1. 国家自然科学基金重点国际合作研究项目，PSC介导胰腺内外分泌对话的机制研究及靶向干预策略，2024-2028，主持。

2. 国家工信部5G+健康医疗项目，基于5G的远程康复与中医诊疗智能平台，2022-2025，主持。

3. 国家重点研发计划，干细胞研究与器官修复项目子课题，基于特定脑区类器官移植及评价体系研究-基于人源性干细胞移植的重大脑疾病神经环路重建研究，2021-2026，主持。

4. 国家自然科学基金面上项目，重塑纤维化失衡基质在调控胰腺外分泌糖尿病发生中的机制研究，2022-2025，主持。

5. 国家自然科学基金面上项目， Reg1 在 3c 型糖尿病中促进胰岛 β 细胞再生的机制研究，2020-2023，主持。

6. 国家自然科学基金面上项目，胰腺星状细胞 PSC 在慢性胰腺炎后 T3cDM 发生发展中的作用机制研究，2016-2019，主持。

7. 国家自然科学基金面上项目，胰腺应激蛋白 PSP/reg 抑制 T2DM 胰岛纤维化和胰腺癌发生的细胞分子机制，2013-2016，主持。

8. 国家自然科学基金青年基金项目，胰腺分泌应激蛋白 PSP/reg 逆转胰腺纤维化的实验研究，2010-2012，主持。

9. 江苏省重点研发计划社会发展项目，人工仿生胰岛关键技术研究及临床转化应用，2022-2026，主持。

10. 江苏省卫健委重点项目，构建胰腺纤维化靶向的脂质纳米颗粒RM-PLNPs 防治 3c 型糖尿病的研究，2022-2024，主持。

11. 江苏省重点研发计划面上项目，2型糖尿病预警标志物—胰岛再生蛋白 reg 应用研究，2018-2021，主持。

代表性期刊论文：

1. Huan Z, Li J, Guo J, Yu Y*, Li L*(Co-Corresponding Author). Pancreatic islet cells in microfluidic-spun hydrogel microfibers for the treatment of diabetes. Acta Biomater. 2024 Oct 1;187:149-160. (IF=9.4)

2. Li JB, Fang YL, Wu ZH, Shang LR*, Li L*(Co-Corresponding Author). Biomimetic artificial islet model with vascularized microcapsule structures for durable glycemic control. Materials Futures, 2024, accepted. (IF=12.0)

3. Wang H#, Liang Qi#, Han Han#, Xuena Li, Mengmeng Han, Lei Xing, Ling Li*(Co-Corresponding Author), Hulin Jiang*. Nanomedicine regulating PSC-mediated intercellular crosstalk: mechanisms and therapeutic strategies. Acta Pharm Sin B, 2024, accepted. (IF=14.7)

4. Huan ZK, Li JB, Luo ZQ, Yu YY*, Li L*(Co-Corresponding Author). Hydrogel-encapsulated pancreatic islet cells as a promising strategy for diabetic cell therapy. Research, 2024;7:0403.(IF=8.5)

5. Qi L, Duan B, Wang H, Liu Y, Han H, Han M, Xing L, Jiang H*, Pandol SJ*, Li L*(Co-Corresponding Author). Reactive Oxygen Species-Responsive Nanoparticles towards Extracellular Matrix Normalization for Pancreatic Fibrosis Regression. Adv Sci, 2024; e2401254. (IF=15.1)

6. Wang Y#, Yi H#, Sun W#, Yu H, Tao W, Yu X, Jia D, Liu Y, Pandol SJ, Li L*(Corresponding Author). Comparative Efficacy of Drug Interventions on NAFLD Over 24 Weeks: A Traditional and Network Meta-Analysis of Randomized Controlled Trials. Drugs. 2024;84(4):425-439. (IF=13.0)

7. Fan L, Zhang X, Wang L, Song Y, Yi K, Wang X, Zhang H*, Li L*(Co-corresponding Author), Zhao Y. Bio-Inspired Porous Microneedles Dwelled Stem Cells for Diabetic Wound Treatment. Adv Funct Mater. 2024; 2316742. (IF=19)

8. Wang J, Zhu H, Gan J, Liang G*, Li L*(Co-corresponding Author), Zhao Y*. Engineered mRNA Delivery Systems for Biomedical Applications. Adv Mater. 2023:e2308029. (IF=29.4)

9. Sun J, Li JB, Huan ZK, Pandol SJ, Liu DC*, Shang LR*, Li L*(Co-corresponding Author). Mesenchymal stem cell-laden composite β cell porous microgel for diabetes treatment. Adv Funct Mater. 2023; 2211897. (IF=19)

10. Li JB, Zhang H, Sun L, Fan L, Fu X, Liu X, Liu DC, Wei Q*, Zhao YJ*, Pandol SJ*, Li L* (Co-corresponding Author). Porous Microcarriers with Pancreatic β Cell Aggregates Loading for Diabetic Care. Chemical Engineering Journal 2022; 436:135174.

11. Liu Y, Yang Y, Xu C, Liu J, Chen J, Li G, Huang B, Pan Y, Zhang Y, Wei Q, Pandol SJ, Zhang F*, Li L*(Co-corresponding Author), Jin L*. Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity. Nat Commun. 2023;14(1):351. (IF=16.6)

12. Han H, Xing L, Chen BT, Liu Y, Zhou TJ, Wang Y, Zhang LF, Li L*(Co-corresponding Author), Cho CS, Jiang HL. Progress on the pathological tissue microenvironment barrier-modulated nanomedicine. Adv Drug Deliv Rev. 2023; 200:115051.(IF=16.1)

13. Qi L, Han H, Han MM, Sun Y, Xing L, Jiang HL*, Pandol SJ*, Li L*(Co-corresponding Author). Remodeling of imbalanced extracellular matrix homeostasis for reversal of pancreatic fibrosis. Biomaterials. 2023;292:121945. (IF=14.0)

14. Liu XY, Yu YR, Liu DC, Li JB, Sun J, Wei Q*, Zhao YJ*, Pandol SJ*, Li L* (Co-corresponding Author). Porous Microcapsules with β cell Encapsulation from Microfluidic Electrospray for Diabetes Treatment. NPG Asia Materials 2022; 14, 39.

15. Zhang LF, Wang XH, Zhang CL, Lee J, Duan BW, Xing L, Li L*(Co-corresponding Author), Oh YK*, Jiang HL*. Sequential Nano-Penetrators of Capillarized Liver Sinusoids and Extracellular Matrix Barriers for Liver Fibrosis Therapy. ACS Nano. 2022;16(9):14029-14042. (IF=17.1)

16. Zhang F#, Yang Y#, Chen X, Liu Y, Hu Q, Huang B, Liu Y, Pan Y, Zhang Y, Liu D, Liang R, Li G, Wei Q*, Li L*(Co-corresponding Author), Jin L*. The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice. Nat Commun. 2021;12(1):3997. (IF=16.6)

17. Xing L#, Yang CX#, Zhao D#, Shen LJ, Zhou TJ, Bi YY, Huang ZJ, Wei Q, Li L* (Co-corresponding Author), Li F*, Jiang HL*. A carrier-free anti-inflammatory platinum (II) self-delivered nanoprodrug for enhanced breast cancer therapy. J Control Release. 2021; 331: 460-471. (IF=10.8)

18. Fan L, Zhang X, Liu X, Sun B*, Li L*(Co-corresponding Author), Zhao Y*. Responsive hydrogel microcarriers integrated microneedles for versatile and controllable drug delivery. Adv Healthc Mater. 2021;e2002249. (IF=10.0). 

19. Zhao X, Bian F, Sun L, Cai L, Li L*(Co-corresponding Author), Zhao Y*. Microfluidic generation of nanomaterials for biomedical applications. Small. 2020; 16: e1901943. (IF=13.3)

20. Ma X#, Zhao Z#, Wang H, Liu Y, Xu Y, Zhang J, Chen B*, Li L*(Co-corresponding Author), Zhao Y*. P-glycoprotein antibody decorated porous hydrogel particles for capture and release of drug-resistant tumor cells. Adv Healthc Mater. 2019;8: e1900136. (IF=10.0)

21. Wu C, Qiu S, Zhu X, Li L*(Corresponding Author). Vitamin D supplementation and glycemic control in type 2 diabetes patients: a systematic review and meta-analysis. Metabolism 2017; 73: 67-76.1. (IF=10.8)