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发表论文
1. Zhu LJ, Li TY, Luo CX,Jiang N, Chang L, Lin YH, Zhou HH, Chen C, Zhang Y, Lu W, Gao LY, Ma Y, ZhouQG, Hu Q, Hu XL, Zhang J, Wu HY, Zhu DY*. CAPON-nNOS coupling can serve astarget for developing new anxiolytics. Nat Med. 2014Sep;20(9):1050-4. 2. Shi HJ, Xue YR, Shao H, Wei C,Liu T, He J, Yang YH, Wang HM, Li N, Ren SQ, Chang L, Wang Z, Zhu LJ*.Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor inmodulating depressive behaviours. Brain. 2024 Nov4;147(11):3764-3779. 3. Zhu LJ*, Shi HJ, Chang L,Zhang CC, Si M, Li N, Zhu DY*. nNOS-CAPON blockers produce anxiolytic effectsby promoting synaptogenesis in chronic stress-induced animal models ofanxiety. Br J Pharmacol. 2020 Apr 28. 4. Liu MY#, Yin CY#, Zhu LJ#,Zhu XH, Xu C, Luo CX, Chen H*, Zhu DY*, Zhou QG*. Sucrose preference test formeasurement of stress-induced anhedonia in mice. Nat Protoc. 2018Jul;13(7):1686-1698. (co-first author) 5. Zhuang F, Shi X, Qiao S, LiuB, WangZ, Huo H, Liang F, Shen L, Zhu L, He B, Wang H. Allicinpromotesfunctional recovery in ischemic stroke via glutathione peroxidase-1activationof Src-Akt-Erk. Cell Death Discov. 2023 Sep 6;9(1):335. 6. Zhu LJ, Li F, Zhu DY.nNOS andNeurological, Neuropsychiatric Disorders: A 20-Year Story. Neurosci Bull. 2023 Sep;39(9):1439-1453. 7. Shi HJ, Zhu LJ*.Discoveryof rapid-onset antidepressant by uncoupling nNOS-SERT. Chinese Science Bulletin, Volume 68, Issue 1: 9 - 11 (2023) （通讯作者） 8. Shi HJ, Wang S, Wang XP,ZhangRX, Zhu LJ*. Hippocampus: Molecular, Cellular, and CircuitFeaturesin Anxiety. Neurosci Bull. 2023 Jun;39(6):1009-1026. （通讯作者） 9. ZhuLJ*, Ni HY, Chen R, Chang L, Shi HJ, Qiu D, Zhang Z, Wu DL, Jiang ZC, XinHL, Zhou QG, Zhu DY. Hippocampal nuclear factor kappa B accounts forstress-induced anxiety behaviors via enhancing neuronal nitric oxide synthase(nNOS)-carboxy-terminal PDZ ligand of nNOS-Dexras1 coupling. JNeurochem. 2018 Sep;146(5):598-612.
10. Zhou QG#, Zhu LJ#, Chen C, Wu HY, Luo CX, Chang L, Zhu DY*.Hippocampal neuronal nitric oxide synthase mediates the stress-relateddepressive behaviors of glucocorticoids by downregulating glucocorticoidreceptor. J Neurosci. 2011 May25;31(21):7579-90. (co-firstauthor)
11. Zhu LJ, Xu C, Ren J, Chang L, Zhu XH, Sun N, Meng GL, Liu MY,Zhang J, Li YY, Tang YL, Zhou QG*.Dentate nNOS accounts for stress-induced 5-HT1A receptordeficiency: Implication in anxiety behaviors. CNS Neurosci Ther.2020 Apr;26(4):453-464.
12. Zhu LJ*, Chang L, Shi HJ, Li N. Systemic administration ofZLc-002 exerts anxiolytic-like effects by dissociation of nNOS from CAPON inadult mice. Biochem Biophys Res Commun. 2020 Mar 5;523(2):299-306.
13. Zhu LJ#, Liu MY#, Li H#,Liu X, Chen C, Han Z, Wu HY, Jing X,Zhou HH, Suh H, Zhu DY, Zhou QG*. Thedifferent roles of glucocorticoids in thehippocampus and hypothalamus inchronic stress-induced HPA axis hyperactivity.PLoS One. 2014 May15;9(5):e97689.
14. Hu Y, Wu DL, Luo CX, Zhu LJ, Zhang J, Wu HY, Zhu DY.Hippocampal nitric oxide contributes to sex difference in affectivebehaviors. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14224-9.
15. Zhou QG, Hu Y, Wu DL, Zhu LJ, Chen C, Jin X, Luo CX, Wu HY,Zhang J, Zhu DY. Hippocampal telomerase is involved in the modulation ofdepressive behaviors. J Neurosci.2011 Aug 24;31(34):12258-69. 发明专利
1. nNOS-CAPON解偶联化合物及其制备方法和应用
2. 一种用于预防或治疗抑郁症的药物及其应用 3.一种小鼠认知功能智能分析实验设备 4. DEXRAS1工具病毒的构建以及检测方法和应用 5. DEXRAS1抑制剂及其应用 |
