Gu L,Chao Y, Li L, Liu C, Yang L, Chao J#, Yao H#.  Mutual regulation of noncoding RNAs and RNA modifications in psychopathology: Potential therapeutic targets for psychiatricdisorders? Pharmacol Ther. 2022,108254.(SCI, IF:13.5, Q1) PubMed Review WOS:000843902000002 T-34

82. Li S#, Chen Z, Zhang W, WangT, Wang X, Wang C, Chao J#, Liu L#. Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression. Carcinogenesis. 2022, 43(11):1092-1102.(SCI, IF:4.7,Q2) PubMed WOS:000851216300001 T-33

81. Hua X, Feng X, Liang G, Chao J,Wang D. Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans. Sci Total Environ. 2022, 861:160591. (SCI, IF:9.8, Q1) PubMed

80. Yu X, Bai Y, Han B, Ju M, Tang T, Shen L, Li M, Yang L, Zhang Z, Hu G, Chao J, Zhang Y#, Yao H#. Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. J Extracell Vesicles. 2022 Jan;11(1):e12185. (SCI,IF:16, Q1) PubMed WOS:000742199800001

79. Wang L, Wen L, Zheng S, Tao F, Chao J, Wang F, Li C. Integrating peroxidase-mimicking NH2-MIL-101(Fe) with molecular imprinting forhigh-performance ratiometric fluorescence sensing of domoic acid. Sensor Actuat B-Chem. 2022, 361:131688.(SCI, IF:8.4, Q1) PubMed WOS:000782121600003

78. Wang L, Wen L, Zhao L, Chao J, Tao F, Wang F, Li C. Development of fluorescence sensor and test paper based on molecularlyimprinted carbon quantum dots for spiked detection of domoic acid in shellfishand lake water. Anal Chim Acta. 2022,1197,338515. (SCI,IF:6.2, Q1) PubMed WOS:000750845200011

77. LiuX, Wang F, Meng Y, Zhao L, Shi W, Wang X, He Z, Chao J, Li C. Electrochemical/visual microfluidic detection with a covalent organic framework supported platinum nanozyme-based device for early diagnosis of pheochromocytoma. Biosens Bioelectron. 2022 Mar 23;207:114208. (SCI, IF:12.6, Q1) PubMedWOS:000788141300001

76. 周馨蓓, 张伟, 巢杰#. 基于单细胞RNA 测序和空间转录组测序分析矽肺中巨噬细胞差异基因及其功能. 环境与职业医学. 2022, 39(12): 1350-1358. T-32

75. 杨少奇, 史晓妮, 成于思, 巢杰#. 基于单细胞转录组测序探索FABP5在矽肺纤维化中II型肺泡上皮细胞的特异性表达. 环境与职业医学. 2022, 39(10):1089-1094. T-31

74. 史晓妮，杨少奇，成于思，巢杰#. PPP2R3A通过调控p53的表达促进矽肺肺纤维化. 中国药科大学学报. 2022. 53(4):491 - 498 T-30

2021

73. Dai X, Cheng Y, Wang C, Huang J, Chao J#. Role of Circular RNAs in Visceral Organ Fibrosis. Food Chem Toxicol. 2021.150:112074.(SCI, IF:5.572, Q1) PubMed Review WOS:000632294100026 T-29

72. Jiang R#, Han L, Gao Q, Chao J#. ZC3H4 MediatesSilica-induced EndoMT via ER Stress and Autophagy. Environ Toxicol Pharmacol. 2021, 84:103605. (SCI, IF:5.785, Q2) PubMedWOS:000643672100005 T-28

71. 成于思，罗薇，沈灵，巢杰#。疫情背景下医学“生理学”课程思政的探索。科教文汇. 2021,517(1),54-58 T-27

70. 罗薇，王莎，李永琪，王静，杨少奇，巢杰#。矽肺早期炎症中环状RNA氮6-腺苷酸甲基化修饰差异。中华劳动卫生职业病杂志. 2021, 39(12), 899-902 MEDLINE:35164417 T-26