1.FAK基因的表达调控及在肿瘤治疗中的应用,       国家自然科学基金面上项目31070706，34万  2011.01-2013.12       主持. 完成结题    

2.MALAT1-SP1的转录反馈环路在肺癌转移中作用机制的研究,江苏省自然科学基金面上研究项目BK20161416, 10万,       2016.07-2019.06    主持,完成结题     

3. MALAT1/mascRNA双分子体系在调节巨噬细胞固有免疫应答及抗类风湿关节炎疾病中的作用和机制研究,     国家自然科学基金面上项目, 81772308, 55万，2018.01-2021.12  ,参加完成结题     

4.肺癌中转录因子SP1对MALAT1的调控研究 南京市卫生局重点项目, 10万，主持 完成结题      

5.抗人PD1纳米抗体的研发,常州南京大学高新技术研究院, 21万，    2018.5—2019.6      主持,完成结题     

6. 抗人PDL1纳米抗体的研发,   常州南京大学高新技术研究院（技术开发H201910383）, 5万,   2019.6-2020.6       ,主持, 完成结题    

7. 抗PD-L1纳米抗体及其编码序列、制备方法和应用等1项发明转让,成果转化, 12万,2021.12-2023.12,   主持,在研     

1.Ming Li, Minke Shi , Chaoyue Hu , BaojunChen , Shufeng Li. MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcriptionand drived NSCLC proliferation. Oncogene (2021) 40:3870–3884

2. Wang T, Zhang W, Huang W, Hua Z, Li S.LncRNA MALAT1 was regulated by HPV16 E7 independently of pRB in cervical cancercells. J Cancer. 2021 Aug 28;12(21):6344-6355.

3.Wei Zhang, Haitao Shan, Kunpeng Jiang,Wenbin Huang, Shufeng Li. A novel intracellular nanobody against HPV16 E6oncoprotein. Clin Immunol.2021;225: 108684.

4. Li S, Zheng X, Wang T, Xue J. Clinicalcharacterization of novel HSPA9 splice variant in a Chinese woman. Clin Genet.2021;99(4):609-610.

5.Shufeng Li , Haitao Shan, Ting Wang ,Xiaojuan Zheng , Minke Shi, Baojun Chen , Haiqin Lu , Ying Zhang , Sheng Zhao,Zichun Hua.  Generation of mWasabifluorescent protein-binding nanobodies. Anal Biochem. 2020; 608:113875.

6.Shufeng Li, Kunpeng Jiang, Ting Wang, WeiZhang, Minke Shi, Baojun Chen, Zichun Hua.Nanobody Against PDL1. BiotechnolLett. 2020 May;42(5):727-736.

7.Shufeng Li,Zhang wei,Jiang kunpeng , Shanhaitao, Shi minke, Chen baojun, Hua zichun.Nanobody againgst the E7 oncoproteinof human papillomavirus 16.Mol.immunol.2019,109:12-19.

8.Shufeng li, Fang ma, Kunpeng jiang,Haitao shan,Minke shi, Baojun chen. lncRNA malat1 promotes lung adenocarcinomaby directly interacting with SP1. Cancer Science.2018;109:1346-1356

9.Anran Liu, Haitao Shan, Mengyao Ma,LiShangguan, Kunpeng Jiang, Minke Shi, Yuewu Zhao, Songqin Liua, Shufeng Li.Anultrasensitive photoelectrochemical immunosensor by integration ofnanobody,TiO2 nanorod arrays and ZnS nanoparticles for the detection of tumornecrosisfactor-α. Journal of Electroanalytical Chemistry 803 (2017) 1–10

10. Shufeng Li, Yifan Chen, HaitaoShan,Fang Ma, Minke Shi, Jun Xue. Novel heterozygous NOTCH3 pathogenic variantfoundin two Chinese patients with CADASIL. Journal of ClinicalNeuroscience 46(2017) 85–89

11.Lishufeng,Qiangqian,Shanhaitao,Shiminke,Ganguangming,Mafang,Chenbaojun.Mir20a and miR20b negatively regulate autophagy by targeting RB1CC1/FIP200 inbreast cancercells. Life Sci. 2016,147:143-152

12.ShufengLi,QiweiWang,QianQiang,HaitaoShan,MinkeShi,BaojunChen. Sheng Zhao,Liudi Yuan.Sp1 mediated transcriptional regulationof MALAT1 plays a critical rolein tumor. J Cancer ResClinOncol(2015)141:1909–1920

13.HaoYu, Shufeng Li, LiandongFeng, YuchengLiu, Xiaoliang Qi, Wei Wei, Junjian Li, and Wei Dong,Diglycidyl EstersCrossLinked with LowMolecularWeight Polyethyleneimine for Magnetofection. Aust.J.Chem.2015.http://dx.doi.org/10.1071/CH14731

14.YuchengLiu,ShufengLi,LiandongFeng,HaoYu,XiaoliangQi,WeiWei,JunjianLi,andWeiDong,Novel Disulfide-Containing Poly(b-aminoester Functionalised MagneticNanoparticles for Efficient Gene Delivery. Aust. J. Chem.2015.http://dx.doi.org/10.1071/CH14731

15.ShufengLi, Jun Xue,Baojun Chen, Qiwei Wang,Minke Shi,Xiaojing Xie, Liang Zhang. Two middle-age-onset hemochromatosispatients with heterozygous mutations in the hemojuvelingene in a Chinesefamily. Int J Hematol 2014;99: 487-492

16.LiS, Huang X, Zhang D, Huang Q, Pei G,Wang L, Jiang W, Hu Q,Tan R, Hua ZC. Requirement of PEA3 for transcriptionalactivation of FAK gene in tumor metastasis. PLoS One. 2013;8(11):e79336:1-13.

17.LiS, Dong W, ZongY, Yin W, JinG, Hu Q,Huang X, Jiang W, Hua ZC.Polyethylenimine-complexed plasmid particles targetingfocal adhesion kinase function as melanoma tumor therapeutics. Mol Ther.2007Mar;15(3):515-23.

18.LiS, Li J, Cheng J, Zhou B, Tong X, DongX, Wang Z, Hu Q, Chen M,HuaZC. Nonsyndromic tooth agenesis in two Chinesefamilies associated with novel missense mutations in the TNF domain of  EDA (ectodysplasin A).  PLoS One.2008Jun 11;3(6)

19.LiS, Hua ZC.FAK expression regulationand therapeutic potential. Adv Cancer Res. 2008;101:45-61.

20.Dong W, Li SF,JinGH, Sun QM , Ma DY, HuaZC. Efficient genetransfection into mammalian cellsmediated by cross-linkedpolyethylenimine. Int J MolSci 2006;7:1-32.

发明专利

1. 李淑锋 单海涛 马芳, 发明专利名称：wasabi蛋白纳米抗体及其编码序列与应用       中华人民共和国国家知识产权局    授权号CN105399827B

2. 李淑锋 张微 单海涛, 发明专利名称：能够特异结合HPVl6-E6蛋白的纳米抗体 及其编码序列、制备方法和应用,中华人民共和国国家知识产权局    授权号CN109206511B

3. 李淑锋 姜昆鹏 王婷, 发明专利名称：抗PD-L1纳米抗体及其编码序列、制备方法和应用, 授权号CN109265548B