|
发表论文
1. Zhu LJ, Li TY, Luo CX, Jiang N, Chang L, Lin YH, Zhou HH, Chen C, Zhang Y, Lu W, Gao LY, Ma Y, Zhou QG, Hu Q, Hu XL, Zhang J, Wu HY, Zhu DY*. CAPON-nNOS coupling can serve as target for developing new anxiolytics. Nat Med. 2014 Sep;20(9):1050-4.
2. Zhu LJ*, Shi HJ, Chang L, Zhang CC, Si M, Li N, Zhu DY*. nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety. Br J Pharmacol. 2020 Apr 28.
3. Liu MY#, Yin CY#, Zhu LJ#, Zhu XH, Xu C, Luo CX, Chen H*, Zhu DY*, Zhou QG*. Sucrose preference test for measurement of stress-induced anhedonia in mice. Nat Protoc. 2018 Jul;13(7):1686-1698. (co-first author) 4. Zhuang F, Shi X, Qiao S, LiuB, Wang Z, Huo H, Liang F, Shen L, Zhu L, He B, Wang H. Allicin promotesfunctional recovery in ischemic stroke via glutathione peroxidase-1 activationof Src-Akt-Erk. Cell Death Discov. 2023 Sep 6;9(1):335. 5. Liu Y, Lyu Y, Zhu L,Wang H. Role of TRP Channels in Liver-Related Diseases. Int J Mol Sci. 2023 Aug7;24(15):12509. 6. Zhu LJ, Li F, Zhu DY. nNOS andNeurological, Neuropsychiatric Disorders: A 20-Year Story. Neurosci Bull.2023 Sep;39(9):1439-1453. 7. Shi HJ, Zhu LJ*.Discovery of rapid-onset antidepressant by uncoupling nNOS-SERT. ChineseScience Bulletin, Volume 68, Issue 1: 9 - 11 (2023) （通讯作者） 8. Shi HJ, Wang S, Wang XP,Zhang RX, Zhu LJ*. Hippocampus: Molecular, Cellular, and CircuitFeatures in Anxiety. Neurosci Bull. 2023 Jun;39(6):1009-1026. （通讯作者） 9. Zhu LJ*, Ni HY, Chen R, Chang L, Shi HJ, Qiu D, Zhang Z, Wu DL, Jiang ZC, Xin HL, Zhou QG, Zhu DY. Hippocampal nuclear factor kappa B accounts for stress-induced anxiety behaviors via enhancing neuronal nitric oxide synthase (nNOS)-carboxy-terminal PDZ ligand of nNOS-Dexras1 coupling. J Neurochem. 2018 Sep;146(5):598-612.
10. Zhou QG#, Zhu LJ#, Chen C, Wu HY, Luo CX, Chang L, Zhu DY*. Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor. J Neurosci. 2011 May25;31(21):7579-90. (co-first author)
11. Zhu LJ, Xu C, Ren J, Chang L, Zhu XH, Sun N, Meng GL, Liu MY, Zhang J, Li YY, Tang YL, Zhou QG*.Dentate nNOS accounts for stress-induced 5-HT1A receptor deficiency: Implication in anxiety behaviors. CNS Neurosci Ther. 2020 Apr;26(4):453-464.
12. Zhu LJ*, Chang L, Shi HJ, Li N. Systemic administration of ZLc-002 exerts anxiolytic-like effects by dissociation of nNOS from CAPON in adult mice. Biochem Biophys Res Commun. 2020 Mar 5;523(2):299-306.
13. Xu Y#, Fang SJ#, Zhu LJ#, Zhu LQ*, Zhou XZ*. DNA-PKcs-SIN1 complexation mediates low-dose X-ray irradiation (LDI)-induced Akt activation and osteoblast differentiation. Biochem Biophys Res Commun. 2014 Oct 24;453(3):362-7. (co-first author)
14. Zhu LJ#, Liu MY#, Li H#,Liu X, Chen C, Han Z, Wu HY, Jing X, Zhou HH, Suh H, Zhu DY, Zhou QG*. Thedifferent roles of glucocorticoids in the hippocampus and hypothalamus inchronic stress-induced HPA axis hyperactivity. PLoS One. 2014 May15;9(5):e97689.
15. Liu MY#, Zhu LJ#, Zhou QG*. Neuronal nitric oxide synthase is an endogenous negative regulator of glucocorticoid receptor in the hippocampus. Neurol Sci. 2013 Jul;34(7):1167-72. (co-first author)
16. Hu Y, Wu DL, Luo CX, Zhu LJ, Zhang J, Wu HY, Zhu DY. Hippocampal nitric oxide contributes to sex difference in affective behaviors. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14224-9.
17. Zhou QG, Hu Y, Wu DL, Zhu LJ, Chen C, Jin X, Luo CX, Wu HY, Zhang J, Zhu DY. Hippocampal telomerase is involved in the modulation of depressive behaviors. J Neurosci.2011 Aug 24;31(34):12258-69.
18. Zhang J, Huang XY, Ye ML, Luo CX, Wu HY, Hu Y, Zhou QG, Wu DL, Zhu LJ, Zhu DY*. Neuronal nitric oxide synthase alteration accounts for the role of5-HT1A receptor in modulating anxiety-related behaviors. J Neurosci. 2010 Feb 17;30(7):2433-41.
19. Shen X, Sun Y, Wang M, Shu H, Zhu LJ, Yan PY, Zhang JF, Jin X. Chronic N-acetylcysteine treatment alleviates acute lipopolysaccharide-induced working memory deficit through upregulating caveolin-1 and synaptophysin in mice. Psychopharmacology (Berl).2018 Jan;235(1):179-191.
20. Zhang J, Cai CY, Wu HY, Zhu LJ, Luo CX, Zhu DY. CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1areceptors in modulating anxiety behaviors. Sci Rep. 2016 Jul12;6:29551.
发明专利
1. nNOS-CAPON解偶联化合物及其制备方法和应用
2. 一种用于预防或治疗抑郁症的药物及其应用 3.一种小鼠认知功能智能分析实验设备 4. DEXRAS1工具病毒的构建以及检测方法和应用 5. DEXRAS1抑制剂及其应用 |
