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赵春杰,东南大学首席教授,医学院副院长,教育部“发育与疾病相关基因”重点实验室副主任。获国家杰出青年科学基金资助,曾作为首席科学家/首席专家主持科技部重点基础研究计划973项目和863项目。入选“新世纪百千万人才工程”国家级人选、江苏省特聘教授,获得江苏省“333”工程突出贡献奖以及全国“五一”巾帼标兵、江苏省有突出贡献中青年专家、江苏省十行百星科技之星等荣誉称号。
历任江苏省细胞与发育生物学会副理事长、江苏省神经科学学会副理事长、中国神经科学学会儿童认知与脑功能障碍分会委员、神经发育与再生分会委员、神经干细胞与组织工程分会委员等。
长期从事包括自闭症、认知缺陷、情感障碍在内的脑智发育相关疾病的发病机制及干预研究,通过绘制不同类型神经细胞的发育图谱、发现细胞命运决定因子进而阐释大脑发育的转录调控规律;通过基因编辑建立脑发育相关疾病风险基因突变的动物模型,从基因、神经环路、脑以及个体行为层次探究脑发育相关疾病的致病机制,为疾病的早期诊断提供指导并研发干预手段,研究工作发表于Cell、Science Advances、Development、J.Neurosci. Cerebral Cortex等学术刊物。
代表性论文:
1. Ba R#, Yang L#, Zhang B, Jiang P,Ding Z, Zhou X, Yang Z, Zhao C*.FOXG1 drives transcriptomic networks to specify principal neuron subtypesduring the development of the medial pallium. Science Advances. 2023 Feb 15: 9 (7), DOI:10.1126/sciadv.ade2441.
2. Liu J, Yang M, Su M, Liu B, Zhou K, Sun C, Ba R, Yu B,Zhang B, Zhang Z, Fan W, Zhong M, Han J, ZhaoC*. FOXG1 sequentially orchestratessubtype specification of postmitotic cortical projection neurons. Science Advances.2022 May 27;8 (21): eabh3568. doi: 10.1126/sciadv.abh3568.
3. Han X#, Wei Y#, Ba R, Sun L, ZhaoC*. PDK1 regulates the lengthening of G1 phase to balance RGC proliferationand differentiation during cortical neurogenesis. Cerebral Cortex. 2022 Aug., Vol 32(6):3488-3500. doi.org/10.1093/cercor/bhab428.
4. Zhang G, Zhou Z, Guo J, Gu H, Su M, Yu B, Zhou F, Han B,Jia M, Ji M, Tao Y, Zhao C, YangJ*. Histone deacetylase 3 in hippocampus contributes to memory impairment afterchronic constriction injury of sciatic nerve in mice. Pain. 2021 Feb 1;162(2):382-395. doi:10.1097/j.pain.0000000000002056.
5. Ni Y#, Liu B, Wu X, Liu J, Ba R, Zhao C*, FOXG1 Directly SuppressesWnt5a During the Development 3 of the Hippocampus. Neuroscience Bulletin. 2021 Jan 3. doi: 10.1007/s12264-020-00618-z.
6. Han X#, Wei Y#, Wu X, Gao J, YangZ, Zhao C*. PDK1Regulates Transition Period of Apical Progenitors to Basal Progenitors byControlling Asymmetric Cell Division. Cerebral Cortex. 2020, Jan 10; 30 (1):406-420, doi: 10.1093/cercor/bhz146.
7. Du A#, Wu X#, Chen H, Bai QR, HanX, Liu B, Zhang X, Ding Z, Shen Q, ZhaoC*. Foxg1 Directly Represses Dbx1 to Maintain the POA andSubsequently Regulates the Ventral Telencephalic Patterning. Cerebral Cortex. 2019, Dec 17; 29 (12): 4968-4981. doi:10.1093/cercor/bhz037.
8. Chen D, Wang C, Li M, Yuan Y, Chen H*, Zhang W*, Zhao C*. Loss of Foxg1 Impairs the Development ofCortical SST-interneurons Leading to Abnormal Emotional and Social Behaviors. Cerebral Cortex. 2019 Aug 29 (8),3666-3682, doi: 10.1093/cercor/bhz114.
9. Shen W#, Ba R#, Su Y, Ni Y, Chen D,Xie W, Pleasure SJ, Zhao C*. Foxg1regulates the postnatal development of cortical interneurons. Cerebral Cortex. 2019 Apr. 29 (4),1547–1560, doi: 10.1093/cercor/bhy051.
10. Xu M#,Han X#, Liu R, Qi C, Yang Z, Zhao C*, Gao J*. PDK1 Deficit Impairs the Development of the DentateGyrus in Mice. Cerebral Cortex. 2019Mar 29 (3) 1185-1198. doi: 10.1093/cercor/bhy024.
11. Yang Y#, Shen W#,Ni Y, Su Y, Yang Z, Zhao C*. Impaired interneuron development after Foxg1 disruption. Cerebral Cortex.. doi:10.1093/cercor/bhv297. 2017, Jan 27(1)793-808.
12. Wu X, Gu X, Han X, Du A, Jiang Y, Zhang X, Wang Y, Cao G, Zhao C*. A Novel Function for FoxM1 in Interkinetic Nuclear Migration in the DevelopingTelencephalon And Anxiety-related Behavior. J Neurosci.. 2014Jan; 34(4):1510-1522.
13. Tian C, Gong Y, Yang Y, Shen W, Wang K, Liu J, Xu B, ZhaoJ, Zhao C*. Foxg1 Has An essential Role in PostnatalDevelopment of The Dentate gyrus. J Neurosci.. 2012. Feb., 32(9):2931-2949.
14. Zhao C*, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ*. Hippocampal and Visuospatial LearningDefects in Mice with Deletion of Frizzled9, a Gene in the Williams SyndromeDeletion Interval. Development. 2005 Jun; 132(12):2917-2927.
15. Zhao C,Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T,Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N*. Charcot-Marie-Tooth DiseaseType
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