课题组于2021年3月成立，现有研究生若干。组内配备有机合成化学研究所需的所有实验仪器与条件。课题组有系统的科研训练方法，在注重保障实验安全的同时提升学生的研究能力与科学素养。课题组营造自由平等的学术讨论和科研工作氛围。希望学生能够在提升学识、收获成果的同时，体会到科研的乐趣。欢迎本科毕业生报考（任何与化学、化工、生物学、食品等相关专业均可）！

课题组长同时承担多项科研项目，组内经费充裕。

已发表高水平学术论文40余篇，其中以第一作者在NatCommun，Angew. Chem. Int. Ed 等权威刊物上发表论文20余篇，撰写国外学术书籍3章。总他引次数800+，H-指数17。获MarieSklodowska-Curie Actions Seal ofExcellence (玛丽居里奖学金卓越勋章)等学术性奖项。

1.          Jia-chenXiang, Jia-Wei Wang, Peng Yuan, Jin-Tian Ma, An-Xin Wu*, Zhi-xin Liao*, SwitchingOver of the Chemoselectivity: I2-DMSO-Enabled, Dichlorination ofFunctionalized Methyl Ketones. J. Org. Chem., 2022,10.1021/acs.joc.2c01591. (Q1, top)

2.          Jin-Tian Ma, Ting Chen, Xiang-Long Chen, You Zhou, Zhi-Cheng Yu, Shi-Yi Zhuang, Maierhaba Alimu, Yan-Dong Wu, Jia-Chen Xiang* and An-Xin Wu*. One-step synthesis of azepino[3,4-b]indoles by cooperative aza [4 + 3] cycloaddition from  readily available feedstocks Org. Chem. Front., 2022, 9, 4640–4648. (Q1, top)

3.         Jia-chen Xiang, Cédric Fung, Qian WangandJieping Zhu*, Taming the radical cation intermediate enabledone-step access to structurally diverse lignans, Nat Commun. 2022,13, 3481.(Q1, top)

4.        Jia-chenXiang, Qian Wang, Jie-ping Zhu*, Radical CationCascade to Aryltetralin Cyclic Ether Lignans Enabled by Visible LightPhotoredox Catalysis, Angew. Chem. Int.Ed. 2020, 59, 21195-21202. (Q1, Top)

5.        Jia-chenXiang, Yan Cheng, Zi-xuan Wang, Jin-tian Ma, MiaoWang, Bo-cheng Tang, Yan-dong Wu, and An-xin Wu*, Oxidative Trimerization of Amino Acids: Selective Synthesis of2,3,5-Trisubstituted Pyridines, Org. Lett. 2017, 19, 2997−3000. (Q1, Top)

6.        Jia-chenXiang, Yan Cheng, Miao Wang, Yan-dong Wu,* and An-xinWu*, Direct Construction of4-Hydroxybenzils via para-Selective C-C Bond Coupling of Phenols and ArylMethyl Ketones, Org. Lett. 2016,18, 4360−4363. (Q1, Top)

7.        Jia-chenXiang, Miao Wang, Yan Cheng, and An-xin Wu*, Molecular Iodine-Mediated ChemoselectiveSynthesis of Multisubstituted Pyridines through Catabolism and Reconstruction Behaviorof Natural Amino Acids, Org. Lett., 2016,18, 24-27. (Q1, Top)

8.        Jia-chenXiang†，Zhi-jie Wu,†Qing Gu*, Shu-li You*, Palladium-CatalyzedC–H Diarylation of Ferrocenecarboxylic Acids with Aryl Iodides, J. Org.Chem., 2019, 84, 13144-13149. (Q1,Top)

9.        Jia-chenXiang, Zi-xuan Wang, Yan Cheng, Shi-qing Xia, MiaoWang, Bo-cheng Tang, Yan-dong Wua and An-xin Wu*, Divergent Synthesis of Functionalized Quinolines from Aniline and TwoDistinct Amino Acids, J. Org. Chem., 2017, 82, 9210−9216. (Q1, Top)

10.        Jia-chenXiang, Zi-xuan Wang, Yan Cheng, Jin-tian Ma, MiaoWang, Bo-cheng Tang, Yan-dong Wu and An-xin Wu*, A C−H Oxidation/Two-Fold Cyclization Approach to ImidazopyridoindoleScaffold under Mild Oxidizing Conditions, J. Org. Chem. 2017, 82, 13671-13677. (Q1, Top)

11.        Zi-Xuan Wang†, Jia-chen Xiang†, Yan Cheng, Jin-Tian Ma,Yan-Dong Wu, and An-Xin Wu*, DirectBiomimetic Synthesis of β-Carboline Alkaloids from Two Amino Acids, J. Org.Chem., 2018, 83, 12247–12254.(Q1, Top)

12.        Jia-chenXiang, Jun-gang Wang, Miao Wang, Xiang-gao Meng andAn-xin Wu*, One-pot total synthesis ofstreptindole, arsindoline B and their congeners through tandem decarboxylativedeaminative dual-coupling reaction of amino acids with indoles, Org. Biomol.Chem., 2015, 13, 4240-4247. (Q1)

13.      Jia-chen Xiang, Jun-gangWang, Miao Wang, Xiang-gao Meng, An-xin Wu*, One-pot total synthesis: the first total synthesis of chiral alkaloid pimprinolA and the facile construction of its natural congeners from amino acids, Tetrahedron,2014, 70, 7470-7475.

14.      Jia-chen Xiang, Miao Wang,Yu Sun, and An-xin Wu*,<MulticomponentReactions: Synthesis of Bioactive Heterocycles> Chapter 8: One-Pot Total Synthesis of Bioactive NaturalProducts (国外专业书籍章节)CRC Press, 2017, ISBN 9781498734127 doi:10.1201/9781315369754-9

15.      Jia-chen Xiang, Qing-He Gao, and An-xinWu* <Solvents as Reagents in OrganicSynthesis: Reactions and Applications> Chapter 7: The Applications of DMSO. (国外专业书籍章节)Wiley-VCH,2017, ISBN: 978-3-527-80563-1 doi:10.1002/9783527805624.ch7

发展“机制新颖的化学转化”用于“优化天然产物全合成”一直是有机合成方法学研究的重要归宿之一。不仅有助于化学机理的深入理解，创造新的反应类型，还能开拓逆合成思路，助力复杂、多样化、优势骨架分子群的快速构建，为研究药物活性、构效关系提供物质基础。

课题组致力于天然产物导向型反应方法学的构建---旨在利用逻辑设计的逆合成分析，以多米诺串联反应为手段，为天然产物提供简洁的构筑策略，从而减少全合成步骤，乃至实现“一锅法”全合成。现以完成33例天然产物的合成工作，涵盖吲哚生物碱，鬼臼类、呋喃类木脂素，多羟基苯偶酰等多类天然产物家族，全合成步骤均不超过3步，具有显著的步骤经济性优势。其中包括“一锅法”全合成17例，首次全合成12例。