【黄志海导师】招生“材料科学与工程学院”研究生介绍

更新于 2025-11-22 导师主页
黄志海 副教授 硕士生导师
材料科学与工程学院
材料科学与工程
多功能贵金属基纳米材料,常温液态金属生物医学材料, 仿生/遗态材料及生物矿化,生物材料与组织工程,材料先进加工制备技术
huangzhihai@seu.edu.cn

        生物材料与组织工程专业博士,生物医学工程专业博士后。曾入选首批国家博士后国际交流计划派出项目(2013年);主持完成国家自然科学基金青年项目和面上项目各1项,参与国家自然科学基金项目6项。已在Journalof Materials Chemistry ABiomaterialsBioactive MaterialsNanoscaleSmallAutophagy等SCI期刊发表研究论文30余篇;相关成果被Chemical ReviewsACS NanoBiomaterialsSmallPRLJournal of Materials Chemistry ANanoscaleActa BiomaterialiaACS Applied Materialsand Interface等国际高水平期刊他引1400多次,H-index:18。现阶段研究兴趣主要在贵金属纳米酶及荧光成像、常温液态金属材料及柔性器件、仿生/遗态材料及生物矿化、创面修复材料等领域。

研究兴趣2024

教育经历:

1. 2005.3~2010.6东南大学材料科学与工程学院,生物材料与组织工程专业,工学博士,导师:林萍华教授,董寅生教授

2. 2002.9~2005.3东南大学机械学院/材料科学与工程学院,材料加工工程专业,工学硕士,导师:林萍华教授,董寅生教授

3. 1998.9~2002.6东南大学机械工程系,材料成型及控制工程专业(主修)/工业管理工程专业(辅修),工学学士

工作经历:

1. 2025.11~今,材料学院材料加工工程系,系主任

2. 2020.9~2025.11,材料学院材料加工工程系,副系主任

3. 2019.5~今,东南大学材料科学与工程学院,副教授

4. 2016.12~2022.9,江苏省先进金属材料高技术研究重点实验室,秘书(兼职)

5. 2016.12~2019.4,东南大学材料科学与工程学院,讲师

6. 2014.5~2016.12,密西根大学化学系/东南大学生物科学与医学工程学院,博士后,合作导师:Prof. Zhan Chen,顾宁教授

7. 2010.7~2014.5,东南大学生物科学与医学工程学院,生物医学工程专业,博士后,合作导师:顾宁教授


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科研项目

主持项目:

1. 国家自然科学基金面上项目:Ag@CPPs(细胞穿膜肽)纳米簇的生理微环境稳定性、光致发光及辐照增敏效应研究,60万,项目号:51871055, 2019.1-2022.12

2. 国家自然科学基金青年科学基金项目:医用胶体银的可控连续合成及其在脑胶质瘤放疗中的特殊效应与敏化,25万,项目号:51201034, 2013.1-2015.12

3. 中央高校基本科研业务费-东南大学-南京医科大学合作项目:Ag@CPPs(细胞穿膜肽)纳米胶囊靶向脑胶质瘤放射增敏研究,6万,项目号:2242017K3DN13, 2017.7-2020.6

4. 中央高校基本科研业务费-基础扶持项目:合成银纳米颗粒中纳米棒、线等副产物的电场辅助去除研究,4万,项目号:2242018K40113, 2018.1-2018.12

5. 中央高校基本科研业务费-基础扶持项目:交变电场诱导胶体银形貌转变的研究,4万,项目号:2242017K40193, 2017.1-2017.12

6. 江苏省重点实验室自主研究课题项目:外场辅助聚乳酸骨支架体外矿化研究,10万,2018.11~2020.10

7. 东南大学新进教师科研启动项目:基于微流控技术宏量合成纳米银研究,10万,2019.1~2019.12

8. 人力资源和社会保障部2013年度中国博士后国际交流计划派出项目,30万,2014.5-2016.4

9. 江苏省博士后科研资助计划项目:基于电化学方法连续可控制备高纯度胶体银溶液,2万,项目号:1101008C, 2011.11- 2012.10


参与项目:

1. 国家自然科学基金面上项目:双靶点靶向载药银纳米复合物光热-化疗联合治疗乳腺癌的实验研究,50万,项目号:81771980,2018.1-2021.12,参与东南大学医学院合作

2. 国家自然科学基金面上项目:新型靶向探针GMT8-Ag@Au的构建及其在脑胶质瘤CT成像和辐射增敏一体化中的实验研究,67.2万,项目号:81571805, 2016.1-2019.12,参与东南大学医学院合作

3. 国家自然科学基金面上项目:纳米银体内外动力学和生物毒物动力学模型(PBTK)研究,68.4万,项目号:81573186, 2016.1-2019.12,参与东南大学公共卫生学院合作

4. 国家自然科学基金面上项目:新型靶向纳米药物Angio-Ag-NRPMAb的制备及其抑制胶质瘤的机制研究,72万,项目号:81471780, 2015.1-2018.12,参与东南大学附属中大医院合作

5. 国家自然科学基金青年科学基金项目:常用金属纳米材料的毒性效应及定量构效关系(QSAR)研究,23万,项目号:81302461, 2014.1-2016.12,参与东南大学公共卫生学院合作

6. 国家自然科学基金海外及港澳学者合作研究基金项目:基于氮化铝镓/氮化镓场效应的细胞电生理传感研究,20万,项目号:61328104,2014/01-2015/12


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研究成果

期刊论文:

1.      Lu Zhang, Xin Zhang, Jianwei Dai, Juyi Yang, JingBai, Zhihai Huang, Chao Guo,Feng Xue, Linyuan Han, Chenglin Chu. Effects of different magnitudes of staticstress on the in vitro corrosion behavior of biodegradable zinc[J]. Corrosion Science, 2024, 227: 111763

2.      Yanbin Zhao, Peng He, Junyan Yao, Mei Li, Bin Wang,Linyuan Han, Zhihai Huang,Chao Guo, Jing Bai, Feng Xue, Yu Cong, Weihua Cai, Paul K. Chu, Chenglin Chu. pH/NIR-responsiveand self-healing coatings with bacteria killing, osteogenesis, and angiogenesisperformances on magnesium alloy[J]. Biomaterials, 2023, 301: 122237

3.      Xin Zhang, Lu Zhang, Dekang Zhang, Linyuan Han,Jing Bai, Zhihai Huang, ChaoGuo, Feng Xue, Paul K. Chu, Chenglin Chu. Effects of bovine serum albumin onthe corrosion behavior of biodegradable Zn-Cu alloy under dynamic flowingconditions[J]. Materials Chemistry and Physics, 2023, 304: 127838

4.      Shanyun Sun, Lei Gao, Zhihai Huang, Chao Guo, Chenglin Chu, Yinsheng Dong. Novel polylacticacid porous scaffold reinforced with oriented magnesium wires for potentialbone repair application[J]. Materials Today Communications,2023, 36: 106643

5.      Shanyun Sun, Lei Gao, Bin Liang, Zhaowei Yin,Shaowei Pan, Chen Shi, Chao Guo, ZhihaiHuang, Chenglin Chu, Yinsheng Dong. Long-term and uniform release ofmagnesium ions from PLA porous composite materials oriently reinforced by Mgwires for potential bone repair application[J]. Surfaces and Interfaces,2023, 40: 103018

6.      Linyuan Han, Zhenwei Zhang, Jianwei Dai, Xuan Li,Jing Bai, Zhihai Huang, ChaoGuo, Feng Xue, Chenglin Chu. In vitro bio-corrosion behaviors of biodegradableAZ31B magnesium alloy under static stresses of different forms and magnitudes[J].Journalof Magnesium and Alloys, 2023, 11(3): 1043-1056

7.      Lu Zhang, Xin Zhang, Jiaer Chen, Jianwei Dai,Jing Bai, Zhihai Huang, Chao Guo, FengXue, Linyuan Han, Chenglin Chu. Effects of different concentrations of BSA on invitro corrosion behavior of pure zinc in artificial plasma[J]. ACSBiomaterials Science and Engineering, 2022, 8(10): 4365-4376

8.      Linyuan Han, Zhenwei Zhang, Jianwei Dai, Xuan Li,Jing Bai, Zhihai Huang, ChaoGuo, Feng Xue, Chenglin Chu. The influence of alternating cyclic dynamic loadswith different low frequencies on the bio-corrosion behaviors of AZ31Bmagnesium alloy in vitro[J]. Bioactive Materials, 2022, 7:263-274

9.      Jinglong Feng, ZhihaiHuang, Yinsheng Dong. Preparation of ice microspheres and theirapplication in the preparation of porous poly(L-lactic acid) (PLLA)scaffolds[J]. Journal of Materials Science, 2019, 54(4): 3661-3670

10.   Jinglong Feng, ZhihaiHuang, Yinsheng Dong. Effect of mixed solvents on the thermalproperties of poly(L-lactic acid) (PLLA) solution and micromorphology of porousPLLA scaffolds[J]. Materials Research Express, 2019, 015314

11.   Xulong An, Hui Zhao, Ting Dai, Hongguang Yu, Zhihai Huang, Chao Guo, Paul K.Chu, Chenglin Chu. Effects of heat treatment on the microstructure andproperties of cold-forged CoNiFe medium entropy alloy[J]. Intermetallics, 2019,110: 106477

12.   Xulong An, Hui Zhao, Chenglin Chu, Ting Dai, TaoLu, Zhihai Huang, Chao Guo,Paul K Chu. Hall-Petch relationship and corrosion behavior of cold-rolledCoNiFe medium entropy alloy[J]. Journal of Alloys and Compounds,2019, 807: 151698

13.   Jun Lin, Yiming Liu, HaoWu, Zhihai Huang, Jingfan Ma, Chang Guo, Feng Gao, Peipei Jin,Pengfei Wei, Yunjiao Zhang, Liu Liu, Rui Zhang, Longxin Qiu, Ning Gu, LongpingWen. Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-InducedCytoprotective Autophagy[J]. Small,2018, 13(14): 1703711(1-10)

14.   Lingying Zhu, Dawei Guo (co-first author), LiliSun, Zhihai Huang, XiuyanZhang, Wenjuan Ma, Jie Wu, Lu Xiao, Yun Zhao, Ning Gu. Activation of autophagy by elevated reactive oxygen species rather thanreleased silver ions promotes cytotoxicity of polyvinylpyrrolidone-coatedsilver nanoparticles in hematopoietic cells[J]. Nanoscale, 2017, 9(17): 5489-5498

15.   Qi Ding, Dongfang Liu, Dawei Guo, Fang Yang, XingyunPang, Renchao Che, Naizhen Zhou, Jun Xie, Jianfei Sun, Zhihai Huang, Ning Gu. Shape-controlled fabrication of magnetitesilver hybrid nanoparticles with high performance magnetic hyperthermia[J]. Biomaterials,2017, 124: 35-46

16.   Hao Wu, Jun Lin, Peidang Liu, Zhihai Huang, Peng Zhao, Haizhen Jin, Jun Ma, Longping Wen,Ning Gu. Reactive oxygen species acts as executor in radiation enhancement andautophagy inducing by AgNPs[J]. Biomaterials, 2016, 101: 1-9

17.   Zhihai Huang, Hao Jiang, Peidang Liu, Jianfei Sun, Dawei Guo, Jieling Shan, Ning Gu.Continuous synthesis of size-tunable silver nanoparticles by green electrolysismethod and multi-electrode design for high yield[J]. Journal of Materials Chemistry A,2015, 3: 1925-1929

18.   Hao Wu, Jun Lin, Peidang Liu, Zhihai Huang, Peng Zhao, Haizhen Jin, Cailian Wang, LongpingWen, Ning Gu. Is the autophagy a friend or foe in the silver nanoparticlesassociated radiotherapy for glioma?[J]. Biomaterials, 2015, 62: 47-57

19.   Dawei Guo, Dandan Dou, Lin Ge, Zhihai Huang, Liping Wang, Ning Gu. A caffeic acid mediatedfacile synthesis of silver nanoparticles with powerful anti-cancer activity[J].Colloidsand Surfaces B: Biointerfaces, 2015,134: 229-234

20.   Dawei Guo, Junren Zhang, Zhihai Huang, Shanxiang Jiang, Ning Gu. Colloidal silvernanoparticles improves anti-leukemic drug efficacy via amplification ofoxidative stress[J]. Colloids and Surfaces B: Biointerfaces, 2015, 126: 198-203

21.   Jun Lin, ZhihaiHuang, Hao Wu, Wei Zhou, Peipei Jin, Pengfei Wei, Yunjiao Zhang, FangZheng, Jiqian Zhang, Jing Xu, Yi Hu, Yanhong Wang, Yajuan Li, Ning Gu, LongpingWen. Inhibition of autophagy enhances the anticancer activity of silvernanoparticles[J]. Autophagy, 2014, 10(11): 2006-2020

22.   Dawei Guo, Yun Zhao, Yu Zhang, Qing Wang, Zhihai Huang, Qi Ding, ZhiruiGuo, Xuefeng Zhou, Lingying Zhu, Ning Gu, The Cellular Uptake and CytotoxicEffect of silver Nanoparticles on Chronic Myeloid Leukemia Cells[J]. Journalof Biomedical Nanotechnology, 2014, 10(4): 669-678

23.   Peidang Liu, ZhihaiHuang (co-first author), Zhongwen Chen, Ruizhi Xu, Hao Wu, FengchaoZang, Cailian Wang, Ning Gu. Silver nanoparticles: a novel radiation sensitizerfor glioma?[J]. Nanoscale, 2013, 5: 11829-11836

24.   Zhihai Huang, Qing Wang, Zhirui Guo, Lina Xu, Dongfang Liu, Qi Ding, Ning Gu. Rapidsynthesis of high-stable silver nanoparticles by electrochemical method[J]. Nanoscience and Nanotechnology Letters, 2013, 5(2): 232-236

25.   Dawei Guo, Lingying Zhu, Zhihai Huang, Haixia Zhou, Yue Ge, Wenjuan Ma, Jie Wu,Xiuyan Zhang, Xuefeng Zhou, Yu Zhang, Yun Zhao, Ning Gu. Anti-leukemia activityof PVP-coated silver nanoparticles via generation of reactive oxygen speciesand release of silver ions[J]. Biomaterials, 2013, 34(32):7884-7894

26.   Peidang Liu, ZhihaiHuang, Ning Gu. Exposure to silver nanoparticles does not affectcognitive outcome or hippocampal neurogenesis in adult mice[J]. Ecotoxicologyand Environmental Safety, 2013, 87: 124-130

27.   Jun Dou, Xiangfeng He (co-first author), YunjingLiu (co-first author), Zhihai Huang,Cuiping Yang, Fangfang Shi, Dengyu Chen, Ning Gu. Targeted therapeutic effectof anti-ABCG2 antibody combined with nano silver and vincristine on mousemyeloma cancer stem cells[J]. Journal of Nanoparticle Research,2013, 15: 2127-2141

28.   Dawei Guo, Xiuyan Zhang (co-first author), Zhihai Huang, Xuefeng Zhou, Lingying Zhu, Yun Zhao, Ning Gu. Comparison ofcellular responses across multiple passage numbers in Ba/F3-BCR-ABL cellsinduced by silver nanoparticles[J]. Science China (Life Sciences), 2012,55(10), 898-905

29.   Zhihai Huang, Xiaoli Jiang, Dawei Guo, Ning Gu. Controllable synthesis and biomedicalapplications of silver nanomaterials[J]. Journal of Nanoscience and Nanotechnology,2011, 11: 9395-9408

30.   Zhihai Huang, Yinsheng Dong, Pinghua Lin. Depositing an Apatite Coating in/on MassiveChitosan Porous Scaffolds by an Alternate Soaking Method[J]. ActaPhysico-Chimica Sinica, 2009, 25(7): 1285-1289 (in Chinese)

31.   Zhihai Huang,Jihong Li, Pinghua Lin, Yinsheng Dong, Chao Guo,Xiaobo Sheng, Chenglin Chu. Electrochemistry assisted depositing hydroxyapatitecoating in chitosan porous scaffold[J]. Acta Polymerica Sinica, 2009, (3): 273-277 (in Chinese)

32.   Zhihai Huang, Yinsheng Dong, Chenglin Chu, Pinghua Lin. Electrochemistry assistedreacting deposition of hydroxyapatite in porous chitosan scaffolds[J]. MaterialsLetters, 2008, 62(19): 3376-3378

33.   Zhihai Huang, Lei Yang, Yinsheng Dong, Pinghua Lin. Fabrication of chitosan sponge asdressings by phase separation-extraction method[J]. The Chinese Journal of NonferrousMetals, 2007, 17(s1): 268-274 (in Chinese)

34.   Zhihai Huang, Yinsheng Dong, Chao Guo, Pinghua Lin. Study of freeze-drying process ofnatural polymer porous scaffolds[J]. Journal of China Biotechnology,2004, 24(11): 76-79 (in Chinese)

35.   Zhihai Huang, Yinsheng Dong, Chao Guo, Pinghua Lin. Study on fabrication of porouschitosan-collagen scaffolds[J]. Chemical Industry Times, 2004,18(10): 36-39 (in Chinese)

授权专利:

1.       储成林,吴嫦青,李旋,白晶,薛烽,郭超,黄志海. 一种双层膜固态磷酸根离子选择电极及其制备方法[P].中国发明专利,ZL202110457125.7. 2023-10-27

2.       董寅生,余亮,徐雨生,黄志海,郭超,储成林,盛晓波. 一种铝锌磷酸盐涂料及使用方法[P].中国发明专利,ZL202110458255.2. 2022-11-01

3.       储成林,赵延斌,郭超,黄志海,白晶,薛烽. 一种能自愈合和促骨生长的热敏响应性可吸收骨科器械材料及其制备方法[P].中国发明专利,ZL202110463753.6. 2022-09-23

4.       董寅生,占韵,郭超,黄志海,储成林,盛晓波. 一种具有良好可注射性的磷酸钙骨水泥及其制备方法[P]. ZL202110463584.6. 2022-03-08

5.       董寅生,王德洋,余亮,郭超,黄志海,储成林,盛晓波. 一种在铸造铝合金表面制造耐腐蚀防护层的复合处理工艺[P]. 中国发明专利,ZL202010396598.6. 2021-10-19

6.       盛晓波,张鹏,王晶晶,董寅生,储成林,郭超,黄志海.一种用聚乙二醇改善铸造用水玻璃流动性的方法[P]. 中国发明专利,ZL201910310254.6. 2021-10-19

7.       董寅生,孙善云,黄志海,郭超,储成林,盛晓波.一种可降解金属丝定向增强聚乳酸多孔骨修复材料及其制备方法[P]. 中国发明专利,ZL201910875344.X. 2021-10-19

8.       董寅生,孙善云,黄志海,郭超,储成林,盛晓波.一种骨水泥定向增强聚乳酸多孔骨修复材料及其制备方法[P]. 中国发明专利,ZL201910875683.8. 2021-10-19

9.       郭超,库勇昌,林萍华,董寅生,储成林,盛晓波,黄志海.一种纳米银、纳米氧化锌双相沉积掺锌纳米羟基磷灰石的制备方法及其所得材料[P]. 中国发明专利,ZL201810376830.2. 2021-08-10

10.    盛晓波,王晶晶,张鹏,董寅生,储成林,郭超,黄志海.一种用聚醚胺改善铸造用水玻璃性能的方法[P]. 中国发明专利,ZL201910310255.0. 2021-04-16

11.    董寅生,朱文杰,柯瑞,盛晓波,郭超,黄志海,储成林.一种利用木质材料制备的水溶性陶瓷型芯及其制备方法[P]. 中国发明专利,ZL201810244521.X. 2021-01-26

12.    董寅生,肖夫兰,耿银雪,郭超,黄志海,储成林,盛晓波.用于磷酸钙骨水泥的含钙化合物添加剂的合成方法[P].中国发明专利,ZL201710256324.5. 2019-9-10

13.    董寅生,肖夫兰,耿银雪,郭超,黄志海,储成林,盛晓波.一种用作生物材料的钙盐混合物制备方法[P].中国发明专利,ZL201710256366.9. 2019-5-31

14.    董寅生,王家凯,张成明,黄志海,郭超,盛晓波.一种铸造铝合金型内氧化处理用涂料及利用其制备表面氧化层的方法[P]. 中国发明专利,ZL201710256406.X. 2019-04-30

15.    董寅生,孙善云,刘新来,任彦军,黄志海,郭超. 一种用于铸造铝合金表面制备复合涂层的涂料及使用方法[P].中国发明专利,ZL201710344063.2. 2019-03-29

16.    董寅生,黄志海,盛晓波,储成林,郭超,林萍华,浦跃朴.胶原-羟基磷灰石复合球形颗粒的制备方法 [P].中国发明专利,ZL200810235064.4;2013-4-3

17.    董寅生,黄志海,盛晓波,储成林,郭超,林萍华,浦跃朴.胶原-β-磷酸三钙复合球形颗粒的制备方法[P].中国发明专利,ZL200810235061.0. 2012-10-24

18.    董寅生,林萍华,浦跃朴,郭超,黄志海,黄拙.聚合物多孔材料的冷冻干燥装置[P].中国发明专利,ZL03152860.0. 2005-11-23

19.    董寅生,林萍华,浦跃朴,郭超,黄志海,黄拙.对流式真空冷冻干燥装置 [P].中国发明专利,ZL03152861.9.2005-9-14

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