【陈立娟导师】招生“医学院”研究生介绍
陈立娟
其他
硕，博士生导师
女
医学院
内科学
,临床医学
心肌梗死后心室重构的临床及机制研究,心肌肥厚的机制研究
chenlijuan@seu.edu.cn
江苏省医学会心血管病学分会基层学组副组长，南京地区胸痛救治中心建设专家组副组长，中国胸痛中心核查专家。国家自然科学基金同行评议专家组成员。中国医师协会心血管内科医师分会女医师工作组委员，江苏省医师协会心脏重症专业委员会委员，江苏省免疫学会心血管免疫专委会常委，冠心病介入诊疗培训基地培训导师
申请者一直致力于冠心病及心肌肥厚的临床及机制研究。与美国佐治亚州立大学唐耀亮教授实验室长期合作，研究缺氧预适应在干细胞治疗急性心肌梗死中的保护作用，证实Notch1/RBP-J信号系统在心室重构中的作用。关键核转录因子GATA4增强了心脏来源的集落成纤维细胞分泌的外泌体的抗凋亡效应。近年来在国家自然科学基金及江苏省自然科学基金的资助下，探讨TRIM家族成员通过泛素化降解影响压力超负荷导致的心肌肥厚。明确TRIM家族中TRIM32,TRIM8通过TRIM32/Akt信号通路及TRIM8/TAK1信号通路在心肌肥厚病理及生理过程中的作用及机制。同时利用大数据系统建立急性冠脉综合征患者近期及长期不良事件的预测模型。
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科研项目
1.江苏省卫健委重点项目：基于纳米探针的冠心病高危患者早期多模态分子影像诊断研究
2. 国家自然科学基金面上项目（NO:81770231）:泛素化连接酶TRIM38在心肌肥厚中的作用及机制研究，2018/01-2021/12，资助金额55万元，在研，主持
3. 江苏省自然科学基金面上项目（NO:SBK20161436）：TRIM8在心肌肥厚中的作用及机制研究，2016/07-2019/06，资助金额10万元，在研，主持
4．国家自然科学基金面上项目（NO:81270203/H0203）:利用条件性敲除 RBP-J 的心脏祖细胞研究 Notch 信号通路在增强干细胞心脏修复中的作用，2013/01-2016/12，资助金额70万元，结题，主持。
5. 国家自然科学基金青年基金项目（NO:81400219）： SDF-1对心脏干细胞C-kit基因DNA甲基化调控的机制研究 ，2015/01-2018/12，资助金额23.5万元，在研，参加者
6. 国家自然科学基金面上项目（NO:81070083）：缺氧预适应上调SDF-1/CXCR4轴调节的抗凋亡通路改善归巢心脏祖细胞的存活，2011/01-2013/12，资助金额32万元，已经结题，参加者（排名第二）。
7. 国家自然科学基金面上项目（NO:30570743）：磁探针标记自体骨髓间充质干细胞移植治疗急性心肌梗死的核磁共振示踪实验研究,2006/01-2008/12，已经结题，参加者（排名第五）。
8. 江苏省自然科学基金面上项目（NO:SBK20081829）：血红素氧化酶-1涂层支架预防再狭窄实验研究,2008/01-2011/12，资助金额8万元，已经结题，主持。
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研究成果
1. Chunshu Hao, Zhengri Lu,Yuanyuan Zhao, Zhong Chen, Chengxing Shen, Genshan Ma, Lijuan Chen. Overexpression of GATA4 enhances the antiapoptotic effect of exosomes secreted from cardiac colony-forming unit fibroblasts via miRNA221-mediated targeting of the PTEN/PI3K/AKT signaling pathway. Stem cell research & therapy. 2020.
2. Zhengri Lu ,Genshan Ma, Lijuan Chen. Sitagliptin on Carotid Intima-Media Thickness in Type 2 Diabetes Mellitus Patients and Anemia: A Subgroup Analysis of the PROLOGUE Study. Mediators of Inflammation Volume 2020, Article ID 8143835.
3. 陆政日,马根山,陈立娟.中性粒细胞与淋巴细胞比值与老年急性冠脉综合征患者近期预后的关系.第二军医大学学报(Academic Journal of Second Military Medical University).2019.Vol.40.No.10(1103-1110)
4. 庞思,陈忠,朱孔博,何砚如,Gondo Esther Kema Hawa,章晓国,童嘉毅,马根山,陈立娟.药物涂层球囊治疗急性冠脉综合征的系统评价. 东南大学学报( 医学版) 2018,Feb;37(1):31-34
5.Lijuan Chen, Si Pang, Chunshu Hao, Aiming Xie, Kongbo Zhu, Yanru He,Xiaoguo Zhang, Wenbing Lu,Genshan Ma, and Zhong Chen. Prevention of neointimal formation after angioplasty using tetramethylpyrazine-coated balloon catheters in a rabbit iliac artery model. Cardiovasc Diagn Ther .2019;9(5):472-480.
6.He Y, Pang S, Huang J, Zhu K, Tong J, Tang Y, Ma G, Chen L. Blockade of RBP-J-Mediated Notch Signaling Pathway Exacerbates Cardiac Remodeling after Infarction by Increasing Apoptosis in Mice. BioMed Research International, 2018 Jul 3;2018:5207031
7. Lijuan Chen, Jia Huang, Yan-xiao Ji, Fanghua Mei, Pi-xiao Wang, Ke-qiong Deng, Xi Jiang, Genshan Ma, Hongliang Li. Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy through Enhancing TAK1-dependent Signaling Pathways. Hypertension. 2017 ;69(2):249-258(IF=6.857)
8. Chen L, Huang J, Ji Y, Zhang X, Wang P, Deng K, Jiang X, Ma G, Li H. Tripartite Motif 32 Prevents Pathological Cardiac Hypertrophy. Clin Sci (Lond). 2016. 130(10):813-28 (IF=5.598)
9. Jia Huang, Lijuan Chen, Yuyu Yao, Chengchun Tang, Jiandong Ding, Cong Fu, Hongliang Li, Genshan Ma. Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy. Hypertension. 2016;67:1228-1236( IF=6.294)
10.Yingjie Wang, Lan Zhang, Yongjun Li， Lijuan Chen, Xiaolong Wang ,Wei Guo ,Xue Zhang, Gangjian Qin, Sheng-hu He ,Arthur Zimmerman, Yutao Liu, Il-man Kim, Neal L.Weintraub, Yaoliang Tang. Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. International Journal of Cardiology 192 (2015) 61–69(IF=4.036 共同第一作者)
11. Chen L, Phillips MI, Miao HL, Zeng R, Qin G, Kim IM, Weintraub NL, Tang Y. Infrared fluorescent protein 1.4 genetic labeling tracks engrafted cardiac progenitor cells in mouse ischemic hearts. PLoS One 2014;9(10):e107841. (IF=3.234)
12. Chen L, Pan Y, Zhang L, Wang Y, Weintraub N, Tang Y. Two-step protocol for isolation and culture of cardiospheres. Methods Mol Biol 2013;1036:75-80.
13. Lijuan Chen, Yingjie Wang, Yaohua Pan, Lan Zhang, Chengxing Shen, Gangjian Qin, Muhammad Ashraf, Neal Weintraub, Genshan Ma, and Yaoliang Tang. Cardiac progenitor-derived Exosomes protect ischemic myocardium from acute ischemia/reperfusion injury. Biochem Biophys Res Commun. 2013 February 15; 431(3): 566–571. (IF=2.297)
14. Chen L, Ashraf M, Wang Y, Zhou M, Zhang J, Qin G, Rubinstein J, Weintraub NL, Tang Y. The role of notch 1 activation in cardiosphere derived cell differentiation. Stem Cells Dev 2012;21(12):2122-9. (IF=3.727)
15. Zhang L, Pan Y, Qin G, Chen L, Chatterjee TK, Weintraub NL, Tang Y. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle 2014;13(5):762-71. (IF=4.565)
16.Wenbin Lu, Lijuan Chen, YuWang, Yuyu Yao, Cong Fu, Pengfei Zuo, Genshan Ma. Rationale and design of MANJUSRI trial: A randomized, open-label, active-controlled multicenter study to evaluate the safety of combined therapy with ticagrelor and warfarin in AF subjects after PCI-eS. Contemporary Clinical Trials 40 (2015) 166–171. (IF=1.597)
17. Tang YL, Wang YJ, Chen LJ, Pan YH, Zhang L, Weintraub NL. Cardiac-derived stem cell-based therapy for heart failure: progress and clinical applications. Exp Biol Med (Maywood) 2013;238(3):294-300. (IF=2.165)
18. Tang Y, Wang Y, Chen L, Pan Y, Weintraub N. Cross talk between the Notch signaling and noncoding RNA on the fate of stem cells. Prog Mol Biol Transl Sci 2012;111:175-93. (IF=3.488)
19. Yan F, Yao Y, Chen L, Li Y, Sheng Z, Ma G. Hypoxic preconditioning improves survival of cardiac progenitor cells: role of stromal cell derived factor-1alpha-CXCR4 axis. PLoS One 2012;7(7):e37948. (IF=3.234)
20. Jiang YB, Chen LJ, TangYL, Ma GS, Shen CX Qi CM, Zhu Q, Yao YY, Liu NF. HO-1 gene overexpression enha nces the beneficial effects of superparamagnetic iron oxide labeled bone marrow stromal cells transplantation in swine hearts underwent ischemia/reperfusion: an MRI study. Basic Res Cardiol. 2010 May;105(3):431-42. Epub 2009 Dec 24.(IF=5.973)
21. Tang YL, Zhu W, Cheng M, Chen L, Zhang J, Sun T, Kishore R, Phillips MI, Losordo DW, Qin G. Hypoxic preconditioning enhances the benefit of cardiac progenitor-cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ. Res. 2009 ;104:1209-1216.(IF=9.214) (with editorial comment titled “Importance of the SDF-1:CXCR4 axis in myocardial repair”, Penn MS. Circ Res. 2009 104(10):1133-5).
22. Ma GS, Chen LJ, Chen Z, Ding S, Shen CX , Feng,Y. Biocompatibility of TMP-elutingstents in normal porcine coronary arteries. Biomedicine & Pharmacotherapy. 2008;62(2):125-129.
23. 陈立娟，冯毅，丁澍，沈成兴，陈忠，李璇，马根山. 川芎嗪药物涂层支架预防猪冠状动脉再狭窄的实验研究. 中华心血管病杂志. 2008 36(9):843-846
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