主持的科研项目：

1. 国家自然科学基金面上项目：

    基于优势T细胞表位谱的肝癌患者特异性细胞免疫功能的普适性检测系统和临床应用

    项目号：82272402；2023.01-2026.12

2. “十四五” 国家重点研发计划重点专项：

    新冠与流感等大流行风险病原体多肽疫苗的研制

    项目号：2022YFC2304100；2023.01-2025.12（课题任务负责人）

   中国人群新冠病毒优势CD4+ T细胞表位谱的分析与应用研究

   项目号：SKLPBS2139；2021.7-2022.6

4. 国家自然科学基金专项项目：

   新型冠状病毒疫苗免疫保护作用及安全性评估的实验研究

   项目号：82041006；2020.3-2022.3 (子课题负责人)

5. 浙江大学新型冠状病毒肺炎应急攻关项目：

   基于新型冠状病毒优势T细胞表位的多肽纳米疫苗喷雾剂研制

   项目号：2020XGZX021；2020.2-2020.8

6. 江苏省科技厅重点研发项目：

    乙型肝炎特异性细胞免疫个体化检测试剂盒的研发与应用

   项目号：BE2017714；2017-2020年

7. 国家自然科学基金面上项目：

   多功能PLGA微粒式人工抗原提呈细胞对肿瘤的主动免疫治疗

   项目号：81372448；2014.01-2017.12

8. 国家自然科学基金面上项目：

    PLGA纳米球吸附MHC同种抗原和负调节分子诱导皮肤移植耐受的研究

   项目号：81172823；2012.01-2015.12

9. 江苏省科技支撑计划项目：

   磁性人工抗原提呈细胞微孔反应板的研制及特异性细胞免疫功能的检测

   项目号：BE2012739；2012-2015年

  胶乳微球式人工抗原提呈细胞诱导抗肿瘤主动免疫反应的研究

  项目号：30771998；2008.01- 2010.12

科研论文： 

1. Min Peng, Hui Li, Huan Cao, Yamei Huang, Weiping Yu, Chuanlai Shen*, Jinyang Gu*. Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma. Journal of Gastroenterology, 2023, Jul 11. DOI: 10.1007/s00535-023-02012-8   IF: 6.3

2. Juan Shi , Yu Zhao, Min Peng, Suyue Zhu, Yandan Wu , Ruixue Ji and Chuanlai Shen*. Screening of efficient adjuvants for the RBD-based subunit vaccine of SARS-CoV-2. Vaccines, 2023, 11. 713: 1-10.  IF: 7.8

3. Xiaoxiao Jin, Xiaotao Liu, Chuanlai Shen*. A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2. Virus Research, 2023, 324:199024 (41 pages).  IF: 5.00

4. Yuanyong Ouyang, Zihao Zhang, Wei Huang, Wenzhong Yang*, Chuanlai Shen*, Yun Chen*, Xiaoshuang Yin, Ying Liu. Electrodeposition of F-doped hydroxyapatite-TiO2 coating on AZ31 magnesium alloy for enhancing corrosion protection and biocompatibility. Journal of Material Science, 2022, Sep 27, https://doi.org/10.1007/s10853-022-07732-5  IF: 4.682

5. Xueyin Mei#, Xingyu Li#, Chen Zhao#, Anna Liu, Yan Ding, Chuanlai Shen*, Jian Li*. The use of molecular dynamics simulation method to quantitatively evaluate the affifinity between HBV antigen T cell epitope peptides and HLA-A molecules. International Journal of Molecular Sciences, 2022, 23: 4629.  IF: 6.208

6. Yan Ding#, Zining Zhou#, Xingyu Li#, Chen Zhao, Xiaoxiao Jin, Xiaotao Liu, Yandan Wu, Xueyin Mei, Jian Li*, Jie Qiu*, Chuanlai Shen*. Screening and identification of HBV epitopes restricted by multiple prevalent HLA-A allotypes. Frontiers in Immunology, 2022,13: 847105.  IF: 8.786

7. Yandan Wu, Yan Ding, Chuanlai Shen*. A systematic review of T cell epitopes defined from the proteome of hepatitis B virus. Vaccines, 2022, 10(2): 257.  IF: 4.961

8. Xiaoxiao Jin , Xiaotao Liu , Zining Zhou, Yan Ding, Yandan Wu, Jie Qiu*, Chuanlai Shen*. Identification of HLA-A2 restricted epitopes of glypican-3 and induction of CTL responses in HLA-A2 transgenic mice. Cancer Immunology, Immunotherapy, 2022, 71(1): 1569-1582.  IF: 6.630

9. Xiaoxiao Jin#, Yan Ding#, Shihui Sun#, Xinyi Wang, Zining Zhou, Xiaotao Liu, Miaomiao Li, Xian Chen, Anran Shen, Yandan Wu, Bicheng Liu, Jianqiong Zhang, Jian Li, Yi Yang, Haibo Qiu, Chuanlai Shen*, Yuxian He*, Guangyu Zhao*. Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8+ T cell responses in HLA-A transgenic mice. Cellular & Molecular Immunology, 2021, 18: 2588-2608.  IF: 22.10

10. Juan Shi, Xiaoxiao Jin, Yan Ding, Xiaotao Liu, Anran Shen, Yandan Wu, Min Peng and Chuanlai Shen*. Receptor-binding domain proteins of SARS-CoV-2 variants elicited robust antibody responses crossly reacting with wild-type and mutant viruses in mice. Vaccines, 2021, 9:1190.  IF: 4.961

11. Shahzad KA, Naeem M, Zhang L, Wan X, Song S, Pei W, Zhao C, Jin X, Shen C*. Design and optimization of PLGA particles to deliver immunomodulatory drugs for the prevention of skin allograft rejection. Immunological Investigations, 2020, 49(7): 840-857.  IF: 3.657

12. Xinyi Wang, Wanbo Tai, Xiaolu Zhang, Yusen Zhou, Lanying Du* and Chuanlai Shen*. Effects of Adjuvants on the Immunogenicity and Efficacy of a Zika Virus Envelope Domain III Subunit Vaccine. Vaccines, 2019, 7, 161: 1-15. IF: 4.086

13. Yan Ding, Anning Fang, Jialai Yan, Jie Duan, Nianyue Wang, Yongxiang Yi*, Chuanlai Shen*. Selective downregulation of distinct circRNAs in the tissues and plasma of patients with primary hepatic carcinoma. Oncology Letters, 2019, 18: 5255-5268.  IF: 2.311 

14. Lei Zhang, Shilong Song, Xiaoxiao Jin, Xin Wan, Khawar Ali Shahzad, Weiya Pei, Chen Zhao, Chuanlai Shen*. An Artificial Antigen-Presenting Cell Delivering 11 Immune Molecules Expands Tumor Antigen-Specific CTLs in Ex Vivo and In Vivo Murine Melanoma Models. Cancer Immunology Research, 2019 Jul;7(7):1188-1201.  IF: 9.188

15. Shilong Song, Xiaoxiao Jin, Lei Zhang, Chen Zhao, Yan Ding, Qianqian Ang, Odontuya Khaidav, Chuanlai Shen*. PEGylated and CD47-conjugated nanoellipsoidal artificial antigen-presenting cells minimize phagocytosis and augment anti-tumor T cell responses. International Journal of Nanomedicine, 2019; 14: 1-19.   IF 5.116

16. Xin Wan, Weiya Pei, Khawar Ali Shahzad, Lei Zhang, Shilong Song, Xiaoxiao Jin, Limin Wang, Chen Zhao and Chuanlai Shen*. A tolerogenic artificial APC durably ameliorates experimental autoimmune encephalomyelitis by directly and selectively modulating myelin peptide-autoreactive CD4+ and CD8+ T Cells. Journal of Immunology, 2018; 201(4):1194-1210 (cover paper)   IF 4.886

17. Khawar Ali Shahzad, Xin Wan, Lei Zhang, Weiya Pei, Aifeng Zhang, Muhammad Younis, Wei Wang, Chuanlai Shen*. On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation. Drug Delivery, 2018; 25(1): 703-715.  IF: 6.402

18. Weiya Pei, Xin Wan, Khawar Ali Shahzad, Lei Zhang, Shilong Song, Xiaoxiao Jin, Limin Wang, Chen Zhao and Chuanlai Shen*. Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules. International journal of nanomedicine, 2018; 13: 3731-3750.  IF: 4.37

19. Xin Wan, Weiya Pei, Yiming Zhang, Lei Zhang, Khawar Ali Shahzad, Tao Xu, Chuanlai Shen*. Inconsistence between number and function of autoreactive T cells in the course of experimental autoimmune encephalomyelitis. Immunological Investigations, 2018; 47(1): 1-17.   IF: 2.588

20. Wang W, Shahzad KA, Li M, Zhang A, Zhang L, Xu T, Wan X, Shen C*. An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells. Frontiers in Immunolology. 2017; 8: 657.  IF: 5.511  

21. Zhang L, Wang L, Shahzad KA, Xu T, Wan X, Pei W, Shen C*. Paracrine release of IL-2 and anti-CTLA-4 enhances the ability of artificial polymer antigen-presenting cells to expand antigen-specific T cells and inhibit tumor growth in a mouse model. Cancer Immunology, Immunotherapy. 2017, 66(9): 1229-1241.  IF 5.442

22. Chuanlai Shen*#, Tao Xu#, You Wu, Xiaoe Li, Lingzhi Xia, Wei Wang, Khawar Ali Shahzad, Lei Zhang, Xin Wan, Jie Qiu. Frequency and reactivity of antigen-specific T cells were concurrently measured through the combination of artificial antigen-presenting cell, MACS and ELISPOT. Scientific reports; 2017, 7(1): 16400  IF: 4.259

23. Tao Xu, Xiaoe Li, You Wu, Khawar Ali Shahzad, Wei Wang, Lei Zhang, and Chuanlai Shen*. A Combination Strategy for Construction of Peptide-β2m-H-2Kb Single Chain with Overlap Extension PCR and One-Step Cloning. Journal of Microbiology and Biotechnology, 2016; 26(12): 2184-2191.  IF: 1.75

24. Wei Wang, Kun Fang, Miaochen Li, Di Chang，Khawar Ali Shahzad, Tao Xu, Lei Zhang, Ning Gu*, Chuanlai Shen*. A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo. Oncotarget, 2016; 7(11):12176-12190. IF: 5.168

25. Wei Wang, Kun Fang, Xiaobing Wang, Miaochen Li, You Wu, Feng Chen, Khawar Ali Shahzad, Ning Gu*, and Chuanlai Shen*. Antigen-specific killer polylactic-co-glycolic acid (PLGA) microspheres can prolong alloskin graft survival in a murine model. Immunological Investigation, 2015; 44(4): 385-399.   IF: 1.991

26. Chuanlai Shen, Kai Cheng, Shenwei Miao, Wei Wang, Yong He, Fanyan Meng, Jianqiong Zhang. Latex bead-based artificial antigen-presenting cells induce tumor-specific CTL responses in the native T-cell repertoires and inhibit tumor growth. Immunology Letters. 2013; 150(1-2): 1-11.  IF: 2.367 

27. Chuanlai Shen, Yong He, Kai Cheng, Daoping Zhang, Shenwei Miao, Aifeng Zhang, Fanyan Meng, Fengqin Miao, Jianqiong Zhang, Killer artificial antigen-presenting cells deplete alloantigen-specific T cells in a murine model of alloskin transplantation. Immunology Letters. 2011; 138(2): 144-155.  IF: 2.552

28. Chuanlai Shen, Yong He, Fanyan Meng, Kai Cheng, Daoping Zhang, Fengqin Miao, Jianqiong Zhang, Characterization of MHC/peptide complexes refolded by a one-step ion-exchange chromatography. Journal of Immunological Methods, 2011; 369(1-2): 81-90. IF: 2.225

29. Chuanlai Shen, Jianqiong Zhang, Lingzhi Xia, Fanyan Meng, Wei Xie. Induction of tumor antigen-specific cytotoxic T cell responses in naïve mice by microspheres-based artificial antigen-presenting cell constructs. Cellular Immunology, 2007; 247 (1): 28-35. IF: 2.575

30. Chuanlai Shen, Ting Hu, Ling Shen, Lei Gai, Wei Xie, Jianqiong Zhang. Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis C virus genotype 1b infection. Journal of Gastroenterology and Hepatology, 2007; 22(1): 1898-903.  IF:2.0275

31. Chuanlai Shen, Chien-Chung Chang, Jianqiong Zhang, Wei Guo, Lingzhi Xia, Fanyan Meng, Wei Xie. Structural and functional characterization of peptide-β2m fused HLA-A2/MART127-35 complexes. Biochemical and Biophysical Research Communications, 2006; 342: 57-65.  IF: 2.595

发明专利：

1. 沈传来。一种适用于东亚地区广泛人群的抗原特异性胸腺依赖性淋巴细胞普适性检测技术方案。专利受理号：202210283056.7 2022 年 03 月 22 日

2. 沈传来，金萧萧，丁艳，孙世慧，赵光宇，何玉先。一种 SARS-CoV-2 淋巴细胞抗原表位肽及其应用。专利受理号：202110209065.7 2021 年 02 月 24 日；申请人：东南大学，中国人民解放军军事科学院军事医学研究院，中国医学科学院病原生物学研究所。 

3. 沈传来，丁艳，周子宁。乙型肝炎病毒抗原的胸腺依赖性淋巴细胞抗原表位肽及其应用。专利受理号：201911284635.8 2019 年 12 月 13 日 

4. 沈传来，金萧萧。原发性肝癌相关抗原的胸腺依赖性淋巴细胞抗原表位肽及其应用。专利受理号：201911286067.5 2019 年 12 月 13 日 

5. 沈传来。乙型肝炎病毒抗原的胸腺依赖性淋巴细胞抗原表位肽及其应用。专利号：ZL201910408518.1 2019 年 5 月 6 日 

6. 沈传来，张建琼。一种同步检测特异性胸腺依赖性淋巴细胞数量和功能的方法。专利号：ZL2012 1 0145413.X 201408

教学内容：

为医学院各专业的本科生和研究生主讲《医学免疫学》、《医学微生物学》、《临床微生物学检验》、《临床免疫学研究进展》、《微生物学与免疫学实验技术》等五门主干课程，并为留学生和七年制、八年制英文班学生全英文讲授《医学免疫学》课程达8年以上时间，多次获得东南大学教学优秀奖。

主持的教改项目：

1. 双语《病原生物学与免疫学实验指导》课程内容优化的研究与实践

校级重点教改课题，2010年立项，已结题

2. 基于树立科研理念的《医学免疫学实验》课程内容更新改革

校级一般教改课题，2019年，在研

教学论文：

1. 吴优，包雪阳，沈传来。基于树立科研理念的医学免疫学实验课程改革。中国免疫学杂志，2021,37(12)：1513-1525.

2. 窦骏、沈传来、高大庆。病原生物学与免疫学系研究生培养平台建设与实践。教育教学论坛，2012, 01: 57-58.