【周雯导师】招生“化学化工学院”研究生介绍
周雯
副研究员
硕士生导师
女
化学化工学院
化学
化学生物学,药物化学
wzhou@seu.edu.cn
周雯，女，硕士生导师
主要从事化学生物学与药物化学学科领域内心血管药物的设计、生物活性评价以及药理研究
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科研项目
主持科研基金项目：1.国家自然科学基金：缺氧促发型碳酸酐酶9抑制剂的设计合成及其抗心肌缺氧损伤研究，22207016，30万，2023.1–2025.12.
2.江苏省自然科学基金：线粒体靶向性琥珀酸脱氢酶抑制剂的分子设计与抗心肌缺血再灌注损伤研究，BK20180570，20万，2018.7–2021.12.
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研究成果
1. Wanxing Yang#, Wen Zhou#, Shaohua Gou*. Hypoxia Activated Nitric Oxide Donor Compounds for the Prevention and Treatment of Myocardial Hypoxia-Induced Injury. Journal of Medicinal Chemistry, 2025, 68, 491.
2. Wen Zhou, Wanxing Yang, Ping Jiang, Shaohua Gou*. A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough, Journal of Medicinal Chemistry, 2024, 67, 16899.
3. Wen Zhou, Ping Jiang, Chunping Wang, Shaohua Gou*. Discovery of the Synergy between Sulindac and NO Expands the Application of NSAIDs in Cardiac Complications, Bioorganic & Medicinal Chemistry, 2024, 116, 117991.
4. 周 雯，江 萍，杨万祥，苟少华*。基于协同分析设计的阿司匹林衍生物在抗冠心病缺氧损伤中的应用研究，药学学报，2024，59，2800。
5. 一种以阿司匹林或其缺氧促发型衍生物为配体的镁配合物、制备方法及应用。周雯，江萍，杨万祥，苟少华。202410734714.9，2024.09. （发明专利）
6. Wanxing Yang#, Wen Zhou#, Shaohua Gou*. Discovery of Efficient Hypoxia-Targeted NO Donor Compounds to Alleviate Hypoxia Cardiac Disease. Journal of Medicinal Chemistry, 2023, 66, 15977.
7. Wen Zhou, Chunping Wang, Bin Zhang, Shaohua Gou*. Hybrids of Carbonic Anhydrase and Cyclooxygenase Inhibitors Attenuate Cardiac Hypoxic Inflammatory Injuries. European Journal of Pharmacology, 2023, 950, 175751.
8. Wen Zhou, Wanxiang Yang, Keyu Fan, Wuyang Hua and Shaohua Gou*. A Hypoxia-Activated NO Donor for the Treatment of Myocardial Hypoxia Injury. Chemical Science, 2022, 13, 3549.
9. Wen Zhou, Chunping Wang, Zhikun Liu, Shaohua Gou*. Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia. Journal of Medicinal Chemistry, 2022, 65, 13436.
10. Wen Zhou, Keyu Fan, Xiaojian Yin, Yuxuan Wang, Shaohua Gou*. A Tanshinone IIA Derivative Designed to Target Mitochondria Inhibit Myocardial Ischemia/Reperfusion Injury in vivo in a GUF1 Dependent-Pathway. Pharmacological Research–Modern Chinese Medicine. 2022, 2, 100066.
11. Bin Zhang#, Zichen Xu#, Wen Zhou, Zhikun Liu, Jian Zhao, Shaohua Gou*. A Light-Controlled Multi-Step Drug Release Nanosystem Targeting Tumor Hypoxia for Synergistic Cancer Therapy. Chemical Science. 2021, 12, 11810.
12. Wen Zhou, Bin Zhang, Keyu Fan, Xiaojian Yin, jinfeng Liu, Shaohua Gou*. An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection. Cardiovascular Drugs and Therapy. 2021, 36, 605.
13. 乙酰唑胺衍生物及其制备方法和在制备治疗冠心病药物中的应用。苟少华，周雯，张斌。CN111961043A，2020.11.（发明专利）
14. Fei Wang, Qingqing Peng, Jingfeng Liu, R.N. Alolga, Wen Zhou*. A Novel Ferulic Acid Derivative Attenuates Myocardial Cell Hypoxia Reoxygenation Injury through a Succinate Dehydrogenase Dependent Antioxidant Mechanism. European Journal of Pharmacology, 2019, 856, 172417.
15. Yunpeng Zhao, Fei Wang, Wei Jiang, Jinfeng Liu, Baolin Liu, Lianwen Qi, Wen Zhou*. A Mitochondrion-Targeting Tanshinone IIA Derivative Attenuates Myocardial Hypoxia Reoxygenation Injury through a SDH-Dependent Antioxidant Mechanism. Journal of Drug Targeting, 2019, 11, 1.
16. Lanzhu Li, Guoxiu Zhou, Jia Li, Wei Jiang, Baolin Liu, Wen Zhou*. Compounds Containing Trace Element Copper or Zinc Exhibit as Potent Hyperuricemia Inhibitors via Xanthine Oxidase Inactivation. Journal of Trace Elements in Medicine and Biology, 2018, 49, 72.
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