【李新松导师】招生“化学化工学院”研究生介绍

更新于 2022-03-23 导师主页
李新松 教授 博士生导师
化学化工学院
化学
生物材料,药物控释,核酸药物
lixs@seu.edu.cn
李新松 博士,东南大学二级教授,1992年毕业于南开大学,获高分子化学与物理专业博士学位;1992-1995年在北京大学从事博士后研究;1995-1997年在青岛大学工作;1997年至今在东南大学工作,2001年任教授;2007年5-11月在哈佛大学医学院开展基因治疗研究(华英学者)。

2001年创建生物材料和药物释放实验室(Biomaterials and Drug Delivery Laboratory)。2006年初创建东大-海昌(生物材料)研发中心。研究兴趣:高分子生物材料,药物释放系统,核酸药物。

承担国家“重大新药创制”科技重大专项,国家自然科学基金,“863”高技术项目,江苏省高技术研究,省重大科技成果转化基金,省产学研联合创新前瞻性研究基金,国际合作(企业)等研究项目共 26项。其中,政府资助15项,企业资助11项。发表学术论文130篇,获中国发明专利授权 26多项,多次应邀在海内外学术会议和研究机构作邀请报告。研究成果获“2009年度江苏省科学技术进步奖”二等奖(第1)、“2006年度江苏省科学技术进步奖”二等奖(第3)。

开发并成功转让一种医用可吸收高分子纳米纤维生物材料技术,2004年协助企业获得三类医疗器械生产许可注册证,产品进入临床医疗市场,大规模应用于各大医院外科、骨科、妇产科、整形外科,14年来取得巨大的经济效益,单品种年销售额超亿元,同时取得显著的社会效益。


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科研项目

1. 国家重大新药创制科技重大专项,2017ZX09101002-001-004,双氢青蒿素二倍体衍生物高效抗疟创新药物的研究, 2017-2021,436.64万元,项目负责人,结题2021.6.30

2. 江苏省重大科技成果转化基金,BA2017089,系列高精度成套高档功能膜制膜设备的研发及产业化(江苏省科技厅),2017-2020,校企合作,校方负责

3. 江苏省重大科技成果转化基金BA2013037,中空纤维超滤膜及其系统的研发与产业化(江苏省科技厅),2013-2015,企业合作,校方负责

4. 前瞻性联合研究项目,BY2015070-11,中空纤维过滤膜亲水/抗粘附改性研究, 2015 -2017,江苏省科技厅, 项目负责人

5. 国家自然科学基金面上项目,51373034,基于氨基酸两性离子的水凝胶生物材料:制备与眼科应用, 2014/01-2017/12, 80万元,结题,主持

6. 国家自然科学基金面上项目,51073036,新型同步互穿网络硅水凝胶材料的研究, 2011/01-2013/12, 37万元,已结题,主持

7. 国家自然科学基金面上项目,50673019,多重共轭电纺方法制备纳米纤维连续长纱的研究, 2007/01-2009/12, 30万元,已结题,主持

8. 国家自然科学基金面上项目,50573011,电纺玉米蛋白纳米纤维生物材料的基础研究, 2006/01-2008/12, 26万元,已结题,主持

9. 江苏省产学研项目BY2010143:系列高透氧氟硅水凝胶角膜接触镜的研究与产业化开发, 省科技厅,2010.7-2012.12. 100万元,项目负责人

10.  江苏省社会发展研究,BS2001034,生物可吸收聚合物/纳米晶骨折内固定材料研究,2001-2003,主持,完成。6万元,项目负责人

11.  江苏省高技术研究基金,BG2001036,骨组织工程关键技术研究,2001-2003,完成。4万元,参加

12.  江苏省高技术研究基金,BG2002002,生物吸收高分子/纳米晶体复合材料制备技术与临床应用,2002-2004,完成。25万元,项目负责人

13.  南京市科学基金,200301046,壳聚糖防粘连材料制备技术与临床, 2003-2004,完成。6万元,项目负责人

14.  国家科学技术部“863”科技专项,2004AA2Z3540,氯硝柳胺新剂型的研究, 2004-2005,完成。8万元,参加

15.  国家卫生部专项基金, wkj2006-2-024, 血吸虫病新型树枝状载体-DNA疫苗的研究, 2006-2008,完成。4万元,参加


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研究成果

130篇科学论文,25项发明专利。

(1)       Wei He, Yawei Du, Chuncao Li, JiWang, Yang Wang, Con Dogovski, Rui Hu, Zhiyong Tao, Chen Yao, Xinsong Li, Dimeric artesunate-choline conjugate micelles coated with hyaluronic acid as a stable, safe and potent alternative anti-malarial injection of artesunate, International Journal of Pharmaceutics, 2021, 609, 121138.

(2)       Tao Wang, Wei He, Ji Wang, Xinsong Li, Redox-sensitive irinotecan liposomes with active ultra-high loading and enhanced intracellular drug release, Colloids and Surfaces B: Biointerfaces. 2021, 206, 111967.

(3)       He, Wei; Du, Yawei; Wang, Tao; Wang, Ji; Cheng, Lei; Li, Xinsong, Dimeric artesunate-phosphatidylcholine-based liposomes for irinotecan delivery as a combination therapy approach, Mol. Pharmaceutics 2021, 18(10): 3862–3870.

(4)       Wei He, Yawei Du, Tao Wang, Ji Wang, Lei Cheng, Xinsong Li, Redox responsive 7-ethyl-10-hydroxycamptothecin (SN38) lysophospholipid conjugate: synthesis, assembly and anticancer evaluation, International Journal of Pharmaceutics,  2021, 606, 120856.

(5)       Ji Wang, Wei He, Tao Wang, Man Li, Xinsong Li, Sucrose-modified iron nanoparticles for highly efficient microbial production of hyaluronic acid by Streptococcus zooepidemicus, Colloids and Surfaces B: Biointerfaces, 2021, 205:111854.

(6)       Man Li, Longbing Ling,   Qing Xia  and  Xinsong Li, A Reduction-responsive Drug Delivery with Improved Stability: Disulfide Crosslinked Micelles of Small Amiphiphilic Molecules, RSC Adv., 2021,11, 12757-12770

(7)       Yaru Zhang , Wei He , Yawei Du , Ying Du, Chao Zhao , Ying Zhang , Hu Zhang , Lihong Yin*, Xinsong Li*, Dimeric artesunate phospholipid-conjugated liposomes as promising antiinflammatory therapy for rheumatoid arthritis, International Journal of Pharmaceutics, 2020,579:119178.

(8)       Wei He, Yawei Du, Wenya Zhou, Tao Wang, Man Li, XinsongLi,Core-crosslinked nanomicelles based on crosslinkable prodrug and surfactants for reduction responsive delivery of camptothecin and improved anticancer efficacy, European Journal of Pharmaceutical Sciences, 2020, 150:105340.

(9)       Yawei Du, Zhi Wang, Tao Wang, Wei He, Wenya Zhou, Man Li, Chen Yao, Xinsong Li,Improved Antitumor Activity of Novel Redox-Responsive Paclitaxel-Encapsulated Liposomes Based on Disulfide Phosphatidylcholine, Molecular Pharmaceutics. 2020, 17(1): 262-273.

(10)   Zhou, Wenya; Ling, Longbing; Du, Yawei; He, Wei; Yao, Chen; Li, Xinsong , A Novel Thiol-mediated Multidentate Phosphorylcholine as Zwitterionic Ligand for Stablizing Biocompatible Gold Nanoparticles, Langmuir 2019, 35, 13031−13039

(11)   Du, Yawei; He, Wei; Xia, Qing; Zhou, Wenya; Yao, Chen; Li, Xinsong Thioether Phosphatidylcholine Liposomes: A Novel ROS-responsive Platform for Drug Delivery, ACS Applied Materials & Interfaces,2019,11(41):37411-37420

(12)   Du, Yawei; He, Wei; Zhou, Wenya; Li, Xinsong*, Disulfide Phosphatidylcholines: Alternative Phospholipids for the Preparation of Functional Liposomes, Chemical Communication, 2019,55, 8434-8437

(13)   Muhammad Ismail, Yawei Du, Longbing Ling and Xinsong Li*, Artesunate-heparin conjugate based nanocapsules with improved pharmacokinetics to combat malaria, International Journal of Pharmaceutics, 2019, 562:162-171

(14)   Qing Xia, Longbing Ling, Muhammad Ismail,Yawei Du,Wei He, Wenya Zhou, Chen Yao, Xinsong Li*, Paclitaxel encapsulated in artesunate-phospholipid liposomes for combinatorial delivery, Journal of Drug Delivery Science and Technology, 2019, 51:372-382

(15)   Longbing Ling, Muhammad Ismail, Yawei Du, Chen Yao, Xinsong Li* ,Lipoic Acid-derived Cross-linked Liposomes for Reduction-responsive Delivery of Anticancer Drug, International Journal of Pharmaceutics,  2019, 560: 246-260.

(16)   Zhi Wang, Longbing Ling, QingXia, Xinsong Li*, Disulfide-crosslinked reduction-responsive Prodrug Micelles for On-demand Paclitaxel Release, Journal of Drug Delivery Science and Technology, 2019, 53,101168

(17)   Zhi Wang, Yawei Du, ATRA Dimer Phospholipid Liposomes for Doxorubicin Delivery to Reverse Drug Resistance of Breast Cancer, Nanosci Nanotechnology Letters, .

(18)   Zhi Wang, Longbing Ling, Yawei Du, Chen Yao, Xinsong Li*, Reduction responsive liposomes based on paclitaxel-ss-lysophospholipid with high drug loading for intracellular delivery, International Journal of Pharmaceutics 564 (2019) 244–255

(19)   Ling, Longbing; Ismail, Muhammad; Du, Yawei; Xia, Qing; He, Wei; Yao, Chen; Li, Xin-Song*, High Loading, Reversible Disulfide Core-Cross-Linked Multifunctional Micelles for Triggered Release of Camptothecin, Molecular Pharmaceutics, 2018, 15: 5479−5492.

(20)   Shuo Fang, Yongpeng Hou, Longbing Ling, Chen Yao*, Xinsong Li*, Dimeric camptothecin derived phospholipid assembled liposomes with high drug loading for cancer therapy, Colloids and Surfaces B: Biointerfaces, 2018,166 :235–244(未申报奖励)

(21)   Yawei Du, Longbing Ling, Muhammad Ismail, Wei He, Qing Xia, Wenya Zhou, Chen Yao, Xinsong Li, Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery, International Journal of Pharmaceutics, 2018,  549(1–2) : 352-362

(22)   Muhammad Ismail, Longbing Ling, Yawei Du, Ruiyu He, Chen Yao, Jianying Shen,  Xinsong Li*, Liposomes of dimeric artesunate phospholipid: a combination of dimerization and self-assembly to combat malaria,  Biomaterials,2018,163:76-87

(23)   Lu Lu,Yawei Du, Muhammad Ismail, Longbing Ling, ChenYao, ZhenglinFu, Xinsong Li* , Liposomes Assembled from Dimeric Retinoic Acid Phospholipid with Improved Pharmacokinetic Properties, European Journal of Pharmaceutical Sciences, 2018,112: 186-194

(24)   Yongpeng Hou, Chen Yao*, Longbing Ling, Yawei Du, Ruiyu He, Muhammad Ismail, Ying Zhang, Zhenglin Fu, Xinsong Li*, Novel Dual VES Phospholipid Self-assembled Liposomes with an Extremely High Drug Loading Efficiency, Colloids and Surfaces B: Biointerfaces, 2017, 156, 29–37.

(25)   Longbing Ling, Yawei Du, Ruiyu He, Muhammad Ismail, Yongpeng Hou, Chen Yao, Xinsong Li*, Self-assembled nanoparticles of dual paclitaxel-phospholipid prodrug with in vitro and in vivo anticancer activities, International Journal of Pharmaceutics, 2017,  526(1-2),11–22.

(26)   Yawei Du, Wei Zhang, Ruiyu He, Muhammad Ismail, Longbing Ling, Chen Yao and Xinsong Li* Dual 7-Ethyl-10-hydroxycamptothecin Conjugated Phospholipid Prodrug Assembled Liposomes with in vitro Anticancer Effects, Bioorganic & Medicinal Chemistry, 2017, 25(12), 3247–3258.

(27)   Longbing Ling, Chen Yao, Yawei Du, Muhammad Ismail, Ruiyu He, Yongpeng Hou, Ying Zhang, Xinsong Li*, Assembled liposomes of dual podophyllotoxin phospholipid: preparation, characterization and in vivo anticancer activity, Nanomedicine,  2017,12(6): 657-672.

(28)   Ruiyu He, Yawei Du, Longbing Ling, Muhammad Ismail, Yongpeng Hou, Chen Yao and Xinsong Li*, Nanoformulation of dual bexarotene-tailed phospholipid conjugate with high drug loading , European Journal of Pharmaceutical Sciences, 2017, 100: 197–204.

(29)   Chen Xu, Ruiyu He, Binbin Xie, Chen Yao, Jie Luan, and Xinsong Li*,Improved protein resistance of silicone hydrogels by grafting short peptides for ophthalmological application, International Journal of Polymeric Materials and PolymericBiomaterials, 2017, 66(12), 618-625.

(30)   Chen Xu, Xiaojiu Liu, Binbin Xie, Chen Yao, Wenhan Hu, Yi Li, Xinsong Li. Preparation of PES ultrafiltration membranes with natural amino acids based zwitterionic antifouling surfaces[J]. Applied Surface Science, 2016, 385,130–138.

(31)   Chen Xu, Ruiyu He, Binbin Xie, Muhammad Ismail, Chen Yao, Jie Luan, and Xinsong Li*,Silicone hydrogels grafted with natural amino acids for ophthalmological application,Journal of Biomaterials Science, Polymer Edition, 2016, 27(13):1354-68.

(32)   Wei Zhang, Wenjun Zhu, Shuo Fang, Yemin Zhang, Chen Yao, Muhammad Ismail, Xinsong Li*,Improvement of stability and in vitro anticancer activity of chlorambucil-tetrapeptide conjugate vesicles, Chinese Journal of Chemistry, 2016,  34(6), 609–616.

(33)   Xu, Chen; Hu, Xin; W ang, Jie; Zhang, Yemin; Liu, Xiaojiu; Xie, Binbin; Yao, Chen; Li, Yi; Li, Xinsong*, Library of Antifouling Surfaces Derived From Natural Amino Acids by Click Reaction, ACS Applied Materials & Interfaces, 2015, 7(31):17337-45. (一区)

(34)   Zhiping Fan, Yemin Zhang and Xinsong Li*,In situ injectable poly(c-glutamic acid) based biohydrogel formed by enzymatic crosslinking , J. Appl. Polym. Sci. 2015, 132(30), 42301.

(35)   Xiao-jiu Liu, Ye-min Zhang, Xin-song Li*, Tough biopolymer IPN hydrogel fibers by bienzymatic crosslinking approach, Chinese Journal of Polymer Science, 2015,33(12): 1741-1749

(36)   Shuo Fang, Yuge Niu, Wei Zhang, Yemin Zhang, Liangli Yu,Yingyi Zhang, and Xinsong Li*, Liposome-like nanocapsules of dual drug-tailed betaine for cancer therapy, International Journal of Pharmaceutics, 2015, 493(1-2), 460–465

(37)   Shuo Fang, Yuge Niu, Wenjun Zhu, Yemin Zhang, Liangli Yu and Xinsong Li*, Liposomes assembled from a dual drug-tailed phospholipid for cancer therapy, Chemistry- An Asian Journal,  2015, 10(5),1232–1238

(38)   Yemin Zhang, Zhiping Fan, Chen Xu, Shuo Fang, Xiaojiu Liu, Xinsong Li*,Biopolymer based hydrogels with interpenetrating network structure by bienzymatic crosslinking approach, Europe Polymer Journal, in press, 2015.  72: 717-725  

(39)   Zhiping Fan, Yemin Zhang, Jinkai Ji and Xinsong Li*,Hybrid polypeptide hydrogels produced via native chemical ligation RSC Adv., 2015, 5, 16740-16746

(40)   Wenjun Zhu, Shuo Fang, Yemin Zhang, Xinsong Li*, Functional vesicles formed by anticancer drug assembly,Bioorganic & Medicinal Chemistry Letters 25 (2015) 188–191

(41)   Zhiping Fan, Yemin Zhang, Xinsong Li*,Bienzymatically Crosslinked Gelatin/Hyaluronic acid Interpenetrating Network Hydrogels:Preparation and Characterization, RSC Adv., 2015, 5, 1929–1936 |

(42)   Xin Hu, Lingling Lu, Chen Xu, Xinsong Li*, Mechanically tough biomacromolecular IPN hydrogel fibers by enzymatic and ionic crosslinking, International Journal of Biological Macromolecules, 2015,72: 403–409.

(43)   Wu, Yang; Ji, Jingkai; Yang, Ran; Zhang, Xiaoqiang; Li, Yuanhui; Pu, Yuepu; Li, Xinsong, Galactosylated 2-hydroxypropyl methacrylamide-s-3-guanidinopropyl methacrylamide copolymer as small hairpin RNA carrier for inhibiting human telomerase reverse transcriptase expression, Journal of Gene Medicine, 2014, 16(5-6): 109-121.

(44)   Yang Wu, Jinkai Ji, Xinsong Li*, et al., Galactosylated Poly(ethylene glycol) Methacrylate-st-3-Guanidinopropyl Methacrylamide Copolymers as siRNA Carriers for Inhibiting Survivin Expression in vitro and in vivo, Journal of Drug Targeting, 2014,22(4): 352-364.

(45)   Wang, XT ; Dai, Y  ; Zhao, S  ; Tang, JX  ; Li, HJ ; Xing, YT ; Qu, GL; Li, XS  ; Dai, JR  ; Zhu, YC , PAMAM-Lys, a Novel Vaccine Delivery Vector, Enhances the Protective Effects of the SjC23 DNA Vaccine against Schistosoma japonicum Infection, PLoS, 2014;9(1):e86578,DOI: 10.1371/journal.pone.0086578.

(46)   Cai Wen, Lingling Lu and Xinsong Li, Enzymatic and Ionic Crosslinked Gelatin/K-Carrageenan IPN Hydrogels as Potential Biomaterials, JAPS, 2014,132(21): DOI: 10.1002/app.40975.

(47)   Hago, Eltjani Eltahir; Li xinsong, Physical Characteristics Evaluation of IPN Poly(vinyl alcohol)/Gelatin Hydrogels as a Potential Tissue Engineering Scaffolds, Science of Advanced Materials, 2014, 6(8):1836-1844.

(48)   Eltjani Eltahir Hago, Li Xinsong, and Ji Jin Kai, A New Route Toward IPN Photocrosslinked Alginate Hydrogels with Biodegradation Rates, Excellent Biocompatibility and Mechanical Properties, J. Biomater. Tissue Eng. 2014, 4:89-98.

(49)   Cai Wen, Lingling Lu, Xinsong Li*, An IPN Biohydrogel of Gelatin and Gellan Gum by using Combination of Enzymatic and Ionic Crosslinking Approaches, Polymer International,  2014,63:1643-9.

(50)   Yan Mei, Chen Yao, Xinsong Li*, A simple approach to constructing antibacterial and anti-biofouling nanofibrous membranes, Biofouling, 2014, 30(3): 313-322

(51)   Zongzhe Zhu, Xinsong Li, Silicone hydrogels based on a novel amphiphilic poly(2-methyl-2-oxazoline)-b-poly(dimethyl siloxane) copolymer, Journal of Applied Polymer Science, online, 2014, 131(3): ?? DOI: 10.1002/app.39867

(52)   Cai Wen, Lingling Lu, Xinsong Li*, Mechanically Robust Gelatin-Alginate IPN Hydrogels by a Combination of Enzymatic and Ionic Crosslinking Approaches, Macromolecular Materials and Engineering, 2014, 299(4): 504-13.

(53)   Yang Wu, Jinkai Ji, Xinsong Li*, et al., Guanidinylated 3-gluconamidopropyl methacrylamide-s-3-aminopropyl methacrylamide copolymer as siRNA carriers for inhibiting human telomerase reverse transcriptase expression, Drug delivery, 2013;20(7):296-305.

(54)   Yan Mei, Zhiming Wang, Xinsong Li*, Improving filtration performance of electrospun nanofiber mats by a bimodal method, Journal of Applied Polymer Science, 2013, 128(2): 1089–1094.

(55)   Xinsong Li*, Zhu Qin, et al., Improvement of transfection efficiency by galactosylated N -3-guanidinopropylmethacrylamide-co-poly(ethyleneglycol)methacrylate copolymer, European Polymer Journal, 2013, 49(10): 2884–2894

(56)   Hago, EE, Xinsong Li*, Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization, ADVANCES IN MATERIALS SCIENCE AND ENGINEERING,2013,文献号: 328763   DOI: 10.1155/2013/328763, WOS:000321348600001.

(57)   Yan Mei, Chen Yao, Kai Fan, Xinsong Li, Surface modification of polyacrylonitrile nanofibrous membranes with superior antibacterial and easy-cleaning properties through hydrophilic flexible spacers, Journal of Membrane Science, Journal of Membrane Science,  2012,  417–418,  20–27.  

(58)   Zhu Qin, Wei Liu, Liang Guo and Xinsong Li, Studies on Guanidinated N-3-Aminopropyl Methacrylamide-N-2-Hydroxypropyl Methacrylamide Copolymers as Gene Delivery Carrier, Journal of Biomaterials Science-Polymer Edition, 2012, 23: 133–152.

(59)   Zhu Qin, Wei Liu, Liang Guo and Xinsong Li, Galactosylated N-2-Hydroxypropyl Methacrylamide- b- N-3-Guanidinopropyl Methacrylamide Block Copolymers as Hepatocyte- Targeting Gene Carriers, Bioconjugate Chemistry, 2011, 22 (8), 1503–1512

(60)   Xinsong Li, Jingjing Wang, Silicone hydrogels with interpenetrating network (IPN) structure prepared by simultaneous free-radical/cationic hybrid polymerizations,Biomedical Engineering: Applications, Basis and Communications, 2011,23(2),153–162.

(61)   Fuqian Sun, Chen Yao, Tangying Song, Xinsong Li, Fabrication of poly(vinylidenefluoride-co-hexafluoropropylene) nanofiber yarns by conjugate electrospinning, The Journal of the Textile Institute, 2011, 102(7): 633-638.

(62)   Jingjing Wang, Xinsong Li, Enhancing protein resistance of hydrogels based on poly(2-hydroxyethyl methacrylate) and poly(2-methacryloyloxyethyl phosphorylcholine) with interpenetrating network structure, Journal of Applied Polymer Science, 2011, 121(6):3347-3352

(63)   Jinku Xu, Xinsong Li, Fuqian Sun, In vitro and in vivo Evaluation of Fumarate Ketotifen-Loaded Silicone Hydrogel Contact Lenses for Ocular Drug Delivery, Drug Delivery, 2011; 18(2): 150–158.

(64)   Jingjing Wang, Xinsong Li, Interpenetrating polymer network hydrogels based on silicone and poly(2-methacryloyloxyethyl phosphorylcholine),Polymers for Advanced Technologies, 2011, 22(12): 2091–2095.

(65)   Fuqian Sun, Xinsong Li, Jinku Xu, Peiting Cao, Lijian Xiao, Surface modification of silicone hydrogel by APGDP induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine, e-Polymers ,2011, no. 042, p1-12

(66)   Tang-ying Song, Chen Yao and Xin-song Li, Electrospinning of zein/chitosan composite fibrous membranes, Chinese Journal of Polymer Science ,2010,  28( 2), 171-179

(67)   Jinku Xu, Xinsong Li, Fuqian Sun, Cyclodextrin-containing hydrogels for contact lenses as a platform of drug incorporation and release, Acta Biomaterialia, 2010, 6, 486-493. (SCI)

(68)   Jinku Xu, Xinsong Li, Fuqian Sun, Preparation and Evaluation of Contact Lens Vehicle for Puerarin Delivery, Journal of Biomaterials Science-Polymer Edition, 2010,21(3), 271-288. (SCI)

(69)   Jinku Xu, Xinsong Li, Fuqian Sun, Peiting Cao , pPVA Hydrogel Membrane Containing β-cyclodextrin for Enhanced Loading and Sustained Release of Ocular Therapeutics, Journal of Biomaterials Science-Polymer Edition, 2010, 21:1023-1038.(SCI)

(70)   Jingjing Wang, Fuqian Sun, Xinsong Li,Preparation and characterization of interpenetrating polymer network silicone hydrogels with high oxygen permeability, JOURNAL OF APPLIED POLYMER SCIENCE, 2010, 116(5): 2749-2757. (SCI)

(71)   Jingjing Wang, Fuqian Sun, Xinsong Li, Preparation and Antidehydration of Interpenetrating Polymer Network Hydrogels Based on 2-Hydroxyethyl Methacrylate and N-Vinyl-2-pyrrolidone, JOURNAL OF APPLIED POLYMER SCIENCE, 2010, 117, 1851–1858. (SCI)

(72)   Jingjing Wang, Xinsong Li, Improved oxygen permeability and mechanical strength of hydrogels with interpenetrating network structure. Chinese J Polym Sci, 2010. 28( 6), 849-857. (SCI)

(73)   Chen Yao, Xin-song Li, K. G. Neoh, Zhi-long Shi, E. T. Kang, Antibacterial poly(D,L-lactide) fibrous membranes modified with quaternary ammonium moieties. Chinese Journal of Polymer Science, 2010, 28(4), 581-588.

(74)   Sun Fuqian, Li Xinsong, Improving hydrophilicity and protein antifouling of electrospun poly(vinylidenefluoride-hexafluoropropylene) nanofiber membranes, Chinese Journal of Polymer Science, 2010, 28(5), 705-713. (SCI)

(75)   Fu-qian Sun, Xin-song Li, Pei-ting Cao, Jin-ku Xu, Enhancing hydrophilicity and protein resistance of silicone hydrogel by plasma induced grafting with hydrophilic polymer, Chinese Journal of Polymer Science, 2010,28(4),547−554.

(76)   Chen Yao, Xinsong Li, Tangying Song, Yunhui Li, Yuepu Pu, Biodegradable nanofibrous membrane of zein/silk fibroin by electrospinning, Polymer International, 2009, 58(4), 396-402. (SCI)

(77)   Tang-ying Song, Chen Yao, Xinsong Li, Preparation and Characterization of Zein and Zein/Poly-L-lactide (PLLA) Continuous Nanofiber Yarns, JOURNAL OF APPLIED POLYMER SCIENCE, 2009,114(4), 2079-2086 (SCI)

(78)   Chen Yao, Xinsong Li*, Tangying Song, Preparation and characterization of zein and zein/poly-L-lactide nanofiber yarns,Journal of Applied Polymer Science,2009, 114(4), 2079–2086.

(79)   Yao, Chen; Li, Xinsong; Neoh, K. G.; Shi, Zhilong; Kang, E. T., Antibacterial activities of surface modified electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) fibrous membranes, Applied Surface Science, 2009, 255(6),  3854-3858. (SCI)

(80)   Wang, Hai-Sheng; Fu, Guo-Dong; Li, Xin-Song, Functional polymeric nanofibers from electrospinning, Recent Pat Nanotechnol, 2009, 3(10), 21-31.

(81)   B. X. Gu, C. X. Xu, G. P. Zhu, S. Q. Liu, L. Y. Chen, and X. S. Li, Tyrosinase Immobilization on ZnO Nanorods for Phenol Detection, J. Phys. Chem. B, 2009, 113 (1), 377-381. (SCI)

(82)   Ke Zheng, Chunxiang Xu, Hao Zhou, Maocong Zhao, Guangping Zhu, Yiping Cui, Xinsong Li,Patterned growth of ZnO nanofibers, CHINESE OPTICS LETTERS, 2009,7(3), 238-239. (SCI)

(83)   Fu GD, Lei JY, Yao C, Li XS, Yao F, Nie SZ, Kang ET, Neoh, KG, Core-sheath nanofibers from combined atom transfer radical polymerization and electrospinning, MACROMOLECULES, 2008, 41(18), 6854-6858.(SCI)

(84)   Yao, C; Li, XS; Neoh, KG, Surface modification and antibacterial activity of electrospun polyurethane fibrous membranes with quaternary ammonium moieties, JOURNAL OF MEMBRANE SCIENCE, 2008, 320(1-2), 259-267. (SCI)

(85)   Fu, GD; Yao, F; Li, ZG, Li, XS, Solvent-resistant antibacterial microfibers of self-quaternized block copolymers from atom transfer radical polymerization and electrospinning, JOURNAL OF MATERIALS CHEMISTRY, 2008, 18(8), 859-867. (SCI)

(86)   Zhiming Li, Feng Shan, Jiangong Wei, Jun Yang, Xinsong Li and Xinling Wang, High ionic conductive PVDF-based fibrous electrolytes, Journal of Solid State Electrochemistry, 2008,12(12),1629-1635(SCI)

(87)   Li XS, Yao C, Sun FQ, Song TY, Li YH, Pu YP, Conjugate electrospinning of continuous nanofiber yarn of poly(L-lactide)/nanotricalcium phosphate nanocomposite, JOURNAL OF APPLIED POLYMER SCIENCE, 2008, 107(6),  3756-3764. (SCI)

(88)   Chen Yao, Li Xinsong, Song Tangying, Electrospinning and Crosslinking of Zein Nanofiber Mats, Journal of Applied Polymer Science, 2007, 103(1), 380–385. (SCI)

(89)   Chen Yao, Li Xinsong, Song Tangying, Fabrication of zein/hyaluronic acid fibrous membranes by electrospinning, Journal of Biomaterials Science-Polymerization Edition, 2007, 18 (6), 731-742. (SCI)

(90)   抗菌聚合物纳米纤维的研究进展,孙娟 姚琛 李新松,高分子通报,2010, (8), 27-33.

(91)   卢陆洋,秦竹,徐金库,李新松,一株产紫杉醇内生真菌的分离及其代谢产物的研究,中国医药生物技术,2010,5(3):202-207.

(92)   叶倩文,卢陆洋,李新松, 透明质酸高产菌株选育研究, 化学与生物工程, 2010,27(3):51-54.

(93)   王晓婷, 朱荫昌, 高秋端, 郭玲香, 李新松,日本血吸虫病新型树枝状载体DNA疫苗的构建及其评价, 中国血吸虫病防治杂志 2010, 22(1): 5-12.

(94)   孙娟,姚琛,李新松,抗菌聚合物纳米纤维的研究进展, 高分子通报, 2010, (8):27-33.

(95)   孙复钱, 姚 琛, 李新松, 范凯红, 浦跃朴,电纺聚-L-乳酸/β2磷酸三钙复合物纳米纤维膜,东南大学学报, 2010, 40(1):213-217.

(96)   邓赟, 徐金库, 李新松,葛根素脂质体滴眼液的制备及其药动学研究,中国中药杂志, 2010,35(4):301-304.

(97)   李新松, 姚琛, 静电纺丝—从无规纳米纤维膜到取向连续长纱, 化学通报,2009,(7):579-586.

(98)   曹霈挺 孙复钱 李新松,表面接枝MPC硅水凝胶的制备及生物学评价,化工时刊, 2009, 23(4):6-10.

(99)   于光;李云晖;姚琛;尹立红;李新松;浦跃朴,聚己内酯纳米纤维膜固定化溶藻菌对藻类和藻毒素的生物降解作用, 东南大学学报(自然科学版), 2008,38(3), 483-487.

(100)    聚乳酸骨折內固定板的制備與性能研究, 化工新型材料, 2008, (2),

(101)    包鸣晓,李新松*,高秋端,孙复钱,聚乳酸骨折内固定板的制备与性能研究,化工新型材料, 2008, 36(2):76-78.

(102)    李新松, 邹俊, 朱国华, 齐新生, 浦跃朴. 聚-L-乳酸/β-磷酸三钙复合物生物可吸收骨折内固定棒的体内降解和组织相容性,  生物医学工程学杂志, 2007, 24(1): 81-6. 

(103)    宋唐英, 姚琛, 李新松. 生物高分子静电纺丝研究进展, 化学通报, 2007, 70(1): 21-28.

(104)    高秋端,郭玲香,李新松,聚酰胺-胺树枝状高分子的柱色谱提纯研究,化学研究, 2007,18(4):41-44.

(105)    孙 涛 周明阳 李新松,PVDF/ PANI-TSA复合纤维膜的电纺制备及电性能,,化工时刊, 2007, 21(1):9-12.

(106)    吴殊斌, 姚琛, 李新松. 聚(丙交酯-co-乙交酯)/β-磷酸三钙复合物的电纺研究. 高分子学报, 2006,1(1): 11-15. (SCI)

(107)    姜柳,, 李树风, 李新松* 戴建荣, 朱荫昌,氯硝柳胺乙醇胺盐纳米剂的制备与杀螺效果, 中国血吸虫病防治杂志,2006,19(2): 102-106.

(108)    孙复钱,李新松,含氟聚合物纳米多孔纳米纤维膜的制备,化工新型材料2006年06期

(109)    郭峰,李新松 等,"Top-Down"方法制备氯硝柳胺纳米剂的研究,中国血吸虫病防治杂志,2006,18(6),411-416。

(110)    李云晖, 浦跃朴, 李新松, 尹立红两种壳聚糖修饰材料细胞相容性及蛋白吸附行为的评价,东南国防医药,2006,8(5): 343-345

(111)    贺小虎,章庆国,李新松,聚乳酸聚羟乙酸磷酸三钙薄膜预防屈肌腱粘连的实验,中国临床康复,2005,9(38): 36-38.

(112)    邓杰, 李新松, 聚甲基丙烯酸甲酯-b-聚苯乙烯共聚物的合成与表征,南京航空航天大学学报, 2005,37(5): 607-610.

(113)    (a)李新松,聂光宇.纳米多孔超高比表面积超细纤维(封面论文).科学通报, 2004, 49(21): 2160-2163,(b)Li Xinsong, Nie Guangyu.Nano-porous ultra-high specific surface ultrafine fibers (cover article). Chinese Science Bulletin, 2004, 49(22): 2368-2371. (SCI)

(114)    邹俊,李新松,哈涌泉,韩凤俊,超细β-磷酸三钙P聚-L-乳酸复合材料的制备与骨折内固定器的加工,东南大学学报(医学版), 2004,23(3) :155-159.

(115)    邹俊,李新松,韩凤俊,纳米β2磷酸三钙在聚乳酸复合材料中的分散研究, 应用化工, 2004, 33(2):14-17

(116)    王军,李新松,赵艳秋,浦跃朴,壳聚糖多孔支架的制备与生物学性质,东南大学学报(自然科学版),2004,34(1),67。

(117)    赵艳秋,浦跃朴,王军,李新松,尹立红, 牛血清白蛋白改性壳聚糖纤维及其细胞亲和性研究, 东南大学学报, 2003, 33(14):479-482.

(118)    王正梅,李新松,哈涌泉, 含胰岛素肠溶微球的制备,东南大学学报(自然科学版),2002,32(3), 371 (EI).

(119)    Deng J, Li XS, Wang ZM, et al. An observation on the microphase separation of poly(methyl methacrylate)-block-polystyrene copolymer, CHINESE CHEM LETT, 2001,12 (5), 467-470.(SCI)

(120)    李新松, 黄吉普, 张保龙, 含磷芳胺/环氧树脂体系固化反应的DSC研究, 东南大学学报(自然科学版), 1999, 29(1), 113-115.

(121)    Li XS, Wang GC, He BL, Entanglement of polymer chains in concentrated region by fluorescence probe technique, CHINESE CHEM LETT, 1999, 10 (9), 795-798.(SCI)

(122)    Li XS, Wang GC, He BL, Intrachain and interchain interactions in polystyrene: Dilute and semidilute solutions, CHINESE CHEM LETT, 1999, 10 (11), 961-964. (SCI)

(123)    Li, Xinsong; Wang, Guochang; He, Binlin, An observation on excimer formation in pyrenyl-labelled polystyrene: concentrated solution and solvent-plasticized film, Polymer International, 1999,  48(8), 630-632. (SCI/EI)

(124)    Li Xinsong,*  Wang Guochang,  He Binglin, An Investigationon the Polymerization of Styrene by Fluorescence Probe Technique, Journal of Southeast University (EnglishEdition), 1999,15(2), 84-87.

(125)    Li XS, Wang GC, He BL, A study on the concentration dependence of excimer formation in pyrenyl labelled polystyrene solutions, POLYM INT, 1999,48 (7), 529-531. (SCI)

(126)    Li, Xinsong; Chen, Yue, Study on curing reaction of epoxy resin/aroamine containing phosphorous by technique of FT-IR: Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering(Ch), 1998, 14(5),138-140. (EI)

(127)    李新松,陈悦,环氧树脂/含磷的芳胺固化剂体系固化反应的FT-IR研究,高分子材料科学与工程, 1998, 14(5),138-140

(128)    李新松, 孙涛, 黄吉普, 张保龙, 含磷多胺/环氧树脂的固化过程和阻燃性研究, 东南大学学报(自然科学版), 1998, 28(6), 177-181.

(129)    Shi Jinyuan, Wang Haifang, Wu Xiaohong, Li Xinsong, Liu Yuanfang, Li Kun, Luo Xiangyang, Wang Jianjun, Liu Kexin, Genotoxicity of low-dose primicarb studied by accelerator mass spectrometry, Chinese Science Bulletin(Chinese), 1997, 42(15), 1675.(SCI)

(130)    Li, Xinsong; Wang, Guochang; Gao, Huan; He, Binglin; Chen, Liusheng; Du, Jinhuan, Synthesis and photophysical study of some new pyrene derivatives, Ion Exchange and Adsorption (Chinese), 1996, 12(2), 105-113.(EI)

(131)    Li XS, Wang HF, Shi JY, Wang XY, Liu YF, Li K, LU XY, Wang JJ, iu KX, Guo ZY, Genotoxicity study on nicotine and nicotine-derived nitrosamine by accelerator mass spectrometry, Radiocarbon, 1996, 38(2), 347-353 (SCI)

(132)    Li, Xinsong; Wang, Guochang; He, Binglin; Chen, Liusheng; Du, Jinhuan, Synthesis and characterization of styrene/divinylbenzene copolymers containing pyrene groups,Ion Exchange and Adsorption (Chinese), 1995, 11(1) ,73-80.(EI)

(133)    He, Bing-Lin; Wang, Guo-Chang; Li, Xin-Song, Photophysical study of pyrene-labelled St/DVB copolymers, Science in China, Series B: Chemistry, Life Sciences & Earth Sciences, 1994, 37(5), 513-517. (SCI/EI)

(134)    Li Xinsong, et al., A study on DNA adduction with nicotine-derived nitrosamine by accelerator mass spectrometry, Chinese Chemical Letters, 1994, 5(10), 873. (SCI)

(135)    张保龙 李新松 黄吉甫 丁培元 杜宗杰, 含磷胺类固化剂/环氧树脂固化体系性能研究, 高分子材料科学与工程, 1992, (2), 15-19.

授权专利

1.          李新松,可吸收超细纤维组织修复材料及其制备方法,专利号ZL031315879,2005.6.1授权。

2.          李新松,扭曲超细纳米纤维膜材料及其制备方法,专利号ZL2003101065170,2005.11.9授权。

3.          李新松,姚琛,浦跃朴,李云晖,宋唐英,范凯红,玉米蛋白纳米纤维多孔膜及其制备方法,专利号ZL2005100944019,2007.2.28授权。

4.          李新松,姚琛,孙复钱,组合式连续电纺纳米纤维膜制造装置及制备方法,专利号ZL2005100385626,2007.8.29授权。

5.          李新松,姚琛,宋唐英,纳米纤维长丝束的制备方法,专利号ZL2005100385715,2007.8.29授权。

6.          李新松,姚琛,孙复钱,复合纳米纤维长丝束制备装置及其制备方法,专利号ZL2005100953840, 2008.10.22授权.

7.          李新松,徐金库,载药隐形眼镜及其制备方法, 专利号ZL200810021962X,2010.3.31授权。

8.          李新松,王静静,孙复钱, 一种水凝胶接触镜材料及其制备方法专利号,ZL 2009100257912,2011.8.24授权

9.          李新松,孙复钱,一种高透氧氟硅氧烷水凝胶接触镜材料及其制备方法,专利号ZL2009100257908,2011.11.30授权

10.        李新松,文采,方硕,一种生物大分子水凝胶及其制备方法,专利号ZL201210137940.6,2013.11.30授权。

11.        李新松,郭亮,一种水凝胶接触镜,专利号ZL2012100746380,2014.7.9授权。

12.        李新松,方硕,一种氮芥磷脂化合物及其制备方法, 专利号ZL2013101539062,2015.02.11授权。

13.        李新松 王杰 胡昕, 一种氨基酸两性离子水凝胶材料及其制备方法,专利号ZL201310396165.0,2013.09.03 2015.5.26授权。

14.        李新松 樊凯,方硕 王杰,一种水凝胶接触镜及其制备方法,专利号ZL2013103956968,2015.8.26授权。

15.        李新松,方硕,一种紫杉醇类磷脂化合物、其药物组合物及应用,专利号 ZL2014104931996,2016.11.1授权。

16.        李新松,方硕,一种喜树碱类磷脂化合物、其药物组合物及应用, 专利号ZL201410495174X,2017.1.5授权。

17.        李新松,张伟,杜亚伟,一种喜树碱类磷脂化合物、其药物组合物及应用, 专利号ZL2015105982519, 2017.7.19授权。

18.        李新松,方硕,张伟,凌龙兵,张叶敏,一种药物甜菜碱缀合物、其药物组合物及应用, 专利号ZL2014107101287, 2017.4.5授权。

19.        李新松、刘小九、谢彬彬、姚琛、李屹,一种抗生物粘附多孔分离膜、其制备方法及应用, 专利号ZL2015100267464, 2017/4/12授权。

20.        李新松,徐晨,杜亚伟,凌龙兵,侯永鹏,一种亲水性药物的磷脂化合物、其药物组合物及应用, 专利号ZL201510661316X,2018.9.13授权。

21.        李新松,司马,凌龙兵,一种双氢青蒿素二倍体衍生物、其药物组合物及应用,专利号ZL2017101154104, 2019.9.10授权。

22.        Li Xinsong, Si Ma, Ling Longbing, DIHYDROARTEMISININ DIPLOID DERIVATIVE, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION, Issued 09-July-2021, 专利号US 11136339 B2,2021.10.5 授权。

23.        李新松,何伟,李漫,一种还原敏感脂质药物组合物及其应用,专利号ZL20191010527863.7, 2021.12.24授权。

24.        李新松,凌龙兵,何伟,一种大分子前药纳米药物、制备方法及其应用, 专利号ZL2018110799381, 2021.11.26授权。

25.        李新松, 周文雅,一种水溶性纳米粒子及其制备方法和应用, 专利号ZL2019106995660, 2021.10.19授权。


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