近年来，主持国家自然科学基金项目2项，江苏省自然科学基金青年项目1项，参与科技部973项目、国家自然科学基金项目5项。已发表SCI检索论文40余篇。

在国际上首次提出耦合斑块微环境因素的斑块动态发展模型，可结合病人影像数据提供个体化的斑块易损性评估，详见代表性论文[1,2]。

1)     NationalNature Science Foundation of China No. 12072074 (PI)     01/2021-12/2024

The role of VSMC phenotypic switching in theanti-inflammatory therapy of atherosclerotic plaque: coupled modeling ofmicroenvironmental factors

2)     NationalNature Science Foundation of China No. 11302050 (PI)     01/2014-12/2016

The influence of normalization of tumor microenvironmenton the chemotherapeutic drug delivery in non-small cell lung cancer

3)     NatureScience Foundation of Jiangsu Province No. BK20130593 (PI) 07/2013-07/2016

Multiscale mathematical modeling for hypoxicmicroenvironment in solid tumors

[1] Muyi Guo#, Yan Cai#, Chunliu He, Zhiyong Li*. Coupled modeling of lipid deposition, inflammatory response and intraplaque angiogenesis in atherosclerotic plaque. Annals of Biomedical Engineering, 2019;47(2):439-452.

[2] Muyi Guo#, Yan Cai#, Xinke Yao, Zhiyong Li*. Mathematical modeling of atherosclerotic plaque destabilization: Role of neovascularization and intraplaque hemorrhage. Journal of Theoretical Biology, 2018, 450: 53-65.

[3] Pan SY#, Ding M#, Huang J, Cai Y*, Huang YZ*. Airway resistancevariation correlates with prognosis of critically ill COVID-19 patients: Acomputational fluid dynamics study. Comput Methods Programs Biomed. 2021 Jun25;208:106257.

[4] Pan J#, Cai Y#, Liu M, Li Z*. Role of vascularsmooth muscle cell phenotypic switching in plaque progression: A hybridmodeling study. J Theor Biol. 2021 Oct 7;526:110794.

[5] Pan J#, Cai Y#, Wang L, Maehara A, Mintz GS,Tang D, Li Z*. A prediction tool for plaque progression based onpatient-specific multi-physical modeling. PLoS Comput Biol. 2021 Mar29;17(3):e1008344.