1. 国家自然科学基金面上项目，项目名称：中国人群乙型肝炎病毒基因组突变诱发原发性肝癌的机制研究，批准号：31871322，经费数目：59万元；项目起止年月：2019年01月至2022年12月。主持。

2.江苏省自然科学基金面上项目，项目名称：皮肤鳞状细胞癌和角化棘皮瘤发病机制的基因组学研究；编号：BK20151403。经费来源：江苏省科技厅，经费数目：10万元，起止年月：2015年1月至2018年1月。承担责任：主持课题以及生物信息学分析。结题，主持。

3.航天医学实验领域项目，基于人体血液表观遗传学的多生理系统相关性及健康风险预测研究，2019/01-2022/12，50万元。在研。课题组长。

4. 国防科技创新特区，基于XXX数据库构建，2020年 1月 至 2021年 12月，50万元，在研，主持。

4.参与（第二负责人）江苏省创新项目一项，项目名称：基于PCSK9 纳米抗体的降脂药物的研制及功能研究；编号：BY2015070-24。经费来源：江苏省科技厅，经费数目：60万元，起止年月：2015年1月至2018年1月。承担责任：生物信息学分析。

5.参与丹麦课题“Molecular Tools for Optimal Personalized Treatment of Colorectal Cancer”的项目，由The ‘FØSU-CRC’ Project (Grant number: 09-065177/DSF)提供支持，项目时间2010年-2014年。结题。

6.申请人参与中丹联合课题“Molecular Tools for Optimal Personalized Treatment of Breast Cancer”的项目，项目由Danish National Research Foundation (Grundforskningsfonden)和中国国家自然科学基金共同支持，项目时间为2008年-2014年。结题。

7.主持江苏省科技厅产学研项目“基因测序数据和可穿戴设备数据的云计算与云存储的关键技术研究”，项目号BY2019001，2019年-2020年。

8.主持与江苏浪潮信息科技有限公司横向课题“基于高性能计算与云平台的高通量测序数据与可穿戴设备数据的分析与存储的应用技术咨询”，2019年-2021年，30.8万。

9.参与浙江大学新型冠状病毒（SARS-CoV-2）肺炎应急科研项目“基于新型冠状病毒优势T细胞表位的多肽纳米疫苗喷雾剂研制”，2020.03-2020.09，50万。

10.参与国家自然基金委新冠疫情专项项目“新型冠状病毒疫苗免疫保护作用及安全性评估的实验研究”，项目号82041006，2020.03-2022.03，150万元

1.     Shanglin Gu, Li Lv, Xue Lin, Xingyu Li, JunchengDai, Jianqiong Zhang, Ren Kong, Wei Xie, Jian Li（Corresponding author）,Using structural analysis to explore the role ofhepatitis B virus mutations in immune escape from liver cancer in Chinese,European and American populations, Journal of Biomolecular & Dyanmics,2020, Accepted.

2.     Jian Li （Co-corresponding author）, Xue Lin,Mingya Wang, Yunyun Hu, Kaiyu Xue, Shuanglin Gu, Li Lv, Saijun Huang, Wei Xie,Potential Role of Genomic Imprinted Genes and Brain Developmental Related Genesin Autism, BMC Medical Genomics, 2020, Mar 26;13(1):54

3.     Mingliang Tang, Jian Li (Co-firstauthors), Li He, Rongrong Guo, Xiaoqian Yan, Dan Li, YuhuaZhang, Menghui Liao, Buwei Shao, Yangnan Hu, Yun Liu, Qilin Tang, Lin Xia, XingGuo, Renjie Chai, Transcriptomic profiling of neural stem cell differentiationon graphene substrates. Colloids Surf BBiointerfaces. 2019 Jun 25;182:110324. doi: 10.1016/j.colsurfb.2019.06.054. IF: 4.11

4.     Yuzhi Wang, Xue Lin, Xue Gong, Lele Wu, Jun Zhang,Weiguang Liu, Jian Li, Liming Chen. Atypical GATA transcription factorTRPS1 represses gene expression by recruiting CHD4/NuRD(MTA2) and suppressescell migration and invasion by repressing TP63 expression. Oncogenesis. 2018 Dec 19;7(12):96. doi:10.1038/s41389-018-0108-9. IF: 4.692

5.     Yan Liu, Jian Li (Co-first authors),Zhifang Ma, Jun Zhang, Yuzhi Wang, Zhenghong Yu, Xue Lin, Li An, Huilin Zheng,Shuang Yu, Jingzhong Zhang, Zhi Xu, Liming Chen. Oncogenic functions of ProteinKinase D2 and D3 in regulating multiple cancer-related pathways and breastcancer. Cancer Medicine, 2019, 8:729–741.. IF:3.202

6.    Jing Zuo, Jian Li (Co-first author, co-corresponding author), Rongxin Zhang,Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang,Wei Xie, Institute Collection and Analysis ofNanobodies (iCAN): a comprehensive database and analysis platform fornanobodies. BMC Genomics (2017), 18(1):797. doi:10.1186/s12864-017-4204-6. IF: 3.99

7.    Liu Yan, Jian Li (Co-first authors),Jun Zhang, Zhenghong Yu, Shiyi Yu, Lele Wu, Yuzhi Wang, Xue Gong, Chenxi Wu,Xiuxiu Cai, Lin Mo, Mingya Wang, Jun Gu, Liming Chen. Oncogenic protein kinaseD3 regulating networks in invasive breast cancer. International Journal ofBiological Sciences, 2017, 13(6): 748-758. IF:4.057

8.     Yu Xue,Eric-Wubbo Lameijer, Kai Ye, Kunlin Zhang, Suhua Chang, Xiaoyue Wang, JianminWu, Ge Gao, Fangqing Zhao, Jian Li, Chunsheng Han,Shuhua Xu, Jingfa Xiao, Xuerui Yang, Xiaomin Ying, Xuegong Zhang, Wei-Hua Chen,Yun Liu, Zhang Zhang, Kun Huang, Jun Yu. Precision Medicine: What ChallengesAre We Facing? Genomics Proteomics Bioinformatics 14 (2016) 253–261. IF: 6.615

9.     AndersPatrik Gunnarsson, Rikke Christensen, Jian Li, Uffe Birk Jensen.Global gene expression and comparison between multiple populations in the mouseepidermis. Stem Cell Res. 2016 Jul; 17(1):191-202. IF: 4.956

10.  Anders PatrikGunnarsson,Rikke Christensen,Jian Li, Uffe Birk Jensen,Dataset on gene expression profiling ofmultiple murine hair follicle populations, Data in Brief, 2016, 9, 328-34,PMID: 27672671, PMCID: PMC5030336, DOI:10.1016/j.dib.2016.08.063.

11.  XueLin, Jan Stenvang, Mads Kristoffer Heilskov Rasmussen, Shida Zhu, GuangxiaYang, Kirstine Belling, Claus Lindbjerg Andersen*, Jian Li*, LarsBolund*, Nils Brünner*. The Potential Role of Alu Y in the Development ofResistance to SN38 (Irinotecan) and Oxaliplatin in Colon Cancer. BMC Genomics,2015, 16:404.(*corresponding author). IF: 3.99

12.  XueLin, JianLi (co-first author), Guangling Yin, Qian Zhao, Daniel Elias, AnneLykkesfeldt, Jan Stenvang, Nils Brünner, Jun Wang, Huanming Yang, Lars Bolund,Henrik J. Ditzel: Integrative Analyses of Gene Expression and DNA MethylationProfiles in A Breast Cancer Cell Line Model of Tamoxifen-Resistance Indicate ACrucial Role of Cells with Stem-like Properties. Breast Cancer Res. 2013 Dec19;15(6):R119. IF: 6.142

13.  Jian Li, XueLin, Nils Brunner, Lars Bolund, Huanming Yang: Novel methods in the study ofthe breast cancer genome: towards a better understanding of the breast cancerdisease. Journal of Cancer Therapy, 2012, 3, 797-809. IF: 0.52

14. Jian Li, Kai Wang, Fei Gao, Thomas D Jensen, Shengting Li, PM DeAngelis, SKølvraa, C Proby, O Forslund, Lars Bolund, OPF Clausen (2012): Arraycomparative genomic hybridization of keratoacanthomas and squamous cellcarcinomas: Different patterns of genetic aberrations and different recurrentaberrations suggest two distinct entities. J Invest Dermatol, 2012 Aug;132(8):2060-6. doi:10.1038/jid.2012.104. Epub 2012 Apr 26. IF: 7.216

15. Jian Li, Qian Zhao, Lars Bolund (2011): Computational methods for epigeneticanalysis -the protocol of computational analysis for modifiedmethylation-specific digital karyotyping (MMSDK) based on massively parallelsequencing. Methods Mol Biol, 791:313-28.

16. Steffen Durinck, Christine Ho, Nicholas J.Wang, Wilson Liao, Lakshmi R. Jakkula, Eric A. Collisson, Jennifer Pons,Sai-Wing Chan, Ernest T. Lam, Catherine Chu, Kyunghee Park, Sung-woo Hong, JoeS. Hur, Nam Huh, Isaac M. Neuhaus, Siegrid S. Yu, Roy T. Grekin, Theodora M.Mauro, James E. Cleaver, Pui-Yan Kwok, Philip E. Leboit, Gad Getz, KristianCibulskis, Jon C. Aster, Haiyan Huang, Elizabeth Purdom, Jian Li, LarsBolund, Sarah T. Arron, Joe W. Gray, Paul Spellman, Raymond J. Cho (2011):Temporal dissection of tumorigenesis in primary cancers. Cancer Discovery,1:137. IF: 19.453

17. Fei Gao, Yonglun Luo, Shengting Li, JianLi, Lin Lin, Anders Lade Nielsen, Charlotte Brandt Sørensen, JunWang, Xiuqing Zhang,Yutao Du, Huanming Yang, Lars Bolund (2011): Genome-wide DNA methylation andgene expression differences in liver and muscle of phenotypically normal clonedpigs and naturally bred controls. PLoS ONE, 6(10):e25901. Epub 2011 Oct 11. IF: 3.234

18. Fei Gao, Shengting Li, Lin Lin, JianLi, Yonglun Luo, Xiuqing Zhang, Anders Lade Nielsen, Lars Bolund(2011): DNA methylation in peripheral blood cells of pigs cloned by somaticcell nuclear transfer. Cell Reprogram, 13:307. IF: 1.788

19. Thomas D. Jensen, Jian Li, Kai Wang,Jan Lindebjerg, Steen Kølvraa, Lars Bolund, Anders Jakobsen, Gert B. Petersen,Shengting Li, Dorthe G. Crüger (2011): Identification of chromosome aberrationsin sporadic microsatellite stable and instable colorectal cancers usingarray-based comparative genomic hybridization. Cancer Genetics, 204: 84. IF: 2.417

20. Jian Li, KaiWang, Thomas Dyrso Jensen, Lars Bolund, Carsten Wiuf. (2010): Tumorheterogeneity in neoplasms of breast, colon, and skin. BMC Research Notes,3:321.

21. Kai Wang, Jian Li, ShengtingLi, Lars Bolund, Carsten Wiuf. (2009): Estimation of tumor heterogeneity usingCGH array data. BMC Bioinformatics, 10 (1):12. IF: 2.58

22. Jian Li, FeiGao, Ning Li, Shengting Li, Kai Wang, Geng Tian, Shangang Jia, Guangliang Yin,Xiuqing Zhang, Huanming Yang, Anders Lade Nielsen and Lars Bolund, (2009): Animproved method for genome wide DNA methylation profiling correlated totranscription and genomic instability in two breast cancer cell lines. BMCGenomics, 13; 10:223. IF: 3.99

23. Jian Li, KaiWang, Shengting Li, Vera Timmermans-Wielenga, Fritz Rank, Carsten Wiuf, XiuqingZhang, Huanming Yang and Lars Bolund, (2009): DNA copy number aberrations in breastcancer studied by array comparative genomic hybridization. Genomics, Proteomics& Bioinformatics, 7(1-2): 13-24. IF:6.615

24. Jian Li, PavelGromov, Irina Gromova, José M. Moreira, Vera Timmermans-Wielenga, Fritz Rank,Kai Wang, Shengting Li, Heng Li, Carsten Wiuf, Huanming Yang, Xiuqing Zhang,Lars Bolund and Julio E. Celis, (2008): Omics-based profiling of carcinoma ofthe breast and regional lymph node metastasis. Proteomics, 8: 5038-5052. IF: 4.132

研究方向：生物信息学及系统生物学。主要从事基因组学、肿瘤免疫治疗、使用高性能计算、深度学习与基因组学研究复杂疾病及性状、便携式测序设备数据处理分析。

构建中国人代表性基因组参考序列。构建中国人群HBV病毒感染相关肝癌基因组数据库。研究基因组甲基化与人体健康的相关性，并使用基因组甲基化数据指标预测疾病风险。使用基因组学用于国防项目应用。

发表学术论文情况：主要成果发表于Breast Cancer Research、J Invest Dermatol、Cancer Discovery等著名期刊。目前共发表学术论文24篇。在国际学术会议上发表会议摘要16篇，并多次受邀在学术会议发言。申请发明专利4项，授权软件著作权4项。

担任国际学术期刊的编委和审稿人情况：

在International Journal of Genomics杂志的specialissue“New Advances of Cancer Target Therapy in Genomics Era”担任Lead editor（2016年）；担任American Journal of Bioinformatics的编委；ChineseJournal of Clinician （中华临床医师杂志）的reviewer board成员；Frontiers of Oncology杂志的guest associateeditor；BMC Cancer，BMC Genomics，Journal of Biochimie，Cancer Informatics和Experimental Dermatology等杂志的审稿人。Frontiers inSystems Biology and Bioinformatics杂志编委，《中华生物医学工程杂志》第一届青年编委。

担任国内学术机构职务的情况：

1. 江苏省生物信息学专委会委员，副秘书长

2. 江苏省高性能计算专委会委员

3. 中国人工智能委员会生物信息学与人工生命专委会

4. 中国生物医学工程学会人工智能分会会员

5. 中国细胞学会会员

6. 中国遗传学会高级会员

1. ASC17世界大学生超算竞赛（国际级，一等奖）指导教师

2. ASC18世界大学生超算竞赛（国际级，一等奖）指导教师

3. ASC19世界大学生超算竞赛（国际级，二等奖）指导教师

4. 焦廷标奖教金，2019年

5. 江苏省“双创计划”科技副总

6. 中国产学研合作促进会，2020年产学研合作创新（个人）奖