申请者所在的东南大学“发育与疾病相关基因”实验室为教育部重点实验室，实验平台完善，实验设备齐全（包括数台荧光共聚焦显微镜、光遗传设备等、冰冻切片机、光纤记录系统、电生理膜片钳系统，SPF级实验动物中心和动物特殊行为分析环境等）。实验室与南京脑观象台（程和平院士工作站）有合作基础，已有一套FHIRM-TPM 微型双光子显微镜常驻申请者所在实验室。申请人所依托的课题组配备有完善的活体定位注射实验操作台、各种行为学检测系统和常见分子生物学实验如免疫荧光染色等所需的仪器设备。此外，申请人长期从事动物本能行为的神经环路机制研究，具有扎实神经生物学研究背景和经验。

2023年中国神经科学年会大合影

2024年中国神经科学年会大合影

本能行为及相关疾病的神经机制研究

1. 调控本能社交行为的神经机制解析（社交行为）

1.1 丘脑神经元特异性编码及调控主动社交（同性社交）

1.2  繁衍相关社交行为的神经机制（异性社交、亲本/亲子社交）

2. 调控重复刻板行为的神经机制解析（情绪相关本能行为）

 2.1 情绪压力相关重复刻板行为的神经环路机制

2.2  强迫症样相关重复刻板行为的神经环路机制

3. 调控饮食代谢的神经机制解析（饮食行为）

在研项目：

1.  东南大学“医科攀升计划”专项：    社交行为的神经环路基础 （2023--）

2.  江苏自然科学基金（青年项目）： 强迫症的神经环路及分子机制（2022-2025） 

3.  国家自然科学基金（青年项目）:   自闭症的神经环路机制（2023-2025）

4.  江苏省“双创博士” 计划

曾参与科研项目：

1.  RGC Research Grant General Research Fund. PI: Ya Ke; From 2018.09 to 2021.08 (HK$ 971721.00)

Completing the neuralcircuit map of olfactory associative memory: the critical role of dopamine D2receptor.

2.  Health and Medical Research Fund. PI: Ya Ke; From 2019.05 to 2022.04 (HK$ 1499840.00)

Targeting the enzymeKDM5C in the treatment of Alzheimer’s disease. 2019-2022

3.  UGC – Area of Excellence Scheme. PI: Wing-Ho Yung; From 2017.06 to 2025.05 (HK$ 77516000.00).

CellularMechanisms of Synaptic Functions and Plasticity in Health and NeurodegenerativeDiseases.

4.  RGC Research Grant General Research Fund. PI: Ya Ke; From 2017.01 to 2019.12 (HK$ 830497.00)

Novel therapeuticalfunction of the small molecular GSK-J4 in treating Parkinson’s disease targetingiron suppression.

5.  RGC Research Grant General Research Fund. PI: Ya Ke; From 2016.01 to 2019.03 (HK$ 1320676.00)

Involvement oftransferrin receptor 2 mediated mitochondrial iron accumulation in thepathogenesis of Parkinson’s disease.

6.  微量元素稳态代谢. PI:王福俤; 国家杰出青年科学基金2013.01-2016.12

7.  参与编译完成科学出版社两本专著《铁与人类健康》、《锌与人类健康》

科研文章发表情况

1.     Ming-Dao Mu, Hong-Yan Geng, Kang-Lin Rong, Rong-Chao Peng, Shu-Ting Wang, Lin-TingGeng, Zhong-Ming Qian, Wing-Ho Yung, Ya Ke. A limbic grooming circuit foremotional stress response. Nature Communications, 2020 (IF=17.694), 亮点文章

2.     Ming-Dao Mu, Zhong-Ming Qian, Sheng-Xi Yang, Kang-Lin Rong, Wing-Ho Yung, Ya Ke. Therapeutic Effect of aHistone Demethylase Inhibitor in Parkinson's Disease. Cell Death & Disease, 2020 (IF=9.685)

3.     Tuo Liang, Zhongming Qian, Mingdao Mu, Wingho Yung, Ya Ke. Brainhepcidin suppresses major pathologies in experimental Parkinsonism. iScience, 2020 (IF=5.46)

4.     Ming-Dao Mu, Peng An, Qian Wu, Xiaoyun Shen, Dandan Shao, HaoWang, Yingqi Zhang, Shenshen Zhang, Hui Yao, Junxia Min, Fudi Wang. The dietary flavonoid myricetin regulatesiron homeostasis by suppressing hepcidin expression. The Journal ofNutritional Biochemistry, 2016 (IF=4.56)

5.     Ming-Dao Mu, Aimin Wu, PengAn, Xiaoli Du, Qian Wu, Xiaoyun Shen, Fudi Wang. Black soybean seed coatextract regulates iron metabolism by inhibiting the expression of hepcidin. BritishJournal of Nutrition, 2014 (IF=3.45) 亮点文章

Commented by: McClung JP.Nutrition is medicine: dietary inhibition of hepcidin expression. British Journal of Nutrition, 2014.

6.     Zhiyuan Yang, Jinpao Hou, Mingdao Mu, Shang Ying Wu. Subtractive proteomics and systems biology analysis revealed novel drugtargets in Mycoplasma genitalium strain G37. Microbial Pathogenesis, 2020 (IF=2.91)

7.   Meng-Wan Zhang, Guang Yang, Yu-Fu Zhou, Christopher Qian, Mingdao Mu, Ya Ke, Zhong-Ming Qian. Regulatingferroportin-1 and transferrin receptor-1 expression: A novel function ofhydrogen sulfide. Journal of Cellular Physiology, 2019 (IF=4.52)

8.   Yu Fu Zhou, Xiao Mei Wu, Gan Zhou, Mingdao Mu, Fa Li Zhang, Fe Mi Li, Christopher Qian, Fang Du, Wing Ho Yung, ZhongMing Qian, Ya Ke Cystathionine β-synthase is required for body ironhomeostasis. Hepatology, 2018 (IF=14.97)

9.   Qianqian Luo, Gan Zhou, Suna Huang, Mingdao Mu, Yunjin Chen, Zhongming Qian. Ghrelin isNegatively Correlated with Iron in the Serum in Human and Mice. Ann Nutr Metab, 2018 (IF=3.05)

10.   Yingqi Zhang, Xudong Wang, Qian Wu, Hao Wang, Lu Zhao, Xinhui Wang, Mingdao Mu, Enjun Xie, Xuyan He, Dandan Shao, Yanna Shang, Yongrong Lai, YelenaGinzburg, Junxia Min, Fudi Wang. Adenine alleviates iron overload by cAMP/PKA mediatedhepcidin upregulation in mice. Journal of Cellular Physiology, 2018 (IF=4.52)

11.   Zhen Liu, YuYu, Xiaohong Li, Aimin Wu, Mingdao Mu, Nana Li, Ying Deng, XiJin, Shengli Li, Yuan Lin, Xinlin Chen, Fudi Wang, Jun Zhu. Maternal leadexposure and risk of congenital heart defects occurrence in offspring. ReproductiveToxicology, 2014 (IF=3.23)

12.   Xin Guo, Daizhan Zhou, Peng An, Qian Wu, Hao Wang, Aimin Wu, Mingdao Mu, Di Zhang, Zhou Zhang,Hui Wang, Lin He, Yun Liu, Fudi Wang. Associations between serum hepcidin, ferritin,hemoglobin, and type 2 diabetes risks in a Chinese Han population. British Journal of Nutrition, 2013 (IF=3.45)

13.   Peng An, Qian Wu, Hao Wang, Yu Guan, Mingdao Mu, Yijun Liao, Daizhan Zhou, Pengkun Song, Chunrong Wang, Liping Meng,Qingqing Man, Lixiang Li, Jian Zhang, Fudi Wang. TMPRSS6, but not TF, TFR2, orBMP2 Variants are Associated with Increased Risk of Iron Deficiency Anemia. HumanMolecular Genetics, 2012 (IF=7.69)

专利申请

1.  穆明道,周玉付,陈耀富;番茄红素在制备排铅产品中的用途; 专利公开号 CN103462014B（授权）

2.  王福俤,穆明道,伍爱民；杨梅素在制备抑制铁调素表达的制剂中的应用; 专利公开号CN103655542B （授权）

3.  周玉付,陈耀富,穆明道;一种具有增加骨密度功能的组合物及其制备方法和用途;专利公开号CN103083650B （授权）

4.  穆明道,陈耀富,周玉付,马福全,张彦杰; 一种具有促进排铅功能的组合物及其用途; 专利公开号CN103463390A

5.  王福俤,穆明道,伍爱民等; 黑豆及其提取物在制备抑制铁调素表达的制剂中的应用; 专利公开号CN103405493 A