【姚兵导师】招生“医学院”研究生介绍

更新于 2023-11-21 导师主页
姚兵 主任医师 硕，博士生导师
男
医学院
外科学 ,妇产科学
代谢与配子发生
yaobing@nju.edu.cn

姚兵，解放军东部战区总医院生殖医学科主任、主任医师、东南大学医学院教授、博士研究生导师。生殖医学国家重点实验室研究员。长期从事不孕不育症的临床治疗和科研攻关，围绕无、少、弱精子症、卵子老化、卵巢储备功能下降、卵巢早衰、辅助生殖技术对早期胚胎安全性评估、男性性功能障碍等领域进行了多方面临床和基础研究。是“江苏省科教兴卫工程”和“科教强卫工程”的重点培养人才。兼任江苏省医师协会生殖医学分会主任委员、全军计划生育优生优育专业委员会常委等职。以第一贡献者获国家教育部科技进步二等奖和军队科技进步二等奖等7项次。以共同发明人获国家专利14项次。承担国家重大研究专项、江苏省重点研发计划，国家自然科学基金，江苏省自然科学基金等各类课题十余项次，累计科研经费一千余万元。以第一作者或通讯作者在PNAS、GUT、Redox Biol、Aging Cell等国际著名杂志发表SCI论文70余篇, 出版专著6部。是《Asian  Journal  Andrology》杂志的编委。第四批“国之名医-优秀风范”获得者。


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科研项目

“脂代谢异常通过细胞互作干扰生精微环境抑制精子发生的机制研究”国家自然科学基金区域基金项目（U22A20277），研究期限2023.01~ 2026.12，本人可支配经费：102万

“脂代谢异常通过干扰生精微环境细胞相互作用导致生精障碍的机制研究”南京医科大学生殖医学国家重点实验室自主研究课题（重大项目）（SKLRM-2022D3），研究期限2022.11~ 2024.11，资助经费100万元。课题负责人

 “长链非编码RNA TUG1调节睾丸支持细胞功能及作用机制研究”国家自然科学基金面上项目(81971373)，研究期限2020.01~ 2023.12，资助经费：55万。课题负责人

 “长链非编码RNA TUG1调节睾丸支持细胞功能及作用机制研究” 江苏省“333第二层次人才培养工程” (BRA2019109) 研究期限：2020.1~2021.12，资助经费：25万。课题负责人

“基于代谢偶联的生殖细胞发生障碍研究与生育力重塑”国家重点研发计划(2018YFC1004700)，研究期限：2018.12~2021. 12，资助经费：1712万元。课题一经费446万，本人可支配经费为155万。子课题负责人


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研究成果

  1. Jueraitetibaike K*, Tang T*, Ma R*, Zhao S*, Wu R, Yang Y, Huang X, Cheng X, Zhou C, Zhang H, Zheng L, Ge X, Chen L#, Yao B#. MiR-425-5p suppression of Crebzf regulates oocyte aging via chromatin modification. Geroscience. 2023 Aug 3.
  2. Zhang H*, Zheng L*, Li C*, Jing J*, Li Z, Sun S, Xue T, Zhang K, Xue M, Cao C, Ouyang L, Qian Z, Xu R, He Z, Ma R#, Chen L#, Yao B#. Effects of gut microbiota on omega-3-mediated ovary and metabolic benefits in polycystic ovary syndrome mice. J Ovarian Res. 2023 Jul 14;16(1):138.
  3. Ma R*, Wang S*, Xue M*, Zhang H, He Z, Jueraitetibaike K, Ge X, Chen L, Yao B. Effects of n-3 PUFA supplementation on oocyte in vitro maturation in mice with polycystic ovary syndrome. J Ovarian Res. 2023 Apr 29;16(1):87. doi: 10.1186/s13048-023-01162-w. PMID: 37120599; PMCID: PMC10148539.
  4.  Qian Z*, Li C*, Zhao W*, He Z, Xue M, Wang S, Cheng X, Ma R#, Ge X#. Chronic oral exposure to short chain chlorinated paraffins induced testicular toxicity by promoting NRF2-mediated oxidative stress. Toxicol Lett. 2023 Mar 1;376:1-12. doi: 10.1016/j.toxlet.2023.01.004. Epub 2023 Jan 13. PMID: 36642205.
  5.  Qian Z*, Li C*, Zhao S*, Zhang H, Ma R, Ge X, Jing J, Chen L, Ma J, Yang Y, Zheng L, Zhang K, He Z, Xue M, Lin Y, Jueraitetibaike K, Feng Y, Cao C, Tang T, Sun S, Teng H, Zhao W#, Yao B#. Age-related elevation of O-GlcNAc causes meiotic arrest in male mice. Cell Death Discov. 2023 May 15;9(1):163. doi: 10.1038/s41420-023-01433-x. PMID: 37188682; PMCID: PMC10185674.
  6. Xue T*, Zhao S*, Zhang H*, Tang T*, Zheng L, Jing J, Ge X, Ma R, Ma J, Ren X, Jueraitetibaike K, Guo Z, Chen L#, Yao B#. PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism. iScience. 2023 Feb 3;26(3):106131. doi: 10.1016/j.isci.2023.106131. PMID: 36879822; PMCID: PMC9984558.
  7. Ge X, He Z, Cao C, Xue T, Jing J, Ma R, Zhao W, Liu L, Jueraitetibaike K, Ma J, Feng Y, Qian Z, Zou Z, Chen L, Fu C, Song N, Yao B.Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress.Redox Biol. 2022 Aug;54:102380. doi: 10.1016/j.redox.2022.102380. Epub 2022 Jul 2. Q1/Q1  11.4
  8.  Liang G, Zhu X, Zhang Z, Chen L, Feng H, Zhan S, Hu H, Yu R, Zhang CY, Feng Z, Yao B, Wang Y, Chen X.microRNAs in aged sperm confer psychiatric symptoms to offspring through causing the dysfunction of estradiol signaling in early embryos.Cell Discov. 2022 Jul 5;8(1):63. doi: 10.1038/s41421-022-00414-1. Q1/Q1 33.5
  9. Zhao W, Sun J, Yao LY, Hang D, Li YQ, Chen CP, Zhou YW, Chen X, Tao T, Wei LS, Zheng YY, Ge X, Li CJ, Xin ZC, Pan Y, Wang XZ, He WQ, Zhang XN, Yao B, Zhu MS.MYPT1 reduction is a pathogenic factor of erectile dysfunction.Commun Biol. 2022 Jul 25;5(1):744. doi: 10.1038/s42003-022-03716-y. Q2Q1/ 5.9
  10. Cao, S.*, Qian, Z.*, Wu, R.*, Sun, S., Jing, J., Zhang, G., Chen, W., Ge, Y., Ma, J., Wang, S., Ouyang, L., Xue, T., Wang, D., Zhao, S., Liang, K., Ge, X., Lin, Y., Chen, L., and Yao, B#. (2022) SERPINA5 Protein in Cumulus-Oocyte Complexes Increases the Fertilisation Ability of Mouse Sperm. Reprod Sci , 2022 Feb 22. doi: 10.1007/s43032-022-00867-5. Q3/Q3 2.9
  11.  Wang, S.*, Qian, Z.*, Ge, X., Li, C., Xue, M., Liang, K., Ma, R., Ouyang, L., Zheng, L., Jing, J., Cao, S., Zhang, Y., Yang, Y., Chen, Y., Ma, J.#, and Yao, B#. (2022) LncRNA Tug1 maintains blood-testis barrier integrity by modulating Ccl2 expression in high-fat diet mice. Cellular and molecular life sciences :2022 Feb 1;79(2):114  Q2/Q1 8
  12. Chen L, Li W, Liu Y, Peng Z, Cai L, Zhang N, Xu J, Wang L, Teng X, Yao Y, Zou Y, Ma M, Liu J, Lu S, Sun H, Yao B. Non-invasive embryo selection strategy for clinical IVF to avoid wastage of potentially competent embryos.Reprod Biomed Online. 2022 Jul;45(1):26-34. doi: 10.1016/j.rbmo.2022.03.006. Epub 2022 Mar 11. Q3 4.0
  13. Zheng L, Ma J, Yao B.MicroRNAs in aging male reproduction.Aging (Albany NY). 2022 Apr 5;14(7):2928-2929. doi: 10.18632/aging.204003. Epub 2022 Apr 5. Q3 5.2
  14. Liang K, Yao L, Wang S, Zheng L, Qian Z, Ge Y, Chen L, Cheng X, Ma R, Li C, Jing J, Yang Y, Yu W, Xue T, Chen Q, Cao S, Ma J, Yao B. miR-125a-5p increases cellular DNA damage of aging males and perturbs stage-specific embryo development via Rbm38-p53 signaling.Aging Cell. 2021 Dec;20(12):e13508.  Q1/Q1 11.002
  15. Wang D, Jueraitetibaike K, Tang T, Wang Y, Jing J, Xue T, Ma J, Cao S, Lin Y, Li X, Ma R, Chen X, Yao B. Seminal Plasma and Seminal Plasma Exosomes of Aged Male Mice Affect Early Embryo Implantation via Immunomodulation. Front Immunol. 2021 Oct 12;12:723409. doi: 10.3389/fimmu.2021.723409. eCollection 2021. Q1   8.786
  16. Cheng X, Zhang Y, Ma J, Wang S, Ma R, Ge X, Zhao W, Xue T, Chen L, Yao B. NLRP3 promotes endometrial receptivity by inducing epithelial-mesenchymal transition of the endometrial epithelium. Mol Hum Reprod. 2021 Nov 2;27(11):gaab056. doi: 10.1093/molehr/gaab056. Q1 4.518
  17. Chen L, Sun Q, Xu J, Fu H, Liu Y, Yao Y, Lu S, Yao B. A Non-invasive Chromosome Screening Strategy for Prioritizing in vitro Fertilization Embryos for Implantation. Front Cell Dev Biol. 2021 Aug 9;9:708322. (通讯作者) 影响因子：6.684
  18. Chen L, Huang X, Wang L, Wang C, Tang X, Gu M, Jing J, Ma R, Ge X, Yao B. Electroacupuncture Reduces Oocyte Number and Maintains Vascular Barrier Against Ovarian Hyperstimulation Syndrome by Regulating CD200. Front Cell Dev Biol. 2021 Feb 22;9:648578. (通讯作者) 影响因子：6.684 Q1
  19. Wang S, Chen Q, Zhang Y, Zheng F, Xue T, Ge X, Ma R, Li X, Wu R, Liang K, Qian Z, Ge Y, Ma J, Yao B. Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice. Reprod Toxicol. 2020 Dec;98:233-241. (通讯作者) 影响因子：3.143  Q2
  20. Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B. Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells. Cell Death Dis. 2020 Aug 14;11(8):626. (通讯作者) 影响因子：6.304 Q1
  21.  Zhao W, Jing J, Shao Y, Zeng R, Wang C, Yao B, Hang D. Circulating sex hormone levels in relation to male sperm quality. BMC Urol. 2020 Jul 17;20(1):101. (共同通讯作者) 影响因子：1.592
  22. Ma J, Chen Q, Wang S, Ma R, Jing J, Yang Y, Feng Y, Zou Z, Zhang Y, Ge X, Xue T, Liang K, Cao S, Wang D, Chen L, Yao B. Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males. Aging (Albany NY). 2020 May 7;12(9):8321-8338. (通讯作者) 影响因子：4.831
  23. Huang WJ, Zhang D, Hong ZW, Chen ZB, Dong LH, Zhang Y, Chen GY, Liu Y, Yao B. Sequential interval micro-droplet loading in closed hemi-straw carrier system: A convenient and efficient method for ultra-rapid cryopreservation in extreme oligozoospermia. Cryobiology. 2020 Feb 10. pii: S0011-2240(19)30234-2. (通讯作者)影响因子： 2.141
  24. Fan K, Cheng X, Guo W, Liu X, Zhang Z, Yao Q, Nie D, Yao B, Han Z. Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China. Mycotoxin Res. 2020 Feb 3. doi: 10.1007/s12550-020-00387-8. (共同通讯作者)影响因子：3.741
  25. Ding N, Zhang X, Zhang X, Jing J, Liu S, Mu Y, Peng L, Yan Y, Xiao G, Bi X, Chen H, Li F, Yao B, Zhao A. Impairment of spermatogenesis and motility by the high-fat diet induced dysbiosis of gut microbes. Gut. 2020 Jan 2. pii: gutjnl-2019-319127.  doi: 10.1136/gutjnl-2019-319127.  (共同通讯作者)影响因子：19.819
  26. Zhao W, Wang P, He W, Tao T, Li H, Li Y, Jiang W, Sun J, Ge X, Chen X, Zheng Y, Wei L, Chen C, Wang Y, Li C , Chen H , Yao B , Tang W , Zhu M . MYPT1 Down-regulation by LPS-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease. Cell Mol Gastroenterol Hepatol. 2020;9( 2):345-347.e6.  (共同通讯作者) 影响因子：7.076


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