申请者所在的东南大学“发育与疾病相关基因”实验室为教育部重点实验室，实验平台完善，实验设备齐全（包括数台荧光共聚焦显微镜、光遗传设备等、冰冻切片机、光纤记录系统、电生理膜片钳系统，SPF级实验动物中心和动物特殊行为分析环境等）。实验室与南京脑观象台（程和平院士工作站）有合作基础，已有一套FHIRM-TPM 微型双光子显微镜常驻申请者所在实验室。申请人所依托的课题组配备有完善的活体定位注射实验操作台、各种行为学检测系统和常见分子生物学实验如免疫荧光染色等所需的仪器设备。此外，申请人长期从事动物本能行为的神经环路机制研究，具有扎实神经生物学研究背景和经验。

2023年中国神经科学年会大合影

2024年中国神经科学年会大合影

研究方向：核心生存行为的神经环路解析

核心理念：在生存这盘精密的棋局中，大脑是当之无愧的棋手。它指挥着每一次觅食、每一次躲避、每一次社交，并时刻管理着身体这部复杂机器的内部运转。我们实验室的愿景，就是解析驱动这些核心行为的神经环路基础，致力于揭示这些环路是如何编码动机、整合信息、并最终生成精确行为指令。

方向一：饮食与捕食的神经环路

    是什么样的神经指令，能将无形的饥饿感，转化为一场目标明确的觅食或捕猎？我们聚焦于大脑的“能量管理”系统，解析它如何启动并维持动物最原始的生存驱动力，揭示从动机到行动的完整神经环路。

方向二：应激与防御的神经环路

    当危险降临，大脑如何在瞬息之间做出“战、逃或僵”的生死抉择？我们聚焦于大脑的“威胁应对”系统，解析它如何像一个高度灵敏的雷达，快速识别危险信号，并启动一套能凌驾于其他需求之上的、高优先级的防御程序。

方向三：社交行为的神经环路

    从结盟到竞争，从吸引到排斥，大脑如何驾驭复杂的社会关系？我们聚焦于大脑的“社交行为”系统，解析它如何解码微妙的社会信号，并灵活地执行不同的社交策略，从而在群体中谋求生存与繁荣。

方向四：内脏生理活动的神经环路

   大脑并非孤立的指挥官，它时刻与身体内部的广阔世界进行着一场精密而古老的对话。我们探索连接大脑与内脏器官的“脑-体轴”，解析大脑如何调控这些维持生命的后台程序，以及来自器官的“内部感觉”又是如何反向塑造我们的行为。

方法：结合转基因鼠及特色行为范式，整合运用前沿的神经科学工具：包括病毒介导的环路示踪、在体光纤记录和光/化学遗传学操控等等，系统地绘制、监测和验证某些关键神经环路的功能。

目标：旨在解析“大脑生存环路功能图谱”，挖掘复杂的精神与躯体疾病（如进食障碍、焦虑症、社交障碍、肠易激综合征）其背后特定的“环路故障”，确定这些故障节点，为相关疾病的诊断与治疗，提供新的干预策略。

在研项目：

1.  东南大学“医科攀升计划”专项：    社交行为的神经环路基础 （2023--）

2.  江苏自然科学基金（青年项目）： 强迫症的神经环路及分子机制（2022-2025） 

3.  国家自然科学基金（青年项目）:   自闭症的神经环路机制（2023-2025）

4.  江苏省“双创博士” 计划

曾参与科研项目：

1.  RGC Research Grant General Research Fund. PI: Ya Ke; From 2018.09 to 2021.08 (HK$ 971721.00)

Completing the neuralcircuit map of olfactory associative memory: the critical role of dopamine D2receptor.

2.  Health and Medical Research Fund. PI: Ya Ke; From 2019.05 to 2022.04 (HK$ 1499840.00)

Targeting the enzymeKDM5C in the treatment of Alzheimer’s disease. 2019-2022

3.  UGC – Area of Excellence Scheme. PI: Wing-Ho Yung; From 2017.06 to 2025.05 (HK$ 77516000.00).

CellularMechanisms of Synaptic Functions and Plasticity in Health and NeurodegenerativeDiseases.

4.  RGC Research Grant General Research Fund. PI: Ya Ke; From 2017.01 to 2019.12 (HK$ 830497.00)

Novel therapeuticalfunction of the small molecular GSK-J4 in treating Parkinson’s disease targetingiron suppression.

5.  RGC Research Grant General Research Fund. PI: Ya Ke; From 2016.01 to 2019.03 (HK$ 1320676.00)

Involvement oftransferrin receptor 2 mediated mitochondrial iron accumulation in thepathogenesis of Parkinson’s disease.

6.  微量元素稳态代谢. PI:王福俤; 国家杰出青年科学基金2013.01-2016.12

7.  参与编译完成科学出版社两本专著《铁与人类健康》、《锌与人类健康》

科研文章发表情况

19.  Zixu Zhang#, Shengru Hu#, Shuyan Geng#, Tianxiang Xu, Xing Liu, Zixuan Lei, Chuanyao Sun, Haoyu Sun, Wei Xie, Mingdao Mu*#. A Multiscale Atlas of Oprm1-Expressing Neurons in the Central Nervous System: Brain-Wide Distribution, Circuit Function, and Translational Therapeutic Implications. Neurochemistry International, 2025

18. ShuyanGeng, Zixu Zhang, Xing Liu, Haoyu Sun, Tianxiang Xu, Chuanyao Sun, Shengru Hu,Zhiyuan Yang*, Wei Xie*, Mingdao Mu*. Intermittent socialisolation enhances social investigation but impairs social memory in adult malemice. Physiology & Behavior, 2025.

17.  RomeoChen Wei Goh#, Mingdao Mu#, Wingho Yung, Ya Ke. The midlinethalamic nucleus reuniens promotes compulsive-like grooming in rodents. Translational  Psychiatry, 2025.

16.  JunzhouChen#, Mingdao Mu#, Xin Lai, Chen Liu, Yuheng Luo, Jun He, BingYu, Quyuan Wang, Huifen Wang, Daiwen Chen, Aimin Wu. Theaflavins attenuate ironoverload-induced liver oxidative injury by inhibiting hepatocyte ferroptosis. InternationalJournal of Biological Sciences, 2025.

15.  MingdaoMu#*,Haoyu Sun#, Shuyan Geng, Tianxiang Xu, Chuanyao Sun, Zixu Zhang, Sibie Meng,Moyi Li, An Liu, Zhiyuan Yang*, Wei Xie*. Neurexin-3 in the paraventricularnucleus of the hypothalamus regulates body weight and glucose homeostasisindependently of food intake. Molecular Brain, 2024.

14.  Dandan Lv, An Liu, Ziyue Yi, Mingdao Mu, Miao Wu, Xingcan Li, Kun Cao, Ruining Liu, Zhengping Jia, Junhai Han, Wei Xie.Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons. Advanced Science，2024

13.  Ming-Dao Mu, Hong-Yan Geng, Kang-Lin Rong, Rong-Chao Peng, Shu-Ting Wang, Lin-TingGeng, Zhong-Ming Qian, Wing-Ho Yung, Ya Ke. A limbic grooming circuit foremotional stress response. Nature Communications, 2020. 亮点文章

12.  Ming-Dao Mu, Zhong-Ming Qian, Sheng-Xi Yang, Kang-Lin Rong, Wing-Ho Yung, Ya Ke. Therapeutic Effect of aHistone Demethylase Inhibitor in Parkinson's Disease. Cell Death & Disease, 2020

11.  Tuo Liang, Zhongming Qian, Mingdao Mu, Wingho Yung, Ya Ke. Brainhepcidin suppresses major pathologies in experimental Parkinsonism. iScience, 2020

10.  Ming-Dao Mu, Peng An, Qian Wu, Xiaoyun Shen, Dandan Shao, HaoWang, Yingqi Zhang, Shenshen Zhang, Hui Yao, Junxia Min, Fudi Wang. The dietary flavonoid myricetin regulatesiron homeostasis by suppressing hepcidin expression. The Journal of Nutritional Biochemistry, 2016

9.  Ming-Dao Mu, Aimin Wu, PengAn, Xiaoli Du, Qian Wu, Xiaoyun Shen, Fudi Wang. Black soybean seed coatextract regulates iron metabolism by inhibiting the expression of hepcidin. British Journal of Nutrition, 2014 亮点文章

Commented by: McClung JP.Nutrition is medicine: dietary inhibition of hepcidin expression. British Journal of Nutrition, 2014.

8.  Zhiyuan Yang, Jinpao Hou, Mingdao Mu, Shang Ying Wu. Subtractive proteomics and systems biology analysis revealed novel drugtargets in Mycoplasma genitalium strain G37. Microbial Pathogenesis, 2020 

7.  Meng-Wan Zhang, Guang Yang, Yu-Fu Zhou, Christopher Qian, Mingdao Mu, Ya Ke, Zhong-Ming Qian. Regulatingferroportin-1 and transferrin receptor-1 expression: A novel function ofhydrogen sulfide. Journal of Cellular Physiology, 2019 

6.  Yu Fu Zhou, Xiao Mei Wu, Gan Zhou, Mingdao Mu, Fa Li Zhang, Fe Mi Li, Christopher Qian, Fang Du, Wing Ho Yung, ZhongMing Qian, Ya Ke Cystathionine β-synthase is required for body ironhomeostasis. Hepatology, 2018 

5.  Qianqian Luo, Gan Zhou, Suna Huang, Mingdao Mu, Yunjin Chen, Zhongming Qian. Ghrelin isNegatively Correlated with Iron in the Serum in Human and Mice. Ann Nutr Metab, 2018

4.  Yingqi Zhang, Xudong Wang, Qian Wu, Hao Wang, Lu Zhao, Xinhui Wang, Mingdao Mu, Enjun Xie, Xuyan He, Dandan Shao, Yanna Shang, Yongrong Lai, YelenaGinzburg, Junxia Min, Fudi Wang. Adenine alleviates iron overload by cAMP/PKA mediatedhepcidin upregulation in mice. Journal of Cellular Physiology, 2018

3.  Zhen Liu, YuYu, Xiaohong Li, Aimin Wu, Mingdao Mu, Nana Li, Ying Deng, XiJin, Shengli Li, Yuan Lin, Xinlin Chen, Fudi Wang, Jun Zhu. Maternal leadexposure and risk of congenital heart defects occurrence in offspring. Reproductive Toxicology, 2014

2.  Xin Guo, Daizhan Zhou, Peng An, Qian Wu, Hao Wang, Aimin Wu, Mingdao Mu, Di Zhang, Zhou Zhang,Hui Wang, Lin He, Yun Liu, Fudi Wang. Associations between serum hepcidin, ferritin,hemoglobin, and type 2 diabetes risks in a Chinese Han population. British Journal of Nutrition, 2013 

1.   Peng An, Qian Wu, Hao Wang, Yu Guan, Mingdao Mu, Yijun Liao, Daizhan Zhou, Pengkun Song, Chunrong Wang, Liping Meng,Qingqing Man, Lixiang Li, Jian Zhang, Fudi Wang. TMPRSS6, but not TF, TFR2, orBMP2 Variants are Associated with Increased Risk of Iron Deficiency Anemia. Human Molecular Genetics, 2012 

专利申请

5.  穆明道,周玉付,陈耀富;番茄红素在制备排铅产品中的用途; 专利公开号 CN103462014B（授权）

4.  王福俤,穆明道,伍爱民；杨梅素在制备抑制铁调素表达的制剂中的应用; 专利公开号CN103655542B （授权）

3.  周玉付,陈耀富,穆明道;一种具有增加骨密度功能的组合物及其制备方法和用途;专利公开号CN103083650B （授权）

2.  穆明道,陈耀富,周玉付,马福全,张彦杰; 一种具有促进排铅功能的组合物及其用途; 专利公开号CN103463390A

1.  王福俤,穆明道,伍爱民等; 黑豆及其提取物在制备抑制铁调素表达的制剂中的应用; 专利公开号CN103405493 A